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| 1 | Clinical characteristics and outcomes of Chinese patients with KRAS-mutant non-small cell lung cancer after chemotherapy显示文摘Dear Editor,The RAS gene is one of the most frequent oncogenes in human cancers,with significantly different mutation frequencies.The RAS family contains three isoforms:KRAS,HRAS and NRAS,with the KRAS mutations being more common than the other two.The KRAS mutation rate varies in non-small cell lung cancer(NSCLC)patients of different races:27%in Caucasians[1]and approximately 10%in Asians[2,3].Recently,the U.S.Food and Drug Administration(FDA)approved sotorasib(AMG510)and adagrasib(MRTX849)for the treatment of metastatic NSCLC harboring KRAS G12C mutations.In the face of novel treatment choices for KRAS-mutated NSCLC,it is indispensable to learn more about the systemic treatment of these patients.Clinical studies have shown that Caucasian patients with KRAS-mutated NSCLC had poor outcomes following first-line chemotherapy[4,5].However,studies on treatment outcomes of Asian patients with KRAS-mutated NSCLC are lacking.As the overwhelming majority of cases are diagnosed with lung adenocarcinoma,the standard first-line treatment for metastatic disease is pemetrexed-based doublet chemotherapy in combination with bevacizumab and/or immunotherapy in China.Herein,we investigated the clinical characteristics of KRAS mutation subtypes,co-occurring genomic alterations,and efficacy of first-line pemetrexed-platinum chemotherapy in Chinese KRAS-mutated NSCLC patients. | Yawen Zheng Qinghua Lai Hanxi Zhao Xiaolin Li Xiaorong Sun Ligang Xing | 2021 | Cancer Communications2021，41，11： | 4 |
| 2 | One Step Ball-Milling Synthesis of LiFePO_ 4 Nanoparticles as the Cathode Material of Li-Ion Batteries显示文摘A one-step synthetic method was used to synthesize Olivline LiFePO_ 4 powders by direct ball milling the stoichiometric mixture of Fe, Li_ 3 PO_ 4 , and FePO_ 4 powders. XRD and TEM measurements revealed that the as-prepared LiFePO_ 4 powder have a homogeneous Olivine structure and a uniform size distribution of ca.50 nm. Based on this material, a LiFePO_ 4 /C composite was prepared and used for the cathode material of Li-ion batteries. The charge-discharge experiments demonstrated that the LiFePO_ 4 /C composite material has a high capacity of 132 mAh/g at 0.1 C and a quite high-rate capability of 95 mAh/g at 1 C. This new ball-milling method may provide a completely green synthetic route for preparing the materials of this type cost-effectively and in large volume. | AI Xinping LI Hai LI Xiaoyan LIAO Qinli LIU Bingdong YANG Hanxi | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 3 |
| 3 | A polyethylene microsphere-coated separator with rapid thermal shutdown function for lithium-ion batteries显示文摘Thermal runaway is the main factor contributing to the unsafe behaviors of lithium-ion batteries(LIBs)in practical applications.The application of separators for the thermal shutdown has been proven as an effective approach to protecting LIBs from thermal runaway.In this work,we developed a thermal shutdown separator by coating a thin layer of low-density polyethylene microspheres(PM)onto a commercial porous polypropylene(PP)membrane and investigated the thermal response behaviors of the as-prepared PM/PP separator in LIBs.The structural and thermal analysis results revealed that the coated PM layer had a porous structure,which facilitated the occurrence of normal charge-discharge reactions at ambient temperature,although it could melt completely and fuse together within very short time periods:3 s at 110℃and 1 s at 120℃,to block off the pores of the PP substrate,thereby cutting off the ion transportation between the electrodes and interrupting the battery reaction.Consequently,the PM/PP separator exhibits very similar electrochemical performance to that of a conventional separator at ambient temperature.However,it performs a rapid thermal shutdown at an elevated temperature of^110℃,thus controlling the temperature rise and maintaining the cell in a safe status.Due to its synthetic simplicity and low cost,this separator shows promise for possible application in building safe LIBs. | Chongrong Zhang Hui Li Shixuan Wang Yuliang Cao Hanxi Yang Xinping Ai Faping Zhong | 2020 | Journal of Energy Chemistry2020，29，5： | 2 |
| 4 | Boosting Through Optimization of Margin Distributions显示文摘 | Shen Chunhua Li Hanxi | | 0，，04： | 1 |
