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| 1 | Neuronal reprogramming in treating spinal cord injury显示文摘Spinal cord injury represents a devastating central nervous system injury that could impair the mobility and sensory function of afflicted patients.The hallmarks of spinal cord injury include neuroinflammation,axonal degeneration,neuronal loss,and reactive gliosis.Furthermore,the formation of a glial scar at the injury site elicits an inhibitory environment for potential neuroregeneration.Besides axonal regeneration,a significant challenge in treating spinal cord injury is to replenish the neurons lost during the pathological process.However,despite decades of research efforts,current strategies including stem cell transplantation have not resulted in a successful clinical therapy.Furthermore,stem cell transplantation faces serious hurdles such as immunorejection of the transplanted cells and ethical issues.In vivo neuronal reprogramming is a recently developed technology and leading a major breakthrough in regenerative medicine.This innovative technology converts endogenous glial cells into functional neurons for injury repair in the central nervous system.The feasibility of in vivo neuronal reprogramming has been demonstrated successfully in models of different neurological disorders including spinal cord injury by numerous laboratories.Several reprogramming factors,mainly the pro-neural transcription factors,have been utilized to reprogram endogenous glial cells into functional neurons with distinct phenotypes.So far,the literature on in vivo neuronal reprogramming in the model of spinal cord injury is still small.In this review,we summarize a limited number of such reports and discuss several questions that we think are important for applying in vivo neuronal reprogramming in the research field of spinal cord injury as well as other central nervous system disorders. | Xuanyu Chen Hedong Li | 2022 | Neural Regeneration Research2022，17，7： | 6 |
| 2 | Applications of online monitoring technology for tailings dam on digital mine显示文摘Considering its structural features, geometric shapes, service mode, environmental media, mechanical behavior, etc, the special nature and complexity of tailings dam were summarized. The technical approach to safety management for tailings dam was proposed, which is the on-line automated monitoring and early warning information. The results show that a strong theoretical basis can be provided for security monitoring and security management of tailings dam. Online automated monitoring system for tailings dam has full implementation of the information. It is applied widely in Lingnan gold mine, Xiadian gold mine and Hedong gold mine in Zhaoyuan, Shandong Province, and achieves good effect. | YU Guang-ming1, SONG Chuan-wang1, ZOU Jing-bo1, WU Yan-xia1, PAN Yong-zhan1, LI Liang1, LI Ran1, WANG Pei-shou2, WANG Yan-lei2 1. School of Civil Engineering, Qingdao Technological University, Qingdao 266033, China 2. Hedong Goldmine, Zhaojin Mining Industry Company, Zhaoyuan 265400, China | 2011 | 中国有色金属学会会刊:英文版2011，21，S3： | 5 |
| 3 | Improved Mechanical Properties of Textile Reinforced Concrete Thin Plate显示文摘Textile reinforced concrete (TRC) is especially suitable for the thin-walled and light-weight structural elements with a high load-bearing capacity. For this thin element, the concrete cover thickness is an important factor in affecting the mechanical and anti-crack performance. Therefore, the influences of the surface treatment of the textile and mixing polypropylene fiber into the concrete on the properties of the components with different cover thickness were experimentally studied with four-point bending tests. The experimental results show that for the components with the same cover thickness, sticking sand on epoxy resin-impregnated textile and adding short fiber into the concrete are helpful to improve their mechanical performance. The 2-3 mm cover thickness is enough to meet the anchorage requirements of the reinforcement fiber and the component has good crack pattern and mechanical behavior at this condition. Comparison between the calculated and the experimental values of flexural capacity reveals satisfactory agreement. Finally, based on the calculation model of the crack spacing of reinforced concrete structures, the crack extension of this thin-wall component was qualitatively analyzed and the same results with the experimental were obtained. | 尹世平 徐世烺 LI Hedong | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，1： | 4 |
