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| 1 | Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation显示文摘ABSTRACTHuman placenta-derived mononuclear cells (MNC) were isolated by a Percoll density gradient and cultured in mesen-chymal stem cell (MSC) maintenance medium. The homogenous layer of adherent cells exhibited a typical fibroblast-like morphology, a large expansive potential, and cell cycle characteristics including a subset of quiescent cells. In vitrodifferentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic, osteogenic andchondrogenic lineages. Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was ahomogeneous cell population devoid of hematopoietic cells, which uniformly expressed CD29, CD44, CD73, CD105,CD166, laminin, fibronectin and vimentin while being negative for expression of CD31, CD34, CD45 and α-smoothmuscle actin. Most importantly, immuno-phenotypic analyses demonstrated that these cells expressed class I majorhistocompatibility complex (MHC-I), but they did not express MHC-II molecules. Additionally these cells could sup-press umbilical cord blood (UCB) lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli. Thisstrongly implies that they may have potential application in allograft transplantation. Since placenta and UCB arehomogeneous, the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells(HSC) from UCB to reduce the potential graft -versus-host disease (GVHD) in recipients. | Chang Dong LI Wei Yuan ZHANG He Lian LI Xiao Xia JIANG Yi ZHANG Pei Hsien TANG Ning MAO | 2005 | Cell Research2005，15，7： | 36 |
| 2 | Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012显示文摘Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31,was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies(RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma(ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma(SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study(Z=17.909,P<0.0001; Z=-6.117,P<0.0001). The RF of ADC increased from 28.72% in 2000-2004,36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas. Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced. | ZOU Xiao Nong LIN Dong Mei WAN Xia CHAO Ann FENG Qin Fu DAI Zhen YANG Gong Huan LV Ning | 2014 | Biomedical and Environmental Sciences2014，27，1： | 19 |
| 3 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 4 | Increased expression of CSP and CYP genes in adult silkworm females exposed to avermectins显示文摘我们分析了 20 化学感应的蛋白质(CSP ) 蚕 Bombyx mori 的基因。我们发现了在 introns 插入的 retrotransposons 的一个高数字。我们然后用量的即时聚合酶链反应(PCR ) 越过纸巾分析了 20 BmorCSP 基因的表示。BmorCSPs 的相对低的表示层次在内脏和胖身体纸巾被发现。我们因此在 BmorCSP 基因表示上测试了 endectocyte 杀虫药剂 abamectin (B1a 和 B1b avermectins ) 的效果。量的即时 PCR 实验证明到杀虫药剂 abamectin 的单个简短暴露戏剧性地不仅在天线而且在大多数纸巾增加了 CSP 表示,包括内脏和胖身体。而且,我们的学习响应杀虫药剂以一种织物依赖者方式显示出 CSP 和新陈代谢的细胞色素 P450 酶的并列表示。CSP 的功能仍然保持未知。基于我们的结果,我们在检测然后被细胞色素 P450 anti-xenobiotic 酶除去的 xenobiotics 建议一个角色。 | Ning Xuan Xia Guo Hong-Yan Xie Qi-Nian Lou Xing-Bo Lu Guo-Xia Liu Jean-Francois Picimbon | 2015 | Insect Science2015，22，2： | 18 |
| 5 | Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing: a Time Series Study显示文摘Objective To investigate the association between ambient air pollution and hospital emergency admissions in Beijing. Methods In this study, a semi-parametric generalized additive model(GAM) was used to evaluate the specific influences of air pollutants(PM10, SO2, and NO2) on hospital emergency admissions with different lag structures from 2009 to 2011, the sex and age specific influences of air pollution and the modifying effect of seasons on air pollution to analyze the possible interaction. Results It was found that a 10 μg/m3 increase in concentration of PM10 at lag 03 day, SO2 and NO2 at lag 0 day were associated with an increase of 0.88%, 0.76%, and 1.82% respectively in overall emergency admissions. A 10 μg/m3 increase in concentration of PM10, SO2 and NO2 at lag 5 day were associated with an increase of 1.39%, 1.56%, and 1.18% respectively in cardiovascular disease emergency admissions. For lag 02, a 10 μg/m3 increase in concentration of PM10, SO2 and NO2 were associated with 1.72%, 1.34%, and 2.57% increases respectively in respiratory disease emergency admissions. Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing. | ZHANG Ying WANG Shi Gong MA Yu Xia SHANG Ke Zheng CHENG Yi Fan LI Xu NING Gui Cai ZHAO Wen Jing LI Nai Rong | 2015 | Biomedical and Environmental Sciences2015，28，5： | 18 |
