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| 1 | Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells显示文摘Oxaliplatin 是在 colorectal 癌,而是它的毒性的化疗的重要的药,特别剂量相关的 neurosensory 毒性,很好没被容忍。在这研究,我们调查了 honokiol 是否能在 vitro 在结肠癌 HT-29 房间扩充 oxaliplatin 的反肿瘤效果并且 honokiol 是否能与 oxaliplatin 被使用到减少 oxaliplatin 剂量。我们使用了正常冒号房间,人的结肠的上皮的房间(HCoEpiCs ) 作为控制房间。细胞增长, apoptosis,前列腺素 E2 (PGE2 ) 和脉管的 endothelial 生长因素(VEGF ) 层次也被调查。cyclo-oxygenase 的表示层次 2 (COX-2 ) , VEGF, AKT/p-AKT,细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 1/2/p-ERK1/2,原子因素 kappa B (NF-B ) P65/p-P65,和 caspase-3 被测量。Honokiol 或 oxaliplatin 以一种集中依赖者方式,而是 honokiol 的仅仅高的集中压制了 HT-29 房间的增长将压制 HCoEpiCs 的增长。HT-29 房间面对 honokiol 对 oxaliplatin 治疗更敏感。与 honokiol 相结合的 Oxaliplatin 改进了 HT-29 房间的 apoptosis 率并且减少了 PGE2 和 VEGF 分泌物层次。COX-2 和 VEGF 蛋白质和 AKT, ERK1/2,和 NF-B P65 的 phosphorylation 的表示层次也被禁止。Caspase-3 层次是在 honokiol 处理以后的 upregulated。因此, honokiol 能在结肠癌的化疗与 oxaliplatin 在联合被使用。这联合在 oxaliplatin 剂量允许减小,并且从而减少它的不利效果。它可以也为这疾病提高 oxaliplatin 的化学疗法的效果。 | Hanju Hua Wenbin Chen Ling Shen Qinsong Sheng Lisong Teng | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 7 |
| 2 | KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China显示文摘Dear Editor,Natural killer(NK)cells are lymphocytes that play important roles in the host defense against hepatitis C virus(HCV)infection.Killer cell immunoglobulin-like receptors(KIRs)are a group of regulatory molecules expressed on NK cells and a subset of T cells(Parham 2005).Ligands for KIRs are human leukocyte antigen(HLA)class Ⅰ molecules,and HLA-C1 is a ligand for the | Song Hu Fahu Yuan Lingyan Feng Fang Zheng Feili Gong Hanju Huang Binlian Sun | 2018 | Virologica Sinica2018，33，4： | 3 |
| 3 | Human activity recognition based on HMM by improved PSO and event probability sequence显示文摘This paper proposes a hybrid approach for recognizing human activities from trajectories.First,an improved hidden Markov model(HMM) parameter learning algorithm,HMM-PSO,is proposed,which achieves a better balance between the global and local exploitation by the nonlinear update strategy and repulsion operation.Then,the event probability sequence(EPS) which consists of a series of events is computed to describe the unique characteristic of human activities.The analysis on EPS indicates that it is robust to the changes in viewing direction and contributes to improving the recognition rate.Finally,the effectiveness of the proposed approach is evaluated by data experiments on current popular datasets. | Hanju Li Yang Yi Xiaoxing Li Zixin Guo | 2013 | Journal of Systems Engineering and Electronics2013，24，3： | 3 |
| 4 | Design and Control of Proportional-Resonant Controller Based Photovohaic Power Conditioning System 显示文摘 | Hanju Cha Trung-Kien Vu Jae-Eon Kim | 2009 | Energy Conversion Congress and Exposition2009，，： | 1 |
| 5 | Optimization of enzymatic hydrolysis conditions for preparation of gingko peptides from ginkgo nuts显示文摘 | HANJU SUN ZHE CHEN PENG WEN | 2012 | International Journal of Food Engineering2012，8，1： | 1 |
| 6 | Fractionation of polysaccharides from rapeseed by ultrafiltration: Effect of molecular pore size and operation conditions on the membrane performance显示文摘 | Hanju Sun Ding Qi Jiaoyun Xu Shi Juan Chen Zhe | 2011 | Separation and Purification Technology2011，，3： | 1 |
| 7 | A three-phase cur-rent-fed DC/DC converter with a three-leg high frequencytransformer for fuel cells显示文摘 | CHAA Hanju CHOI Jungwan ENJETI P | 2008 | Journal of Power Sources2008，182，1： | 1 |
