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| 1 | Thermochemical sulfate reduction in fossil Ordovician deposits of the Majiang area:Evidence from a molecular-marker investigation显示文摘The main reservoirs of Majiang fossil deposits consist of the Silurian Wengxiang group,dominantly sandstones,and the Ordovician Honghuayuan formation,dominantly carbonate rocks,and the Lower Cambrian Niutitang Formation mudstones serve as the major source rocks.Thermochemical sulfate reduction(TSR)might have taken place in the Paleozoic marine carbonate oil pools,as indicated by high concentrations of dibenzothiophenes in the extracts(MDBT=0.27 4.32 g/g extract,and MDBT/MPH=0.71 1.38).Hydrocarbons in the Pojiaozhai Ordovician carbonate reservoirs have undergone severe TSR and are characterized by higher quantities of diamondoids and MDBT and heavier isotopic values(13C=28.4‰).The very large amounts of dibenzothiophenes might be products of reactions between biphenyls and sulfur species associated with TSR. | WANG GuangLi LI NingXi GAO Bo LI XianQing SHI ShengBao WANG TieGuan | 2013 | Chinese Science Bulletin2013，58，28： | 2 |
| 2 | Electromyographic evaluation of functional electrical stimulation to injured oculomotor nerve显示文摘Functional electrical stimulation delivered early after injury to the proximal nerve stump has been proposed as a therapeutic approach for enhancing the speed and specificity of axonal regeneration following nerve injury. In this study, the injured oculomotor nerve was stimulated functionally by an implantable electrode. Electromyographic monitoring of the motor unit potential of the inferior oblique muscle was conducted for 12 weeks in two injury groups, one with and one without electric stimulation. The results revealed that, at 2, 4, 6, 8 weeks after functional electric stimulation of the injured oculomotor nerve, motor unit potentials significantly increased, such that amplitude was longer and spike duration gradually shortened. These findings indicate that the injured oculomotor nerve has the potential for regeneration and repair, but this ability is not sufficient for full functional recovery to occur. Importantly, the current results indicated that recovery and regeneration of the injured oculomotor nerve can be promoted with functional electrical stimulation. | Min Yang Youqiang Meng Ningxi Zhu Xuhui Wang Liang Wan Wenchuan Zhang JunZhong Shugan Zhu Massimiliano Visocchi Shiting Li | 2011 | Neural Regeneration Research2011，6，11： | 2 |
| 3 | Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy显示文摘The clinical outcomes of cancer nanovaccine have been largely impeded owing to the low antigen-specific T cell response rate and acquired resistance caused by the immunosuppressive tumor microenvironment(TME).Here,we reported a tumor acidity-responsive nanovaccine to remodel the immunosuppressive TME and expand the recruitment of tumor infiltrating lymphocytes(TILs)using hybrid micelles(HM),which encapsulated colony stimulating factor 1 receptor(CSF1-R)inhibitor BLZ-945 and indoleamine 2,3-dioxygenase(IDO)inhibitor NLG-919 in its core and displayed a model antigen ovalbumin(OVA)on its surface(denoted as BN@HM-OVA).The bioactive nanovaccine is coated with a polyethylene glycol(PEG)shell for extending nanoparticle circulation.The shell can be shed in response to the weakly acidic tumor microenvironment.The decrease in size and the increase in positive charge may cause the deep tumor penetration of drugs.We demonstrated that the bioactive nanovaccine dramatically enhance antigen presentation by dendritic cells(DCs)and drugs transportation into M1-like tumor-associated macrophages(TAMs)and tumor cells via size reduction and increasing positive charge caused by the weakly acidic TME.Such bioactive nanovaccine could remodel the immunosuppressive TME into an effector T cells favorable environment,leading to tumor growth inhibition in prophylactic and therapeutic E.G7-OVA tumor models.Furthermore,combining the bioactive nanovaccine with simultaneous anti-PD-1 antibody treatment leads to a long-term tumor inhibition,based on the optimal timing and sequence of PD-1 blockade against T cell receptor.This research provides a new strategy for the development of efficient cancer immunotherapy. