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| 1 | Value of diffusion-weighted imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis: a meta-analysis显示文摘 | Niu Xiangke Sushant Kumar Das Anup Bhetuwal Xiao Yingquan Sun Feng Zeng Lichuan Wang Wenxuan Yang Hanfeng Yang Hanyu | 2014 | Chinese Medical Journal2014，，19： | 11 |
| 2 | Applications of Lithium-Ion Batteries in Grid-Scale Energy Storage Systems显示文摘In the electrical energy transformation process,the grid-level energy storage system plays an essential role in balancing power generation and utilization.Batteries have considerable potential for application to grid-level energy storage systems because of their rapid response,modularization,and flexible installation.Among several battery technologies,lithium-ion batteries(LIBs)exhibit high energy efficiency,long cycle life,and relatively high energy density.In this perspective,the properties of LIBs,including their operation mechanism,battery design and construction,and advantages and disadvantages,have been analyzed in detail.Moreover,the performance of LIBs applied to grid-level energy storage systems is analyzed in terms of the following grid services:(1)frequency regulation;(2)peak shifting;(3)integration with renewable energy sources;and(4)power management.In addition,the challenges encountered in the application of LIBs are discussed and possible research directions aimed at overcoming these challenges are proposed to provide insight into the development of grid-level energy storage systems. | Tianmei Chen Yi Jin Hanyu Lv Antao Yang Meiyi Liu Bing Chen Ying Xie Qiang Chen | 2020 | Transactions of Tianjin University2020，26，3： | 9 |
| 3 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 4 | Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model显示文摘Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell. | HANYU WANG YUANHAO YANG XIAO ZHANG YAN WANG HUI FAN JINFENG SHI XUELIAN TAN BAOSHI XU JINGCHAO QIANG ENZHUANG PAN MINGYI CHU ZIBO DONG JINGQUAN DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 4 |
| 5 | NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling显示文摘Previously,Nucleolar protein 66(NO66)was reported to be closely associated with alcohol exposure-induced injury.However,the role of NO66 in alcohol-induced cytotoxicity remains unclear.In this study,we explored the potential effect and mechanism of NO66 on ethanol-induced apoptosis in human AC16 cardiomyocytes.The AC16 cell lines with NO66 and phosphatase and tensin homolog(PTEN)overexpression were constructed.Cell counting kit-8(CCK-8),lactate dehydrogenase(LDH)assay,Annexin V-FITC/PI staining,and flow cytometry were used to evaluate the cell viability,membrane damage,and apoptosis,respectively.Quantitative real-time PCR(qRT-PCR)and western blot analysis were applied to measure mRNA and protein expression.The results showed that acute ethanol exposure markedly augmented cytotoxicity and reduced NO66 level in AC16 cardiomyocytes.Overexpression of NO66 partially reversed ethanol-induced apoptosis.NO66 upregulation reversed the decrease in phosphorylation of protein kinase B(Akt)and B-cell lymphoma-2/Bcl-2-associated x(Bcl-2/Bax)ratio and the increase in PTEN,p53,and caspase-3 activity induced by ethanol treatment.Meanwhile,the application of PI3K inhibitor(LY294002)and PTEN overexpression attenuated the inhibition efficiency of NO66 on cell apoptosis.In addition,PTEN overexpression weakened the effect of NO66 on PI3K/Akt activation,without affecting the level of NO66.Our data suggested that NO66 overexpression might play an anti-apoptotic role in ethanol-induced cell injury via reducing PTEN and upregulating the PI3K/Akt pathway. | Hanyu Deng Bo Yu Yang Yu Ge Tian Liu Yang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 3 |
| 6 | Transferring quantum entangled states between multiple single-photon-state qubits and coherent-state qubits in circuit QED显示文摘We present a way to transfer maximally-or partially-entangled states of n single-photon-state(SPS)qubits onto ncoherent-state(CS)qubits,by employing 2nmicrowave cavities coupled to a superconducting flux qutrit.The two logic states of a SPS qubit here are represented by the vacuum state and the single-photon state of a cavity,while the two logic states of a CS qubit are encoded with two coherent states of a cavity.Because of using only one superconducting qutrit as the coupler,the circuit architecture is significantly simplified.The operation time for the state transfer does not increase with the increasing of the number of qubits.When the dissipation of the system is negligible,the quantum state can be transferred in a deterministic way since no measurement is required.Furthermore,the higher-energy intermediate level of the coupler qutrit is not excited during the entire operation and thus decoherence from the qutrit is greatly suppressed.As a specific example,we numerically demonstrate that the high-fidelity transfer of a Bell state of two SPS qubits onto two CS qubits is achievable within the present-day circuit QED technology.Finally,it is worthy to note that when the dissipation is negligible,entangled states of n CS qubits can be transferred back onto n SPS qubits by performing reverse operations.This proposal is quite general and can be extended to accomplish the same task,by employing a natural or artificial atom to couple 2nmicrowave or optical cavities. | Qi-Ping Su Hanyu Zhang Chui-Ping Yang | 2021 | Frontiers of physics2021，16，6： | 2 |
