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| 1 | Total body irradiation of donors can alter the course of tolerance and induce acute rejection in a spontaneous tolerance rat liver transplantation model显示文摘Liver transplantation is an established therapy for end-stage liver diseases. Graft rejection occurs unless the recipient receives immunosuppression after transplantation. This study aimed to explore the mechanism of acute rejection of liver allografts in rats pre-treated with total body irradiation to eliminate passenger lymphocytes and to define the role of CD4 + CD25 + regulatory T cells in the induction of immunotolerance in the recipient. Male Lewis rats were used as donors and male DA rats were recipients. Rats were randomly assigned to the following four groups: control group, homogeneity liver transplantation group, idio-immunotolerance group and acute rejection group. After transplantation, the survival time of each group, serum alanine aminotransferase, total bilirubin levels, number of Foxp3 + CD4 + CD25 + regulatory T cells, expression of glucocorticoid-induced tumor necrosis factor receptor on T cell subgroups, histopathology of the hepatic graft and spleen cytotoxic T lymphocyte lytic activity were measured. In the acute rejection group, where donors were preconditioned with total body irradiation before liver transplantation, all recipients died between day 17 and day 21. On day 14, serum alanine aminotransferase increased signifi- cantly to (459.2±76.9) U L -1 , total bilirubin increased to (124.1±33.7) μmol L -1 (P<0.05) and the ratio of Foxp3 + CD4 + CD25 + regulatory T cells decreased significantly to 1.50%±0.50% (P<0.05) compared with the other groups. Analysis of the T cell subpopulations in the acute rejection group varied from the other groups. Histological analysis showed typical changes of acute rejection in the acute rejection group only. Preconditioning of the donors with total body irradiation eliminated passenger lymphocytes of the liver graft, and thus affected the course of tolerance and induced acute rejection after liver transplantation. | ZHANG YeWei ZHAO HeWei BO Lin YANG YinXue LU Xiang SUN JingFeng WEN JianFei HE Xia YIN GuoWen | 2012 | Science China(Life Sciences)2012，55，9： | 4 |
| 2 | Uranium adsorption by dry and wet immobilized Saccharomyces cerevisiae显示文摘 | Xiaoliang Wang Guowen Peng Yan Yang Yanfei Wang Tingting He | 2012 | Journal of Radioanalytical and Nuclear Chemistry2012，，3： | 2 |
| 3 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 4 | Modulation of optical absorption edge in TiO_2/SiO_2 mesoporous composites显示文摘TiO-2/SiO-2 mesoporous composite was synthesized by soaking_hydrolyzing method and its structure was characterized. The relationship between the shift of absorption edge and the amount of TiO-2 nanoparticles within the mesopores of SiO-2 as well as the annealing temperature was investigated. The results indicate that the extent of the blue shift of absorption edge increases with the decreasing amount of nanoparticles and decreases wtih the increasing annealing temperature. | FENG Suping, MENG Guowen, ZHANG Lide, JIA Junhuiand HE Guoliang Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China | 1998 | Chinese Science Bulletin1998，43，24： | 1 |
| 5 | Optimization of microwave - assisted enzymatic extraction of polyphenols from waste peanut shells and evaluation of its antioxidant and antibacterial activities in vitro 显示文摘 | Guowen Zhang Mingming Hu Li He | 2013 | Food and Bioprod- ucts Processing2013，91，2： | 1 |
| 6 | Optimized ultrasonic-assisted extraction of flavonoids from Prunella vulgaris L and evaluation of antioxidant activities in vitro显示文摘 | Zhang Guowen Li He Hu Mingming | | 0，，12： | 1 |
| 7 | Optimized ultrasonic-assisted extraction of flavonoids from Prunella vulgaris L. and evaluation of antioxidant activities in vitro显示文摘 | Guowen Zhang Li He Mingming Hu | 2010 | Innovative Food Science and Emerging Technologies2010，，1： | 1 |
| 8 | Optimization of microwave-assisted enzymatic of polyphenols from waste peanut shells and evaluation of its antioxidant and antibacteria activities in vitro 显示文摘 | Guowen Zhang Mingming Hu Li He | 2013 | Food and Bioproducts Processing2013，91，2： | 1 |
| 9 | A Novel Turn-on Fluorescent Probe for Highly Selective Detection of Phosphate Ion in Living Cell显示文摘A novel fluorescent probe was synthesized and studied.Fluorescent probe 1 undergoes a unique Pi induced hydrolytic reaction in DMSO-HEPES at physiological pH that produces a colorimetric change associated with a 76nm red-shift in the UV-vis absorption maximum and up to a 210-fold enhancement in the fluorescence intensity.It has successfully been used to stain and record microscopy images of HeLa cells.Moreover,the mechanistic proposal that these spectroscopic changes are associated with the reaction of Pi and probe 1 to form 2-(2-hydroxyphenyl)benzothiazole gains support from the results of mass spectrometry studied. | Jin Zhang Si Wang Changhui Liu Guowen He Tianying Peng | 2018 | Chinese Journal of Chemistry2018，36，12： | 1 |