| 8 | Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat,oxygen and reactive oxygen species for suppressing hypoxic tumors显示文摘Inspired by erythrocytes that contain oxygen-carrying hemoglobin(Hb)and that exhibit photo-driven activity,we introduce homogenous-sized erythrocyte-like Hb microgel(μGel)systems(5-6μm)that can(i)emit heat,(ii)supply oxygen,and(iii)generate reactive oxygen species(ROS;1O2)in response to near-infrared(NIR)laser irradiation.Hb μGels consist of Hb,bovine serum albumin(BSA),chlorin e6(Ce6)and erbium@lutetium upconverting nanoparticles(UCNPs;~35 nm)that effectively convert 808 nm NIR light to 660 nm visible light.These Hb μGels are capable of releasing oxygen to help generate sufficient reactive oxygen species(^(1)O_(2))from UCNPs/Ce6 under severely hypoxic condition upon NIR stimulation for efficient photodynamic activity.Moreover,the Hb μGels emit heat and increase surface temperature due to NIR light absorption by heme(iron protoporphyrin IX)and display photothermal activity.By changing the Hb/UCNP/Ce6 ratio and controlling the amount of NIR laser irradiation,it is possible to formulate bespoke Hb μGels with either photothermal or photodynamic activity or both in the context of combined therapeutic effect.These Hb μGels effectively suppress highly hypoxic 4T1 cell spheroid growth and xenograft mice tumors in vivo. | Hanju Kim Johyun Yoon Hwang Kyung Kim Woo Tak Lee Nguyen Thi Nguyen Xuan Thien Le Eun-Hee Lee Eun Seong Lee Kyung Taek Oh Han-Gon Choi Yu Seok Youn | 2023 | Bioactive Materials2023，，4： | 1 |
| 9 | 显示文摘 | ZhangHongwei(张洪伟) ZuoFengjiang(左凤江) JiaDongmin(贾东民) LiuYan(刘艳) LiuYanmei(刘彦妹) HeWeiping(何伟平) TianHui(田惠) LiuXueling(刘学玲) HanJu(韩菊) SunLingqin(孙令琴) | 2011 | 钻井液和完井液2011，28，1： | 1 |
| 10 | Heat transfer cor- relation for boiling flows in small rectangular horizontal channels with low aspect ratios显示文摘 | LEE Hanju LEE Sangyong | 2001 | Int J Multiphase Flow2001，27，6： | 1 |
| 11 | The protective effect of MT-α-glucan against streptozotocin (STZ)-induced NIT-1 pancreatic β-cell damage显示文摘 | Lei Hong Wang Qin Guo Shuzhen Han Juncheng Sun Hanju Zhang Xiaoxiang Wu Wutong | 2013 | Carbohydrate Polymers2013，，2： | 1 |
| 12 | Excitation energy transport processes of porphyrin monomer, dimer, cyclic trimer, and hexamer probed by ultrafast fluorescence anisotropy secay 显示文摘 | HYUN S C HANJU R JAE K S | 2003 | J Am Chem Soc2003，125，19： | 1 |
| 13 | Purification, chemical compositionand in vitro antioxidant activity of two protein-bound polysac- charides from rapeseed meal 显示文摘 | Sun Hanju | 2009 | Food Science and Biotech- nology2009，18，6： | 1 |
| 14 | Interactive effect of hot air roasting processes on the sensory property,allergenicity,and oil extraction of sesame(Sesamum indicum L.)seeds显示文摘Sesame seeds are a healthy food ingredient and an oil crop for sesame oil production;however,it has recently been recognized as an essential allergenic food by FAO/WHO.This research investigated the relationship between the hot air roasting process(at 120,150,and 180℃ for 10,20,and 30 min)and several quality attributes of sesame seeds since roasting is the key process for preparing sesame seeds for both consumption and oil production.The hot air process followed the central composite design.The changes of sesame in terms of color,sensory properties(odor,texture,color,and taste),allergenicity caused by oleosins(ses i 4 and ses i 5),as well as oil extraction and quality were monitored using a colorimeter,sensory evaluation panelists,ELISA,as well as oil yield and acid value,respectively.Roasting temperature influenced the product quality more than roasting time,although the two processing parameters significantly interacted with each other(P<0.001).Sensory evaluation indicated medium roasting generated attractive flavor,order,appearance,and crispy texture.Allergenicity was high in sesame seeds after high-temperature roasting,according to IgE binding capacity test.Sesame oil extraction was favored by high-temperature roasting,which,however,adversely affected the oil quality.The optimal roasting conditions were 150.5℃ for 15 min for optimized sesame seeds quality in terms of sensory properties and allergenicity,while roasting at 158℃ for 10 min was optimal for sesame oil production.The finding will benefit the sesame seed industry. | Shudong He Tiange Pan Zuoyong Zhang Yanni Wu Hanju Sun Youshui Ma Yi Zhang | 2023 | Grain & Oil Science and Technology2023，6，2： | 0 |
