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| 1 | Analysis of status and countermeasures of cancer incidence and mortality in China显示文摘Cancer is the leading cause of human deaths in the world and produces serious economic burdens. On September 12, 2018, the academic journal A Cancer Journal for Clinicians published an article about the latest statistics of cancers worldwide, which provided a status report on the global burden of 36 cancers in 185 countries worldwide. Cancer has also become a serious public health problem in China and caused more and more attention of the government and people in recent years. This review analyzes the incidence, mortality and prevalent trend of cancers in China, discusses the reasons behind this status, and reviews the potential countermeasures for cancer prevention and control in China. | Chunchun Wu Mengna Li Hanbing Meng Yukun Liu Weihong Niu Yao Zhou Ran Zhao Yumei Duan Zhaoyang Zeng Xiaoling Li Guiyuan Li Wei Xiong Ming Zhou | 2019 | Science China(Life Sciences)2019，62，5： | 175 |
| 2 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 3 | Trend analysis of cancer incidence and mortality in China显示文摘The National Central Cancer Registry of China(NCCRC)updated their nationwide statistics of cancer incidence and mortality in China according to 2013 population-based cancer registration data(due to the time required for data collection,quality control and analysis,the latest cancer statistics available in China have a 3-year lag behind the current year).In this report,the NCCRC provides a comprehensive review of cancer incidence and mortality rates,as well as the statistics overall and by geographical area,cancer sites or age groups(Chen et al.,2017a).It shows that the burden of cancer | Fang Wei Yingfen Wu Le Tang Fang Xiong Can Guo Xiayu Li Ming Zhou Bo Xiang Xiaoling Li Guiyuan Li Wei Xiong Zhaoyang Zeng | 2017 | Science China(Life Sciences)2017，60，11： | 16 |
| 4 | Nasopharyngeal carcinoma:Advances in genomics and molecular genetics显示文摘Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution,being of high prevalence in southern China but rare in other parts of the world [2]. | ZENG ZhaoYang HUANG HongBin ZHANG WenLing XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan | 2011 | Science China(Life Sciences)2011，54，10： | 13 |
| 5 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 6 | Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas显示文摘Epstein-Barr virus(EBV)is associated with nasopharyngeal carcinoma(NPC)tumorigenesis.However,the mechanism(s)connecting EBV infection and NPC remain unclear.Recently,a new class of EBV microRNAs(miRNAs)has been described.To determine how EBV miRNAs control the expression of host genes,and to understand their potential role in NPC tumorigenesis,we profiled the expression of 44 mature EBV miRNAs and potential host genes in NPC and non-tumor nasopharyngeal epithelial tissues.We found that 40 EBV miRNAs from the BART transcript were highly expressed in NPC.Analysis of potential BART miRNA target genes revealed that 3140 genes and several important pathways might be involved in the carcinogenesis of NPC.A total of 105 genes with potential EBV miRNA binding sites were significantly downregulated,suggesting that EBV miRNAs may regulate these genes and contribute to NPC carcinogenesis.An EBV miRNA and host gene regulation network was generated to provide useful clues for validating of EBV miRNA functions in NPC tumorigenesis. | ZENG ZhaoYang HUANG HongBin HUANG LiLi SUN MengXi YAN QiJia SONG YaLi WEI Fang BO Hao GONG ZhaoJian ZENG Yong LI Qiao ZHANG WenLing LI XiaYu XIANG Bo LI XiaoLing LI Yong XIONG Wei LI GuiYuan | 2014 | Science China(Life Sciences)2014，57，3： | 10 |
| 7 | Overview and countermeasures of cancer burden in China显示文摘Cancer is one of the leading causes of human death worldwide.Treatment of cancer exhausts significant medical resources,and the morbidity and mortality caused by cancer is a huge social burden.Cancer has therefore become a serious economic and social problem shared globally.As an increasingly prevalent disease in China,cancer is a huge challenge for the country’s healthcare system.Based on recent data published in the Journal of the National Cancer Center on cancer incidence and mortality in China in 2016,we analyzed the current trends in cancer incidence and changes in cancer mortality and survival rate in China.And also,we examined several key risk factors for cancer pathogenesis and discussed potential countermeasures for cancer prevention and treatment in China. | Yian Wang Qijia Yan Chunmei Fan Yongzhen Mo Yumin Wang Xiayu Li Qianjin Liao Can Guo Guiyuan Li Zhaoyang Zeng Wei Xiong He Huang | 2023 | Science China(Life Sciences)2023，66，11： | 5 |
