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| 1 | THE PREPARATION OF CROSSLINKED N,O-CARBOXYMETHYL CHITOSAN RESINSAND THEIR ADSORPTION PROPERTIESFOR TRIGLYCERIDE IN SERUM显示文摘Crosslinked N, O-carboxymethyl chitosan resins which can selectively adsorb triglyceride, were prepared by the reaction of N, O- carboxymethyl chitosan with glutaraldehyde solution. Adsorption experiments were performed by adding the resins to the serum. The results showed that this type of adsorbent could cut down the concentration of triglyceride in serum by 56. 4% (3. 35mg/gresin ) at most, while concentration of the total protein (TP ) decreased only by 10. 9% at least, so this novel adsorbent can be used to cure hypertriglyceridemia by hemoperfusion in the future. | Yu Yihau He Binglin(Institute of Polymer Chemistry, The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Nankai University, Tianjin 300071, P. R. China)Gu Hanqing(Tianjin Institute of Urological Surgery) | 1997 | Chinese Journal of Reactive Polymers1997，6，1： | 2 |
| 2 | In-situ growth of flexible 3D hollow tubular Cu_(2)S nanorods on Cu foam for high electrochemical performance supercapacitor显示文摘For pursing high-performance supercapacitors,both of the design strategy and structural characteristic of electrode materials are crucial.Herein,we report the in-situ growth of flexible self-assembled 3D hollow tubular Cu_(2)S nanorods on Cu foam substrate(Cu_(2)S@Cu).The Cu substrate is simultaneously acted as a copper source and a collector,which reduces the contact resistance.Moreover,the highly ordered 3D unique structure increases the redox reactive sites and enhances the ion transmission effectively,resulting in greatly improved electrochemical performance.Based on the Cu_(2)S@Cu electrode,the supercapacitor exhibits high areal capacitance of 1000 mF cm^(-2) at a current density of 2 mA cm^(-2),and great cycle stability,maintaining 96.9% capacitance after 10,000 cycles.Furthermore,the supercapacitor also shows an excellent flexibility with no significant decrease in the twisting or bending state.The capacity retention rates are 99.8% and 86.1%,respectively,and finally recover to 99.3%,confirming its great potential in practical application for portable electronic devices. | Xinrui He Yalin Hu Hanqing Tian Zhipeng Li Pei Huang Jing Jiang Chao Wang | 2020 | Journal of Materiomics2020，6，1： | 2 |
| 3 | Adsorption of bilirubin by amine-containing crosslinked chitosan resins 显示文摘 | Yu Yihua He Binglin Gu Hanqing | 2000 | Aritif Cells Blood Substit Immobil Biotechnol2000，28，4： | 1 |
| 4 | Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis显示文摘Aging-elevated DNMT3A R882H-driven clonal hematopoiesis(CH)is a risk factor for myeloid malignancies remission and overall survival.Although some studies were conducted to investigate this phenomenon,the exact mechanism is still under debate.In this study,we observed that DNMT3 A R878 H bone marrow cells(human allele:DNMT3 A R882 H)displayed enhanced reconstitution capacity in aged bone marrow milieu and upon inflammatory insult.DNMT3 A R878 H protects hematopoietic stem and progenitor cells from the damage induced by chronic inflammation,especially TNFa insults.Mechanistically,we identified that RIPK1-RIPK3-MLKL-mediated necroptosis signaling was compromised in R878 H cells in response to proliferation stress and TNFa insults.Briefly,we elucidated the molecular mechanism driving DNMT3 A R878 H-based clonal hematopoiesis,which raises clinical value for treating DNMT3 A R882 H-driven clonal hematopoiesis and myeloid malignancies with aging. | Min Liao Ruiqing Chen Yang Yang Hanqing He Liqian Xu Yuxuan Jiang Zhenxing Guo Wei He Hong Jiang Jianwei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 5 | Waning Immunity to Measles in Young Adults and Booster Effects of Revaccination in Secondary School Students 显示文摘 | Hanqing He En-fu Chen Qian Li | 2013 | Vaccine2013，31，3： | 1 |
