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| 1 | Hydrogen sulfide, a signaling molecule in plant stress responses显示文摘Gaseous molecules, such as hydrogen sulfide(H_2S)and nitric oxide(NO), are crucial players in cellular and(patho)physiological processes in biological systems. The biological functions of these gaseous molecules, which were first discovered and identified as gasotransmitters in animals, have received unprecedented attention from plant scientists in recent decades. Researchers have arrived at the consensus that H_2S is synthesized endogenously and serves as a signaling molecule throughout the plant life cycle.However, the mechanisms of H_2S action in redox biology is still largely unexplored. This review highlights what we currently know about the characteristics and biosynthesis of H_2S in plants. Additionally,we summarize the role of H_2S in plant resistance to abiotic stress. Moreover, we propose and discuss possible redox-dependent mechanisms by which H_2S regulates plant physiology. | Jing Zhang Mingjian Zhou Heng Zhou Didi Zhao Cecilia Gotor Luis CRomero Jie Shen Zhenglin Ge Zhirong Zhang Wenbiao Shen Xingxing Yuan Yanjie Xie | 2021 | Journal of Integrative Plant Biology2021，63，1： | 8 |
| 2 | Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration显示文摘Stable integration of hydrogel implants with host tissues is of critical importance to cartilage tissue engineering.Designing and fabricating hydrogels with high adhesive strength,stability and regeneration potential are major challenges to be overcome.This study fabricated injectable adhesive hyaluronic acid(HA)hydrogel modified by aldehyde groups and methacrylate(AHAMA)on the polysaccharide backbone with multiple anchoring mechanisms(amide bond through the dynamic Schiff base reaction,hydrogen bond and physical interpenetration).AHAMA hydrogel exhibited significantly improved durability and stability within a humid environment(at least 7 days),together with higher adhesive strength(43 KPa to skin and 52 KPa to glass),as compared to commercial fibrin glue(nearly 10 KPa)and HAMA hydrogel(nearly 20 KPa).The results showed that AHAMA hydrogel was biocompatible and could be easily and rapidly prepared in situ.In vitro cell culture experiments showed that AHAMA hydrogel could enhance proliferation(1.2-folds after 3 days)and migration(1.5-folds after 12 h)of bone marrow stem cells(BMSCs),as compared to cells cultured in a culture dish.Furthermore,in a rat osteochondral defect model,implanted AHAMA hydrogel significantly promoted integration between neo-cartilage and host tissues,and significantly improved cartilage regeneration(modified O’Driscoll histological scores of 16.0±4.1 and 18.3±4.6 after 4 and 12-weeks of post-implantation in AHAMA groups respectively,12.0±2.7 and 12.2±2.8 respectively in HAMA groups,9.8±2.4 and 11.5±2.1 respectively in untreated groups).Hence,AHAMA hydrogel is a promising adhesive biomaterial for clinical cartilage regeneration and other biomedical applications. | Jiaqing Chen Jiabei Yang Li Wang Xuewei Zhang Boon Chin Heng Dong-An Wang Zigang Ge | 2021 | Bioactive Materials2021，6，6： | 6 |
