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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and progression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical intervention.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed. | Danyu Du Chan Liu Mengyao Qin Xiao Zhang Tao Xi Shengtao Yuan Haiping Hao Jing Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 27 |
| 3 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 4 | Shanghai Synchrotron Radiation Facility显示文摘The Shanghai Synchrotron Radiation Facility (SSRF) is an intermediate energy, third generation light source located in Zhangjiang High-Tech Park, Shanghai. In December 2007, an electron beam was first stored and accumulated in the SSRF storage ring. Since then the accelerator commissioning and beam line installation had steadily progressed toward routine user operation in May 2009. This article presents an overview of the SSRF design, construction, commissioning and current status of its user operation. | JIANG MianHeng YANG Xiong XU HongJie ZHAO ZhenTang DING Hao | 2009 | Chinese Science Bulletin2009，54，22： | 19 |
| 5 | Relative position determination of a lunar rover using high-accuracy multi-frequency same-beam VLBI显示文摘Multi-frequency same-beam VLBI means that two explorers with a small separation angle are simultaneously observed with the main beam of receiving antennas. In the same-beam VLBI, the differential phase delay between two explorers and two receiving telescopes can be obtained with a small error of several picoseconds. The differential phase delay, as the observable of the same-beam VLBI, gives the separation angular information of the two explorers in the celestial sphere. The two-dimensional relative position on the plane-of-sky can thus be precisely determined with an error of less than 1 m for a distance of 3.8×105 km far away from the earth, by using the differential phase delay obtained with the four Chinese VLBI stations. The relative position of a lunar rover on the lunar surface can be determined with an error of 10 m by using the differential phase delay data and the range data for the lander when the lunar topography near the rover and the lander can be determined with an error of 10 m. | LIU QingHui1, CHEN Ming1, XIONG WeiMing2, QIAN ZhiHan1, LI JinLing1, HAO WangHong1,4, WANG GuangLi1, ZHENG WeiMin1, GUAN Di3, ZHU RenJie1, WANG WeiHua1, ZHANG XiuZhong1, JIANG DongRong1, SHU FengChun1, PING JinSong1 & HONG XiaoYu11 Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China 2 Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190, China 3 Lunar Explorer Engineering General Department, Chinese Academy of Sciences, Beijing 100012, China 4 Beijing Institute of Tracking and Telecommunications Technology, Beijing 100094, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 17 |
| 6 | Intelligent transportation systems for smart cities:a progress review显示文摘To better meet the challenge of providing effective,low-cost,energy efficient transport services,the concept of intelligent transport systems(ITS) has been proposed and lauded as an innovative and promising solution for next generation transport networks.In this paper,the progress of ITS research around the world is briefly reviewed and current challenges are outlined,thereby offering further insight into ITS development for all researchers in this area. | XIONG Zhang SHENG Hao RONG WenGe COOPER Dave E | 2012 | Science China(Information Sciences)2012，55，12： | 16 |