| 6 | Waning immunity to measles in young adults and booster effects of revaccination in secondary school students 显示文摘 | Hanqing He Enfu Chen Qian li | 2013 | Vaccine2013，31，1： | 1 |
| 7 | Waning immunity to measles in young adults and booster effects of revaccination in sec- ondary school students显示文摘 | Hanqing He En-fu Chen Qian Li | 2013 | Vaccine2013，31，3： | 1 |
| 8 | Impact history and origin of lunar meteorite Northwest Africa 15528显示文摘No samples from the Moon’s far side have been returned to Earth.Thus,lunar meteorite study can deepen the understanding of the Moon’s far side(if we can identify which lunar meteorites came from the Moon’s far side).The Northwest Africa(NWA)15528 meteorite is a lunar feldspathic regolith breccia meteorite and we speculated it might originate from the Feldspathic Highlands Terrane(FHT)on the far side of the Moon.Here,we report detailed petrography,major and trace elements,and noble gas(He,Ne,and Ar)isotopes for the clasts and matrix,respectively.The results show that the NWA 15528 lunar meteorite contains diverse clasts,including anorthosite,granulite,basalt,and impact melt clasts.The coarse,wellcrystallized,uniform chemical composition minerals may come from intrusive plutonic rocks.Among the anorthosite clasts,the norite/olivine clasts originate from the deep lunar crust,whereas the other anorthosite clasts are from lunar highlands.The Sm concentrations in NWA 15528 were similar to those in the fourth group of Apollo 16 melt samples,demonstrating that NWA 15528 has a typical plagioclase highland meteorite composition.Compared with the Apollo sample data and remote sensing results,the chemical composition of NWA 15528 indicated strong affinities with the FHT area and ferroan anorthosite(FAN)material from the far side of the Moon.The noble gas isotopic composition of NWA 15528 is consistent with a binary mixture of solar wind and cosmogenic components;during stepwise pyrolytic extractions,we observed that the abundance of cosmogenic components decreased,whereas that of solar wind components increased with increasing temperature.The average cosmic-ray exposure(CRE)age of the matrix and granulite is 42±6 Ma,with a shielding depth in the same range of 10-20 g cm^(−2).The gas retention age of NWA 15528 is 2.14 Ga,and the antiquity age of NWA 15528 is(0.69-0.74)±0.2 Ga(considering 50%40Arm is 40Artrap)which indicates the different clasts of NWA 15528 are assembled after 0.69-0.74 Ga. | Runchuan LIU Huaiyu HE Thomas SMITH Hanqing YE Huapei WANG Xuhang ZHANG Fei SU Ziheng LIU Wei GUO Peng YANG Chuantong ZHANG Dingshuai Xue Ting CAO Jiannan LI Xuelong JIANG Ye HE Chao LU | 2023 | Science China Earth Sciences2023，66，6： | 0 |
| 9 | GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis显示文摘GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis.Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells(HSCs).While,how GSDME-mediated pyroptosis regulates HSCs remains unknown.Here,we show that hematopoietic stem and progenitor cells are capable to undergo pyroptosis in response to cisplatin treatment and GSDME is one of the genes mediating such process.Gsdme^(-/-)mice revealed no difference in the steady state of blood system while Gsdme^(-/-)HSCs exhibited compromised reconstitution capacity due to increased apoptosis.Briefly,this study reveals that GSDME modulates HSC function by coordinating pyroptosis and apoptosis. | Xiuxiu Yang Tingting Cong Hanqing He Jianwei Wang | 2021 | Blood Science2021，3，2： | 0 |
| 10 | UV诱导的RPA1乙酰化促进核苷酸切除修复显示文摘文章简介本研究在国际上首次报道了RPA复合体中的大亚基RPA1能够发生乙酰化修饰。这一研究工作发现,RPA1的163位赖氨酸残基在细胞受到UV损伤后发生乙酰化修饰,该位点在哺乳动物中高度保守。这一修饰在细胞内由GNAT家族的乙酰转移酶GAN5和PCAF协同催化,并由去乙酰化酶HDAC6进行去乙酰化调控。 | Hanqing He Jiajia Wang 刘婷 | 2018 | 科学新闻2018，0，4： | 0 |
