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| 1 | Trend of China land water storage redistribution at medi- and large-spatial scales in recent five years by satellite gravity observations显示文摘卫星严肃使命提供了的优雅(严肃恢复和气候实验) 学习土地的一个新方法在最近的年里在 medi 空间、长空间的规模浇集体再分配。我们在 2003 ~ 2007 期间用优雅观察在中国估计大陆人水团再分配。结果随增加显示出一些大区域或土地的减少在 Xinjiang Uygur 自治区域在中央北区域,西藏的高原,三个峡区域, Qinghai,四川和 Gansu 省相遇的地方,和 Altun 山区域浇集体存储。在开始的二个区域,水(冰) 集中,是明显的存储正在减少。在以 2.4 cm/a 等价物的线性率的中央北区域减少的水质量浇高度,在五年的时期期间每年等于到 52 亿立方的米,并且浇集体弄空在 Hebei 省是 ∼45 亿立方的米每滥用的地下的水的年每在一样的时期,它与一般水准一致的年浇 40 亿立方的米的集体弄空在最近 Hebei 省估计的 30 年浇资源局。而且,优雅能检测 ∼ 的水团累积在散布超过大约 12 万的区域以内的 5 厘米相等的水高度由于三峡摆平公里在 2003 年 6 月的水坝建设。我们也发现 ∼ 的水团获得在 Qinghai,四川和 Gansu 省相遇的区域的 1.1 cm/a。这显示这些区域的气候在最近的年里一直在变得逐渐地潮湿。 | ZHONG Min DUAN JianBin XU HouZe PENG Peng YAN HaoMing ZHU YaoZhong | 2009 | Chinese Science Bulletin2009，54，5： | 35 |
| 2 | Effect of Short-term Forest Bathing in Urban Parks on Perceived Anxiety of Young-adults: A Pilot Study in Guiyang, Southwest China显示文摘Forest can be taken as a natural therapy to alleviate perceived anxiety of visitors. Given the geographical difference between urban and rural forest environments, little is known about the urban forest therapy effect of anxiety alleviation with reference to the rural forest. In this study, forty-three university students(aged from 19 to 23) were recruited as participants to visit the forest parks at urban and rural areas of Guiyang City on 21 and 23 December 2016. The forest experience was separated by four sceneries. Participants were asked to complete questionnaires by self-evaluating specific anxiety change from 12 questions with scores from 1 to 10 at both entrance and exit of the parks. The Wilcoxon signed-rank test and paired t-test were used to compare the change of anti-anxiety scores during forest bathing and between urban and rural forests, respectively. Results revealed that forest bathing in the urban park can alleviate the anxiety from financial state(P = 0.0028), exam-pass pressure(P = 0.0040) and love-affair relationship(P = 0.0286). Although rural forest bathing can also alleviate the anxiety from financial state(P = 0.0222), meanwhile, it maintained the anxiety about campus life(P < 0.0001). Forest tree richness tended to be higher in the rural forest park than in the urban one, which in contrast decreased the anxiety alleviation from inter-communication in the rural forest park(P = 0.0487). Principle component analysis indicated that participants tended to perceive more decline of anxiety from social contact in the urban forest. In conclusion, university students were recommended to pay a short visit to the urban forest with partners if they felt anxious about personal affairs and felt necessary to talk with others. For general people's visiting, urban forest trees can be controlled in diversity to some extent to look orderly and alleviate perceived anxiety. | ZHOU Changwei YAN Lingbin YU Lifei WEI Hongxu GUAN Haoming SHANG Chongfei CHEN Feiyu BAO Junzhou | 2019 | Chinese Geographical Science2019，29，1： | 5 |
| 3 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 4 | Apoptosis in suspension culture of tobacco cells induced by heat shock显示文摘The induction of apoptosis in suspension culture of tobacco cells by heat shock is reported for the first time. Heat treatment (48℃ for 4 h) of tobacco cells led to the appearance of typical hallmarks of apoptosis. It was demonstrated by DNA laddering analysis that the cells treated with heat shock at 48℃ for 4 h had a serious degradation of nuclear DNA into multi-nu-cleosomal sizes, suggesting that heat shock activated endogenous nuclease which led to DNA cleavage at the linkage sites between the nucleosomes, but ladders were very faint for DNA from 2 and 9 h heat-treated cells. The terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labelling (TUNEL) detection also showed that most of these treated cells (48℃ for 4 h) displayed positive reactions, indicating a serious DNA 3’-OH cleavage in their nuclei. Moreover, some other cytological changes in apoptotic cells, such as cell shrinkage, chromatin aggregation, nucleus collapse, have also been observed by 4’, | Haoming Chen Changhui Yan Xiaofang Jiang Yaoren Dai | 1999 | Chinese Science Bulletin1999，44，12： | 2 |
| 5 | Elevated expression levels of androgen receptors and matrix metalloproteinase-2and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissuesas predictors of cancer invasion and staging显示文摘 | Yan Zhang Yucheng Shen Bin Cao Aiting Yan Haoming Ji | 2015 | Experimental and Therapeutic Medicine2015，，： | 1 |