| 5 | The gut microbiome and metabolome of Himalayan Griffons(Gyps himalayensis):insights into the adaptation to carrion-feeding habits in avian scavengers显示文摘Background:Himalayan Griffons(Gyps himalayensis),large scavenging raptors widely distributed in Qinghai-Tibetan Plateau,have evolved a remarkable ability to feed on carcasses without suffering any adverse effects.The gut microbiome plays an important role in animal physiological and pathological processes,and has also been found to play a health protective role in the vulture adaptation to scavenging.However,the microbial taxonomic diversity(including nonculturable and culturable microbes),functions,and metabolites related to Himalayan Griffons have not been fully explored.Methods:In the present study,the 28 fecal samples of the Himalayan Griffons and 8 carrion samples were collected and sequenced using high-throughput 16 S rRNA gene sequencing methods to analyze the composition and functional structures of the microbiomes.Twelve fecal samples of the Himalayan Griffons were analyzed using untargeted Liquid Chromatography Mass Spectroscopy(LC-MS)to identify metabolites.We used different culture conditions to grow Himalayan Griffons gut microbes.Inhibitory effects of gut beneficial bacteria on 5 common pathogenic bacteria were also tested using the Oxford cup method.Results:According to the results of the culture-independent method,a high abundance of four major phyla in Himalayan Griffons were identified,including Fusobacteria,Firmicutes,Bacteroidetes,and Proteobacteria.The most abundant genera were Fusobacterium,followed by Clostridium_sensu_stricto_1,Cetobacterium,Epulopiscium,and Bacteroides.The predicted primary functional categories of the Himalayan Griffons'gut microbiome were associated with carbohydrate and amino acid metabolism,replication and repair,and membrane transport.LC-MS metabolomic analysis showed a total of 154 metabolites in all the fecal samples.Cultivation yielded 184 bacterial isolates with Escherichia coli,Enterococcus faecium,Enterococcus hirae,and Paeniclostridium sordellii as most common isolates.Moreover,7 potential beneficial gut bacteria isolated showed certain inhibition to 5 common pathogenic bacteria.Conclusions:Our findings broaden and deepen the understanding of Himalayan Griffons'gut microbiome,and highlighted the importance of gut microbiome-mediated adaptation to scavenging habits.In particular,our results highlighted the protective role of gut beneficial bacteria in the Himalayan Griffons against pathogenic bacteria that appear in rotten food resources. | Wen Wang Xiaolong Gao Sisi Zheng Zhuoma Lancuo Ying Li Lilin Zhu Jianping Hou Jiayi Hai Xin Long Hanxi Chen Alexey Druzyaka Kirill Sharshov | 2021 | Avian Research2021，12，4： | 1 |
| 6 | Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy显示文摘The clinical outcomes of cancer nanovaccine have been largely impeded owing to the low antigen-specific T cell response rate and acquired resistance caused by the immunosuppressive tumor microenvironment(TME).Here,we reported a tumor acidity-responsive nanovaccine to remodel the immunosuppressive TME and expand the recruitment of tumor infiltrating lymphocytes(TILs)using hybrid micelles(HM),which encapsulated colony stimulating factor 1 receptor(CSF1-R)inhibitor BLZ-945 and indoleamine 2,3-dioxygenase(IDO)inhibitor NLG-919 in its core and displayed a model antigen ovalbumin(OVA)on its surface(denoted as BN@HM-OVA).The bioactive nanovaccine is coated with a polyethylene glycol(PEG)shell for extending nanoparticle circulation.The shell can be shed in response to the weakly acidic tumor microenvironment.The decrease in size and the increase in positive charge may cause the deep tumor penetration of drugs.We demonstrated that the bioactive nanovaccine dramatically enhance antigen presentation by dendritic cells(DCs)and drugs transportation into M1-like tumor-associated macrophages(TAMs)and tumor cells via size reduction and increasing positive charge caused by the weakly acidic TME.Such bioactive nanovaccine could remodel the immunosuppressive TME into an effector T cells favorable environment,leading to tumor growth inhibition in prophylactic and therapeutic E.G7-OVA tumor models.Furthermore,combining the bioactive nanovaccine with simultaneous anti-PD-1 antibody treatment leads to a long-term tumor inhibition,based on the optimal timing and sequence of PD-1 blockade against T cell receptor.This research provides a new strategy for the development of efficient cancer immunotherapy. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 7 | Real-time visual track- ing using compressive sensing 显示文摘 | Li Hanxi Shen Chunhua Shi Qinfeng | 2011 | IEEE Conference on Com- puter Vision Pattern Recognition2011，42，7： | 1 |