| 8 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 9 | Leucine-rich repeat C4 protein is Involved in Nervous Tissue Development and Neurite Outgrowth, and Induction of Glioma Cell Differentiation显示文摘LRRC4,充满白氨酸的重复 C4 蛋白质,在人被识别了(GenBankaccession 没有。AF196976 ) ,老鼠(GenBank 同意没有。DQ177325 ) ,老鼠(GenBank 就职 No.DQ119102 ) 并且牛(GenBank 同意没有。DQ164537 ) 与相同领域。以他们的类似,把 LRRC4 编码为这的基因四哺乳动物的种是剩菜公猪因此对应于一样的基因实体。基于以前的研究,并且在 situ 杂交使用,我们发现那 LRRC4 有最强壮的表示在海马趾的 CA1 和 CA2,有牙齿的回转区域的小粒房间, mediodoral thalamic 原子核,和小脑 Purkinje 房间层。用 aP19 房间模型,我们也发现 LRRC4 参予神经原和神经胶质房间的区别。另外,两个都包含一个 LRR 盒子的细胞外的蛋白质和免疫球蛋白领域被显示了参予轴突指导。我们从神经突长出试金的数据显示 LRRC4 支持了海马趾的神经原的神经突扩展,并且导致了 glioblastoma U251 房间的区别进像星形细胞的房间,由形态学观察和 glialfibrillary 证实了酸的蛋白质表示。 | Minghua WU He HUANG Qiong CHEN Dan LI Zhaoyang ZENG Wei XIONG Yanhong ZHOU Xiaoling LI Ming ZHOU Jianhong LU Shourong SHEN Guiyuan LI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 4 |
| 10 | Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy显示文摘Mounting evidence has revealed that the therapeutic efficacy of immunotherapies is restricted to a small portion of cancer patients.A deeper understanding of how metabolic reprogramming in the tumor microenvironment(TME)regulates immunity remains a major challenge to tumor eradication.It has been suggested that metabolic reprogramming in the TME may affect metabolism in immune cells and subsequently suppress immune function.Tumor cells compete with infiltrating immune cells for nutrients and metabolites.Notably,the immunosuppressive TME is characterized by catabolic and anabolic processes that are critical for immune cell function,and elevated inhibitory signals may favor cancer immune evasion.The major energy sources that supply different immune cell subtypes also undergo reprogramming.We herein summarize the metabolic remodeling in tumor cells and different immune cell subtypes and the latest advances underlying the use of metabolic checkpoints in antitumor immunotherapies.In this context,targeting both tumor and immune cell metabolic reprogramming may enhance therapeutic efficacy. | Chunmei Fan Shanshan Zhang Zhaojian Gong Xiayu Li Bo Xiang Hao Deng Ming Zhou Guiyuan Li Yong Li Wei Xiong Zhaoyang Zeng Xiaoling Li | 2021 | Science China(Life Sciences)2021，64，4： | 4 |
| 11 | Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA显示文摘Nasopharyngeal carcinoma(NPC)is a malignant tumor that usually occurs in people from Southeast Asia and Southern China.NPC is prone to migration and invasion,leading to poor prognosis.A large number of circular RNAs(circ RNAs)exacerbate the process of metastasis in NPC;however,their underlying mechanisms remain unclear.We found that the circular RNA circ CCNB1,encoded by the oncogene CCNB1,was downregulated in NPC biopsies and cell lines.In vitro assays show that circ CCNB1 inhibits NPC cell migration and invasion.Moreover,circ CCNB1 induces a protein,nuclear factor 90(NF90),to bind and prolong the half-life of tight junction protein 1(TJP1)m RNA.Upregulation of TJP1 enhances tight junctions between cancer cells and inhibits NPC cell migration and invasion.This study reveals a novel biological function of circ CCNB1 in the migration and invasion of NPC by enhancing the tight junctions of cancer cells by binding to NF90 proteins and TJP1 m RNA,and may provide a potential therapeutic target for NPC. | Mengyao Zhao Yian Wang Fenghua Tan Lingyun Liu Xiangchan Hou Chunmei Fan Le Tang Yongzhen Mo Yumin Wang Qijia Yan Zhaojian Gong Zheng Li Qianjin Liao Can Guo He Huang Xi Zeng Guiyuan Li Zhaoyang Zeng Wei Xiong Fuyan Wang | 2022 | Science China(Life Sciences)2022，65，11： | 4 |
| 12 | printed electrode immunosensors for Schistosoma japonicum显示文摘 | ZENG Shaohua TIAN Zhi CHE Hongli YANG Huihui CHEN Xiuchun FENG Qimei ZHOU Yunfei ZHANG Shuju WU Zhaoyang WANG Shiping | 2012 | 中南大学学报(医学版)2012，37，6： | 3 |