| 7 | Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model显示文摘This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically difTerential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases. | Hanyu Zhu Bo Fu Yong Wang Jing Gao Qiuxia Han Wenjia Geng Xiaoli Yang Guangyan Cai Xiangmei Chen Dong Zhang | 2019 | Frontiers of Medicine2019，13，5： | 2 |
| 8 | X-ray enabled detection and eradication of circulating tumor cells with nanoparticles显示文摘 | Mainul Hossain Yang Luo Zhaoyong Sun Chaoming Wang Minghui Zhang Hanyu Fu Yong Qiao Ming Su | 2012 | Biosensors and Bioelectronics2012，，1： | 1 |
| 9 | Improved corrosion resistance and biofilm inhibition ability of copper-bearing 304 stainless steel against oral microaerobic Streptococcus mutans显示文摘304 stainless steel(SS) used as orthodontic wire during orthodontics faces the risk of microbiologically influenced corrosion(MIC) due to diverse flora environment. Hereinto, Streptococcus mutans(S. mutans)is the most important cariogenic bacteria. In this work, MIC behavior of a new 304-Cu SS in presence of S. mutans was studied by the observations using scanning electron microscopy(SEM) and confocal laser scanning microscopy(CLSM) including live/dead staining, extracellular polymeric substance(EPS)staining and pitting corrosion, electrochemical test, and X-ray photoelectron spectroscopy(XPS). Above results showed that 304-Cu SS possessed excellent biofilm inhibition ability and presented lower corrosion current density(icorr), larger polarization resistance(Rp) and charge transfer resistance(Rct) in the presence of S. mutans, indicating that 304-Cu SS had a better MIC resistance against S. mutans. It was further affirmed by XPS results that the presence of Cu-oxide in passive film of 304-Cu SS inhibited the formation of biofilm. | Hanyu Zhao Yupeng Sun Lu Yin Zhao Yuan Yiliang Lan Dake Xu Chunguang Yang Ke Yang | 2021 | Journal of Materials Science & Technology2021，，7： | 1 |
| 10 | Pre-Drilling Prediction Techniques on the High-Temperature High-Pressure Hydrocarbon Reservoirs Offshore Hainan Island,China显示文摘Decreasing the risks and geohazards associated with drilling engineering in high-temperature high-pressure(HTHP) geologic settings begins with the implementation of pre-drilling prediction techniques(PPTs). To improve the accuracy of geopressure prediction in HTHP hydrocarbon reservoirs offshore Hainan Island, we made a comprehensive summary of current PPTs to identify existing problems and challenges by analyzing the global distribution of HTHP hydrocarbon reservoirs, the research status of PPTs, and the geologic setting and its HTHP formation mechanism. Our research results indicate that the HTHP formation mechanism in the study area is caused by multiple factors, including rapid loading, diapir intrusions, hydrocarbon generation, and the thermal expansion of pore fluids. Due to this multi-factor interaction, a cloud of HTHP hydrocarbon reservoirs has developed in the Ying-Qiong Basin, but only traditional PPTs have been implemented, based on the assumption of conditions that do not conform to the actual geologic environment, e.g., Bellotti's law and Eaton's law. In this paper, we focus on these issues, identify some challenges and solutions, and call for further PPT research to address the drawbacks of previous works and meet the challenges associated with the deepwater technology gap. In this way, we hope to contribute to the improved accuracy of geopressure prediction prior to drilling and provide support for future HTHP drilling offshore Hainan Island. | ZHANG Hanyu LIU Huaishan WU Shiguo SUN Jin YANG Chaoqun XIE Yangbing CHEN Chuanxu GAO Jinwei WANG Jiliang | 2018 | Journal of Ocean University of China2018，17，1： | 1 |
| 11 | Quantification of traffic-induced compaction based on soil and agricultural implement parameters显示文摘Vehicle-induced soil compaction occurs when agricultural machinery is working in the fields.The accumulated soil compaction could destroy soil structure and inhibit crop growth.The low degree of visualization of soil compaction has always been an important reason for restricting the development of compaction alleviation technology.Therefore,the main objective of this study was to predict soil compaction based on soil and agricultural implement parameters.The component of soil compaction prediction includes traffic-induced stress transmission evaluation and the quantitative relationship between soil stress and bulk density.The modified FRIDA model was used to elucidate the soil stress propagation,which has been validated by previous studies.The Bailey formula was used to establish