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| 1 | Frozen shoulder:A systematic review of therapeutic options显示文摘Frozen shoulder is a common disease which causes significant morbidity. Despite over a hundred years of treating this condition the definition, diagnosis, pathology and most efficacious treatments are still largely unclear. This systematic review of current treatments for frozen shoulder reviews the evidence base behind physiotherapy, both oral and intra articular steroid, hydrodilatation, manipulation under anaesthesia and arthroscopic capsular release. Key areas in which future research could be directed are identified, in particular with regard to the increasing role of arthroscopic capsular release as a treatment. | Harpal Singh Uppal Jonathan Peter Evans Christopher Smith | 2015 | World Journal of Orthopedics2015，6，2： | 33 |
| 2 | Cardiometabolic Aspects of the Polycystic Ovary Syndrome显示文摘 | Harpal S. Randeva Bee K. Tan Martin O. Weickert Konstantinos Lois John E. Nestler Naveed Sattar Hendrik Lehnert | 2012 | Endocrine Reviews2012，，5： | 3 |
| 3 | Not only ACE2-the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19显示文摘Two recently published studies published in Science by Daly et al.1 and Cantuti-Castelvetri et al.2 identified neuropilin-1(NRP1)as an additional cellular mediator which may facilitate the entry of the new severe acute respiratory syndrome(SARS)-coronavirus(CoV)-2(SARS-CoV-2)into host cells.The findings of these elegant studies collectively indicate that,in addition to the role of angiotensin-converting enzyme 2(ACE2)in mediating the cellular entry of SARS-CoV-2;NRP1 may act as a host cell mediator that can increase the infectivity and may thus contribute to the tissue/organ tropism of this coronavirus. | loannis Kyrou Harpal S.Randeva Demetrios A.Spandidos Emmanouil Karteris | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 4 | A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration显示文摘Age-related macular degeneration(AMD) is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race,hyperopia,iris-color,smoking,sun-light and pyroptosis have varying roles in AMD,but oxidative stress-induced inflammation remains a significant driver of pathobiology.Eye is a unique organ as it contains a remarkable oxygengradient that generates reactive oxygen species(ROS) which upregulates inflammatory pathways.ROS becomes a source of functional and morphological impairments in retinal pigment epithelium(RPE),endothelial cells and retinal ganglion cells.Reports demonstrated that hydrogen sulfide(H_2S) acts as a signaling molecule and that it may treat ailments.Therefore,we propose a novel hypothesis that H_2S may restore homeostasis in the eyes thereby reducing damage caused by oxidative injury and inflammation.Since H_2S has been shown to be a powerful antioxidant because of its free-radicals' inhibition properties in addition to its beneficial effects in age-relatedconditions,therefore,patients may benefit from H_2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity. | Akash K George Mahavir Singh Rubens Petit Homme Avisek Majumder Harpal S SANDhu Suresh C Tyagi | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 3 |
| 5 | Protective Actions of Globular and Full-Length Adiponectin on Human Endothelial Cells: Novel Insights into Adiponectin-Induced Angiogenesis显示文摘 | Adya Raghu Tan Bee K Chen Jing Randeva Harpal S | 2012 | Journal of Vascular Research2012，，6： | 2 |
| 6 | Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis显示文摘AIM: To investigate the applications of hydrogen sulfide(H2 S) in eye-specific ailments in mice.METHODS: Heterozygous cystathionine-β-synthase(CBS+/-) and wild-type C57 BL/6 J(WT) mice fed with or without high methionine diet(HMD) were administered either phosphate buffered saline(PBS) or the slow-release H2 S donor: GYY4137. Several analyses were performed to study GYY4137 effects by examining retinal lysates for key protein expressions along with plasma glutamate and glutathione estimations. Intraocular pressure(IOP) was monitored during GYY4137 treatment; barium sulfate and bovine serum albumin conjugated fluorescein isothiocyanate(BSA-FITC) angiographies were performed for examining vasculature and its permeability post-treatment. Visionguided behavior was also tested employing novel object recognition test(NORT) and light-dark box test(LDBT) recordings.RESULTS: CBS deficiency(CBS+/-) coupled with HMD led disruption of methionine/homocysteine(Hcy) metabolism leading to hyperhomocysteinemia(HHcy) in CBS+/-mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase(SAHH) levels. Unlike CBS, cystathionine-γ lyase(CSE), methylenetetrahydrofolate reductase(MTHFR) levels which were reduced but compensated by GYY4137intervention. Heightened oxidative and endoplasmic reticulum(ER) stress responses were mitigated by GYY4137 effects along with enhanced glutathione(GSH) levels. Increased glutamate levels in CBS+/-strain were prominent than WT mice and these mice also exhibited higher IOP that was lowered by GYY4137 treatment. CBS deficiency also resulted in vision-guided behavioral