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 4 | Accumulation conditions and exploration directions of Ordovician lower assemblage natural gas, Ordos Basin, NW China显示文摘Based on drilling cores, well logging and seismic data, source rocks and reservoirs are evaluated;and the natural gas genesis is identified through the analysis of natural gas isotopes, components and fluid inclusions, to study the gas accumulation conditions of the gypsum salt rock related strata of the Ordovician lower assemblage in Ordos Basin.(1) The natural gas from Ordovician lower assemblage is high thermal evolution dry gas from marine source rock, characterized by relatively light δ^(13)C value of methane and heavy δ^(13)C value of ethane. The natural gas is identified as gas cracking from crude oil according to component analysis. Thermochemical sulfate reduction(TSR) reaction has happened between the hydrocarbon fluid and sulfate as sulfur crystals are found in the cores, hydrogen sulfide is found in the natural gas, and hydrocarbon and hydrogen sulfide fluid inclusions are widespread in secondary minerals.(2) Around the gypsum-salt lows, argillaceous rocks are extensive in the Ordovician lower assemblage, reaching a cumulative thickness of 20–80 m. The effective source rocks include argillaceous rock rich in organic laminae, algal clump and algal dolomite. Analysis shows that the source rocks have a dominant TOC of 0.1%–0.5%, 0.31% on average and 3.24% at maximum. The source rocks have an average TOC of 0.58% after recovered through organic acid salt method, indicating the source rocks have high hydrocarbon supply potential.(3) In the sedimentary period, the palaeo-uplift controlled the distribution of reservoirs. The inherited secondary palaeo-uplift in Wushenqi–Jingbian east of the central palaeo-uplift and the low uplift formed by thick salt rocks near Shenmu–Zizhou area controlled the distribution of penecontemporaneous grain shoal dolomite reservoirs. The salinization sedimentary environment of gypsum salt rock can promote the development of reservoir. There are three types of dolomite reservoirs, the one with intercrystalline pore, with dissolution pore, and with fracture;intercrystalline and dissolution pores are main reservoir spaces.(4) There are two types of cap rocks, namely tight carbonate rock and gypsum-salt rock, constituting two types of source-reservoir-cap assemblages respectively. The general accumulation model is characterized by marine source rock supplying hydrocarbon, beach facies limy dolomite reservoir, small fractures acting as migration pathways, and structural-lithologic traps as accumulation zones.(5) The third and fourth members of Majiagou Formation are major target layers in the lower assemblage. The Wushengqi–Jingbian secondary paleo-uplift area and Shenmu–Zizhou low uplift are dolomite and limestone transition zone, there develops tight limestone to the east of the uplift zone, which is conducive to the formation of gas reservoir sealed by lithology in the updip. Two risk exploration wells drilled recently have encouraging results, indicating that the two uplift zones are important prospects. | XU Wanglin LI Jianzhong LIU Xinshe LI Ningxi ZHANG Caili ZHANG Yueqiao FU Ling BAI Ying HUANG Zhengliang GAO Jianrong SUN Yuanshi SONG Wei | 2021 | Petroleum Exploration and Development2021，48，3： | 0 |
