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| 1 | Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185^(c-erbB-2)显示文摘The c-erbB-2 proto-oncogene encodes a 185kDa protein p185, which belongs to epidermal growth factorreceptor family. Amplification of this gene has been shown to correlate with poor clinical prognosis forcertain cancer patients. The monoclonal antibody A21 which directed against p185 specifically inhibitsproliferation of tumor cells overexpressing p185, hence allows it to be a candidate for targeted therapy. Inorder to overcome several drawbacks of murine MAb, we cloned its VH and VL genes and constructed thesingle-chain Fv (scFv) through a peptide linker. The recombinant scFvA21 was expressed in Escherichiacoli and purified by the affinity column. Subsequently it was characterized by ELISA, Western blot, cellimmunohistochemistry and FACS. All these assays showed the binding activity to extracellular domain(ECD) of p185. Based on those properties of scFvA21, we further constructed the scFv-Fc fusion moleculewith a homodimer form and the recombinant product was expressed in mammalian cells. In a series ofsubsequent analysis this fusion protein showed identical antigen binding site and activity with the parentantibody. These anti-p185 engineered antibodies have promised to be further modified as a tumor targetingdrugs, with a view of application in the diagnosis and treatment of human breast cancer. | LIAN SHENG CHENG, AI PING LIU, JIA HONG YANG, YAN QIU DONG, LIANG WEI LI, JING WANG, CHAO CHEN WANG, JING LIUSchool of Life Science, University of Science and Technology of China, Hefei 230027, China | 2003 | Cell Research2003，13，1： | 24 |
| 2 | Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3-hydroxybutyrate) for drug delivery显示文摘Biodegradable and amphiphilic triblock copolymers poly(ethyl ethylene phosphate)-poly(3-hydroxybutyrate)-poly(ethyl ethylene phosphate) (PEEP-b-PHB-b-PEEP) have been successfully synthesized through ring-opening polymerization. The structures are confirmed by gel permeation chromatography and NMR analyses. Crystallization investigated by X-ray diffraction reveals that the block copolymer with higher content of poly(ethyl ethylene phosphate) (PEEP) is more amorphous, showing decreased crystallizability. The obtained copolymers self-assemble into biodegradable nanoparticles with a coreshell micellar structure in aqueous solution, verified by the probe-based fluorescence measurements and transmission electronic microscopy (TEM) observation. The hydrophobic poly(3-hydroxybutyrate) (PHB) block serves as the core of the micelles and the micelles are stabilized by the hydrophilic PEEP block. The size and size distribution are related to the compositions of the copolymers. Paclitaxel (PTX) has been encapsulated into the micelles as a model drug and a sustained drug release from the micelles is observed. MTT assay also demonstrates that the block copolymers are biocompatible, rendering these copolymers attractive for drug delivery. | CHENG Jing1 & WANG Jun2 1 Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China 2 Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China | 2009 | Science China Chemistry2009，52，7： | 10 |
| 3 | Multi-isotopic system geochronology of low temperature eclogite from Huangzhen,Southern Dabie Terrain显示文摘Zircon U-Pb thermal ionization mass-spectrometer (TIMS) and secondary ion mass-spectrometer (SIMS) dating, mica and amphibole 40Ar-39Ar dating and mineral Sm-Nd isotopic compositions of Huangzhen low temperature eclogite and country granitic gneiss are carried out. The zircon U-Pb weighted average SIMS age is (231.6±9.7) Ma for one eclogite. The mica Ar-39Ar isochron age is (232.6±2.1) Ma and the lowest plateau age is (221.7±2.4) 40 Ma from same sample. U-Pb TIMS concordant ages from other eclogite zircons are from (221.3 ±1.4) Ma to (222.5±2.3) Ma. U-Pb SIMS low intercept age from country granitic gneiss is (221 ±35) Ma. The retrograde amphibole Ar-39Ar isochron age is (205.9±1.0) Ma. Except for mica, 40 which may contain excess Ar, all the ages represent peak and retrograde metamorphism of low 40 temperature eclogites. It is indicated that the Huangzhen low temperature eclogites differ from Xiongdian low temperature eclogites of north of the Northern Dabie Terrain in metamorphic ages. Huangzhen low temperature eclogites share one coherent HP-UHP terrain with high temperature eclogites from Southern Dabie Terrain and they may have differences in subduction depth and cooling rates during exhumation. | CHEN Daogong1, E. Deloule2, CHENG Hao1, XIA Qunke1 & WU Yuanbao1 1. School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China 2. CRPG-CNRS Nancy, 54501, France | 2004 | Science China Earth Sciences2004，47，10： | 9 |