| 8 | Talanta显示文摘 | Li Rong Jiang Zitao Mao Luyuan Shen Hanxi | 1998 | 47(5):11211998，47，5： | 1 |
| 9 | Electrochemical behavior of biphenyl as polymerizable additive forovercharge protection of lithium ion batteries显示文摘 | Li fen Xiao Xinping Ai Yuliang Cao Hanxi Yang | 2004 | Electrochimica Acta2004，，49： | 1 |
| 10 | On the Dual Formulation of Boosting Algorithms显示文摘 | Shen Chunhua Li Hanxi | 2010 | IEEE Transactions on Pattern Analysis and Machine Intellgence2010，32，12： | 1 |
| 11 | Identification of Genes Related to Mesocarp Development in Cucumber显示文摘Cucumber(Cucumis sativus L.)is an agriculturally and economically important vegetable crop worldwide.The thickness of mesocarp is an important quality pertaining to edibility.The development of mesocarp,however,has received little attention.In this study,we selected one thick mesocarp line D8 to analyze the gene expression profiles of mesocarp at 0,3,6,and 9 days after pollination(DAP)by RNA sequencing.Genes mainly related to ribosomes,carbon metabolism,biosynthesis of amino acids,and oxidative phosphorylation were up-regulated at 3 DAP.From 3 to 6 DAP,the genes related to oxidative phosphorylation,photosynthesis,and phagosome were highly induced.From6 to 9 DAP,the genes related to plant hormone signal transduction were highly induced.Differentially expressed genes linked to cyclin,hormone biosynthesis and signaling,carbon metabolism,and transcription factors MYB and WRKY were common up-regulated at 3,6,9 DAP in comparison with 0 DAP.The auxin-responsive and cytokinin-responsive genes were significantly up-regulated in mesocarp development.The higher expression levels of the auxin-responsive gene indole-3-acetic acid-amido synthetase 3.6 and the cytokinin response regulator 3/4b in the thick mesocarp cultivar D8 than in the thin mesocarp cultivar XUE1 might have explained the different growth rates of the mesocarp. | Xiaohua Qi Yamei Zhu Shuifeng Li Hanxi Zhou Xuewen Xu Qiang Xu Xuehao Chen | 2020 | Horticultural Plant Journal2020，6，5： | 1 |
| 12 | A high-loading and cycle-stable solid-phase conversion sulfur cathode using edible fungus slag-derived microporous carbon as sulfur host显示文摘Developing a high sulfur(S)-loading cathode with high capacity utilization and long term cyclability is a key challenge for commercial implementation of Li-S battery technology.To overcome this challenge,we propose a solid-phase conversion sulfur cathode by using an edible fungus slag-derived porous carbon(CFS)as sulfur host to fabricate the S/CFS composite and meanwhile,utilizing the vinyl carbonate(VC)as co-solvent of the ether-based electrolyte to in-situ form a protective layer on the S/CFS composite surface through its nucleophilic reaction with the freshly generated lithium polysulfides(LiPSs)at the very beginning of initial discharge,thus isolating the interior sulfur from the outer electrolyte and inhibiting the further generation of soluble LiPSs.Benefitting from the ultrahigh specific surface area of>3,000 m^(2)·g^(−1),ideal pore size of<4 nm,and large pore volume of>2.0 cm^(3)·g^(−1)of the CFS host matrix,the S/CFS cathode even with a high S-loading of 80 wt.%(based on the weight of S/CFS composite)can still operate in a solid-phase conversion manner in the VC-ether co-solvent electrolyte to exhibit a high reversible capacity of 1,557 mAh·g^(−1),a high rate capability with 50%remaining capacity at 2 A·g^(−1)and a high cycling efficiency of 99.9%over 500 cycles.The results presented in this work suggest that a combined action of solid-phase conversion electrochemistry and nanoarchitectured host structure may provide a new path for the design and development of practical lithium-sulfur batteries. | Hui Li Xiangjiang Wu Sijie Jiang Qian Zhang Yuliang Cao Hanxi Yang Feifei Cao Xinping Ai | 2023 | Nano Research2023，16，6： | 0 |
| 13 | An Analysis of Urban Vacant Land on the Macao Peninsula显示文摘With the development and construction of the city,the urban development of the Macao Peninsula has entered an era of stock development against the background of the limited scale of urban land.With the shortage of land resources,the problem of unused land on the Macao Peninsula is coming to the fore.This paper mainly studies the problem of idle land in the Macao Peninsula,based on the urban development and particular historical background of the region,investigates and elaborates on its complex formation causes through the literature research method,and analyzes the spatial distribution characteristics of idle land in the current situation of the Macao Peninsula by using GIS technology.Based on the above research,suggestions are put forward to prevent and manage the urban vacant land problem in the future urban management and development of Macao. | Ye Lin Hanxi Li | 2022 | Journal of Geographical Research2022，5，3： | 0 |