| 5 | Geological conditions, reservoir evolution and favorable exploration directions of marine ultra-deep oil and gas in China显示文摘By analyzing the structural background,petroleum geological conditions,and typical regional(paleo) oil and gas reservoirs in marine ultra-deep oil and gas regions in China,this paper reveals the evolution processes of the marine ultra-deep oil and gas reservoirs and the key controlling factors of accumulation.The marine ultra-deep oil and gas resources in China are buried at depth of greater than 6000 m,and are mainly distributed in the Precambrian and Lower Paleozoic strata in the Sichuan,Tarim and Ordos cratonic basins.The development of marine ultra-deep source rocks in China is controlled by cratonic rifts and cratonic depressions with the background of global supercontinent breakup-convergence cycles.The source rocks in Sichuan Basin have the most developed strata,followed by Tarim Basin,and the development strata and scale of Ordos Basin needs to be further confirmed.The marine ultra-deep reservoir in China is dominated by carbonate rocks,and the reservoir performance is controlled by high-energy sedimentary environment in the early stage,superimposed corrosion and fracture in the later stage.The regional caprocks are dominated by gypsum salt rocks,shale,and tight carbonate rock.The ultra-deep oil and gas fields in China have generally experienced two stages of oil-reservoir forming,cracking(or partial cracking) of paleo-oil reservoirs,and late finalization of cracked gas(or highly mature to over mature oil and gas).The oil and gas accumulation is controlled by static and dynamic geological elements jointly.Major hydrocarbon generation center,high quality and large-scale reservoir resulted from karstification of high energy facies belt,thick gypsum rock or shale caprock,and stable trapping and preservation conditions are the key factors for accumulation of ultra-deep oil and gas.We propose three favorable exploration directions,i.e.the areas around intracratonic rift and intracratonic depression,and craton margin. | LI Jianzhong TAO Xiaowan BAI Bin HUANG Shipeng JIANG Qingchun ZHAO Zhenyu CHEN Yanyan MA Debo ZHANG Liping LI Ningxi SONG Wei | 2021 | Petroleum Exploration and Development2021，48，1： | 0 |
| 6 | Biomimetic“Gemini nanoimmunoregulators”orchestrated for boosted photoimmunotherapy by spatiotemporally modulating PD-L1 and tumor-associated macrophages显示文摘A novel strategy of not only stimulating the immune cycle but also modulating the immunosuppressive tumor microenvironment is of vital importance to efficient cancer immunotherapy.Here,a new type of spatiotemporal biomimetic“Gemini nanoimmunoregulators”was engineered to activate robust systemic photoimmunotherapy by integrating the triple-punch of amplified immunogenic cell death(ICD),tumor-associated macrophages(TAMs)phenotype reprogramming and programmed cell death ligand 1(PD-L1)degradation.The“Gemini nanoimmunoregulators”PM@RM-T7 and PR@RM-M2 were constructed by taking the biocompatible mesoporous polydopamine(mPDA)as nanovectors to deliver metformin(Met)and toll-like receptor 7/8 agonist resiquimod(R848)to cancer cells and TAMs by specific biorecognition via wrapping of red blood cell membrane(RM)inlaid with T7or M2 peptides.mPDA/Met@RM-T7(abbreviated as PM@RM-T7)was constructed to elicit an amplified in situ ICD effect through the targeted PTT and effectively stimulated the anticancer immunity.Meanwhile,PD-L1 on the remaining cancer cells was degraded by the burst metformin to prevent immune evasion.Subsequently,mPDA/R848@RM-M2(abbreviated as PR@RM-M2)specifically recognized TAMs and reset the phenotype from M2 to M1 state,thus disrupting the immunosuppressive microenvironment and further boosting the function of cytotoxic T lymphocytes.This pair of sister nanoimmunoregulators cooperatively orchestrated the comprehensive anticancer activity,which remarkably inhibited the growth of primary and distant 4T1 tumors and prevented malignant metastasis.This study highlights the spatiotemporal cooperative modalities using multiple nanomedicines and provides a new paradigm for efficient cancer immunotherapy against metastatic-prone tumors. | Honglin Huang Ningxi Li Xiaodan Wei Qingzhi Li Junhan Guo Geng Yang Hong Yang Lulu Cai Yiyao Liu Chunhui Wu | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 7 | Corrigendum to “Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy” [Bioactive Mater. 16 107-119]显示文摘The authors regret that the published version of the above article contained two errors which were not identified during the proofing stage.Also,Figure 2A and 6C have been replaced.The authors apologize for these errors and state that these corrections do not change the scientific conclusions of the article in any way. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2023 | Bioactive Materials2023，，3： | 0 |
