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| 1 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studiesonpattern formation in coculturecell systemscan provide insights intomany physiological and pathologicalprocesses Here,we investigate how theextracellular matrix(ECM)may influence the patterning in coculture systems.Themodel coculture system we use is composed of highly motile invasivebreast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“cllective pulling”effect resultingfrom ECM-mediated transmssion of active contractile forces generated bythe polarized migration of the invasive cells along the vertical direction.Themechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangu Ye Yang Jiao Liyu Liu | 2022 | Research2022，，2： | 0 |
| 2 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studies on pattern formation in coculture cell systems can provide insights into many physiological and pathological processes.Here,we investigate how the extracellular matrix(ECM)may influence the patterning in coculture systems.The model coculture system we use is composed of highly motile invasive breast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“collective pulling”effect resulting from ECM-mediated transmission of active contractile forces generated by the polarized migration of the invasive cells along the vertical direction.The mechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangfu Ye Yang Jiao Liyu Liu | 2021 | Research2021，，1： | 0 |
| 3 | Mouse model for pangolin-origin coronavirus GX/P2V/2017 infection and cross-protection from COVID-19 ZF2001 subunit vaccine显示文摘Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available vaccines are effective against these coronaviruses.Here,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine ZF2001.We found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in mice.These results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development. | Xiao Qu Yunfei Jia Na Jia Huahao Fan Anqi Zheng Luoyuan Xia Zhenfei Wang Di Tian Sheng Niu Yu Hu Wenxia Tian Zhihai Chen Yigang Tong Yuwei Gao Wuchun Cao Qihui Wang George Fu Gao | 2023 | hLife2023，1，1： | 0 |
| 4 | Collective cell behaviors manipulated by synthetic DNA nanostructures显示文摘Cellular collective motion in confluent epithelial monolayers is involved in many processes such as embryo development,carcinoma invasion,and wound healing.The development of new chemical strategies to achieve largescale control of cells’collective motion is essential for biomedical applications.Here a series of DNA nanostructures with different dimensions were synthesized and their influences on cells’collective migration and packing behaviors in epithelial monolayers were investigated.We found that the framed DNA nanoassemblies effectively reduced the cells’speed by increasing the rigidity of cells,while the lipid-DNA micelles had a more pronounced effect on cells’projection area and shape factor.These DNA nanostructures all significantly enhanced the dependence of cells’speed on their shape factor.Our results indicate that cells’mobility in monolayers can be manipulated by chemical intercellular interactions without any genetic intervention.This may provide a new chemical strategy for tissue engineering and tumor therapy. | Xiaochen Wang Xiwen Xing Shuang Lu Guangle Du Yi Zhang Yubin RenYulong Sun Jing Sun Qihui Fan Kai Liu Fan Wang Fangfu Ye | 2023 | Fundamental Research2023，3，5： | 0 |
| 5 | Adsorptive carbon-based materials for biomedical applications显示文摘Adsorption or enrichment has been an indispensable and important measure in biomedical engineering since it is promising in diagnosis and treatment of complex diseases.The ongoing development in this arena starves for exploration of outstanding adsorptive materials.As an excellent candidate for adsorption or enrichment carriers,carbon-based material has demonstrated unique superiority in biomedical arena owing to its integrated charac-teristics.Herein,we review the lasted advance in adsorptive carbon-based materials for biomedical application with emphasis on carbon nanotubes(CNTs)-based,graphene-based,and biomass/polymer-based ones.We begin with the classification of different carbon-based materials and elaborate the respective preparation approaches that are utilized to realize optimized microstructure and physicochemical property.Afterwards,we introduce the different applications of carbon-based materials in biomedical arena,including blood purification,enrichment of glycopeptide and phosphopeptide,and breath analysis.Finally,we present a concise summary and give an outlook of this arena. | Xiaomin Ye Qihui Fan Luoran Shang Fangfu Ye | 2022 | Engineered Regeneration2022，3，4： | 0 |
| 6 | Small bandgap non-fullerene acceptor enables efficient PTB7-Th solar cell with near 0 eV HOMO offset显示文摘Three small bandgap non-fullerene(SBG NFAs) acceptors,BDTI,BDTI-2 F and BDTI-4 F,based on a carbon-oxygen bridged central core and thieno[3,4-b]thiophene linker,end-capped with varied electronwithdrawing terminal groups,were designed and synthesized.The acceptors exhibit strong absorption from 600 nm to 1000 nm.The optimal device incorporating designed NFA and PTB7-Th polymer donor achieves a power conversion efficiency of 9.11% with near 0 eV HOMO offset.The work presents a case study of efficient non-fullerene solar cells with small HOMO offsets,which is achieved by blending PTB7-Th with fine-tuned SBG acceptor. | Chao Li Qihui Yue Hao Wu Baolin Li Haijun Fan Xiaozhang Zhu | 2021 | Journal of Energy Chemistry2021，30，1： | 0 |
| 7 | EFFICIENT CYCLIC PREFIX RECONSTRUCTION USING DECISION FEEDBACK FILTER FOR CODED SINGLE-CARRIER SYSTEMS WITH FREQUENCY-DOMAIN EQUALIZATION (SC-FDE)显示文摘In this paper,an efficient Cyclic Prefix (CP) reconstruction scheme is proposed for Sin-gle-Carrier systems with Frequency-Domain Equalization (SC-FDE) that employ insufficient length of CP at the transmitter. By utilizing a decision feedback filter to cancel the residual InterSymbol In-terference (ISI) in the equalized signal,the proposed scheme can effectively lower the low bound of performance for the CP reconstruction schemes and can greatly improve the Bit Error Rate (BER) performance of SC-FDE systems. In addition,the existing methods and the proposed scheme are also optimized. It is shown in the simulation results that,when the Signal-to-Noise Ratio (SNR) exceeds a certain threshold,the proposed scheme can achieve the low bound of performance for the existing methods. Moreover,by increasing the number of iteration or through optimization,the low bound can be outperformed. | Wei Shengqun Wu Qihui Wang Jinlong Wang Fan | 2007 | Journal of Electronics(China)2007，24，1： | 0 |