| 10 | Preparation, morphology and properties of acylchloride-grafted multi- wall carbon nanotubes/fluorinated polyimide composites显示文摘 | He Guowen Zhou Jicheng Tan Kaiyuan | 2011 | Composites Science and Technology2011，71，16： | 1 |
| 11 | ∑HfF_5^- current monitoring with off-axis Faraday cup in AMS measurement of ^(182)Hf at CIAE显示文摘In order to reduce the systematic uncertainties caused by the sequential injection in AMS measurement of ^(182)Hf,a technique for instantaneous monitoring of off-axis∑HfF_5^- current was developed in the AMS laboratory at China Institute of Atomic Energy(CIAE).The stability and reliability of this method have been experimentally verified.As a result,the accuracy for AMS measurement of^(182)Hf was significantly improved. | LI Zhenyu HE Ming DONG Kejun LI Chaoli HE Guozhu HE Xianwen ZHANG Wei HU Hao ZHENG Guowen LI Heng WU Shaoyong JIANG Shan | 2012 | Nuclear Science and Techniques2012，23，4： | 1 |
| 12 | Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer显示文摘Objective:Real-word data on long-acting luteinizing hormone-releasing hormone(LHRH)agonists in Chinese patients with prostate cancer are limited.This study aimed to determine the real-world effectiveness and safety of the LHRH agonist,goserelin,particularly the long-acting 10.8-mg depot formulation,and the follow-up patterns among Chinese prostate cancer patients.Methods:This was a multicenter,prospective,observational study in hormone treatment-na?ve patients with localized or locally advanced prostate cancer who were prescribed goserelin 10.8-mg depot every 12 weeks or 3.6-mg depot every 4 weeks with or without an anti-androgen.The patients had follow-up evaluations for 26 weeks.The primary outcome was the effectiveness of goserelin in reducing serum testosterone and prostate-specific antigen(PSA)levels.The secondary outcomes included testosterone and PSA levels,attainment of chemical castration(serum testosterone<50 ng/d L),and goserelin safety.The exploratory outcome was the monitoring pattern for serum testosterone and PSA.All analyses were descriptive.Results:Between September 2017 and December 2019,a total of 294 eligible patients received≥1 dose of goserelin;287 patients(97.6%)were treated with goserelin 10.8-mg depot.At week 24±2,the changes from baseline[standard deviation(95%confidence interval)]in serum testosterone(n=99)and PSA(n=131)were-401.0 ng/d L[308.4 ng/d L(-462.5,-339.5 ng/d L)]and-35.4 ng/m L[104.4 ng/m L(-53.5,-17.4 ng/m L)],respectively.Of 112 evaluable patients,100(90.2%)achieved a serum testosterone level<50 ng/d L.Treatment-emergent adverse events(TEAEs)and severe TEAEs occurred in 37.1%and 10.2%of patients,respectively.The mean testing frequency(standard deviation)was 1.6(1.5)for testosterone and 2.2(1.6)for PSA.Conclusions:Goserelin 10.8-mg depot effectively achieved and maintained castration and was well-tolerated in Chinese patients with localized and locally advanced prostate cancer. | Nanhui Chen Zengjun Wang Ming Chen Qi Ma Yi He Yujie Wang Xin Li Mingxing Qiu Lei Shi Shaoxing Zhu Qun Xie Xiuheng Liu Benkang Shi Guowen Lin Weizhong Yang Yongbin Liao Haibin Zhang Shusheng Wang Jiexian Li Shaogang Wang Lijun Dong Hui Chen Jiaju Lu YongyiCheng Xiaoping Zhang Lulin Ma Liqun Zhou He Wang Shen Li Dingwei Ye | 2023 | Cancer Biology & Medicine2023，20，12： | 0 |
| 13 | Synthesis of Vertically Oriented GaN Nanowires on a LiAlO_(2) Substrate via Chemical Vapor Deposition显示文摘Vertically oriented nanowires(NWs)of single-crystalline wurtzite GaN have been fabricated on a-LiAlO_(2)(100)substrate coated with a Au layer,via a chemical vapor deposition process at 1000℃ using gallium and ammonia as source materials.The GaN NWs grow along the nonpolar[10]direction with steeply tapering tips,and have triangular cross-sections with widths of 50100 nm and lengths of up to several microns.The GaN NWs are formed by a vapor liquid solid growth mechanism and the tapering tips are attributed to the temperature decrease in the final stage of the synthesis process.The aligned GaN NWs show blue-yellow emission originating from defect levels,residual impurities or surface states of the GaN NWs,and have potential applications in nanotechnology. | Xiaoli He Guowen Meng Xiaoguang Zhu Mingguang Kong | 2009 | Nano Research2009，2，4： | 0 |
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