3篇
您的检索式：作者名="Hanqing Nan"
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| 1 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studiesonpattern formation in coculturecell systemscan provide insights intomany physiological and pathologicalprocesses Here,we investigate how theextracellular matrix(ECM)may influence the patterning in coculture systems.Themodel coculture system we use is composed of highly motile invasivebreast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“cllective pulling”effect resultingfrom ECM-mediated transmssion of active contractile forces generated bythe polarized migration of the invasive cells along the vertical direction.Themechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangu Ye Yang Jiao Liyu Liu | 2022 | Research2022，，2： | 0 |
| 2 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studies on pattern formation in coculture cell systems can provide insights into many physiological and pathological processes.Here,we investigate how the extracellular matrix(ECM)may influence the patterning in coculture systems.The model coculture system we use is composed of highly motile invasive breast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“collective pulling”effect resulting from ECM-mediated transmission of active contractile forces generated by the polarized migration of the invasive cells along the vertical direction.The mechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangfu Ye Yang Jiao Liyu Liu | 2021 | Research2021，，1： | 0 |
| 3 | Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies显示文摘The increasing production and extensive application of chemicals have led to their unintended release and contamination in the environment,posing a hazardous threat to wildlife and human health.Numerous studies have demonstrated that developmental toxicity could be induced by various emerging chemicals,causing abnormal embryonic and placental development,adverse pregnancy outcomes,obesity,and dysfunction of lipid metabolism in neonates.Given the currently-available experimental technology for developmental toxicological studies,an in vitro model based on stem cells showed promising performance in high-throughput screening of the early-stage developmental toxicity of emerging chemicals.In this review,the deleterious effects of environmental pollutants on stem cells were systemically assorted from the aspects of cytological dysfunction,self-renewal impairment,perturbation in embryoid body(EB)formation,and disruption of committed lineage differentiation.The toxicological data on the molecular level,including the altered expressions of gene and protein biomarkers,epigenomic regulation,and enhanced oxidative stress,were collected and summarized to provide the mechanism explanation for the link between environmental pollutant exposure and unfavorable phenotypes in stem cells.The advantage of the stem cell model in developmental toxicological studies was specifically emphasized.And the perspectives for stem cells were ultimately highlighted in the research field of environmental toxicology,especially developmental toxicology during the early stage of life. | REN Zhihua KU Tingting REN Mengyao LIANG Jiefeng NING Xia XU Hanqing REN Danqin ZHOU Qunfang SANG Nan | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
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