| 14 | Aβ-Carotene Ketolase Gene NfcrtO from Subaerial Cyanobacteria Confers Drought Tolerance in Rice显示文摘Nostoc flagelliforme is a terrestrial cyanobacterium that can resist many types of stressors,including drought,ultraviolet radiation,and extreme temperatures.In this study,we identified the drought tolerance gene NfcrtO,which encodes aβ-carotene ketolase,through screening the transcriptome of N.flagelliforme under water loss stress.Prokaryotic expression of NfcrtO under 0.6 mol/L sorbitol or under 0.3 mol/L NaCl stress significantly increased the growth rate of Escherichia coli.When NfcrtO was heterologously expressed in rice,the seedling height and root length of NfcrtO-overexpressing rice plants were significantly higher than those of the wild type(WT)plants grown on½Murashige and Skoog solid medium with 120 mmol/L mannitol at the seedling stage.Transcriptome analysis revealed that NfcrtO was involved in osmotic stress,antioxidant,and other stress-related pathways.Additionally,the survival rate of the NfcrtO-overexpression lines was significantly higher than that of the WT line under both hydroponic stress(24%PEG and 100 mmol/L H_(2)O_(2))and soil drought treatment at the seedling stage.Physiological traits,including the activity levels of superoxide dismutase,peroxidase,catalase,total antioxidant capacity,and the contents of proline,trehalose,and soluble sugar,were significantly improved in the NfcrtO-overexpression lines relative to those in the WT line under 20%PEG treatment.Furthermore,when water was withheld at the booting stage,the grain yield per plant of NfcrtO-overexpression lines was significantly higher than that of the WT line.Yeast two-hybrid analysis identified interactions between NfcrtO and Dna J protein,E3 ubiquitin-protein ligase,and pyrophosphate-energized vacuolar membrane proton pump.Thus,heterologous expression of NfcrtO in rice could significantly improve the tolerance of rice to osmotic stress,potentially facilitating the development of new rice varieties. | GAO Ningning YE Shuifeng ZHANG Yu ZHOU Liguo MA Xiaosong YU Hanxi LI Tianfei HAN Jing LIU Zaochang LUO Lijun | 2024 | Rice science2024，31，1： | 0 |
| 15 | Corrigendum to “Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy” [Bioactive Mater. 16 107-119]显示文摘The authors regret that the published version of the above article contained two errors which were not identified during the proofing stage.Also,Figure 2A and 6C have been replaced.The authors apologize for these errors and state that these corrections do not change the scientific conclusions of the article in any way. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2023 | Bioactive Materials2023，，3： | 0 |
| 16 | Core processing neuron-enabled circuit motifs for neuromorphic computing显示文摘Based on brain-inspired computing frameworks,neuromorphic systems implement large-scale neural networks in hardware.Although rapid advances have been made in the development of artificial neurons and synapses in recent years,further research is beyond these individual components and focuses on neuronal circuit motifs with specialized excitatory-inhibitory(E-I)connectivity patterns.In this study,we demonstrate a core processor that can be used to construct commonly used neuronal circuits.The neuron,featuring an ultracompact physical configuration,integrates a volatile threshold switch with a gate-modulated two-dimensional(2D)MoS2 field-effect channel to process complex E-I spatiotemporal spiking signals.Consequently,basic neuronal circuits are constructed for biorealistic neuromorphic computing.For practical applications,an algorithm-hardware co-design is implemented in a gatecontrolled spiking neural network with substantial performance improvement in human speech separation. | Hanxi Li Jiayang Hu Anzhe Chen Yishu Zhang Chenhao Wang Beiduo Wang Yi Tong Jiachao Zhou Kian Ping Loh Yang Xu Tawfique Hasan Bin Yu | 2023 | InfoMat2023，5，11： | 0 |