| 8 | Eliminating Explicit Contention from Channel Access in Distributed Wireless Networks显示文摘Emerging techniques such as WiFi direct makes the objective of always-on be true. People can easily chat and share files with nearby friends even without AP(Access Point) or cellular coverage. In this paper, we focus on the channel efficiency issue of APfree Wi-Fi networks, which can be easily constructed in the subway, in a high-speed railway, or when camping in the wild. Today IEEE 802.11 DCF is the most commonly used MAC protocol for Wi-Fi networks, however, due to the control messages and backoff time, channel efficiency in high data rate networks can be extremely low. To solve this, we propose CD-MAC, which allows control messages to be transmitted with data packets concurrently, and thus eliminates the overheads of backoff and explicit contention. To maintain the reception reliability, we redesign the control messages and use signal detection in PHY instead of bits decoding to detect them. In MAC layer, CD-MAC is built upon our Correlation Detection based PHY. We have implemented and evaluated CD-MAC using USRP N210. Evaluation results show that CD-MAC can achieve over 95.5% channel efficiency and provide throughput gains of up to 80%, 60%, and 29.1% compared with DCF, 802.11 ec, and back2F, respectively. | Aijing Li Chao Dong Fan Wu Shaojie Tang Guihai Chen Qihui Wu | 2019 | China Communications2019，16，5： | 0 |
| 9 | Construction and application of liver cancer models in vitro显示文摘Primary liver cancer is the fifth most common malignancy and the third leading cause of cancer death worldwide.Although current advances in the treatment of liver cancer,the prognosis of this cancer remains unfavorable.Appropriate liver cancer model in vitro is an important way to study the pathogenesis and drug screening of liver cancer.This review provides a comprehensive summary and discussion on the construction and application of liver cancer models in vitro,in particular hepatocellular carcinoma(HCC).Specifically,after introducing the current methods or techniques for preparing 3D in vitro liver cancer models,this review summarizes the relevant applications of these liver cancer models in vitro,e.g.drug screening,personalized medicine,and other applications.In the end,this review discusses the advantages and disadvantages of the liver cancer models in vitro,and proposes future prospects and research directions. | Changmin Shao Qingfei Zhang Gaizhen Kuang Qihui Fan Fangfu Ye | 2022 | Engineered Regeneration2022，3，3： | 0 |
| 10 | Uncovering potential distinctive acoustic features of healing music显示文摘S Background Music therapy is a promising complementary intervention for addressing various mental health conditions.Despite evidence of the beneficial effects of music,the acoustic features that make music effective in therapeutic contexts remain elusive.Aims This study aimed to identify and validate distinctive acoustic features of healing music.Methods We constructed a healing music dataset(HMD)based on nominations from related professionals and extracted 370 acoustic features.Healing-distinctive acoustic features were identified as those that were(1)independent from genre within the HMD,(2)significantly different from music pieces in a classical music dataset(CMD)and(3)similar to pieces in a five-element music dataset(FEMD).We validated the identified features by comparing jazz pieces in the HMD with a jazz music dataset(JMD).We also examined the emotional properties of the features in a Chinese affective music system(CAMS).Results The HMD comprised 165 pieces.Among all the acoustic features,74.59%shared commonalities across genres,and 26.22%significantly differed between the HMD classical pieces and the CMD.The equivalence test showed that the HMD and FEMD did not differ significantly in 9.46%of the features.The potential healing-distinctive acoustic features were identified as the standard deviation of the roughness,mean and period entropy of the third coefficient of the mel-frequency cepstral coefficients.In a three-dimensional space defined by these features,HMD's jazz pieces could be distinguished from those of the JMD.These three features could significantly predict both subjective valence and arousal ratings in the CAMS.Conclusions The distinctive acoustic features of healing music that have been identified and validated in this study have implications for the development of artificial intelligence models for identifying therapeutic music,particularly in contexts where access to professional expertise may be limited.This study contributes to the growing body of research exploring the potential of digital technologies for healthcare interventions. | Yue Ding Jiaqi Jing Qihui Guo Jiajia Zhou Xinyao Cheng Xiaoya Chen Lihui Wang Yingying Tang Qing Fan | 2023 | General Psychiatry2023，36，6： | 0 |
| 11 | Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection Recapitulation显示文摘SARS-CoV-2 has caused asevere pneumoniapandemic worldwide with high morbidity and mortality.Howto developa preclinical model for recapitulating SARS-CoV-2 pathogenesis is stil urgent and essential for the control of the pandemic.Here,we have established a 3D biomimetic alveolus-on-a-chip with mechanical strain and extracellular matrix taken into consideration.We have validated that the alveolus-on-a-chip is capable of recapitulating key physiological characteristics of human alveolar units,which lays a fundamental basis for viral infection studies at the organ level.Using virus-analogous chemicals and pseudovirus,we have explored virus pathogenesis and blocking ability of antibodies during viral infection.This work provides a favorable platform for SARS-Cov-2-related researches and has a great potential for physiology and pathophysiology studies of the human lung at the organ level in vitro. | Ting Cao Changmin Shao Xiaoyu Yu Ruipei Xie Chen Yang Yulong Sun Shaohua Yang Wangjian He Ye Xu Qihui Fan Fangfu Ye | 2022 | Research2022，，2： | 0 |
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