| 7 | Selective laser melting of NiTi alloy with superior tensile property and shape memory effect显示文摘It is a challenge to develop complex-shaped Ni Ti shape memory alloy parts by traditional processing methods, due to the poor machinability of Ni Ti alloy. It is reported that selective laser melting(SLM) of additive manufacturing could overcome this problem. However, the reported SLM-produced Ni Ti exhibits poor tensile ductility due to the inner defects and adverse unidirectional columnar grains from SLM process. In this work, the defect-less SLM-Ni Ti with nondirective columnar grains was fabricated by optimizing the intraformational laser scanning length and interformational laser scanning direction. The obtained lath-shaped SLM-Ni Ti sample exhibits tensile strain of 15.6%, more than twice of the reported maximum result(7%). Besides, the SLM-Ni Ti part with complex geometry displays a shape memory recovery of 99% under compressive deformation of 50%. | Zhiwei Xiong Zhonghan Li Zhen Sun Shijie Hao Ying Yang Meng Li Changhui Song Ping Qiu Lishan Cui | 2019 | Journal of Materials Science & Technology2019，35，10： | 15 |
| 8 | Hyperparameter Optimization for Machine Learning Models Based on Bayesian Optimization显示文摘Hyperparameters are important for machine learning algorithms since they directly control the behaviors of training algorithms and have a significant effect on the performance of machine learning models. Several techniques have been developed and successfully applied for certain application domains. However, this work demands professional knowledge and expert experience. And sometimes it has to resort to the brute-force search.Therefore, if an efficient hyperparameter optimization algorithm can be developed to optimize any given machine learning method, it will greatly improve the efficiency of machine learning. In this paper, we consider building the relationship between the performance of the machine learning models and their hyperparameters by Gaussian processes. In this way, the hyperparameter tuning problem can be abstracted as an optimization problem and Bayesian optimization is used to solve the problem. Bayesian optimization is based on the Bayesian theorem. It sets a prior over the optimization function and gathers the information from the previous sample to update the posterior of the optimization function. A utility function selects the next sample point to maximize the optimization function.Several experiments were conducted on standard test datasets. Experiment results show that the proposed method can find the best hyperparameters for the widely used machine learning models, such as the random forest algorithm and the neural networks, even multi-grained cascade forest under the consideration of time cost. | Jia Wu Xiu-Yun Chen Hao Zhang Li-Dong Xiong Hang Lei Si-Hao Deng | 2019 | Journal of Electronic Science and Technology2019，17，1： | 14 |
| 9 | Comparison of the ability of wavelet index and bispectral index for reflecting regain of consciousness in patients undergone surgery显示文摘背景小浪索引(WLI ) 是一个新参数因为基于小浪 analysis.We 监视麻醉的深度在病人观察了 WLI 和 bispectral 索引(二度) 的变化当 frontalis electromyographic (EMG ) 不在时知觉(巨鸟) 重获干扰。这研究的目的是比较 WLI 和二度的能力因为在病人反映巨鸟经历 surgery.Methods 为 maxillofacial 手术被安排的 12 个病人在学习被注册。二度和 WLI 价值不断地被监视。在被给 midazolam 和 remifentanil 以后,病人们被要求曾经挤压调查者的手 30 秒。病人们连续地被给 propofol 直到知觉(LOC1 ) 的损失 .Tunstall 的孤立的前臂技术被用来在病人测试外科的知觉。在全部的肌肉松驰以后,气管内膜的 intubations 被执行,并且病人被连接到一台通风机。然后, propofol 被撤退直到给看的病人知觉(ROC1 ) 和了解反应重获。在命令测试以后,病人们与 propofol 被重新管理直到知觉(LOC2 ) 的损失。在外科以后,所有 sedatives 被撤退,并且病人被让重获知觉( ROC2 )二度在使用肌肉以后在 ROC1 12 个病人珍视的 .Results 弛缓没有使用肌肉,是比在 LOC1 和 ROC2 的那些低得多的弛缓,出现统计意义( P < 0.05 )。同时, WLI 在使用肌肉以后在 ROC1 12 个病人珍视弛缓没有使用肌肉,比在 LOC1 和平等者的那些高得多到 ROC2 弛缓的、出现统计意义( P < 0.05 )在 ROC1 和 LOC1.Conclusions 之间,这研究在肌肉松驰或面部麻痹下面显示出那,当没有 EMG 信号时,二度不能精确地思考在外科的病人知觉重获,但是 WLI 能精确地反映它。WLI 可以因此为在外科的病人反映知觉的状态有优点。 | ZHANG Xiao-tong CHENG Hao XIONG Wei WANG Bao-guo | 2010 | Chinese Medical Journal2010，，12： | 12 |