the intrinsic relationship between soil stress and bulk density.The soil uniaxial compression test was applied to obtain the parameters of the Bailey formula,and soil samples were prepared with three different levels of water content.After fitting with the Bailey formula,under the condition that the soil moisture contents were 16%,20%,and 24%,the fitting coefficients of soil bulk density were respectively 0.980,0.959,and 0.975,which were close to 1.The results indicated that the Bailey formula could be used to calculate soil bulk density based on the stress conditions of the soil.To verify the practicality of the soil compaction prediction model,a field experiment was carried out in Zhuozhou City,Hebei Province,China.The treatment was set for 1,3,5,7,and 9 times compaction with two different loads of compaction equipment.The results showed that the fit coefficient between the predicted and measured values of soil bulk density was greater than 0.641.The slope of the equation was greater than 0.782,proving that the soil bulk density prediction model based on agricultural implements and soil parameters has a good predictive effect on soil bulk density.The soil compaction evaluation model can provide a theoretical basis to further understand the soil compaction mechanism,allowing rational measures of soil compaction alleviation to be made. | Xianliang Wang Xiangcai Zhang Xiaona Lin Luming Sha Hanyu Yang Zhaoyang Guo Zeyu Chen Rongyan Sun | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 1 |
| 12 | PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway显示文摘Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor(PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemia by impairing hepatic glucose metabolism due to inhibition of the hepatocyte nuclear factor 4-alpha(HNF4 a)-glucose transporter 2(GLUT2) pathway. The PXR agonists atorvastatin and rifampicin significantly downregulated GLUT2 and HNF4 a expression, and impaired glucose uptake and utilization in HepG2 cells. Overexpression of PXR downregulated GLUT2 and HNF4 a expression, while silencing PXR upregulated HNF4 a and GLUT2 expression.Silencing HNF4 a decreased GLUT2 expression, while overexpressing HNF4 a increased GLUT2 expression and glucose uptake. Silencing PXR or overexpressing HNF4 a reversed the atorvastatininduced decrease in GLUT2 expression and glucose uptake. In human primary hepatocytes, atorvastatin downregulated GLUT2 and HNF4 a mRNA expression, which could be attenuated by silencing PXR. Silencing HNF4 a downregulated GLUT2 mRNA expression. These findings were reproduced with mouse primary hepatocytes. Hnf4 a plasmid increased Slc2 a2 promoter activity. Hnf4 a silencing or pregnenolone-16 a-carbonitrile(PCN) suppressed the Slc2 a2 promoter activity by decreasing HNF4 a recruitment to the Slc2 a2 promoter. Liver-specific Hnf4 a deletion and PCN impaired glucose tolerance and hepatic glucose uptake, and decreased the expression of hepatic HNF4 a and GLUT2. In conclusion, PXR activation impaired hepatic glucose metabolism partly by inhibiting the HNF4 aGLUT2 pathway. These results highlight the molecular mechanisms by which PXR activators induce hyperglycemia/diabetes. | Peihua Liu Ling Jiang Weimin Kong Qiushi Xie Ping Li Xiaonan Liu Jiayi Zhang Ming Liu Zhongjian Wang Liang Zhu Hanyu Yang Ying Zhou Jianjun Zou Xiaodong Liu Li Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 13 | Perturbation Analysis for the Hyperbolic QR Factorization 显示文摘 | LI Hanyu YANG Hu SHAO Hua | 2012 | Comput Math Appl2012，63，12： | 1 |
| 14 | Weighted Polar Decomposition and WGL Partial Ordering of Rectangular Complex Matrices 显示文摘 | YANG Hu LI Hanyu | 2008 | SIAM J Matrix Anal Appl2008，30，2： | 1 |
| 15 | Multiplicative Perturbation Bounds for the SR Factorization显示文摘In this paper, we present the first order perturbation bounds for the SR factorization with respect to left multiplicative perturbation, and the first order and rigorous perturbation bounds for this factorization with respect to right multiplicative perturbation.Moreover, taking the properties of SR factors into consideration, we also provide some refined perturbation bounds. | Yanfei YANG Hanyu LI | 2014 | Journal of Mathematical Research with Applications2014，34，4： | 1 |
| 16 | Weighted Polar Decomposition and WGL Partial Ordering of Rectangular Complex Matrices 显示文摘 | YANG Hu LI HanyU | 2008 | SIAM J Matrix Anal Appl2008，30，2： | 1 |