| 15 | Dynamic Control System of Automatic Monitoring Equipment for Waste Gas Pollution Source显示文摘In order to improve the quality of automatic monitoring data of pollution sources and apply the automatic monitoring data to verify the environmental tax,Shandong Province took the lead in adopting the Internet of Things technology and drawing on the successful experience of air automatic monitoring stations and surface water automatic monitoring stations in management,and developed a dynamic management and control system for automatic monitoring equipment of pollution sources to improve and strengthen the quality audit of automatic monitoring data,further improve the quality of automatic monitoring data and better provide a basis for environmental management and decision making.The system realizes the simultaneous monitoring of monitoring data,running state and parameters of the automatic monitoring equipment,eliminates the phenomenon of falsification by modifying equipment parameters,and judges the validity of the collected data by acquiring the working state of the equipment remotely and randomly.After the actual operation test of the Department of Ecological Environment of Shandong Province,the system is proved to have the characteristics of practicality,real time and high efficiency,and be able to make up for low frequency and narrow coverage of manual inspection,with good application prospect in the field of environment and pollution source monitoring. | Yun WU Chengxin PAN Hanju BAO | 2021 | Asian Agricultural Research2021，13，5： | 0 |
| 16 | LNG Development Booms in China显示文摘China's LNG imports were 6.769 million tons from January to September in 2010, 70.95% higher than the same period of 2009.42% was from Australia and 16% from Indonesia.LNG is now becoming a major gas source in China.Meanwhile, China is evolving into an important target market for major LNG producing countries. | Tao Decan Hanju | 2011 | China Oil & Gas2011，18，1： | 0 |
| 17 | Application of Intelligent Power Consumption Management and Control Technology in Enterprise Off-site Enforcement显示文摘Regarding the current difficulties in SME(small and medium enterprise)supervision,especially considering the problem that the emission reduction task cannot be effectively implemented under the off-site daily supervision and the new normal of epidemic prevention with control of heavily polluted weather,a new type of intelligent power management technology has been proposed.Power information collection equipment and intelligent data collection and transmission terminal are installed to collect power consumption information of enterprise production facilities and pollution control facilities,and their operating conditions are monitored in 24 h.Abnormal operation alarm and closed-loop disposal management are provided through the software platform.The practical application of power monitoring technology in Rizhao City proves that the system alarms accurately and monitors efficiently.On the one hand,it has improved the efficiency of daily supervision of the ecological environment department,and can accurately investigate and correct corporate pollution control violations.On the other hand,it has enriched environmental supervision methods to accurately control the implementation of emergency emission reduction measures.The application of this technology has realized the transformation from civil defense to technical defense,from random law enforcement to precise law enforcement,and from on-site law enforcement to off-site law enforcement in the supervision of polluting enterprises in the jurisdiction,creating a new mode of off-site law enforcement for enterprises. | Chengxin PAN Hanju BAO Yun WU Gaihua XU | 2021 | Meteorological and Environmental Research2021，12，3： | 0 |