| 13 | Simulation Performance Evaluation and Uncertainty Analysis on a Coupled Inundation Model Combining SWMM and WCA2D显示文摘Urban floods are becoming increasingly more frequent,which has led to tremendous economic losses.The application of inundation modeling to predict and simulate urban flooding is an effective approach for disaster prevention and risk reduction,while also addressing the uncertainty problem in the model is always a challenging task.In this study,a cellular automaton(CA)-based model combining a storm water management model(SWMM)and a weighted cellular automata 2D inundation model was applied and a physical-based model(LISFLOOD-FP)was also coupled with SWMM for comparison.The simulation performance and the uncertainty factors of the coupled model were systematically discussed.The results show that the CA-based model can achieve sufficient accuracy and higher computational efficiency than can a physical-based model.The resolution of terrain and rainstorm data had a strong influence on the performance of the CA-based model,and the simulations would be less creditable when using the input data with a terrain resolution lower than 15 m and a recorded interval of rainfall greater than 30 min.The roughness value and model type showed limited impacts on the change of inundation depth and occurrence of the peak inundation area.Generally,the CA-based coupled model demonstrated laudable applicability and can be recommended for fast simulation of urban flood episodes.This study also can provide references and implications for reducing uncertainty when constructing a CA-based coupled model. | Zhaoyang Zeng Zhaoli Wang Chengguang Lai | 2022 | International Journal of Disaster Risk Science2022，13，3： | 2 |
| 14 | Influence of radial seepage on temperature distribution around a cylindrical cavity in a porous medium显示文摘 | Brown Jim Vardy Alan Zeng Zhaoyang | 1998 | Int J Heat Mass Transfer1998，41，11： | 1 |
| 15 | 中高层大气环流模式的初步评估与敏感性分析显示文摘提高大气环流模式的模式顶层高度对中高层大气(如平流层准两年振荡)的准确模拟至关重要.本研究将IAP大气环流模型(IAP-AGCM)延伸至中层大气顶(~0.01 hPa,~80 km)并提高垂直方向分辨率(91层),发展了一个中高层大气环流模型(IAP-AGCML91).结果表明,与低层模式相比,该中高层大气模式在整体上显著减小了平流层尤其是上平流层的冷偏差.研究发现这种改善与两种机制有关:与低层模式相比,高层模式模拟的短波加热更大,极区平流层附近的经向涡动热通量更大.上述结果表明,垂直分辨率和模式顶层高度对IAP-AGCML91的气候模拟有重要影响. | Zhaoyang Chai Minghua Zhang Qingcun Zeng He Zhang Jiangbo Jin Jinbo Xie Ting You | 2021 | Atmospheric and Oceanic Science Letters2021，14，2： | 1 |
| 16 | Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc显示文摘Actin filament associated protein 1 antisense RNA 1(named AFAP1-AS1)is a long non-coding RNA and overexpressed in many cancers.This study aimed to identify the role and mechanism of AFAP1-AS1 in lung cancer.The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization.The migration and invasion abilities of AFAP1-AS1 were investigated in lung cancer cells.To uncover the molecular mechanism about AFAP1-AS1 function in lung cancer,we screened proteins that interact with AFAP1-AS1 by RNA pull down and the mass spectrometry analyses.AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients'poor prognosis.In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis.AFAP1-AS1 promoted lung cancer cells migration and invasion through interacting with Smad nuclear interacting protein 1(named SNIP1),which inhibited ubiquitination and degradation of c-Myc protein.Upregulation of c-Myc molecule in turn promoted the expression of ZEB1,ZEB2,and SNAIL gene,which ultimately enhanced epithelial to mesenchymal transition(EMT)and lung cancer metastasis.Understanding the molecular mechanism by which AFAP1-AS1 promotes lung cancer's migration and invasion may provide novel therapeutic targets for lung cancer patients'early diagnosis and therapy. | Yu Zhong Liting Yang Fang Xiong Yi He Yanyan Tang Lei Shi Songqing Fan Zheng Li Shanshan Zhang Zhaojian Gong Can Guo Qianjin Liao Yujuan Zhou Ming Zhou Bo Xiang Xiaoling Li Yong Li Zhaoyang Zeng Guiyuan Li Wei Xiong | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 1 |
| 17 | Field and Temperature Dependence of Susceptibility of Single Crystal Bi_(2)Sr_(2)CaCu_(2)O_(8)显示文摘Susceptibility measurements on Bi_(2)Sr_(2)CaCu_(2)O_(8) single crystals do reveal field-induced-suppression of sharp phase transition.No apparent anisotropy of the susceptibility was observed when magnetic field was applied along the three main directions a,b and c.The three dimensional isotropic fluctuation diamagnetism theory is proposed to explain our experimental finding of isotropic susceptibility.In a wide range of magnetic field,the temperature dependence of susceptibility does not show any obvious change in its character when the sample enters into expected vortex-lattice state from vortex-liquid state. | YU Zheng DING Shiying ZENG Zhaoyang SHI Kexin YAO Xixian YANG Guang ZHAO Zhongxian WANG Hong WANG Zhuo | 1992 | Chinese Physics Letters1992，9，11： | 0 |