| 11 | Quantum light source devices of In(Ga)As semiconductor self-assembled quantum dots显示文摘A brief introduction of semiconductor self-assembled quantum dots (QDs) applied in single-photon sources is given. Single QDs in confined quantum optical microcavity systems are reviewed along with their optical properties and coupling characteristics. Subsequently, the recent progresses in In(Ga)As QDs systems are summarized including the preparation of quantum light sources, multiple methods for embedding single QDs into different microcavities and the scalability of single-photon emitting wavelength. Particularly, several In(Ga)As QD single-photon devices are surveyed including In(Ga)As QDs coupling with nanowires, InAs QDs coupling with distributed Bragg reflection microcavity and the In(Ga)As QDs coupling with micropillar microcavities. Furthermore, applications in the field of single QDs technology are illustrated, such as the entangled photon emission by spontaneous parametric down conversion, the single-photon quantum storage, the chip preparation of single-photon sources as well as the single-photon resonance-fluorescence measurements. | Xiaowu He Yifeng Song Ying Yu Ben Ma Zesheng Chen Xiangjun Shang Haiqiao Ni Baoquan Sun Xiuming Dou Hao Chen Hongyue Hao Tongtong Qi Shushan Huang Hanqing Liu Xiangbin Su Xinliang Su Yujun Shi Zhichuan Niu | 2019 | Journal of Semiconductors2019，40，7： | 0 |
| 12 | Terrestrial carbon cycle model-data fusion:Progress and challenges显示文摘The terrestrial carbon cycle is an important component of global biogeochemical cycling and is closely related to human well-being and sustainable development.However,large uncertainties exist in carbon cycle simulations and observations.Model-data fusion is a powerful technique that combines models and observational data to minimize the uncertainties in terrestrial carbon cycle estimation.In this paper,we comprehensively overview the sources and characteristics of the uncertainties in terrestrial carbon cycle models and observations.We present the mathematical principles of two model-data fusion methods,i.e.,data assimilation and parameter estimation,both of which essentially achieve the optimal fusion of a model with observational data while considering the respective errors in the model and in the observations.Based upon reviewing the progress in carbon cycle models and observation techniques in recent years,we have highlighted the major challenges in terrestrial carbon cycle model-data fusion research,such as the“equifinality”of models,the identifiability of model parameters,the estimation of representativeness errors in surface fluxes and remote sensing observations,the potential role of the posterior probability distribution of parameters obtained from sensitivity analysis in determining the error covariance matrixes of the models,and opportunities that emerge by assimilating new remote sensing observations,such as solar-induced chlorophyll fluorescence.It is also noted that the synthesis of multisource observations into a coherent carbon data assimilation system is by no means an easy task,yet a breakthrough in this bottleneck is a prerequisite for the development of a new generation of global carbon data assimilation systems.This article also highlights the importance of carbon cycle data assimilation systems to generate reliable and physically consistent terrestrial carbon cycle reanalysis data products with high spatial resolution and longterm time series.These products are critical to the accurate estimation of carbon cycles at the global and regional scales and will help future carbon management strategies meet the goals of carbon neutrality. | Xin LI Hanqing MA Youhua RAN Xufeng WANG Gaofeng ZHU Feng LIU Honglin HE Zhen ZHANG Chunlin HUANG | 2021 | Science China Earth Sciences2021，64，10： | 0 |