| 10 | GID1 modulates stomatal response and submergence tolerance involving abscisic acid and gibberellic acid signaling in rice显示文摘Plant responses to abiotic stresses are coordinated by arrays of growth and developmental programs.Gibberellic acid(CA) and abscisic acid(ABA) play critical roles in the developmental programs and environmental responses,respectively,through complex signaling and metabolism networks.However,crosstalk between the two phytohormones in stress responses remains largely unknown.In this study,we report that CIBBERELLIN-INSENSITIVE DWARF 1(GID1),a soluble receptor for GA,regulates stomatal development and patterning in rice(Oryza sativa L.).The gid1 mutant showed impaired biosynthesis of endogenous ABA under drought stress conditions,but it exhibited enhanced sensitivity to exogenous ABA.Scanning electron microscope and infrared thermal image analysis indicated an increase in the stomatal conductance in the gid1 mutant under drought conditions.Interestingly,the gid1 mutant had increased levels of chlorophyll and carbohydrates under submergence conditions,and showed enhanced reactive oxygen species(ROS)-scavenging ability and submergence tolerance compared with the wild-type.Further analyses suggested that the function of GID1 in submergence responses is partially dependent on ABA,and GA signaling by GID1 is involved in submergence tolerance by modulating carbohydrate consumption.Taken together,these findings suggest GID1 plays distinct roles in stomatal response and submergence tolerance through both the ABA and GA signaling pathways in rice. | Hao Du Yu Chang Fei Huang Lizhong Xiong | 2015 | Journal of Integrative Plant Biology2015，57，11： | 12 |
| 11 | Effects of Main Parameters on Rheological Properties of Oil-Coal Slurry显示文摘Oil-coal slurry prepared in coal direct liquefaction is a dispersed solid-liquid suspension system. In this paper, some factors such as solvent properties, solid concentrations and temperatures, which affect viscosity change of oil-coal slurry, were studied. The viscosity of coal slurry was measured using rotary viscometer, and the rheological properties have been investigated. The viscosity and rheological curves were plotted and regressed, respectively. The results show that the coal slurry behaves a pseudoplastic and thixotropic property. The rheological type of coal slurry was ascertained and its rheological equations were educed. The oil-coal slurry changes to non-Newtonian fluid from Newtonian fluid with the increasing of solid concentration. | WANG Yong-gang HAO Li-fang XIONG Chu-an SUN Xiu-ying | 2006 | Journal of China University of Mining and Technology2006，16，3： | 12 |
| 12 | Laparoscopic vs open total gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis comparing laparoscopic total gastrectomy(LTG)with open total gastrectomy(OTG)for the treatment of gastric cancer.METHODS:Major databases such as Medline(PubMed),Embase,Academic Search Premier(EBSCO),Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials(CENTRAL)in The Cochrane Library were searched for studies comparing LTG and OTG from January 1994 to May 2013.Evaluated endpoints were operative,postoperative and oncological outcomes.Operative outcomes included operative time and intraoperative blood loss.Postoperative recovery included time to first fatus,time to first oral intake,hospital stay and analgesics use.Postoperative complications comprised morbidity,anastomotic leakage,anastomotic stenosis,ileus,bleeding,abdominal