| 3 | Spatio-temporal variation in rock exhumation linked to large-scale shear zones in the southeastern Tibetan Plateau显示文摘Crustal-scale shear zones are believed to have played an important role in the tectonic and landscape evolution of orogens. However, the variation of long-term rock exhumation between the interior of shear zones and adjacent regions has not been documented in detail. In this study, we obtained new zircon U-Pb, biotite ^(40)Ar/^(39)Ar, zircon and apatite(U-Th)/He data, and conducted inverse thermal history modeling from two age-elevation profiles(the Pianma and Tu'er profiles) in the southeastern Tibetan Plateau. Our goal is to constrain the exhumation history of the Gaoligong and Chongshan shear zones and adjacent regions, so as to explore the effect of the shear zones on exhumation and their thermal effect on cooling that should not be ignored. Our results suggest that during the interval of 18–11 Ma the exhumation rates of rocks within the Gaoligong shear zone are anomalously high compared with those outside of. The rapid cooling during 18–11 Ma appears to be restricted to the shear zone, likely due to localized thermal effects of shearing and exhumation. After 11 Ma, both the areas within and outside of the shear zones experienced a similar two-stage exhumation history: slower cooling until the early Pliocene, and then a rapid increase in cooling rate since the early Pliocene. Our results indicate a synchronized exhumation but with spatially varied exhumation rates. Our study also highlights the important role of large-scale shear zones in exposing rocks, and thus the importance of the structural context when interpreting thermochronological data in the southeastern margin of the Tibetan Plateau. | Yukui GE Jing LIU-ZENG Jinyu ZHANG Wei WANG Yuntao TIAN Matthew FOX Lingsen ZENG Xiaoming SHEN Heng WANG Ze SU Kejia XIE | 2020 | Science China Earth Sciences2020，63，4： | 5 |
| 4 | Regulation of Leaf Angle by Auricle Development n Maize显示文摘 | Fanying Kong Tingting Zhang Jisheng Liu Siqi Heng Qingbiao Shi Haisen Zhang Zeli Wang Lei Ge Pinghua Li Xiaoduo Lu Gang Li | 2017 | Molecular Plant2017，10，3： | 5 |
| 5 | Alda-1 treatment promotes the therapeutic effect of mitochondrial transplantation for myocardial ischemia-reperfusion injury显示文摘Mitochondrial damage is a critical driver in myocardial ischemia-reperfusion(I/R)injury and can be alleviated via the mitochondrial transplantation.The efficiency of mitochondrial transplantation is determined by mitochondrial vitality.Because aldehyde dehydrogenase 2(ALDH2)has a key role in regulating mitochondrial homeostasis,we aimed to investigate its potential therapeutic effects on mitochondrial transplantation via the use of ALDH2 activator,Alda-1.Our present study demonstrated that time-dependent internalization of exogenous mitochondria by cardiomyocytes along with ATP production were significantly increased in response to mitochondrial transplantation.Furthermore,Alda-1 treatment remarkably promoted the oxygen consumption rate and baseline mechanical function of cardiomyocytes caused by mitochondrial transplantation.Mitochondrial transplantation inhibited cardiomyocyte apoptosis induced by the hypoxia-reoxygenation exposure,independent of Alda-1 treatment.However,promotion of the mechanical function of cardiomyocytes exposed to hypoxia-reoxygenation treatment was only observed after mitochondrial Alda-1 treatment and transplantation.By using a myocardial I/R mouse model,our results revealed that transplantation of Alda-1-treated mitochondria into mouse myocardial tissues limited the infarction size after I/R injury,which was at least in part due to increased mitochondrial potential-mediated fusion.In conclusion,ALDH2 activation in mitochondrial transplantation shows great potential for the treatment of myocardial I/R injury. | Xiaolei Sun Rifeng Gao Wenjia Li Yongchao Zhao Heng Yang Hang Chen Hao Jiang Zhen Dong Jingjing Hu Jin Liu Yunzeng Zou Aijun Sun Junbo Ge | 2021 | Bioactive Materials2021，6，7： | 5 |