| 6 | High-yield and low-cost separation of high-purity semiconducting single-walled carbon nanotubes with closed-loop recycling of raw materials and solvents显示文摘Semiconducting single-walled carbon nanotubes (s-SWCNTs) are the foundation of CNT-based electronics and optoelectronics. For practical applications, s-SWCNTs should be produced with high purity, high structural quality, low cost, and high yield. Currently conjugated polymer wrapping method shows great potential to fulfill these requirements due to its advantages of simple operation process, high purity separation, and easy scaling-up. However, only a small portion of both CNTs and polymers go into the final solution, and most of them are discarded after a single use, resulting in high cost and low yield. In this paper, we introduce a closed-loop recycling strategy, in which raw materials (CNTs and polymers) and solvents were all recycled and reused for multiple separation cycles. In each cycle, high-purity (> 99.9%) s-SWCNTs were obtained with no significant change of structural quality. After 7 times of recycling and separation, the material cost was reduced to ∼ 1% in comparison with commercially available products, and total yield was increased to 36% in comparison with 2%–5% for single cycle separation. Our proposed closed-loop recycling strategy paves the way for low-cost and high-yield mass production of high-quality s-SWCNTs. | Fang Liu Xingxing Chen Haoming Liu Jie Zhao Meiqi Xi Hongshan Xiao Tongkang Lu Yu Cao Yan Li Lianmao Peng Xuelei Liang | 2021 | Nano Research2021，14，11： | 1 |
| 7 | Nontidal oceanic contribution to length-of-day changes estimated from two ocean models during 1992-2001显示文摘 | YAN Haoming ZHONG Min ZHU Yaozhong | 2006 | Journal of Geophysics Research-Solid Earth2006，111，02： | 1 |
| 8 | Nontidal oceanic contribution to polar wobble estimated from two oceanic assimilation data sets显示文摘 | ZHONG Min YAN Haoming WU Xiaoping | 2006 | Journal of Geodynamics2006，41，13： | 1 |
| 9 | Contributions of thermal expansion of monuments and nearby bedrock to observed GPS height changes显示文摘 | Yan Haoming Chen Wu Zhu Yaozhong Zhang Weimin Zhong Min | 2009 | Geophysical Research Letters2009，，13： | 1 |
| 10 | Indexing the relationship between polar motion and water mass change in a giant river basin显示文摘Previous studies on the relationship between polar motion and water mass change have mainly concentrated on the excitation of polar motion via global terrestrial water storage changes(TWSC). In view of the uneven distribution of global terrestrial water storage, the relationship between regional water mass change and polar motion needs to be further explored owing to the lack of documented results. In addition, given the uncertainty in the estimation of TWSC, it is required to develop appropriate indices to describe water mass change from different perspectives. The Amazon River basin(referred to Amazon hereafter), containing the world's largest river, located at around the 90°W longitude, is selected as the study area. Water vapor flux, precipitation, runoff and TWSC are selected as the indices of water mass changes to reveal the relationship between polar motion and water mass change in this giant basin. The Mann-Kendall(M-K) method, the accumulated anomaly analysis method and the curvature method are used to identify the abrupt change points; the least squares method is used to estimate the trends,and the Fast Fourier Transform(FFT) and the Ensemble Empirical Mode Decomposition(EEMD) are used to perform a periodic analysis, for all the above indices. It is shown that, of all the indices from 1948 to 2011, water vapor flux is the most closely related index to polar motion. In detail, precipitation and water vapor flux contain beat periods of polar motion; water vapor flux,precipitation and polar motion have a common M-K test abrupt change point(occurring in ca. 1968) at the 0.05 significance level; water vapor flux has a similar accumulated anomaly curve with that of polar motion; and water vapor flux is more highly correlated with polar motion than most other indexes. It is found, just like global TWSC, the χ2 component of the excitation via water vapor flux and water storage change in the Amazon follows that of observed polar motion; χ1 does not follow. However, the pattern in the Amazon that the χ2 component of the excitation by water follows that of observed polar motion is at a more significant level than in global. Finally, the new index termed Location of Vapor-based Inter Tropical Convergence Zone(LVITCZ) we proposed to describe the annual mean latitudinal location of water mass change shows a more close and visual relationship between water mass change and polar motion than other chosen indices do. | Suxia LIU Shanshan DENG Xingguo MO Haoming YAN | 2018 | Science China Earth Sciences2018，61，8： | 1 |
| 11 | Multi-scale Analysis of the Relationships between Solar Activity, CO_(2) and Global Surface Temperature显示文摘To reveal whether the dynamics of solar activity precede those of global temperature, especially in terms of global warming, the relationship between total solar irradiance(TSI), which is treated as a proxy of solar activity, and global surface temperature(GST) is investigated in the frequency domain using wavelet coherence. The results suggest that the effect of TSI on GST is mainly reflected on the characteristic scale around 22 yr, and variations in TSI lead to changes in GST with some delay effect as shown by the phase difference arrows. However, this implicated relationship has been perturbed by excessive CO_(2) emissions since 1960. Through the combination of co-integration analysis and wavelet coherence, the hidden relationship between TSI and GST has been uncovered without the CO_(2) effect and the results further indicate that TSI has a positive effect on GST at the characteristic scale around 22 yr with a 3 yr lead. | Zhen Li Lijun Chang Jiahui Lou Yi Shen Haoming Yan | 2022 | Research in Astronomy and Astrophysics2022，22，9： | 0 |