abscess,wound problems and mortality.Oncological outcomes included positive resection margins,number of retrieved lymph nodes,and proximal and distal resection margins.The pooled effect was calculated using either a fixed effects or a random effects model.RESULTS:Fifteen non-randomized comparative studies with 2022 patients were included(LTG-811,OTG-1211).Both groups had similar short-term oncological outcomes,analgesic use(WMD-0.09;95%CI:-2.39-2.20;P=0.94)and mortality(OR=0.74;95%CI:0.24-2.31;P=0.61).However,LTG was associated with a lower intraoperative blood loss(WMD-201.19 mL;95%CI:-296.50--105.87 mL;P<0.0001)and overall complication rate(OR=0.73;95%CI:0.57-0.92;P=0.009);fewer wound-related complications(OR=0.39;95%CI:0.21-0.72;P=0.002);a quicker recovery of gastrointestinal motility with shorter time to frst fatus(WMD-0.82;95%CI:-1.18--0.45;P<0.0001)and oral intake(WMD-1.30;95%CI:-1.84--0.75;P<0.00001);and a shorter hospital stay(WMD-3.55;95%CI:-5.13--1.96;P<0.0001),albeit with a longer operation time(WMD 48.25 min;95%CI:31.15-65.35;P<0.00001),as compared with OTG.CONCLUSION:LTG is safe and effective,and may offer some advantages over OTG in the treatment of gastric cancer. | Jun-Jie Xiong Quentin M Nunes Wei Huang Chun-Lu Tan Neng-Wen Ke Si-Ming Xie Xun Ran Hao Zhang Yong-Hua Chen Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，44： | 11 |
| 13 | Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘 | Zhu, Jie Ming, Chang Fu, Xin Duan, Yaou Duc Anh Hoang Rutgard, Jeffrey Zhang, Runze Wang, Wenqiu Hou, Rui Zhang, Daniel Zhang, Edward Zhang, Charlotte Hao, Xiaoke Xiong, Wenjun Zhang, Kang | 2017 | Cell Research2017，27，6： | 11 |
| 14 | Pd-Ag alloy hollow nanostructures with interatomic charge polarization for enhanced electrocatalytic formic acid oxidation显示文摘蚁的酸氧化是在膜(PEM ) 燃料细胞,活跃地点和种吸附 / 激活在玩调音的 protonexchange 的重要 electrocatalytic 反应角色。在这研究,我们为申请与高活跃的表面区域开发了空 Pd-Ag 合金 nanostructures 到 electrocatalytic 蚁的酸氧化。当 Ag 的某个数量被合并到 Pd 时格子,已经是为蚁的酸氧化的高度活跃的材料, electrocatalytic 活动能显著地被增加。是由理论模拟显示了,在 Pd 和 Ag 之间联合在 Pd 催化地点上导致极化费用,它能提高 HCOO 的吸附 * 种类。作为结果,设计 electrocatalysts 能完成减少的 Pd 用法并且同时提高催化性质。这研究代表同时制作空结构增加活跃地点的数字并且利用 interatomic 相互作用向改进 electrocatalytic 性能调节种类吸附 / 激活的一条途径。 | Dong Liu Maolin Xie Chengming wang Lingwen Liao Lu Qiu Jun Ma Hao Huang Ran Long Jun Jiang Yujie Xiong | 2016 | Nano Research2016，9，6： | 11 |
| 15 | An open-labeled, randomized, multicenter phase Ⅱa study of gambogic acid injection for advanced malignant tumors显示文摘 | CHI Yihebali ZHAN Xiao-kai YU Hao XIE Guang-ru WANG Zhen-zhong XIAO Wei WANG Yong-gang XIONG Fu-xing HU Jun-feng YANG Lin CUI Cheng-xu WANG Jin-wan | 2013 | Chinese Medical Journal2013，，9： | 10 |
| 16 | Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas显示文摘Epstein-Barr virus(EBV)is associated with nasopharyngeal carcinoma(NPC)tumorigenesis.However,the mechanism(s)connecting EBV infection and NPC remain unclear.Recently,a new class of EBV microRNAs(miRNAs)has been described.To determine how EBV miRNAs control the expression of host genes,and to understand their potential role in NPC tumorigenesis,we profiled the expression of 44 mature EBV miRNAs and potential host genes in NPC and non-tumor nasopharyngeal epithelial tissues.We found that 40 EBV miRNAs from the BART transcript were highly expressed in NPC.Analysis of potential BART miRNA target genes revealed that 3140 genes and several important pathways might be involved in the carcinogenesis of NPC.A total of 105 genes with potential EBV miRNA binding sites were significantly downregulated,suggesting that EBV miRNAs may regulate these genes and contribute to NPC carcinogenesis.An EBV miRNA and host gene regulation network was generated to provide useful clues for validating of EBV miRNA functions in NPC tumorigenesis. | ZENG ZhaoYang HUANG HongBin HUANG LiLi SUN MengXi YAN QiJia SONG YaLi WEI Fang BO Hao GONG ZhaoJian ZENG Yong LI Qiao ZHANG WenLing LI XiaYu XIANG Bo LI XiaoLing LI Yong XIONG Wei LI GuiYuan | 2014 | Science China(Life Sciences)2014，57，3： | 10 |
