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| 1 | An on-chip intestine-liver model for multiple drugs absorption and metabolism behavior simulation显示文摘A double-layer microfluidic chip integrated with a hollow fiber(HF)was developed to reconstitute the intestine-liver functionality for studying the absorption and metabolism of combination drugs.Caco-2 cells were inoculated in the HF cavity at the top of the serpentine channel to simulate the intestinal tissue for drug absorption and transport studied,and Hep G2 cells,seeded in the bottom chamber,were used to mimic the liver for metabolism-related studies.Genistein and dacarbazine were selected for combination drug therapy and its effects on cell viability,hepatotoxicity,and cell cycle arrest under drug-conditioned culture were investigated.The results suggested that the combined concentration below-100μg/m L had no significant inhibitory effect on Hep G2 cell viability,and therefore Hep G2 cells maintained their drug metabolism ability.When the drug concentration was increased above 250μg/m L,Hep G2 cells underwent apoptosis.Detection of metabolites by mass spectrometry proved the effective metabolism in the microchip model.This dynamic,co-culture microchip successfully provided a podium for long-term observation of absorption,transport,and metabolism of combination drugs,and could be an effective in vitro simulation model for further clinical research. | Mingsha Jie Haifeng Lin Ziyi He Hanyang Liu Haifang Li Jin-Ming Lin | 2018 | Science China Chemistry2018，61，2： | 3 |
| 2 | Repulsive firefly algorithm-based optimal switching device placement in power distribution systems显示文摘To achieve optimal configuration of switching devices in a power distribution system,this paper proposes a repulsive firefly algorithm-based optimal switching device placement method.In this method,the influence of territorial repulsion during firefly courtship is considered.The algorithm is practically applied to optimize the position and quantity of switching devices,while avoiding its convergence to the local optimal solution.The experimental simulation results have showed that the proposed repulsive firefly algorithm is feasible and effective,with satisfying global search capability and convergence speed,holding potential applications in setting value calculation of relay protection and distribution network automation control. | Yuanpeng Tan Hai Chen Wei Liu Mingze Zhang Yinong Li Xincong Li Hanyang Lin | 2019 | Global Energy Interconnection2019，2，6： | 3 |
| 3 | Ground-Based Hyperspectral Stereoscopic Remote Sensing Network: A Promising Strategy to Learn Coordinated Control of O_(3) and PM_(2.5) over China显示文摘With the coming of the“14th Five-Year Plan,”the coordinated control of particulate matter with an aerodynamic diameter no greater than 2.5 lm(PM_(2.5))and O_(3) has become a major issue of air pollution prevention and control in China.The stereoscopic monitoring of regional PM_(2.5) and O_(3) and their precursors is crucial to achieve coordinated control.However,current monitoring networks are currently inadequate for monitoring the vertical profiles of both PM_(2.5) and O_(3) simultaneously and support air quality control.The University of Science and Technology of China(USTC)has established a nationwide ground-based hyperspectral stereoscopic remote sensing network based on multi-axis differential optical absorption spectroscopy(MAX-DOAS)since 2015.This monitoring network provides a significant opportunity for the regional coordinated control of PM_(2.5) and O_(3) in China.One-year vertical profiles of aerosol,NO_(2) and HCHO monitored from four MAX-DOAS stations installed in four megacities(Beijing,Shanghai,Shenzhen,and Chongqing)were used to characterize their vertical distribution differences in four key regions,Jing–Jin–Ji(JJJ),Yangtze River Delta(YRD),Pearl River Delta(PRD),and Sichuan Basin(SB),respectively.The normalized and yearly averaged aerosol vertical profiles below 400 m in JJJ and PRD exhibit a box shape and a Gaussian shape,respectively,and both show exponential shapes in YRD and SB.The NO_(2) vertical profiles in four regions all exhibit exponential shapes because of vehicle emissions.The shape of the HCHO vertical profile in JJJ and PRD was Gaussian,whereas an exponential shape was shown in YRD and SB.Moreover,a regional transport event occurred at an altitude of 600–1000 m was monitored in the southwest–northeast pathway of the North China Plain(NCP)by five MAX-DOAS stations(Shijiazhuang(SJZ),Wangdu(WD),Nancheng(NC),Chinese Academy of Meteorological Sciences(CAMS),and University of Chinese Academy of Sciences(UCAS))belonging to the above network.The aerosol optical depths(AOD)in these five stations decreased in the order of SJZ>WD>NC>CAMS>UCAS.The short-distance regional transport of NO2 in the 700–900 m layer was monitored between WD and NC.As an important precursor of secondary aerosol,the peak of NO_(2) air mass in WD and NC all occurred 1 h earlier than that of aerosol.This was also observed for the short-distance regional transport of HCHO in the 700–900 m layer between NC and CAMS,which potentially affected the O_(3) concentration in Beijing.Finally,CAMS was selected as a typical site to determine the O_(3)–NO_(x)–volatile organic compounds(VOCs)sensitivities in vertical space.We found the production of O_(3) changed from predominantly VOCs-limited conditions to mainly mixed VOCs–NO_(x)-limited condition from the 0–100 m layer to the 200–300 m layer.In addition,the downward transport of O_(3) could contribute to the increase of ground surface O_(3) concentration.This ground-based hyperspectral stereoscopic remote sensing network provide a promising strategy to support management of PM_(2.5) and O_(3) and their precursors and conduct attribution of sources. | Cheng Liu Chengzhi Xing Qihou Hu Qihua Li Haoran Liu Qianqian Hong Wei Tan Xiangguang Ji Hua Lin Chuan Lu Jinan Lin Hanyang Liu Shaocong Wei Jian Chen Kunpeng Yang Shuntian Wang Ting Liu Yujia Chen | 2022 | Engineering2022，，12： | 0 |
| 4 | A Linearized Branch Flow Model Considering Line Shunts for Radial Distribution Systems and Its Application in Volt/VAr Control显示文摘When urban distribution systems are gradually modernized,the overhead lines are replaced by underground cables,whose shunt admittances can not be ignored.Traditional power flow(PF)model withπequivalent circuit shows non-convexity and long computing time,and most recently proposed linear PF models assume zero shunt elements.All of them are not suitable for fast calculation and optimization problems of modern distribution systems with non-negligible line shunts.Therefore,this paper proposes a linearized branch flow model considering line shunt(LBFS).The strength of LBFS lies in maintaining the linear structure and the convex nature after appropriately modeling theπequivalent circuit for network equipment like transformers.Simulation results show that the calculation accuracy in nodal voltage and branch current magnitudes is improved by considering shunt admittances.We show the application scope of LBFS by controlling the network voltages through a two-stage stochastic Volt/VAr control(VVC)problem with the uncertain active power output from renewable energy sources(RESs).Since LBFS results in a linear VVC program,the global solution is guaranteed.Case study exhibits that VVC framework can optimally dispatch the discrete control devices,viz.substation transformers and shunt capacitors,and also optimize the decision rules for real-time reactive power control of RES.Moreover,the computing efficiency is significantly improved compared with that of traditional VVC methods. | Hanyang Lin Firdous Ul Nazir Bikash C.Pal Ye Guo | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，4： | 0 |
| 5 | Comparative Research on Payment Protocols SSL and SET in Electronic Commerce显示文摘 | Hanyang Luo Xudong Lin | 2004 | Chinese Business Review2004，3，3： | 0 |
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