| 18 | Application of endoscopic mucosal advancement in the treatment of chronic anastomotic leakage:A case report显示文摘Anastomotic leakage is one of the most serious postoperative complications after colorectal surgery.A fistula or chronic sinus formation is one kind of anastomotic leakage.Most fistulas may heal after conservative treatment,but some patients will develop a chronic anastomotic leakage,which definitely requires elective surgery due to the formation of a sinus tract or an internal fistula.This study reports a case of an 88-year-old man with sigmoid colon cancer who developed a chronic anastomotic leakage after colorectal surgery.Endoscopic mucosal advancement combined with titanium clips was success-fully performed to close the fistula.The patient was discharged 12 days after the operation and resumed a normal diet 1 week after discharge.Endoscopic mucosal advancement could be an alternative choice for the treatment of chronic anastomotic leakage and can prevent a secondary surgery;however,good bowel preparation and strict inclusion criteria are required. | Qunmin Wang Feixia Wang Saisai Wang Hanju Hua | 2022 | Laparoscopic, Endoscopic and Robotic Surgery2022，5，3： | 0 |
| 19 | A microwell-based impedance sensor on an insertable microneedle for real-time in vivo cytokine detection显示文摘Impedance-based protein detection sensors for point-of-care diagnostics require quantitative specificity,as well as rapid or real-time operation.Furthermore,microfabrication of these sensors can lead to the formation of factors suitable for in vivo operation.Herein,we present microfabricated needle-shaped microwell impedance sensors for rapid-sample-to-answer,label-free detection of cytokines,and other biomarkers.The microneedle form factor allows sensors to be utilized in transcutaneous or transvascular sensing applications.In vitro,experimental characterization confirmed sensor specificity and sensitivity to multiple proteins of interest.Mechanical characterization demonstrated sufficient microneedle robustness for transcutaneous insertion,as well as preserved sensor function postinsertion.We further utilized these sensors to carry out real-time in vivo quantification of human interleukin 8(hIL8)concentration levels in the blood of transgenic mice that endogenously express hIL8.To assess sensor functionality,hIL8 concentration levels in serum samples from the same mice were quantified by ELISA.Excellent agreement between real-time in vivo sensor readings in blood and subsequent ELISA serum assays was observed over multiple transgenic mice expressing hIL8 concentrations from 62 pg/mL to 539 ng/mL. | Naixin Song Pengfei Xie Wen Shen Hanju Oh Yejia Zhang Flavia Vitale Mehdi Javanmard Mark G.Allen | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
| 20 | Study on Factors Influencing the Quality of Automatic Monitoring Data of Pollution Sources and Technical Assurance Measures显示文摘Automatic monitoring data of pollution sources is an important basis for environmental supervision and management.At present,it is difficult to guarantee the quality of automatic monitoring data of pollution sources,and it is difficult to play the role of the monitoring data.In response to this problem,the factors influencing the quality of automatic monitoring data of pollution sources were analyzed in detail,and technical assurance measures for the quality of automatic monitoring data of pollution sources in Shandong Province were studied.Besides,the dynamic management and control idea of automatic monitoring of pollution sources was proposed,and specific technical measures were analyzed from five aspects of standardizing automatic monitoring equipment of pollution sources,improving the data collection and transmission system,establishing a mechanism for reporting operating status information of monitoring equipment,setting alarm rules and alarm processing procedures,and statistically analyzing the operating status of the equipment.Practice has proved that the dynamic management and control system can effectively ensure the quality of automatic monitoring data of pollution sources. | Hanju BAO Yun WU Chengxin PAN | 2021 | Meteorological and Environmental Research2021，12，6： | 0 |
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