| 18 | Study of Flux Pinning in Zone-melted YBCO by SQUID显示文摘Magnetic hysteresis loops and magnetization relaxation of a zone-melted Y Ba_(2)Cu_(3)O_(6+x) sample were measured by superconducting quantum interference device(SQUID)at temperature from 4.5 to 70K.The logarithmic behavior of niagnetic decay at 4.5 K and the gritdua,l deviation as the temperature is increased deinon-stra.ted the important role of nonlinea.r current density dependence of effective flux pinning potential U(J)in high temperature supcrconductors. | JI Helin SHI Zhixian ZENG Zhaoyang JIN Xin YAO Xixian FAN Zhanguo SHAN Yuqiao | 1993 | Chinese Physics Letters1993，10，8： | 0 |
| 19 | CAS-ESM2.0 Dataset for the Carbon Dioxide Removal Model Intercomparison Project(CDRMIP)显示文摘Understanding the response of the Earth system to varying concentrations of carbon dioxide(CO_(2))is critical for projecting possible future climate change and for providing insight into mitigation and adaptation strategies in the near future.In this study,we generate a dataset by conducting an experiment involving carbon dioxide removal(CDR)—a potential way to suppress global warming—using the Chinese Academy of Sciences Earth System Model version 2.0(CASESM2.0).A preliminary evaluation is provided.The model is integrated from 200–340 years as a 1%yr^(−1) CO_(2) concentration increase experiment,and then to~478 years as a carbon dioxide removal experiment until CO_(2) returns to its original value.Finally,another 80 years is integrated in which CO_(2) is kept constant.Changes in the 2-m temperature,precipitation,sea surface temperature,ocean temperature,Atlantic meridional overturning circulation(AMOC),and sea surface height are all analyzed.In the ramp-up period,the global mean 2-m temperature and precipitation both increase while the AMOC weakens.Values of all the above variables change in the opposite direction in the ramp-down period,with a delayed peak relative to the CO_(2) peak.After CO_(2) returns to its original value,the global mean 2-m temperature is still~1 K higher than in the original state,and precipitation is~0.07 mm d^(–1) higher.At the end of the simulation,there is a~0.5°C increase in ocean temperature and a 1 Sv weakening of the AMOC.Our model simulation produces similar results to those of comparable experiments previously reported in the literature. | Jiangbo JIN Duoying JI Xiao DONG Kece FEI Run GUO Juanxiong HE Yi YU Zhaoyang CHAI He ZHANG Dongling ZHANG Kangjun CHEN Qingcun ZENG | 2024 | Advances in Atmospheric Sciences2024，41，5： | 0 |
| 20 | CAS-ESM2.0 Model Datasets for the CMIP6 Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP)显示文摘The second version of the Chinese Academy of Sciences Earth System Model(CAS-ESM2.0)is participating in the Flux-Anomaly-Forced Model Intercomparison Project(FAFMIP)experiments in phase 6 of the Coupled Model Intercomparison Project(CMIP6).The purpose of FAFMIP is to understand and reduce the uncertainty of ocean climate changes in response to increased CO2 forcing in atmosphere-ocean general circulation models(AOGCMs),including the simulations of ocean heat content(OHC)change,ocean circulation change,and sea level rise due to thermal expansion.FAFMIP experiments(including faf-heat,faf-stress,faf-water,faf-all,faf-passiveheat,faf-heat-NA50pct and faf-heat-NA0pct)have been conducted.All of the experiments were integrated over a 70-year period and the corresponding data have been uploaded to the Earth System Grid Federation data server for CMIP6 users to download.This paper describes the experimental design and model datasets and evaluates the preliminary results of CAS-ESM2.0 simulations of ocean climate changes in the FAFMIP experiments.The simulations of the changes in global ocean temperature,Atlantic Meridional Overturning Circulation(AMOC),OHC,and dynamic sea level(DSL),are all reasonably reproduced. | Jiangbo JIN He ZHANG Xiao DONG Hailong LIU Minghua ZHANG Xin GAO Juanxiong HE Zhaoyang CHAI Qingcun ZENG Guangqing ZHOU Zhaohui LIN Yi YU Pengfei LIN Ruxu LIAN Yongqiang YU Mirong SONG Dongling ZHANG | 2021 | Advances in Atmospheric Sciences2021，38，2： | 0 |
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