| 4 | MicroRNAs as potential therapeutics for treating spinal cord injury显示文摘MicroRNAs are a class of recently discovered,small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes.Very little is known about the role of microRNAs during spinal cord injury.This review summarizes the changes in expression levels of microRNAs after spinal cord injury.These aberrant changes suggest that microRNAs play an important role in inflammation,oxidative stress,apoptosis,glial scar formation and axonal regeneration.Given their small size and specificity of action,microRNAs could be potential therapeutics for treating spinal cord injury in the future.There are rapidly developing techniques for manipulating microRNA levels in animals;we review different chemical modification and delivery strategies.These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic. | Hualin Yan Peiwei Hong Mei Jiang Hedong Li | 2012 | Neural Regeneration Research2012，7，17： | 3 |
| 5 | Tensile and flexural properties of ultra high toughness cemontious composite显示文摘 | Hedong Li Shilang Xu Christopher K. Y. Leung | 2009 | Journal of Wuhan University of Technology - Mater Sci Ed2009，，4： | 2 |
| 6 | Tensile and flexural properties of ultra high toughness cemontious composite显示文摘 | Hedong Li Shilang Xu Christopher K. Y. Leung | 2009 | Journal of Wuhan University of Technology - Mater Sci Ed2009，，4： | 1 |
| 7 | Improved mechanical properties of textile reinforced concrete thin plate显示文摘 | Shiping Yin Shilang Xu Hedong Li | 2013 | Journal of Wuhan University of Technology-Mater Sci Ed2013，，1： | 1 |
| 8 | Simultaneous determination of Repaglinide and Irbesartan in biological plasmas using micellar enhanced excitation-emission matrix fluorescence coupled with ATLD method显示文摘A highly sensitive and selective 3D excitation-emission fluorescence method has been proposed to rapidly quantify the combined antidiabetics Repaglinide(Re) and Irbesartan(Ir) in rat and human plasmas with the aid of second-order calibration method based on alternating trilinear decomposition(ATLD) method. Re and Ir with weak fluorescence can be endowed with strong fluorescent property by changing the microenvironment in samples and improving the fluorescence quantum yield by using an appropriate micellar enhanced surfactant. The enhanced excitation-emission matrix fluorescence of Re and Ir can be accurately resolved and can simultaneously attain the optimal concentration even in the presence of a potentially strong intrinsic fluorescence from complex biological matrices, such as rat and human plasmas, by using the ATLD method, which completely exploits the 'second-order advantage'. The average recoveries of Re and Ir obtained from ATLD with the factor number of 3(N=3) were 101.0%±4.3% and 99.1%±4.1% for rat plasma and 100.5%±5.4% and 97.1%±3.6% for human plasma. Several statistical methods, including Student's t-test, figures of merit, and elliptical joint confidence region, have been utilized to evaluate the accuracy of the proposed method. Results show that the developed method can maintain second-order advantage in simultaneous determinations of the weak fluorescent analytes of interest in different biological plasma matrices. | Haiyan Fu Hedong Li Mei Shao Tianming Yang Xu Zhang Rujing Xu Yujuan Wei Shuhua Chen Chuang Ni Hailong Wu | 2016 | Science China Chemistry2016，59，7： | 1 |
| 9 | Potential use of strain hardening ECC in permanent formwork with small scale flexural beams显示文摘 | Hedong Li Christopher K. Y. Leung Shilang Xu Qian Cao | 2009 | Journal of Wuhan University of Technology - Mater Sci Ed2009，，3： | 1 |
| 10 | Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation显示文摘Sleep deprivation(SD)is a severe public health threat that can cause systemic inflammation and nerve damage.Few effective and side-effect-free drugs are available to address SD.However,the bidirectional communications between the brain and gut provide new strategies for anti-SD therapeutics.Here we explored oral delivery of fullerene nano-antioxidants(FNAO)in the SD model to improve sleep by regulating abnormal intestinal barrier and systemic inflammation via the brain-gut axis.SD caused excessive reactive oxygen species(ROS)production and hyperactive inflammatory responses in the intestines of zebrafish and mouse models,leading to disturbed sleep patterns and reduced brain nerve activity.Of note,based on the property of the conjugatedπbond of the C_(60)structure to absorb unpaired electrons,oral FNAO efficiently reduced the excessive ROS in the intestines,maintained redox homeostasis and intestinal barrier integrity,and ameliorated intestinal and systemic inflammation,resulting in superior sleep improvement.Our findings suggest that maintaining intestinal homeostasis may be a promising avenue for SD-related nerve injury therapy. | Zhanfeng Wu Lei Liu Lei Li Xinran Cao Wang Jia Xiaodan Liao Zhongpu Zhao Hedong Qi Guoqiang Fan Huiqiang Lu Chunying Shu Mingming Zhen Chunru Wang Chunli Bai | 2023 | National Science Review2023，10，12： | 1 |
| 11 | Highly sensitive and selective spectrofluorimetric approach for the rapid determination of trace benao pyrene in drinking water and in solutions leached from disposable paper cups显示文摘 | ZHOU Na LUO Hedong LI Na | 2011 | Luminescence2011，26，1： | 1 |
| 12 | Isolation of a novel rat neural progenitor clone that expresses Dlx family transcription factors and gives rise to functional GABAergic neurons in culture 显示文摘 | LI Hedong HADER A T HAN Y R | 2012 | Dev Neurobiol2012，72，6： | 1 |