| 8 | Geochemical characteristics and families of the Paleozoic oil seepage and solid bitumen in the Southern Guizhou Depression,SW China显示文摘Fifteen oil seepage and solid bitumen samples in the Southern Guizhou Depression were analyzed with GC–MS. Characteristics of molecular markers and carbon isotopes are discussed systemically. The results showed that the oil seepage and solid bitumen samples in the Southern Guizhou Depression could be divided into two families: Ordovician and Siluric samples, and Permian samples. The two families are different in alkanes distribution, biomarkers, aromatic hydrocarbon composition,and stable carbon isotopes; differences mainly caused by source rock variation. | Ningxi Li Guangli Wang Bo Gao Xianqing Li Shengbao Shi Tieguan Wang | 2015 | Chinese Journal Of Geochemistry2015，34，1： | 0 |
| 9 | A standardized method to create peripheral nerve injury in dogs using an automatic non-serrated forceps显示文摘This study describes a method that not only generates an automatic and standardized crush injury in the skull base, but also provides investigators with the option to choose from a range of varying pressure levels. We designed an automatic, non-serrated forceps that exerts a varying force of 0 to 100 g and lasts for a defined period of 0 to 60 seconds. This device was then used to generate a crush injury to the right oculomotor nerve of dogs with a force of 10 g for 15 seconds, resulting in a deficit in the pupil-light reflex and ptosis. Further testing of our model with Toluidine-blue staining demonstrated that, at 2 weeks post-surgery disordered oculomotor nerve fibers, axonal loss, and a thinner than normal myelin sheath were visible. Electrophysiological examination showed occasional spontaneous potentials. Together, these data verified that the model for oculomotor nerve injury was successful, and that the forceps we designed can be used to establish standard mechanical injury models of peripheral nerves. | Xuhui Wang Liang Wan Xinyuan Li Youqiang MenG Ningxi Zhu Min Yang Baohui Feng Wenchuan Zhang Shugan Zhu Shiting Li | 2012 | Neural Regeneration Research2012，7，32： | 0 |
| 10 | Tirapazamine encapsulated hyaluronic acid nanomicelles realized targeted and efficient photo-bioreductive cascading cancer therapy显示文摘Currently,architecting a ratio nal and efficient nanoplatform combing with multi-therapeutic modalities is highly obligatory for advanced cancer treatment.In order to remedy the self-limiting hypoxic dilemma of photodynamic therapy(PDT),herein,a facile photosensitizer(i.e.,chlorin e6,Ce6) and bioreductive prodrug(i.e.,tirapazamine,TPZ)-coloaded hyaluronic acid(HA) nanomicelles(denoted as TPZ@HA-Ce6)was developed for the cascading mode of photo-bioreductive cancer therapy.Taking the typical advantage of Ce6 coupled HA conjugate,TPZ was easily and successfully accommodated into the hydrophobic core of HA-Ce6 nanomicelles,yielding TPZ@HA-Ce6.It showed good dispersibility and stability with the hydrodynamic size of ca.170 nm.It targeted the CD44 overexpressed cancer cells by receptor-mediated endocytosis way and killed them effectively with singlet oxygen and the subsequent TPZ radicals resulting from the oxygen depletion of PDT.The later was further verified by the hypoxia probe in vivo.Using murine mammary carcinoma 4 T1 model,TPZ@HA-Ce6 nanomicelles exhibited cascading and synergistic anticancer effect of PDT and TPZ bioreductive therapy compared with each monotherapy.This work suggests the promising prospect of the hybrid hyaluronic nanomicelles for highly efficient cancer combination treatment. | Chunhui Wu Qiuyue Liu Yikun Wang Zhengxin Xie Honglin Huang Ningxi Li Xiaodan Wei Geng Yang Tingting Li Hong Yang Shun Li Xiang Qin Yiyao Liu | 2021 | Chinese Chemical Letters2021，32，8： | 0 |
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