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| 1 | Prognostic factors for transarterial chemoembolization combined with sustained oxaliplatin-based hepatic arterial infusion chemotherapy of colorectal cancer liver metastasis显示文摘Objective: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis(CRCLM)patients treated by transarterial chemoembolization(TACE) and sustained hepatic arterial infusion chemotherapy(HAIC).Methods: Between 2006 and 2015, 162 patients who underwent 763 TACE and HAIC in total were enrolled in this retrospective study, including 110 males and 52 females, with a median age of 60(range, 26–83) years.Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analyses.Results: The median survival time(MST) and median progression-free survival(PFS) of the 162 patients from first TACE/HAIC were 15.6 months and 5.5 months respectively. Normal serum carbohydrate antigen 19-9(CA19-9, <37 U/m L)(P<0.001) and carbohydrate antigen 72-4(CA72-4, <6.7 U/m L)(P=0.026), combination with other local treatment(liver radiotherapy or liver radiofrequency ablation)(P=0.034) and response to TACE/HAIC(P<0.001) were significant factors related to survival after TACE/HAIC in univariate analysis. A multivariate analysis revealed that normal serum CA19-9(P<0.001), response to TACE/HAIC(P<0.001) and combination with other local treatment(P=0.001) were independent factors among them.Conclusions: Our findings indicate that serum CA19-9 <37 U/m L and response to TACE/HAIC are significant prognostic indicators for this combined treatment, and treated with other local treatment could reach a considerable survival benefit for CRCLM. This could be useful for making decisions regarding the treatment of CRCLM. | Hangyu Zhang Jianhai Guo Song Gao Pengjun Zhang Hui Chen Xiaodong Wang Xiaoting Li Xu Zhu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 12 |
| 2 | Pristine PN junction toward atomic layer devices显示文摘In semiconductor manufacturing,PN junction is formed by introducing dopants to activate neighboring electron and hole conductance.To avoid structural distortion and failure,it generally requires the foreign dopants localize in the designated micro-areas.This,however,is challenging due to an inevitable interdiffusion process.Here we report a brand-new junction architecture,called'layer PN junction',that might break through such limit and help redefine the semiconductor device architecture.Different from all existing semiconductors,we find that a variety of van der Waals materials are doping themselves from n-to p-type conductance with an increasing/decreasing layer-number.It means the capability of constructing homogeneous PN junctions in monolayers'dimension/precision,with record high rectification-ratio(>10^(5))and low cut-off current(<1 pA).More importantly,it spawns intriguing functionalities,like gate-switchable-rectification and noise-signal decoupled avalanching.Findings disclosed here might open up a path to develop novel nanodevice applications,where the geometrical size becomes the only critical factor in tuning charge-carrier distribution and thus functionality. | Hui Xia Man Luo Wenjing Wang Hailu Wang Tianxin Li Zhen Wang Hangyu Xu Yue Chen Yong Zhou Fang Wang Runzhang Xie Peng Wang Weida Hu Wei Lu | 2022 | Light(Science & Applications)2022，11，7： | 4 |
| 3 | Optimal observation configuration of UAVs based on angle and range measurements and cooperative target tracking in three-dimensional space显示文摘This article investigates the optimal observation configuration of unmanned aerial vehicles(UAVs) based on angle and range measurements, and generalizes predecessors' researches in two dimensions into three dimensions. The relative geometry of the UAVs-target will significantly affect the state estimation performance of the target, the cost function based on the Fisher information matrix(FIM) is used to derive the FIM determinant of UAVs' observation in three-dimensional space, and the optimal observation geometric configuration that maximizes the determinant of the FIM is obtained. It is shown that the optimal observation configuration of the UAVs-target is usually not unique, and the optimal observation configuration is proved for two UAVs and three UAVs in three-dimension. The long-range over-the-horizon target tracking is simulated and analyzed based on the analysis of optimal observation configuration for two UAVs. The simulation results show that the theoretical analysis and control algorithm can effectively improve the positioning accuracy of the target. It can provide a helpful reference for the design of over-the-horizon target localization based on UAVs. | SHI Haoran LU Faxing WANG Hangyu XU Junfei | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 4 |