| 12 | Sea level rise along China coast from 1950 to 2020显示文摘Global mean sea level rise has been reconstructed using tide gauges. However, long-term sea level rise along the China coast is unclear. To address this issue, a data assimilation approach is developed to reconstruct sea level rise along the China coast from 1950 to 2020 using a global distribution of tide gauges(TGs). This approach combines climate models and sea level fingerprints. The climate models provide stereodynamic sea level changes. The sea level fingerprints include increases in ocean mass due to global ice melting and changes in water storage on land. The reconstructed global mean sea level rise agrees well with previous studies. We quantify sea level rise at 20 TGs along the China coast. The results suggest that sea level rise along the China coast(1.95±0.33 mm yr^(-1)) is greater than the global mean(1.71±0.17 mm yr^(-1)). We also find that China's coastal sea level rise is more than three times faster after 1980, increasing from 0.84±0.28 mm yr^(-1)for 1950–1980 to3.12±0.21 mm yr^(-1)for 1980–2020. This finding implies a significant sea level acceleration along the China coast. Our results advance the understanding of long-term sea level changes along the China coast. | Dapeng MU Tianhe XU Haoming YAN | 2024 | Science China Earth Sciences2024，67，3： | 0 |
| 13 | Single-walled carbon nanotube based SERS substrate with single molecule sensitivity显示文摘In single molecule study,surface-enhanced Raman scattering(SERS)has the advantage of specifically providing structural information of the molecules targeted.The main challenge in single molecule SERS is developing reusable plasmonic substrates that ensures single molecule sensitivity and acquires intrinsic information of molecules.Here,we proposed a strategy to utilize single-walled carbon nanotubes(SWNTs)to construct SERS substrates.Employing ultrasonic spray pyrolysis,we prepared in situ polyhedral gold nanocrystals closely spaced and attached to nanotubes,ensuring valid hot spots formed along the tube-walls.With such SERS substrates,we proved the single molecule detection by the statistical analysis based on the natural abundance of isotopes.Since SWNTs provide non-chemical bonding adsorption sites,our SERS substrates are easily reusable and have a unique advantage of preserving the intrinsic property of the molecules detected.Using SWNTs to build SERS substrates may become a powerful general strategy in various static and dynamic studies of single molecules. | Chenmaya Xia Daqi Zhang Henan Li Sheng Li Haoming Liu Li Ding Xiyan Liu Min Lyu Ruoming Li Juan Yang Yan Li | 2022 | Nano Research2022，15，1： | 0 |
| 14 | Reverence of Life in Teenagers’ Eyes显示文摘This study investigates which factors determine the teenagers’attitudes toward human life among different ethnic groups,based on a unique survey data from Xinjiang juvenile students with their family,school and social information.We find that environment factors and education efforts mainly affect the teenagers’attitudes to life value,but their ethnic groups have no effects.Reverence of life does not come from which ethnic group one belongs in,but comes from one’s environment and education.Reverence of life need to be cultivated. | Haoming Ye Yan Wang Chang Lu Xiaoguang Yang | 2021 | Journal of Systems Science and Systems Engineering2021，30，3： | 0 |
| 15 | Uncertainty analysis of atmospheric friction torque on the solid Earth显示文摘The wind stress acquired from European Centre for Medium-Range Weather Forecasts(ECMWF), National Centers for Environmental Prediction(NCEP) climate models and QSCAT satellite observations are analyzed by using frequency-wavenumber spectrum method. The spectrum of two climate models, i.e., ECMWF and NCEP, is similar for both10 m wind data and model output wind stress data, which indicates that both the climate models capture the key feature of wind stress. While the QSCAT wind stress data shows the similar characteristics with the two climate models in both spectrum domain and the spatial distribution, but with a factor of approximately 1.25 times larger than that of climate models in energy. These differences show the uncertainty in the different wind stress products, which inevitably cause the atmospheric friction torque uncertainties on solid Earth with a 60% departure in annual amplitude, and furtherly affect the precise estimation of the Earth's rotation. | Haoming Yan Yong Huang | 2016 | Geodesy and Geodynamics2016，7，3： | 0 |
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