| 6 | Establishment of hepatocellular carcinoma multidrug resistant monoclone cell line HepG2/mdr1显示文摘multidrug 抵抗(MDR ) 与 mdr1 基因和它的产品 P-glycoprotein 的表示联系了的背景是在癌房间(HCC ) 病人与化疗对待的 hepatocellular 的预后的一个主要因素。我们的学习是建立明确地,与转基因的 mdr1.Methods 的 overexpression 有关, 4.5-kb mdr1 cDNA 从 plasmid pHaMDR1-1 获得了的 multidrug 抵抗的 de novo 获得被克隆进 PCI-neo 哺乳动物的表示向量的一根稳定的 HCC MDR 房间线,后来被 liposome 转移到人的 hepatocarcinoma 房间线 HepG2 。然后,抵抗 G418 的 transfected HepG2 房间被聚类并且有教养并且在这些 HepG2 房间的 mdr1 cDNA, mRNA 和 P-glycoprotein (Pgp ) 的特定的碎片被 PCR, RT-PCR 和流动 cytometry 分别地检测。daunorubicin 的累积同时是由流动 cytometry 的 determinated。grafting 瘤的裸体老鼠模特儿被皮下地在正确腋下注射 HepG2/mdr1 房间建立。当瘤直径到达了 5 公里时, adriamycin 被注入腹洞。瘤的尺寸和生长抑制是 evaluated.Results mdr1 表示向量成功地被构造, MDR HCC 线 HepG2/mdr1 developed.The PCR 分析证明 mdr1 的特定的碎片在 HepG2/mdr1 的 cDNA 房间,然而并非在控制组 HepG2 房间。而且,在 HepG2/mdr1 房间的 mdr1 mRNA 和 Pgp 表示的特定的碎片的内容是(59. | CHEN Yong-bing YAN Mao-lin GONG Jian-ping XIA Ren-pin LIU Li-xin LI Ning LU Shi-chun ZHANG Jing-guang ZENG Dao-bing XIE Jian-guo YANG Jia-yin YAN Lü-nan | 2007 | Chinese Medical Journal2007，，8： | 16 |
| 7 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 8 | Tongqiao Huoxue Decoction ameliorates learning and memory defects in rats with vascular dementia by up-regulating the Ca^(2+)-CaMKII-CREB pathway显示文摘The present study was aimed at determining the effects of Tongqiao Huoxue Decoction(TQHXD) on the Ca2+-Ca MKII-CREB pathway and the memory and learning capacities of rats with vascular dementia(VD). The rat VD model was established by using an improved bilateral carotid artery ligation method. The Morris water maze experiment was used to evaluate the ethology of the VD rats following treatments with TQHXD at 3.01, 6.02, and 12.04 g·kg–1 per day for 31 days. At the end of experiment, the hippocampus were harvested and analyzed. Western blotting and RT-PCR were used to measure the expression levels of calmodulin-binding protein kinase II(Ca MKII), protein kinase A(PKA), c AMP-response element binding protein(CREB), and three N-methyl-D-aspartic acid receptor subunits(NR1, NR2 A, and NR2B). Our results revealed that TQHXD could alleviate the loss of learning abilities and increase the memory capacity(P < 0.05 and P < 0.01 vs the model group, respectively). The treatment with 6.02 and 12.04 g·kg–1 of TQHXD significantly up-regulated the Ca2+-Ca MKII-CREB pathway in the hippocampus. In conclusion, TQHXD showed therapeutic effects on a bilateral carotid artery ligation-induced vascular dementia model, through the up-regulation of calcium signalling pathways. | GE Chao-Liang WANG Xin-Ming HUANG Zhao-Gang XIA Quan WANG Ning XU Du-Juan | 2015 | Chinese Journal of Natural Medicines2015，13，11： | 15 |
| 9 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 10 | Application of community-based and integrated strategy to reduce malaria disease burden in southern Tanzania:the study protocol of China-UK-Tanzania pilot project on malaria control显示文摘Background:During the past six decades,remarkable success on malaria control has been made in China.The major experience could be shared with other malaria endemic countries including Tanzania with high malaria burden.Especially,China’s 1-3-7 model for malaria elimination is one of the most important refined experiences from many years’efforts and key innovation measures for malaria elimination in China.Methods:The China-UK-Tanzania pilot project on malaria control was implemented from April,2015 to June,2018,which was an operational research with two communities receiving the proposed interventions and two comparable communities serving as control sites.The World Health Organization'Test,Treat,Track'(WHO-T3)Initiative,which calls for every suspected case to receive a diagnostic