| 4 | Distinct facets to enhance the process of hydrogen production via methanol steam reforming-a review显示文摘Methanol steam reforming manifests great potential for generating hydrogen owing to its lower reaction temper-ature(200-300°C)and higher hydrogen/carbon ratio comparing with ethanol and methane reforming.In this case,methanol steam reforming is applied in various renewable energy systems to assist the energy conversion and improve the system efficiency.The performance of methanol steam reforming reaction strongly depends on the catalysts and reactor structure.In this paper,the development of the copper-based,the noble metal-based and the nanomaterial catalysts were summarized by analyzing the effects of different modification methods,which indicates that cutting the cost and simplifying the manufacturing process are the future goal of catalyst modifi-cation.Moreover,the reaction mechanism of different catalyst types was discussed.For the reactor performance,conventional,miniature,micro,and membrane reactors were discussed and compared,where conventional reac-tor with high CO tolerance is more suitable for industrial application while membrane reactor with high H 2 purity and compact structure is ideal for fuel cell technology.The integration of the methanol steam reforming system into renewable power systems was reviewed as well.Methanol steam reforming technology is of great potential in exhaust heat recovery,cogeneration system and other renewable energy field,where more comprehensive researches should be performed. | Hangyu Yu Yuanzhi Li Chao Xu Fei Jin Feng Ye Xin Li | 2022 | Energy Storage and Saving2022，1，1： | 1 |
| 5 | Molybdenum oxide nanowires: synthesis & properties显示文摘 | Liqiang Mai Fan Yang Yunlong Zhao Xu Xu Lin Xu Bin Hu Yanzhu Luo Hangyu Liu | 2011 | Materials Today2011，，7： | 1 |
| 6 | Association between epidermal growth factor gene rs4444903 polymorphism and risk of glioma显示文摘 | Mingjun Hu Hangyu Shi Zanfeng Xu Weiping Liu | 2013 | Tumor Biology2013，，3： | 1 |
| 7 | Co‑packaged optics(CPO):status,challenges,and solutions显示文摘Due to the rise of 5G,IoT,AI,and high-performance computing applications,datacenter trafc has grown at a compound annual growth rate of nearly 30%.Furthermore,nearly three-fourths of the datacenter trafc resides within datacenters.The conventional pluggable optics increases at a much slower rate than that of datacenter trafc.The gap between application requirements and the capability of conventional pluggable optics keeps increasing,a trend that is unsustainable.Copackaged optics(CPO)is a disruptive approach to increasing the interconnecting bandwidth density and energy efciency by dramatically shortening the electrical link length through advanced packaging and co-optimization of electronics and photonics.CPO is widely regarded as a promising solution for future datacenter interconnections,and silicon platform is the most promising platform for large-scale integration.Leading international companies(e.g.,Intel,Broadcom and IBM)have heavily investigated in CPO technology,an inter-disciplinary research feld that involves photonic devices,integrated circuits design,packaging,photonic device modeling,electronic-photonic co-simulation,applications,and standardization.This review aims to provide the readers a comprehensive overview of the state-of-the-art progress of CPO in silicon platform,identify the key challenges,and point out the potential solutions,hoping to encourage collaboration between diferent research felds to accelerate the development of CPO technology. | Min Tan Jiang Xu Siyang Liu Junbo Feng Hua Zhang Chaonan Yao Shixi Chen Hangyu Guo Gengshi Han Zhanhao Wen Bao Chen Yu He Xuqiang Zheng Da Ming Yaowen Tu Qiang Fu Nan Qi Dan Li Li Geng Song Wen Fenghe Yang Huimin He Fengman Liu Haiyun Xue Yuhang Wang Ciyuan Qiu Guangcan Mi Yanbo Li Tianhai Chang Mingche Lai Luo Zhang Qinfen Hao Mengyuan Qin | 2023 | Frontiers of Optoelectronics2023，16，1： | 1 |
| 8 | Commonalities and characteristics of aqueous extracts from three Uighur medicines were analyzed by using three-stage infrared spectroscopy combined with ultra-performance liquid chromatography-time of flight-mass spectra显示文摘OBJECTIVE: To establish a method to analyze the commonalities and characteristics of the aqueous extracts from three Uighur medicines.METHODS: In this study, a combination method of three-stage infrared spectroscopy and ultra-performance liquid chromatography-time of flight-mass spectra(UPLC-TOF-MS) method was used to analyze the commonalities and characteristics of the aqueous extracts from Hezi(Fructus Chebulae),Maohezi(Terminalia Belliricae Fructus) and Xiqingguo(Chebulae Fructus Immaturus).RESULTS: In Fourier transform-infrared spectroscopy spectra, all three samples showed the characteristic absorption peaks of tannins similarly. According to UPLC-TOF-MS data analysis, the difference of the position and intensity of the peaks at 1713-1707 cm^(-1) in the three samples were related to the difference in the relative content of tannin and pentacyclic triterpenoids. In second derivative infrared spectroscopy spectra, further analysis of the differences in the infrared spectra of the three samples was performed by increasing the apparent resolution. In combination with UPLC-TOF-MS data, some features infrared absorption peaks were assigned.The absorption peaks at 1032-1030 cm^(-1) assigned to the stretching vibration of C-O-C(ether bond)groups of tannins; 1164-1163, 1063-1062, 1009-1005, 904 cm^(-1) attributed to the stretching vibration of C-O(ether bond) and C-O-C groups of glycosidic compounds. 