| 17 | Enhanced cycling stability of antimony anode by downsizing particle and combining carbon nanotube for high-performance sodium-ion batteries显示文摘Antimony(Sb)nanoparticles(SbNP)encapsulated in multiwalled carbon nanotubes(MWCNTs)matrix has been fabricated by a facile two-step ball milling strategy,including a sand milling process to prepare Sb nanoparticles and following high-energy ball milling to synthesize SbNP-MWCNT composite.As an anode material for sodium-ion batteries(SIBs),the SbNP-MWCNT composite with high Sb content(80%)can deliver a reversible capacity of 471.1 mA hg^(-1)at 50 mA g^(-1)with an initial coulombic efficiency of 73.5%,excellent cycling stability(94.1%capacity retention at 800 mA g^(-1))and high rate capability(210.7 mA h g^(-1)at 3200 mA g^(-1)).The excellent electrochemical performance of the SbNP-MWCNT composite results from the synergistic effect of downsizing Sb particles and combining MWCNTs. | Chuang Liu Fanxin Zeng Li Xu Shuangyu Liu Jincheng Liu Xinping Ai Hanxi Yang Yuliang Cao | 2020 | Journal of Materials Science & Technology2020，52，20： | 0 |
| 18 | Coupled Effects of Heat and Moisture of Early-Age Concrete显示文摘In order to analyze the coupled influence of temperature and humidity on early-age concrete(including cement and copper tailings),a mathematical model is introduced on the basis of the Krstulovic-Dabic hydration reaction kinetic equations.In such a framework,the influence of hydration-released heat and water consumption are also taken into account.The results provided by such a model are verified by means of experiments and related sensor measurements.The research results show that this model can adequately predict the internal temperature and the humidity temporal evolution laws. | Yang Wang Hanxi Wang Linwei Yang Li Qian | 2021 | Fluid Dynamics & Materials Processing2021，17，4： | 0 |
| 19 | Variation and stability analysis of growth traits of poplar clones in the seedling stage in northeast China显示文摘Plant phenotypes are infl uenced by genetic and environmental factors.In this study,the growth traits of 43 one-year-old poplar clones grown at diff erent sites in northeast China(Dongling State-owned Forest Protection Center,DL;Baicheng State-owned forest farm,BC;and Cuohai Forest farm,CH)were evaluated and analyzed across clones and sites.Results show signifi cant diff erences in height and base diameter among sites and clones.Phenotypic and genetic variation coeffi cients ranged from 49.59%(BC)to 58.39%(DL)and from 49.33%(BC)to 58.06%(DL),respectively.Additive main eff ects and multiplicative interaction(AMMI)analysis showed that the eff ects of genotype,environment,and genotype×environment interaction were signifi cantly diff erent.Genetic variation was the main source of variation,accounting for 48.6%.AMMI biplot showed that clone 30 had high and stable yields at the three sites.From an evaluation of multiple traits and GGE biplot that clone 2,clone 30 and clone 25 had higher yield than the other clones at DL,CH and BC,respectively.These clones will provide material for forest regeneration in northeast China. | Xiaoting Liu Qiushuang Zhao Peng Yin Hanxi Li Xuesong Li Liguo Wu Yueji Li Yanbo Hu Xiyang Zhao | 2023 | Journal of Forestry Research2023，34，4： | 0 |
| 20 | Boosting rate and cycling performance of K-doped Na_(3)V_(2)(PO_(4))_(2)F_(3) cathode for high-energy-density sodium-ion batteries显示文摘As a promising cathode material,Na_(3)V_(2)(PO_(4))_(2)F_(3)(NVPF)has attracted wide attention for sodium-ion batteries(SIBs)because of its high operating voltage and high structural stability.However,the low intrinsic electronic conductivity and insufficient Na ion mobility of NVPF limit its development.Herein,K-doping NVPF is prepared through a facile ball-milling combined calcination method.The effects of K-doping on the crystal structure,kinetic properties and electrochemical performance are investigated.The results demonstrate that the Na_(2.90)K_(0.10)V_(2)(PO_(4))_(3)F_(3)(K0.10-NVPF)exhibits a high capacity(120.8 mAh g^(-1) at 0.1 C),high rate capability(66 mAh g^(-1) at 30 C)and excellent cycling performance(a capacity retention of 97.5%at 1 C over 500 cycles).Also,the occupation site of K ions in the lattice,electronic band structure and Na-ion transport kinetic property in K-doped NVPF are investigated by density functional theory(DFT)calculations,which reveals that the K-doped NVPF exhibits improved electronic and ionic conductivities,and located K^(+) ions in the lattice to contribute to high reversible capacity,rate capability and cycling stability.Therefore,the K-doped NVPF serves as a promising cathode material for high-energy and high-power SIBs. | Jiexin Zhang YangYang Lai Peng Li Yanxia Wang Faping Zhong Xiangming Feng Weihua Chen Jianjun Liu Xinping Ai Hanxi Yang Yuliang Cao | 2022 | Green Energy & Environment2022，7，6： | 0 |
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