test,every confirmed case to be treated,and for the disease to be tracked,was integrated with Chinese experiences on malaria control and elimination for exploration of a proper model tailored to the local settings.Application of China’s 1-3-7 model integrating with WHO-T3 initiative and local resources aiming at reducing the burden of malaria in terms of morbidity and mortality by 30%in the intervention communities in comparison with that at the baseline survey.Discussion:The China-UK-Tanzania pilot project on malaria control was that at China’s first pilot project on malaria control in Africa,exploring the feasibility of Chinese experiences by China-Africa collaboration,which is expected that the strategies and approaches used in this project could be potential for scaling up in Tanzania and African countries,and contribute to the acceleration of malaria control and elimination in Africa. | Duoquan Wang Prosper Chaki Yeromin Mlacha Tegemeo Gavana Mihayo Gabriel Michael Rashid Khatibu Jun Feng Zheng-Bin Zhou Kang-Ming Lin Shang Xia He Yan Deus Ishengoma Susan Rumisha Sigbert Mkude Renata Mandike Frank Chacky Charles Dismasi Salim Abdulla Honorati Masanja Ning Xiao Xiao-Nong Zhou | 2019 | Infectious Diseases of Poverty2019，8，1： | 12 |
| 11 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 12 | Crosstalk between the Akt/mTORC1 and NF-kB signaling pathways promotes hypoxia-induced pulmonary hypertension by increasing DPP4 expression in PASMCs显示文摘Abnormal wound healing by pulmonary artery smooth muscle cells(PASMCs)promotes vascular remodeling in hypoxia-induced pulmonary hypertension(HPH).Increasing evidence shows that both the mammalian target of rapamycin complex 1(mTORCI)and nuclear factor-kappa B(NF-kB)are Involved in the development of HPH.In this study,we explored the crosstalk between mTORCI and NF-kB in PASMCs cultured under hypoxic condition and in a rat model of hypoxia-induced pulmonary hypertension(HPH).We showed that hypoxia promoted wound healing of PASMCs,which was dose-dependently blocked by the mTORCI inhibitor rapamycin(5-20 nM).In PASMCs,hypoxia activated mTORCI,which in turn promoted the phosphorylation of NF-k B.Molecular docking revealed that mTOR interacted with IkB kinases(IKKs)and that was validated by immunoprecipitation.In vitro kinase assays and mass spectrometry demonstrated that mTOR phosphorylated IKKa and IKKp separately.Inhibition of mTORCI decreased the level of phosphorylated IKKa/p,thus reducing the phosphorylation and transcriptional activity of NF-kB.Bioinformatics study revealed that dipeptidyl peptidase-4(DPP4)was a target gene of NF-kB;DPP4 inhibitor,sitagliptin(10-500 pM)effectively inhibited the abnormal wound healing of PASMCs under hypoxic condition.In the rat model of HPH,we showed that NF-kB activation(at 3 weeks)was preceded by mTOR signaling activation(after 1 or 2 weeks)in lungs,and administration of sitagliptin(1-5 mg/kg every day,ig)produced preventive effects against the development of HPH.In conclusion,hypoxia activates the crosstalk between mTORCI and NF-kB,and increased DPP4 expression in PASMCs that leads to vascular remodeling.Sitagliptin,a DPP4 inhibitor,exerts preventive effect against HPH. | Ying Li Li Yang Liang Dong Zhi-wei Yang Jing Zhang Sheng-li Zhang Meng-jie Niu Jing-wen Xia Yi Gong Ning Zhu Xiu-juan Zhang Yuan-yuan Zhang Xiao-min Wei You-zhi Zhang Peng Zhang Sheng-qing Li | 2019 | Acta Pharmacologica Sinica2019，40，10： | 10 |
| 13 | Evaluation of serum and pleural levels of endostatin and vascular epithelial growth factor in lung cancer patients with pleural effusion显示文摘Objective:To evaluate the diagnostic value of endostatin(ES),vascular endothelial growth factor (VEGF) and careinoembryonie antigen(CEA) in both serum and pleural effusion of lung cancer patients.Methods:Levels of ES,VEGF and CEA in 52 malignant pleural effusion due to lung cancer and 50 patients with non-malignant disease were measured by using sandwich enzymelinked immunosorbent assay and microparticle enzyme immunoassay.Results:The ES.VEGF and CEA levels in pleural effusion and