| 4 | A high time resolution multi-gap resistive plate chamber显示文摘Research on a single cell Multi-gap Resistive Plate Chamber (MRPC) was carried out for the Time Of Flight detector (TOF) R and D of the STAR experi- ment. The property of the single chamber was tested with the test beam facility T10 at CERN in Geneva. The MRPC was scanned with the test beam to get the efficiency and time resolution at different position of the active area. The HV plateau was also measured. The time resolution is 65 ps which satisfies the requirement of STAR. The working mechanism of the MRPC is also explained. | LI Cheng, WU Jian, WANG Xiao-Lian, CHEN Hong-Fang, XU Zi-Zong, SHAO Ming, YE Shu-Wei, RUAN Li-Juan, HUANG Sheng-Li (Department of Modern Physics, University of Science and Technology of China, Hefei 230027) | 2002 | Nuclear Science and Techniques2002，13，1： | 5 |
| 5 | EMPIRICAL LIKELIHOOD RATIO CONFIDENCE INTERVALS FOR VARIOUS DIFFERENCES OF TWO POPULATIONS显示文摘1.IntroductionThemethodoflikelihoodintroducedbyFisheriscertainlyoneofthemostcommonlyusedtechniquesforparametricmodels.Recentlythelikelihoodhasalsobeenshowntobeveryusefulinnonparametriccontexts.O...II--31hasintroducedempiricallikelihoodratiostatistics... | QIN Yong song ZHAO Lin cheng (Department of Statistics and Finance, University of Science and Technology of China, Hefei 230026, China) | 2000 | Systems Science and Mathematical Sciences2000，13，1： | 5 |
| 6 | 一种解列车控制问题的新算法显示文摘本文提出一种解列车控制问题的新算法。该算法基于遗传算法、罚函数法和RungaKuta法。 | CHENG JinSong (Dept. of Computer, Anhui University, Hefei AH,230039) In this paper, we present a new algorithm for solving train control problem. The algorithm is based on genetic algorithm, penalty function method and the RungaKutta method. | 1999 | 微机发展1999，9，4： | 4 |
| 7 | Encounter probability analysis of typhoon and plum rain in the Taihu Lake Basin显示文摘It is of great significance to study the encounter possibility of typhoon and plum rain in the Taihu Lake Basin in order to adjust the schemes of design storm and utilize flood resource and make the decision of real-time scheduling for flood control in the Basin. Based upon the existing research findings of description of encounter phenomena of typhoon and plum rain, the initial time of typhoon affecting the Taihu Lake Basin, the start time of plum rain season and the end time of plum rain season were selected as the characteristic indices of typhoon and plum rain, respectively. According to their synchronous data from 1954 to 2009, the distribution functions of the above-mentioned three random variables were identified and a formula expressing the encounter possibility of typhoon and plum rain was derived. In view of the complexity and solution of this formula, joint distribution functions of typhoon and plum rain were constructed by the use of Gumbel Copula function on the basis of the adaptability comparison among three functions (Gumbel Copula, Clayton Copula and Frank Copula) in Archimedean functions. For the characteristics of the formula with the joint distribution functions based on Gumbel Copula function, two methods, i.e., numerical integration and Monte Carlo simulation, were selected to solve the encounter probability, and the validity of the computed results was analyzed finally. | HU SiYi1,2, WANG ZongZhi1, WANG YinTang1, WU HaoYun3, JIN JuLiang4, FENG XiaoChong1 & CHENG Liang1 1 State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Nanjing Hydraulic Research Institute, Nanjing 210029, China 2 Ministry of Water Resources, Beijing 100053, China 3 Taihu Basin Authority, Ministry of Water Resources, Shanghai 200434, China 4 School of Civil Engineering, Hefei University of Technology, Hefei 230009, China | 2010 | Science China(Technological Sciences)2010，53，12： | 3 |
