4篇
您的检索式：作者名="He Guanxin"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes显示文摘Dendritic cells (DCs) have the potency to regulate the outcome of autoimmunity through the modulation of immune responses. The induction of antigen specific tolerance is critical for prevention and treatment of allograft rejection. In the present study,we transfected IL-10 gene into DCs and investigated their effect on inhibition of lymphocyte activity in vitro and induction of immune tolerance on islet allograft in mice. An IDDM C57BL/6 mouse model was induced by streptozotocin. The islet cells isolated from the BALB/c mice were transplanted into the kidney capules of the model mice followed by injection of IL-10 modified DCs (mDCs). The results showed that mDCs could significantly inhibit T lymphocyte proliferation mediated by allotype cells and induce its apoptosis,whereas,unmodified DCs (umDCs) could promote the murine lymphocyte proliferation markedly. The injection of mDCs could prolong the survival of allotype islet transplanted IDDM mice. The average plasma glucose (PG) level in mDCs treated mice returned to normal within 3 days and lasted for about 2 weeks. The rejection response in control mice occurred for 5 days after transplantation. The level of IFN-γ was lower while IL-4 was higher in mDCs treated mice than that in umDCs treated mice,which indicated that Th1/Th2 deviation occurred. Our studies suggest that IL-10 gene modified DCs can induce the immune tolerance to islet graft and prolong survival of the recipients by the inhibiting of T cell proliferation in allotype mice. | Huifen Zhu Wenhong Qiu Ping Lei Wei Zhou Xue Wen Fengrong He Li Li Hong Dai Guanxin Shen Feili Gong | 2008 | Cellular & Molecular Immunology2008，5，1： | 14 |
| 2 | Effect of Human WEE1 and Stem Cell Factor on Human CD34^+ Umbilical Cord Blood Cell Damage Induced by Chemotherapeutic Agents显示文摘Myelosuppression 是大多数反癌症 drugs.Toachieve myeloprotection 的主要副作用之一,一 bicistronic 向量编码 anti-apoptotic 蛋白质人 WEE1 (WEEIHu ) 和刺激增长的干细胞因素(SCF ) 被产生。在这研究,我们选择了是的人的脐的绳索血 CD34^+cells 在里面在一次尝试到的 vitro 模型调查 whetherWEEIHu ,而非常规药抵抗的基因,能被介绍由象 cisplatin , adriamycin , mitomycin-c 和5氟尿嘧啶那样的化学疗法的代理人救房间免于损坏 .Cellviability 和 cytotoxicity 试金,在文化试金和外表表现 ofphospholipid phosphatidylserine 分析的形成殖民地的单位出现了在 CD34^+cellsprovided 的 WEEIHu 和 SCF 的表示有一些保护的房间。这些调查结果建议 WEEIHu andSCF 的表示可能救 CD34^+cells 免于导致化疗的 myelosuppression。 | Ping LEI Yong HE Wenfang SHI Jilin PENG Sha WU Huifen ZHU Jianguo CHEN Guanxin SHEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 2 |
| 3 | Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation- induced emission nanoparticles显示文摘 | Xianhe Sun Abudureheman Zebibula Xiaobiao Dong Gonghui Li Guanxin Zhang Deqing Zhang Jun Qian Sailing He | 2018 | Nano Research2018，11，5： | 1 |
| 4 | 走向我们的小康生活显示文摘Deji Tibetan Family Relocation Area for Poverty Alleviation and Resettlement in Pomona Village,Doilungdeqen District,Lhasa City,Tibet Autonomous Region Photo. | He Guanxin Hu Huhu Wei Shunjiang Chao Yiming Yang Wenbin Yang Ying Liang Zhiqiang Mou Quan Fan Peikun Wu Gang Zhang Hongxiang Chen Bin Zeng Xianghui Jiang Hongjing | 2020 | China's Ethnic Groups2020，，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员