| 6 | Efficacy and safety of drug-eluting stent implantation for the treatment of in-stent restenosis occurring within bare-metal stent and drug-eluting stent显示文摘Objective:Although drug-eluting stent(DES) implantation is the primary treatment modality for bare-metal stent(BMS) in-stent restenosis(ISR),little is known about the efficacy and safety profile of DES in the treatment of DES-ISR.The goal of this study was to compare the clinical outcomes following DES treatment for BMS-ISR and DES-ISR.Methods:Rates of major adverse cardiac events(MACE) were compared in 97 consecutive patients who underwent DES implantation for the treatment of ISR(56 BMS-ISR and 41 DES-ISR) from January 2004 to December 2008.Results:Baseline clinical and procedural characteristics were comparable,except that the DES used in the BMS-ISR group was longer and had a larger diameter.The length of follow-up was(28.60±1.96) and(20.34±1.54) months for the BMS-ISR and DES-ISR groups,respectively.One patient(1.8%) experienced non-cardiac mortality and one(1.8%) had target-vessel revascularization(TVR) in the BMS-ISR group.In the DES-ISR group,three patients(7.3%) died of sudden death with a documented acute ST-segment elevation myocardial infarction,and three suffered TVR(7.3%).Kaplan-Meier analysis indicated that cumulative survival probability and MACE-free probability were both significantly lower for the DES-ISR group(log rank test P=0.047 and P=0.005,respectively).In Cox regression analysis,DES-ISR remained an independent predictor for future MACE occurrence after adjustment for other factors(compared with BMS-ISR,risk ratio(RR)=8.743,95% confidence interval(CI) 1.54-49.54,P=0.014).Switching to a different type of DES to treat DES-ISR did not improve the prognosis.Conclusion:DES-ISR patients had a poorer prognosis than BMS-ISR patients after DES therapy. | Heng GE Qing ZHANG WeiZHOU Qing HE Zhi-hua HAN Ben HE | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，8： | 3 |
| 7 | Structural basis of pre-mRNA recognition by the human cleavage factor Im complex显示文摘劈开因素我 m ( CF 我 m ),由 25 kDa 子单元组成( CF 我 m 25)并且三个更大的子单元之一( CF 我 m 59, CF 我 m 68, CF 我 m 72),并且一为 pre-mRNA 的必要蛋白质建筑群 3 ′ ;结束劈开和 polyadenylation 。它认出在上游的顺序 poly 以一种顺序依赖者方式的(A) 地点。这里,我们报导人的 CF 的水晶结构我 m , 包括 CF 我 m 25 和 CF 的 RNA 识别主题领域我 m 68 (CF 我 m 68RRM), 和 CF 的水晶结构我 m -RNA 建筑群。这些结构显示出那二 CF 我 m 68RRM 分子绑在 CF 我 经由形成 heterotetramer 的一个新奇 RRM 蛋白质相互作用模式更暗淡的 m 25。与反平行的取向,二 UGUAA RNA 定序的 RNA 固定的结构表演绑在一 CF 我 m 25-CF 我 m 68RRM heterotetramer,为由 CF 的机制提供结构的基础我 m 同时在 pre-mRNA 的一个分子以内绑二个 UGUAA 元素。点变化和运动分析表明那 CF 我 m 68RRM 能绑立即在上游的 flanking UGUAA 元素的区域,和 CF 我 m 68RRM 绑定显著地增加建筑群的RNA有约束力的亲密关系,建议那 CF 我 m 68 做必要贡献到 pre-mRNA 有约束力。 | Heng Li | 2011 | Cell Research2011，21，7： | 3 |
| 8 | Two-plane painting injection scheme for BRing of HIAF显示文摘The high-intensity heavy-ion accelerator facility(HIAF)is under design at the Institute of Modern Physics(IMP)and will provide an intense ion beam for nuclear physics,atomic mass measurement research,and other applications.As the main ring of HIAF,the BRing accumulates beams to high intensity and accelerates them to high energy.To achieve high intensities up to 1×10^(11)(^(238)U^(34+)),the injection gain of the BRing must be as high as 88.However,multiple multiturn injection supported by the electron cooling system takes a long time,causing substantial beam loss under a strong space charge effect.Hence,a two-plane painting injection scheme is proposed for beam accumulation in the BRing.This scheme uses a tilted injection septum and horizontal and vertical bump magnets to paint the beam into horizontal and vertical phase space simultaneously.In this paper,the two-plane painting injection parameters are optimized,and the resulting injection process is simulated using the Objective Ring Beam Injection and Tracking(ORBIT)code.An injection gain of up to 110.3 with a loss rate of 2:3%is achieved,meeting the requirements of BRing. | Guo-Feng Qu Wei-Ping Chai Jia-Wen Xia Jian-Cheng Yang Heng Du Zhong-Shan Li Wen-Wen Ge Wen-Heng Zheng Peng Shang | 2017 | Nuclear Science and Techniques2017，28，8： | 3 |