| 8 | Numerical simulation of fire development in a single compartment based on cone calorimeter experiments显示文摘The burning characteristics of several kinds of wood and polyurethane materials have been studied using cone calorimeter (CONE2A). A new and simple ignition criterion, heat release rate model and mass loss rate model are proposed based on experiments. Combined with these models, the zone-model of fire can be used to predict fire development in a single compartment according to the species of combustibles, their quantities and distribution. Calculated results show that this method is simple and feasible. | JI Jingwei, CHENG Yuanping, YANG Lizhong and FAN Weicheng( State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, China College of Energy Science and Engineering, China University of Mining and Technology, Xuzhou 221008, China) | 2002 | Progress in Natural Science:Materials International2002，12，5： | 3 |
| 9 | A New Expert System for Structural Interpretation of IR Spectra显示文摘A new expert system has been developed which can be used to aid chemists in structural interpretation of infrared spectra. The system consists of five essential portions: knowledge-base , inference engine, database, knowledge-acquisition module and explanatory interface. The system is implemented in Turbo PROLOG artificial intelligence language. Compared with other spectral interpretation systems this system is of the following advantages, i. e. the system has a friendly user interface, two kinds of methods for managing toowledge-base, several useful explanatory facilities such as why and how should explanation be made, etc. ; in addition, it can be run on the IBM PC/XT and its compatible microcomputers. Another important feature of the system is that it can simulate the reasoning procedure by which experienced chemists may interpret spectra as well as deduce complete molecular structures. So the system can also be used as a helpful learning tool for training chemistry students in IR spectrum | Cheng Lingran (Laboratory of Computer Chemistry, University of Science and Technology of China, Hefei)Zhang Maosen (Department of Modern Chemistry, University of Science and Technology of China, Hefei) | 1990 | Chemical Research in Chinese Universities1990，6，4： | 3 |
| 10 | Comprehensive evaluation of mechanism of 'chimney effect' using principles of magnetism, geochemistry and mineralogy显示文摘Study of forming mechanism of 'chimney-effect' (CE) has important significance for basic theory and applications of non-seismic geophysical and geochemical methods locating oil/gas reservoirs. The theoretical basis of comprehensive evaluation of mechanism of CE using principles of magnetism, geochemistry and mineralogy has been reviewed, with the problems to be solved: (ⅰ) study for the relationship between process of oil/gas migration and geochemical field; (ⅱ) analysis of genesis of magnetic, geochemical and mineralogical anomaly; (ⅲ) interpretation of surface soil magnetism and geochemical anomaly combined with seismic data. | LIU Qingsheng 1, CHENG Tongjin 2 and LIU Shugen 3 1. Department of Applied Geophysics, China University of Geosciences, Wuhan 430074, China 2. Center of Petroleum Geochemistry, China National Star Petroleum Corporation, Hefei 230022, China 3. The St | 1998 | Chinese Science Bulletin1998，43，9： | 3 |
| 11 | ANELASTIC RELAXATIONS ASSOCIATED WITH LOCAL DISORDERING AT GRAIN BOUNDARIES显示文摘Internal friction and micro-creep measurements were performed with high-purity aluminiumbamboo-crystal specimens.The relaxation strength was found to decrease with the decreaseof temperature and became zero at about 0.4 T_m(T_m is the melting temperature).This re-flects the occurrence of local disordering in the bamboo boundary region at this temperature.This result conforms to the picture of grain-boundary disordering constructed by atomicsimulation studies. | CHENG bolin GE Tingsui (T.S.Ke) Laboratory of Internal Friction and Defects in Solids,Institute of Solid State Physics,Academia Sinica,Hefei,China Professor Laboratory of Internal Friction and Defects in Solids,Institute of Solid State Physics,Academia Sinica,Hefei,230031 | 1991 | Acta Metallurgica Sinica(English Letters)1991，4，2： | 2 |
| 12 | The application analyses for primary spectrum pyrometer显示文摘In the applications of primary spectrum pyrometry,based on the dynamic range and the minimum sensibility of the sensor,the application issues,such as the measurement range and the measurement partition,were investigated through theoretical analyses. For a developed primary spectrum pyrometer,the theoretical predictions of measurement range and the distributions of measurement partition were presented through numerical simulations. And the measurement experiments of high-temperature blackbody and standard temperature lamp were processed to further verify the above theoretical analyses and numerical results. Therefore the research in the paper provides the helpful supports for the applications of primary spectrum pyrometer and other radiation pyrometers. | FU TaiRan1,CHENG XiaoFang2 & ZHONG MaoHua1 1 China Academy of Safety Science & Technology,Beijing 100029,China 2 Department of Thermal Science and Energy Engineering,University of Science and Technology of China,Hefei 230026,China | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，6： | 2 |