| 13 | Adaptive connected hierarchical optimization algorithm for minimum energy spacecraft attitude maneuver path planning显示文摘Space object observation requirements and the avoidance of specific attitudes produce pointing constraints that increase the complexity of the attitude maneuver path-planning problem.To deal with this issue,a feasible attitude trajectory generation method is proposed that utilizes a multiresolution technique and local attitude node adjustment to obtain sufficient time and quaternion nodes to satisfy the pointing constraints.These nodes are further used to calculate the continuous attitude trajectory based on quaternion polynomial interpolation and the inverse dynamics method.Then,the characteristic parameters of these nodes are extracted to transform the path-planning problem into a parameter optimization problem aimed at minimizing energy consumption.This problem is solved by an improved hierarchical optimization algorithm,in which an adaptive parameter-tuning mechanism is introduced to improve the performance of the original algorithm.A numerical simulation is performed,and the results confirm the feasibility and effectiveness of the proposed method. | Hanqing He Peng Shi Yushan Zhao | 2023 | Astrodynamics2023，7，2： | 0 |
| 14 | Optimal Energy-Efficient Operation of a Metro Train on a Long and Steep Downhill Segment显示文摘Because the standard four-stage operation and con-trol strategy cannot fully utilize the gravitational potential energy of a train operating on a long and steep downhill segment,this paper further improves the method for train operation and control strategy.The improved operation includes three stages of acceleration,coasting-speed limit cruising,and brak-ing.Taking the speed limit,time limit,and distance limit as the constraints,the coasting condition switching point,braking condition switching point,traction coefficient,and braking force coefficient are used as the decision variables.Then,an improved train traction energy consumption model is constructed,and an improved differential evolution algorithm is designed to solve this model.The improved method is used to simulate two long and steep downhill segments of the Nanning metro.The results show that the improved method can meet the requirements of speed limit,time limit,and distance limit.Compared with the standard four-stage operation,the improved train operation and control strategy can reduce train energy consumption by more than 40%on the two long and steep downhill segments;compared with other similar algorithms,the improved algorithm is more suitable for solving the model. | Deqiang He Hanqing Jian Yanjun Chen Jian Miao Zhixiao Luo Chonghui Ren Lang Zhang | 2023 | CSEE Journal of Power and Energy Systems2023，9，6： | 0 |
| 15 | Inflammation and hematopoietic stem cells aging显示文摘Hematopoietic stem cells(HSCs)replenish all lineages of blood cells throughout the lifespan.During aging,the repopulation capacity of HSCs declined,and aged HSCs display a tendency for myeloid differentiation.Several intrinsic and extrinsic factors have been identified to promote HSCs aging.In this review,we focus on the contribution of aging-associated inflammation in provoking HSCs aging and discuss the future research direction of inflammation and HSC aging. | Hanqing He Jianwei Wang | 2021 | Blood Science2021，3，1： | 0 |
| 16 | ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells显示文摘ALKBH3,a demethylase responsible for demethylating N1-methyladenosine(m^(1)A)in mRNA and N1-methyldeoxyadenosine in single-stranded DNA,plays an important role in DNA repair and cancer cell proliferation.However,its function in hematopoietic stem cells(HSCs)is unknown.In this study,we generated Alkbh3 knockout mice and observed that the deletion of Alkbh3 does not impair the reconstitution capacity of HSCs in both primary and secondary transplantation.Aged hematopoietic stem and progenitor cells exhibit increased expression of ALKBH3.Forced ALKBH3 rescued the differentiation skewing without affecting the reconstitution capacity of aged HSCs.In brief,our study for the first time investigated the functional role of ALKBH3 in hematopoietic system,and observed that ALKBH3 is dispensable for HSCs maintenance and differentiation,but overexpression of ALKBH3 rectified the differentiation skewing of aged HSCs. | Hanqing He Yuqian Wang Jianwei Wang | 2020 | Blood Science2020，2，4： | 0 |
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