| 13 | Isolation of a novel rat neural progenitor clone that expresses Dlx family transcription factors and gives rise to functional GABAergic neurons in culture显示文摘 | LI Hedong HADER A T HAN Y R | 2012 | Dev Neurobiol2012，72，6： | 1 |
| 14 | Compressive properties of a novel slurry-infiltrated fiber concrete reinforced with arc-shaped steel fibers显示文摘Slurry-infiltrated fiber concrete(SIFCON)is a sort of strain hardening cement-based composite material,typically made with 5%–20%steel fibers.This study focused on a novel type of SIFCON in which hooked-end steel fibers were replaced by arc-shaped steel fibers.The quasi-static compressive properties of the SIFCON were first measured.Test results suggested that using arc-shaped steel fibers in lieu of hooked-end steel fibers increased the quasi-static compressive strength by 47.1%and the strain at peak stress by 56.3%.We attribute these improvements to new crack-resisting mechanisms,namely“fiber crosslock”,“dual bridging”,and“confinement loops”,when the arc-shaped steel fibers are introduced into SIFCON.As high impact resistance is a special property of SIFCON that is of practical significance,the dynamic compressive properties of arc-shaped steel fiber SIFCON were studied by using an 80-mm-diameter split Hopkinson pressure bar(SHPB).The results showed that the dynamic compressive strength,dynamic increase factor(DIF),and dynamic toughness of SIFCON all increased with the strain rate.The SIFCON incorporating arc-shaped steel fibers proved to have significant advantages in structural applications requiring high impact resistance. | Hedong LI Yabiao LI Yunfeng PAN P.L.NG Christopher K.Y.LEUNG Xin ZHAO | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，6： | 0 |
| 15 | Efficient development strategies for large ultra-deep structural gas fields in China显示文摘Through analyzing the development of large ultra-deep structural gas fields in China,strategies for the efficient development of such gas fields are proposed based on their geological characteristics and production performance.According to matrix properties,fracture development degree and configuration between matrix and fractures,the reservoirs are classified into three types:single porosity single permeability system,dual porosity dual permeability system,and dual porosity single permeability system.These three types of gas reservoirs show remarkable differences in different scales of permeability,the ratio of dynamic reserves to volumetric reserves and water invasion risk.It is pointed out that the key factors affecting development efficiency of these gas fields are determination of production scale and rapid identification of water invasion.Figuring out the characteristics of the gas fields and working out pertinent technical policies are the keys to achieve efficient development.The specific strategies include reinforcing early production appraisal before full scale production by deploying high precision development seismic survey,deploying development appraisal wells in batches and scale production test to get a clear understanding on the structure,reservoir type,distribution pattern of gas and water,and recoverable reserves,controlling production construction pace to ensure enough evaluation time and accurate evaluation results in the early stage,in line with the development program made according to the recoverable reserves,working out proper development strategies,optimizing pattern and proration of wells based on water invasion risk and gas supply capacity of matrix,and reinforcing research and development of key technologies. | LI Xizhe GUO Zhenhua HU Yong LUO Ruilan SU Yunhe SUN Hedong LIU Xiaohua WAN Yujin ZHANG Yongzhong LI Lei | 2018 | Petroleum Exploration and Development2018，45，1： | 0 |
| 16 | Neural progenitor diversity and their therapeutic potential for spinal cord repair显示文摘Development of the central nervous system(CNS)requires progressive differentiation of neural stem cells,which generate a variety of neural progenitors with distinct properties and differentiation potentials in a spatiotemporally restricted manner.The underlying mechanisms of neural progenitor diversification during development started to be unraveled over the past years.We have addressed these questions by v-myc immortaliza-tion method and generation of neural progenitor clones.These clones are served as in vitro models of neural differentiation and cellular tools for transplantation in animal models of neurological disorders including spinal cord injury.In this review,we will discuss features of two neural progenitor types(radial glia and GABAergic interneuron progenitor)and diversification even within each progenitor type.We will also discuss pathophysiol-ogy of spinal cord injury and our ongoing research to address both motor and sensory malfunctions by trans-plantation of these neural progenitors. | Hedong LI Wei SHI | 2010 | Frontiers in Biology2010，5，5： | 0 |
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