| 13 | Metal-organic framework MIL-53(Al): synthesis, catalytic performance for the Friedel-Crafts acylation, and reaction mechanism显示文摘Metal-organic framework MIL-53(Al) was synthesized by a solvothermal method using aluminum nitrate as the aluminium source and 1,4-benzenedicarboxylic acid(H2BDC) as the organic ligand. The structure of samples was characterized by X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FT-IR). The catalytic activity and recyclability of MIL-53(Al) catalyst for the Friedel-Crafts acylation reaction of indole with benzoyl chloride were evaluated. The reaction conditions were optimized and a reaction mechanism was suggested. The results showed that the MIL-53(Al) catalyst exhibited good catalytic activity and recyclability for the Friedel-Crafts acylation reaction. When the molar ratio of indole and MIL-53(Al) catalyst was 1:0.06(n1:ncatalyst), the molar ratio of indole and benzoyl chloride was 1:3, and the solvent was dichloromethane, the conversion of indole could reach 97.1% and the selectivity of 3-acylindole could reach 81.1% at 25 °C after 8 h. The catalyst can be reused without significant degradation in catalytic activity. After the catalyst was reused five times, the conversion of indole was 87.6% and the selectivity of 3-acylindole was 79.5%. | Junlei Yan Sai Jiang Shengfu Ji Da Shi Hefei Cheng | 2015 | Science China Chemistry2015，58，10： | 2 |
| 14 | Multi-carbazole derivatives for two-photon absorption data storage:Synthesis,optical properties and theoretical calculation显示文摘Two novel quadrupolar organic compounds, 3-(4-((E)-2-(9-butyl-9H-carbazol-6-yl) vinyl)styryl)-9-propyl-9H-carbazole (BCSPC) and 3-(3-(3-((1E)-2-(4-((E)-2-(3-(3,5-bis(9-butyl-9H-carbazol-6-yl)phenyl)-9-butyl-9H-carbazol-6-yl)vinyl)phenyl) vinyl)-9-butyl-9H-carbazol-6-yl)-5-(9-butyl-9H-carbazol-6-yl)phenyl)-9-butyl-9H-carbazole (BCPBC), with different conjugated arms, have been designed and synthesized. Their one-and two-photon absorption (TPA) and excited fluorescence properties have been experimentally investigated. The two-photon absorption cross-sections of two compounds were estimated by two-photon excited fluorescence technique using 200 fs, 76 MHz, Ti:sapphire laser, which are 22 and 154 GM for BCSPC and BCPBC, respectively. The optimal excitation wavelengths are 780 nm for both BCSPC and BCPBC. A data recording experiment proved the potential application of the materials. | LI Lin1, YANG JiaXiang1,2, WANG CaiXia1, HU ZhangJun1, TIAN YuPeng1,2, LI Jing3, WANG ChuanKui3, LI Ming4, CHENG GuangHua4, TANG HuoHong5, HUANG WenHao5, TAO XuTang2 & JIANG MinHua2 1Department of Chemistry, Anhui University, Hefei 230039, China 2State Key Laboratory of Crystal Materials, Institute of Crystal Materials of Shandong University, Jinan 250100, China 3Department of Physics, Shandong Normal University, Jinan 250014, China 4State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China 5Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China | 2010 | Science China Chemistry2010，53，4： | 2 |
| 15 | MICROSTRUCTURE IN LASER FUSED HIGH SPEED STEEL W6Mo5Cr4V2(M2)显示文摘Microstructure of the deepest zone of high speed steel W6Mo5Cr4V2(M2)melt after laser fu-sion was found to be so fine as the ehill zone of a solidified ingot.When narrower chill zoneformed,the long columnar dendrites grow into the melt and then the fine equiaxed cellularstructure appears in upper melt region nearly surface.The substructure of cellular grains anddendrites was observed to consist of martensite and retained austenile,while the carbides asM6C■ Cr7C3 and MC distributed at their boundaries.It is believed that the highermicrohardness up to HV0.1=865—960 of the laser fused structure of the alloy is due to the oc-currence of martensite. | LIU Ning CUI Kun Huazhong University of Science and Technology,Wuhan.China DENG Zonggang Hefei University of Technology,Hefei,China CHENG Benpei KONG Jie Institute of Solid State Physics,Academia Sinica,Hefei,China Doctorate student,Department of Mechanical Engineering No.2,Huazhong University of Science and Technology,Wuhan 430074,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，1： | 2 |