serum,and their ratio(F/S) were higher in lung cancer group than that in benign group,and the differences were statistically significant(P<0.05).The diagnostic efficiency of ES+VEGF for lung cancer was superior to either single detection.The diagnostic efficiency of ES+VEGK+CEA was superior to either ES+VEGF or ES+CEA.Conclusions: The results suggest that ES,VEGF and CEA might be useful in the differentiation between benign and malignant pleural effusion due to lung cancer.In comparison with either single determination of concentration in serum or pleural fluid,the couiljined detection of two or three markers is of important clinical significance in the diagnosis of lung cancer. | Yu Zhang Li-Ke Yu Ning Xia | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，3： | 10 |
| 14 | MicroRNA Expression Signature in Gastric Cancer显示文摘Objective:To identify the miRNA specific signature as novel diagnostic and prognostic tools for gastric cancer. Methods:miRNAs expression profiling of 3 normal gastric tissues,24 malignant tissues,gastric cancer cell SGC7901 and normal gastric cell GES-1 were detected using microarray technology. The hierarchical clustering algorithm of the Cluster software was used to analyse the miRNAs expression of all samples. The expression levels of miR-433 and miR-9 which were significantly down-regulated in gastric cancer tissues and SGC7901 cells by microarray technology were validated by quantitative Real-time PCR(qRT-PCR). Results:Differential expressions of 26 individual miRNAs between normal samples(including 3 normal gastric tissues and GES-1 cells) and carcinomas(including 24 malignant tissues and SGC7901 cells) were discovered,19 of them showing down-regulation and 7 up-regulation in carcinoma samples. Hierarchical clustering of the cancer samples by their miRNA expression accurately separated the carcinomas from normal samples and further their histotypes of carcinomas. The expression levels of miR-433 and miR-9 were significantly down-regulated in gastric cancer tissues and SGC7901cells Conclusion:The differential expression of miR-433 and miR-9 may be used as a novel diagnostic tool for gastric cancer. | Hong-chun Luo Zhen-zhen Zhang Xia Zhang Bo Ning Jin-jun Guo Na Niel Bo Liu Xiao-ling Wu | 2009 | Chinese Journal of Cancer Research2009，21，1： | 9 |
| 15 | All-in-one cellulose based hybrid tribo/piezoelectric nanogenerator显示文摘Aybrid tribo/piezoelectric nanogenerators (HTPENG) have been proven to be highly efficient and versatile as far as the collection and conversion of ambient energy are concerned, and the introduction of flexible and green materials is a key step for their potential applications. Here, we developed a HTPENG by using nitrocellulose nanofibril paper as the triboelectric layer and BaTiCVMWCNT@ bacterial cellulose paper as the piezoelectric layer. The output of the triboelelctric paper has considerable performance as fluorinated ethylene propylene, and the output of piezoelectric paper is more than ten times higher than the BTO/polydimethylsiloxane structure. The integrated outputs of the sandwich structured HTPENG are 18 V and 1.6 pA·cm^-2, which are capable of lighting up three LED bulbs and charging a 1 pF capacitor to 2.5 V in 80 s. In addition, the voltage signal generated by the HTPENG in contact-separation mode can be used for dynamic pressure detection. The linear range of dynamic pressure is from 0.5 to 3 N·cm^-2 with a high sensitivity of 8.276 V·cm^-2·N^-1 and a detection limit of 0.2 N·cm^-2. This work provides new insights into the design and application of cellulose-based hybrid nanogenerators with high flexibility and simple structure. | Ming Li Yang Jie Li-Hua Shao Yilin Guo Xia Cao Ning Wang Zhong Lin Wang | 2019 | Nano Research2019，12，8： | 9 |