| 17 | Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo显示文摘HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env proteins.However,T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical applications.Here,we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells and a 3BNC117-E27(3BE)CAR construct that enabled the expression of programmed cell death protein(PD-1)-blocking scFv E27 and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV Env.Compared with T cells expressing 3BNC117-CAR alone,3BE CAR-T cells showed greater cytotoxic activity against HIV Envt cells with stronger proliferation capability,higher killing efficiency,and enhanced cytokine secretion in the presence of HIV Env-expressing cells.Furthermore,we manufactured TCR-deficient 3BE CAR-T cells through gene editing and demonstrated that these CAR-T cells could effectively kill HIV Env^(+) cells in vivo without the occurrence of severe graft-versus-host disease(GvHD)in NSG mice.These data suggest that we have provided a feasible approach to the generation of“off-theshelf”anti-HIV CAR-T cells in combination with PD-1 checkpoint blockade immunotherapy,which can be a powerful therapeutic candidate for the functional cure of HIV. | Hanyu Pan Xinyi Yang Jing Wang Huitong Liang Zhengtao Jiang Lin Zhao Yanan Wang Zhiming Liang Xiaoting Shen Qinru Lin Yue Liang Jinglong Yang Panpan Lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou Lu Huanzhang Zhu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 18 | Optimal control of automated left-turn platoon at contraflow left-turn lane intersections显示文摘Purpose–This study aims to propose a centralized optimal control model for automated left-turn platoon at contraflow left-turn lane(CLL)intersections.Design/methodology/approach–The lateral lane change control and the longitudinal acceleration in the control horizon are optimized simultaneously with the objective of maximizing traffic efficiency and smoothness.The proposed model is cast into a mixed-integer linear programming problem and then solved by the branch-and-bound technique.Findings–The proposed model has a promising control effect under different geometric controlled conditions.Moreover,the proposed model performs robustly under various safety time headways,lengths of the CLL and green times of the main signal.Originality/value–This study proposed a centralized optimal control model for automated left-turn platoon at CLL intersections.The lateral lane change control and the longitudinal acceleration in the control horizon are optimized simultaneously with the objective of maximizing traffic efficiency and smoothness。 | Hanyu Yang Jing Zhao Meng Wang | 2022 | Journal of Intelligent and Connected Vehicles2022，5，3： | 0 |
| 19 | Predicting the structure and stability of titanium oxide electrides显示文摘The search for new inorganic electrides has attracted significant attention due to their potential applications in transparent conductors,battery electrodes,electron emitters,as well as catalysts for chemical synthesis.However,only a few inorganic electrides have been successfully synthesized thus far,limiting the variety of electride examples.Here,we show the stabilization of inorganic electrides in the Ti-rich Ti–O system through first-principles calculations in conjunction with swarm-intelligence-based CALYPSO method for structure prediction.Besides the known Ti-rich stoichiometries of Ti_(2)O,Ti_(3)O,and Ti_(6)O,two hitherto unknown Ti_(4)O and Ti_(5)O stoichiometries are predicted to be thermodynamically stable at certain pressure conditions.We found that these Tirich Ti–O compounds are primarily zero-dimensional electrides with excess electrons confined in the atom-sized lattice voids or between the cationic layers playing the role as anions.The underlying mechanism behind the stabilization of electrides has been rationalized in terms of the excess electrons provided by Ti atoms and their accommodation of excess electrons by multiple cavities and layered atomic packings.The present results provide a viable direction for searching for practical electrides in the technically important Ti–O system. | Xin Zhong Meiling Xu Lili Yang Xin Qu Lihua Yang Miao Zhang Hanyu Liu Yanming Ma | 2018 | npj Computational Materials2018，，1： | 0 |
| 20 | A comparative study on grid resource utilization rate between China Southern Power Grid and National Grid Plc of UK显示文摘Grid resource utilization rate plays a key role in power grid operation.Although the proportion of population and the area in China Southern Power Grid(CSG)and National Grid Plc of UK(NG)are nearly,grid resources utilization of CSG is lower than that of NG.In this paper,the utilization of human resources and equipment resources of CSG and NG have been reviewed.It is discovered that there is a large gap between these two companies.The results show that the utilization in CSG is about 20%to 50%of that in NG.And it is estimated that if the equipment resources utilization of CSG increases to the level of NG in 2012,the coal consumption and thus CO2 emissions would be reduced by 17 million tons and 21 million tons,respectively.As China is a developing country and Britain is a mature developed country,it is to some extent reasonable that grid resources utilization of CSG is lower than that of NG.The benefits of improving equipment resources utilization are illustrated in detail,which provided the reference for developing the grid resource utilization in China. | Long Zhou Di Zhang Weijie Wu Manman Zhu Hanyu Yang Canbing Li Ge Li Fei Li Mingjian Cui | 2018 | Protection and Control of Modern Power Systems2018，3，1： | 0 |
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