| 17 | The application of antimicrobial peptides as growth and health promoters for swine显示文摘With the widespread ban on the use of antibiotics in swine feed,alternative measures need to be sought to maintain swine health and performance.Antimicrobial peptides(AMPs) are part of the nonspecific defense system and are natural antibiotics produced by plants,insects,mammalians,and micro-organisms as well as by chemical synthesis.Due to their broad microbicidal activity against various fungi,bacteria and enveloped viruses,AMPs are a potential alternative to conventional antibiotics for use in swine production.This review focuses on the structure and mechanism of action of AMPs,as well as their effects on performance,immune function and intestinal health in pigs.The aim is to provide support for the application of AMPs as feed additives replacing antibiotics in swine nutrition. | Hao Xiao Fangyuan Shao Miaomiao Wu Wenkai Ren Xia Xiong Bie Tan Yulong Yin | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 9 |
| 18 | Smart City Architecture: A Technology Guide for Implementation and Design Challenges显示文摘Urban development is becoming increasingly reliant on effective use of intelligent services.In the process of providing better services to all citizens and improving the efficiency of administration processes,the concept of a smart city has been lauded as a promising solution for the coming challenge of global urbanization.However,due to the broad scope of smart cities their definition has not been standardized,thus proposed architectures are diverse.This work proposes a new architecture from the perspective of the data that underpins all the functionality of smart cities.The proposed architecture is discussed,outlining design challenges and offering insight into the development of smart cities. | RONG Wenge XIONG Zhang COOPER Dave LI Chao SHENG Hao | 2014 | China Communications2014，11，3： | 9 |
| 19 | Integrative Regulation of Drought Escape through ABA-Dependent and -Independent Pathways in Rice显示文摘许多植物发展了干旱逃跑(DE ) 机制弄短他们的生命周期当面对水赤字条件时。当干旱忍耐强烈地被调查了时, DE 的基因、分子的机制留下逃犯。在这研究,我们发现在米饭开发的早阶段的低水赤字处理(LWT ) 能触发早 flowering 并且减少 tiller 数字。LWT 导致了 abscisic 酸(骆驼毛的织物) 的累积,它接着由同时地调整许多花相关的基因支持早 flowering 在轻感觉和生理节奏的钟上有反馈效果。而且,,一些包括 OsTOC1 , Ghd7 ,和 PhyB 的轻受体,生理节奏的部件,和花相关的基因被发现以一种骆驼毛的织物依赖者方式涉及 LWT 一些包括 OsGI 的另外的花相关的基因, OsELF3 , OsPRR37 ,并且 OsMADS50 涉及独立于骆驼毛的织物的 DE 的规定。另外,我们发现 strigolactones 和 OsTB1 在 LWT 下面涉及 tillering 抑制,它独立于在米饭的 flowering 小径。一起拿,我们的调查结果提供在米饭的 DE 被多重小径并列地在繁殖(flowering ) 期间调整的引人注目的证据开关。 | Hao Du Fei Huang Nai Wu Xianghua Li Honghong Hu Lizhong Xiong | 2018 | Molecular Plant2018，11，4： | 9 |
| 20 | Flexible cobalt phosphide network electrocatalyst for hydrogen evolution at all pH values显示文摘为根本切开 pH 值的水的高效的 electrocatalysts 在持续的氢进化的领域里吸引了可观的兴趣。此处,我们与 nanocrystalline 钴磷化物(警察) 报导有效 electrocatalyst 为在 0-14 的 pH 范围切开的水的网络。新奇灵活 electrocatalyst 从在一条传导性的 Hastelloy 带上种的一个理想的 nanocrystalline 警察网络被导出。这种 self-supported 警察网络直接为氢进化被用作 electrocatalytic 阴极。在有 ~ 的低发作过电位的优异性能的 nanocrystalline 网络结构结果在 0 ~ 14 的一个宽广 pH 范围上的 45 mV 并且负担得起 100 mAH | Jianwen Huang Yanrong Li YufeiXia Juntong Zhu Qinghua Yi Hao Wang Jie Xiong Yinghui Sun Guifu Zou | 2017 | Nano Research2017，10，3： | 8 |
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