| 16 | Hartree-Fock and Density Functional Theory Studies on the Molecular Recognition of the Cyclodextrin显示文摘This study involves initial Hartree-Fock and Density Functional theory calculations onthe molecular recognition of the cyclodextrins. The α-cyclodextrin-acetophenone complexationsystem was investigated with PM3, HF/3-21G* and B3LYP/3-21G* methods. The results indicatedthat the inclusion orientation in which the acetyl group of the acetophenone points towards thesecondary hydroxyls of the a-cyclodextrin was preferable in energy. The steric effect wassupposed as the physical reason of such a behavior Hence, the simple rule the anti-parallelarrangement of the dipoles of the host and guest molecules in the cyclodextrin complexqtion is notgenerally applicable. | Lei LIU Xiao Song LI Qing Xiang GUO You Cheng LIUDepartment of Chemistry, University of Science and Technology of China, Hefei 230026) | 1999 | Chinese Chemical Letters1999，10，12： | 1 |
| 17 | A Study of the Driving Force for Inclusion Complexation of α- and β-Cyclodextrin with Substituted Benzene显示文摘Introductionα-Cyclodextrinandβ-cyclodextrin(α-andβ-CD)aremacrocyclicoligomersofsixandsevenglucoseunits,respectively.Theyhaveb... | ZHANG Hai ming, LUO Shuang hui, CHEN Chao, LIU Lei GUO Qing xiang ** and LIU You cheng (Department of Chemistry, University of Science and Technology of China, Hefei, 230026 National Laboratory of Applied Organic Chemistry, Lanzhou Universi | 1999 | Chemical Research in Chinese Universities1999，15，1： | 1 |
| 18 | A Novel and Optimized Method for Electro-focusing and Moving Neutralization Reaction Boundary Formed by HCl and NaOH显示文摘A novel method is developed for electro-focusing and moving neutralization reaction boundary (MNRB) created with HCl and NaOH. The optimized conditions are screened out. By using this method, the experiments are performed on MNRB formed with HCl and NaOH in agarose gel. The experiments are quantitatively in coincidence with the predictions with the theory of moving chemical reaction boundary (MCRB). | Shu Lin ZHOU1,2, Cheng Xi CAO1*, You Zhao HE1, Wen Kui CHEN2, Yi Tai QIAN1 1Department of Chemistry, University of Science and Technology of China, Hefei 230026 2Institute of Allergy Research, Wannan Medical College, Anhui Wuhu 241001 | 2001 | Chinese Chemical Letters2001，12，2： | 1 |
| 19 | A potential candidate structural material for molten salt reactor:ODS nickel-based alloy显示文摘The commercialisation of molten salts reactors(MSRs)is hindered by the lack of structural materials capable of withstanding the corrosive environment therein.To address this problem,we herein prepared1 wt%Y_(2)O_(3)mdispersion-strengthened Ni Mo-based alloys using powder metallurgy and evaluated their potential as structural materials for MSRs based on their mechanical properties,He swelling behaviour,and molten salt corrosion resistance.In view of the strengthening provided by homogenously dispersed Y_(2)O_(3)particles,all NiMo-Y_(2)O_(3)samples exhibited ultimate tensile strengths and yield strengths exceeding those of the Hastelloy N alloy,a state-of-the-art structural material for MSRs.Moreover,the volume fraction of He bubbles in the NiMo-Y_(2)O_(3)samples(~0.3%)was lower than that in the Hastelloy N alloy(0.58%),which showed that the introduction of Y_(2)O_(3)nanoparticles effectively inhibited He swelling.All NiMo-Y_(2)O_(3)samples showed excellent resistance to molten salt corrosion(as reflected by the absence of obvious holes therein),thus holding great promise for the development of irradiation-and molten salt corrosion-resistant structural materials for high-temperature MSRs. | Cheng Li Guanhong Lei Jizhao Liu Awen Liu CLRen Hefei Huang | 2022 | Journal of Materials Science & Technology2022，，14： | 1 |
| 20 | U-Pb ZIRCON AGES OF THE ROCKS IN THENORTH DABIE TERRAIN, CHINA显示文摘 | Xie Zhi Cheng Jiangfeng Zhou Taixi (Department of Earth and SPace Sciences University of Science and Technology of China Hefei 230026)Li Huiming Zuo Yicheng and Zhou Hongying(Tianjin institute of Geology and Mineral Resources CAGS Tianjin 300170) | 1998 | Scientia Geologica Sinica1998，，04： | 1 |
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