impairment as revealed by NORT and LDBT findings. Interestingly, GYY4137 was able to improve CBS+/-mice behavior together with lowering their glutamate levels. Blood-retinal barrier(BRB) appeared compromised in CBS+/-with vessels' leakage that was mitigated in GYY4137 treated group. This corroborated the results for occludin(an integral plasma membrane protein of the cellular tight junctions) stabilization.CONCLUSION: Findings reveal that HHcy-induced glutamate excitotoxicity, oxidative damage, ER-stress and vascular permeability alone or together can compromise ocular health and that GYY4137 could serve as a potential therapeutic agent for treating HHcy induced ocular disorders. | Akash K.George Rubens P.Homme Avisek Majumder Anwesha Laha Naira Metreveli Harpal S.SANDhu Suresh C.Tyagi Mahavir Singh | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 7 | Iodinated P(MMA-NVP): An efficient matrix for disinfection of water显示文摘 | Madhulika Tyagi Harpal Singh | 2000 | J Appl Polym Sci2000，76，： | 1 |
| 8 | fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation显示文摘 | Yamaguchi TP Harpal K Henkemeyer M | 1994 | Genes Dev1994，8，24： | 1 |
| 9 | Circadian rhythmicity of salivary leptin in healthy subjects显示文摘 | Harpal S Randeva Emmanouil Karteris Krzysztof C Lewandowski Sankaranarayanan Sailesh Paul O’Hare Edward W Hillhouse | 2003 | Molecular Genetics and Metabolism2003，，3： | 1 |
| 10 | Influence of gas production induced volumetric strain on permeability of coal显示文摘 | Harpalant S Chen G L | 1997 | Geotechnical and Geological Engineering1997，15，4： | 1 |
| 11 | Identification of chemerin receptor (ChemR23) in human endothelial cells: Chemerin-induced endothelial angiogenesis显示文摘 | Jaspreet Kaur Raghu Adya Bee K. Tan Jing Chen Harpal S. Randeva | 2009 | Biochemical and Biophysical Research Communications2009，，4： | 1 |
| 12 | Metformin Treatment May Increase Omentin-1 Levels in Women With Polycystic Ovary Syndrome显示文摘 | Tan Bee K Adya Raghu Farhatullah Syed Chen Jing Lelmert Hendrik Randeva Harpal S | 2010 | Diabetes2010，，12： | 1 |
| 13 | Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals显示文摘 | Harpal SR Krzysztof CL Jan K | 2004 | Circulation2004，109，20： | 1 |
| 14 | Effect of non - genetic factors on herd life, selective value and its components in Holstein Friesian cows 显示文摘 | GOSHU G SINGH H HARPAL PETERSSON K J | 2014 | Indian J Anim Sci2014，84，1： | 1 |
| 15 | Identification of chemerin receptor (ChemR23) in human endothelial cells: Chemerin-induced endothelial angiogenesis显示文摘 | Jaspreet Kaur Raghu Adya Bee K. Tan Jing Chen Harpal S. Randeva | 2009 | Biochemical and Biophysical Research Communications2009，，4： | 1 |
| 16 | fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation显示文摘 | Harpal K Henkemeyer M | 1994 | Genes Dev1994，8，24： | 1 |
| 17 | Targeting MUC1-C suppresses BCL2A1 in triple-negativebreast cancer显示文摘B-cell lymphoma 2-related protein A1(BCL2A1)is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs;however,there are presently no agents that target BCL2A1.The MUC1-C oncoprotein is aberrantly expressed in triple-negative breast cancer(TNBC)cells,induces the epithelial–mesenchymal transition(EMT)and promotes anti-cancer drug resistance.The present study demonstrates that targeting MUC1-C genetically and pharmacologically in TNBC cells results in the downregulation of BCL2A1 expression.The results show that MUC1-C activates the BCL2A1 gene by an NF-κB p65-mediated mechanism,linking this pathway with the induction of EMT.The MCL-1 anti-apoptotic protein is also of importance for the survival of TNBC cells and is an attractive target for drug development.We found that inhibiting MCL-1 with the highly specific MS1 peptide results in the activation of the MUC1-C→NF-κB→BCL2A1 pathway.In addition,selection of TNBC cells for resistance to ABT-737,which inhibits BCL-2,BCL-xL and BCL-W but not MCL-1 or BCL2A1,is associated with the upregulation of MUC1-C and BCL2A1 expression.Targeting MUC1-C in ABT-737-resistant TNBC cells suppresses BCL2A1 and induces death,which is of potential therapeutic importance.These findings indicate that MUC1-C is a target for the treatment of TNBCs unresponsive to agents that inhibit anti-apoptotic members of the BCL-2 family. | Masayuki Hiraki Takahiro Maeda Neha Mehrotra Caining Jin Maroof Alam Audrey Bouillez Tsuyoshi Hata Ashujit Tagde Amy Keating Surender Kharbanda Harpal Singh Donald Kufe | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 1 |
| 18 | Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function:a role for FGFR1 in morphogenetic movement through the primitive streak显示文摘 | Schwartz L Harpal K | 1997 | Development1997，124，14： | 1 |
| 19 | Differential effects of GH replacement on the components of the leptin sys- tem in GH deficient individuals显示文摘 | Harpal S R Murray R D Lewandowski K C | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 20 | Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis显示文摘 | Raghu Adya Bee K. Tan Harpal S. Randeva Francis M. Finucane | 2015 | Journal of Diabetes Research2015，，： | 1 |
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