| 16 | Mechanism of pulse magneto-oscillation grain refinement on pure Al显示文摘Pulse magneto-oscillation (PMO) was developed as a novel technique to refine the solidification structure of pure aluminium.Its grain refining mechanism was proposed.The PMO refinement mechanism is that the nucleus falls off from the mould wall and drifts into the melt under the action of PMO.The solidification structure of Al melt depends on the linear electric current density,and also the discharge and oscillation frequencies.The radial pressure of PMO sound wave is the major factor that contributes to the migration of nucleus into the melt. | Pei Ning Gong Yongyong Li Renxing Xia Zanqi Zhai Qijie | 2011 | China Foundry2011，8，1： | 8 |
| 17 | Serological prevalence and risk factor analysis of hepatitis G virus infection in Hubei Province of China显示文摘INTRODUCTIONHepatitis G virus(HGV),also known as GB virus C,is arecently cloned virus which may be associated with humannon A-E hepatitis.It is parenterally transmitted andusually coinfected or superinfected with hepatitis B orhepatitis C virus.Some investigations have | De Ying Tian Dao Feng Yang Ning Shao Xia Zheng Gang Zhang Hong Bo Lei Yuan Cheng Huang | 2000 | World Journal of Gastroenterology2000，6，4： | 8 |
| 18 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 19 | Ages, Trace Elements and Hf-Isotopic Compositions of Zircons from Claystones around the Permian-Triassic Boundary in the Zunyi Section, South China: Implications for Nature and Tectonic Setting of the Volcanism显示文摘证据的成长身体证明二叠三叠纪的边界(PTB ) 附近的那个火山作用可能在触发 PermianTriassic (PTr ) 是关键的集体扑灭。因此,在华南的 PTB 附近的灰床可以在这个事件上带信息。三暴烈的灰层,改变了到泥土,在在 Zunyi 节的 PTB 床上的 outcropped,贵州省,西南中国。从这三张灰床的锆石谷物的 U-Pb 年龄,踪迹元素,和 Hf 同位素作文用 LA-ICPMS 和 LA-MC-ICPMS 被分析。锆石主要除了二 inherited/xenocrystic 锆石(939 和 2 325 妈) 是在起源(241-279 妈) 的 magmatic。这些 magmatic 锆石的年龄显示发生在中间附近的 magmatism 的三个事件 -- 晚二叠的边界(~ 261.5 妈, MLPB ) , Wuchiapingian-Changhsingian 边界(~ 254.5 妈, WCB ) ,并且 PTB (~ 250.5 妈) 分别地。MLPB 和 WCB 附近的 magmatism 的开始的二个事件可以被归因于 magmatic 继承或重新免职。所有 magmatic 锆石分享类似的踪迹元素和 Hf 同位素作文。他们有 Y, Hf, Th 和 U 内容和 Nb/Ta 比率典型地代表从硅的计算碱的岩浆的锆石。这些锆石也与 -11.4 的 Hf (t) 价值展出充实的 Hf 同位素作文到 +0.2,它建议三个 magmatic 事件涉及大陆人外壳融化。更多的充实的 Hf 同位素作文(床 ZY13 的 Hf (t)=-11.4--4.8)(~ 250.5 妈) 在岩浆暗示古老的外壳的材料的更多的输入。magmatic 锆石的 Hf 同位素和踪迹元素作文的集成建议 magmatism 的这三个事件可以由于 Palaeo-Tethys 海洋的闭合沿着会聚的大陆边缘发生在或在西南的华南附近。 | Qiuling Gao Zhong-Qiang Chen Ning Zhang William L.Griffin Wenchen Xia Guoqing Wang Tengfei Jiang Xuefei Xia Suzanne Y.O'Reilly | 2015 | Journal of Earth Science2015，26，6： | 8 |
| 20 | MicroRNA396-mediated alteration in plant development and salinity stress response in creeping bentgrass显示文摘The conserved microRNA396(miR396)is involved in plant growth,development,and abiotic stress response in multiple plant species through regulating its targets,Growth Regulating Factor(GRF)transcription factor genes.However,the role of miR396 has not yet been characterized in perennial monocot species.In addition,the molecular mechanism of miR396-mediated abiotic stress response remains unclear.To elucidate the role of miR396 in perennial monocot species,we generated transgenic creeping bentgrass(Agrostis stolonifera)overexpressing Osa-miR396c,a rice miRNA396 gene.Transgenic plants exhibited altered development,including less shoot and root biomass,shorter internodes,smaller leaf area,fewer leaf veins,and epidermis cells per unit area than those of WT controls.In addition,transgenics showed enhanced salt tolerance associated with improved water retention,increased chlorophyll content,cell membrane integrity,and Na^(+)exclusion during high salinity exposure.Four potential targets of miR396 were identified in creeping bentgrass and up-regulated in response to salt stress.RNA-seq analysis indicates that miR396-mediated salt stress tolerance requires the coordination of stress-related functional proteins(antioxidant enzymes and Na+/H+antiporter)and regulatory proteins(transcription factors and protein kinases).This study establishes a miR396-associated molecular pathway to connect the upstream regulatory and downstream functional elements,and provides insight into the miRNA-mediated regulatory networks. | Shuangrong Yuan Junming Zhao Zhigang Li Qian Hu Ning Yuan Man Zhou Xiaoxia Xia Rooksie Noorai Christopher Saski Shigui Li Hong Luo | 2019 | Horticulture Research2019，6，1： | 8 |
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