1385-1383 cm^(-1) attributed to the bending vibration of C-H(alkyl hydrogen) of methoxyl group of pentacyclic triterpenoids. Peak 835 cm^(-1) was assigned to the characteristic absorption peak of bending vibration of = C-H groups of pentacyclic triterpenoids. The two dimensional correlation infrared spectroscopy could further quickly distinguish three samples through the dynamic structural information of their chemical components and discrepancy of auto-peaks and cross-peaks intuitively in the range of 1720-419 cm^(-1).CONCLUSION: By comparing the intensity of the infrared characteristic absorption peaks, the main chemical components were assigned, which significantly enriched and perfected the data analysis of the infrared spectra of three Uighur Medicines. It provided a rationale for the identification of medicinal materials with complex and similar chemical components using the three-stage infrared spectroscopy and UPLC-TOF-MS. | Qu Tiange Zhu Yun Zhang Ke Huang Jian Wang Hangyu Gao Le Liang Xu Chen Long Wang Jinhui Pang Xiaobo Duan Xingwu | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 1 |
| 9 | Configurable circular-polarization-dependent optoelectronic silent state for ultrahigh light ellipticity discrimination显示文摘Filterless light-ellipticity-sensitive optoelectronic response generally has low discrimination,thus severely hindering the development of monolithic polarization detectors.Here,we achieve a breakthrough based on a configurable circular-polarization-dependent optoelectronic silent state created by the superposition of two photoresponses with enantiomerically opposite ellipticity dependences.The zero photocurrent and the significantly suppressed noise of the optoelectronic silent state singularly enhance the circular polarization extinction ratio(CPER)and the sensitivity to light ellipticity perturbation.The CPER of our device approaches infinity by the traditional definition.The newly established CPER taking noise into account is 3-4 orders of magnitude higher than those of ordinary integrated circular polarization detectors,and it remains high in an expanded wavelength range.The noise equivalent light ellipticity difference goes below 0.009° Hz-1/2 at modulation frequencies above 1000 Hz by a light power of 281 uW.This scheme brings a leap in developing monolithic ultracompact circular polarization detectors. | Yonghao Bu Xiansong Ren Jing Zhou Zhenhan Zhang Jie Deng Hangyu Xu Runzhang Xie Tianxin Li Weida Hu Xia Guo Wei Lu Xiaoshuang Chen | 2023 | Light(Science & Applications)2023，12，8： | 0 |
| 10 | Graphene/MoS_(2-x)O_(x)/graphene photomemristor with tunable non-volatile responsivities for neuromorphic vision processing显示文摘Conventional artificial intelligence(Al)machine vision technology,based on the von Neumann architecture,uses separate sensing,computing,and storage units to process huge amounts of vision data generated in sensory terminals.The frequent movement of redundant data between sensors,processors and memory,however,results in high-power consumption and latency.A more efficient approach is to offload some of the memory and computational tasks to sensor elements that can perceive and process the optical signal simultaneously.Here,we proposed a non-volatile photomemristor,in which the reconfigurable responsivity can be modulated by the charge and/or photon flux through it and further stored in the device.The non-volatile photomemristor has a simple two-terminal architecture,in which photoexcited carriers and oxygen-related ions are coupled,leading to a displaced and pinched hysteresis in the current-voltage characteristics.For the frst time,non-volatile photomemristors implement computationally complete logic with photoresponse-stateful operations,for which the same photomemristor serves as both a logic gate and memory,using photoresponse as a physical state variable instead of light,voltage and memresistance.The polarity reversal of photomemristors shows great potential for in-memory sensing and computing with feature extraction and image recognition for neuromorphic vision. | Xiao Fu Tangxin Li Bin Cai Jinshui Miao Gennady NPanin Xinyu Ma jinjin Wang Xiaoyong Jiang Qing Li Yi Dong Chunhui Hao Juyi Sun Hangyu Xu Qixiao Zhao Mengjia Xia Bo Song Fansheng Chen Xiaoshuang Chen Wei Lu Weida Hu | 2023 | Light(Science & Applications)2023，12，2： | 0 |
| 11 | Speed-Grading Mobile Charging Policy in Large-Scale Wireless Rechargeable Sensor Networks显示文摘As the technological breakthrough is made in wireless charging, the wireless rechargeable sensor networks (WRSNs) are finally proposed. In order to reduce the charging completion time, most existing works use the “mobilethen- charge” model—the Wireless charging vehicles (WCV) moves to the charging spot first and then charges nodes nearby. These works often aim to reduce the node’s movement delay or charging delay. However, the charging opportunities during the movement are overlooked in this model because WCV can charge nodes when it goes from one spot to the next. In order to use the charging opportunities, a speed grading method is proposed under the circumstance of variable WCV speed, which transformed the problem of final charging delay into a traveling salesman problem with speed grading. The problem was further solved by linear programming method. The simulation experiments show that, compared with the existing charging methods, the proposed method has a significant improvement in charging delay. | Xianhao Shen Hangyu Xu Kangyong Liu | 2019 | 国际计算机前沿大会会议论文集2019，，1： | 0 |
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