| 9 | Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling显示文摘Osmotic stress caused by drought and high salinity is a significant environmental threat that limits plant growth and agricultural yield. Redox regulation plays an important role in plant stress responses, but the mechanisms by which plants perceive and transduce redox signals are still underexplored. Here, we report a critical function for the thiol peroxidase GPX1 in osmotic stress response in rice, where it serves as a redox sensor and transducer. GPX1 is quickly oxidized upon exposure to osmotic stress and forms an intramolecular disulfide bond, which is required for the activation of bZIP68, a VRE-like basic leucine zipper (bZIP) transcription factor involved in the ABA-independent osmotic stress response pathway. The disulfide exchange between GPX1 and bZIP68 induces homo-tetramerization of bZIP68 and thus positively regulates osmotic stress response by regulating osmotic-responsive gene expression. Furthermore, we discovered that the nuclear translocation of GPX1 is regulated by its acetylation under osmotic stress. Taken together, our findings not only uncover the redox regulation of the GPX1-bZIP68 module during osmotic stress but also highlight the coordination of protein acetylation and redox signaling in plant osmotic stress responses. | Heng Zhou Feng Zhang Fengchao Zhai Ye Su Ying Zhou Zhenglin Ge Priyadarshini Tilak Jürgen Eirich Iris Finkemeier Ling Fu Zongmin Li Jing Yang Wenbiao Shen Xingxing Yuan Yanjie Xie | 2022 | Molecular Plant2022，15，4： | 2 |
| 10 | Role playing learning for socially concomitant mobile robot navigation显示文摘 | Mingming Li Rui Jiang Shuzhi Sam Ge Tong Heng Lee | 2018 | CAAI Transactions on Intelligence Technology2018，3，1： | 2 |
| 11 | Proliferation and differentia- tion of human osteoblasts within 3D printed poly-lactic-eo- glycolie acid scaffolds显示文摘 | Ge ZG Wang LS Heng BC | 2009 | J Biomater Appl2009，23，6： | 1 |
| 12 | Realizing the highly reversible Zn^(2+)and Na^(+) dual ions storage in high-crystallinity nickel hexacyanoferrate microcubes for aqueous zinc-ion batteries显示文摘Prussian blue analogues(PBAs)with the 3D open framework are regarded as promising cathode candidates for aqueous Zinc ion batteries(ZIBs).Among various PBAs,nickel hexacyanoferrate(NiHCF)has attracted considerable attention because of its high operating voltage and economic merit.However,the cyclability of NiHCF is unsatisfactory due to poor structural stability during Zn^(2+) ions insertion/deinsertion.Moreover,the ion storage mechanism of NiHCF in aqueous electrolytes has not been fully revealed yet.Herein,high-crystallinity NiHCF(HC-NiHCF)microcubes with improved structural stability and larger crystal plane spacing are synthesized.For the first time,highly reversible Zn2+ions and Na+ions co-insertion/extraction are achieved for the HC-NiHCF microcubes in mixed aqueous electrolyte,as evidenced by various observations including two separated discharge plateaus and sequential changes of Na 1s and Zn 2p signals in ex-situ X-ray photoelectron spectroscopy(XPS).As a result,a high specific capacity of 73.9 mAh g^(−1) is obtained for the HC-NiHCF microcubes at 0.1 A g−1,combined with enhanced cycle stability(75%vs.16.4%)over 1000 cycles at 2 A g^(−1).The reversible Zn^(2+) ions and Na+ions co-insertion in HC-NiHCF microcubes reveals a new ion storage mechanism of Ni-based PBAs in aqueous electrolytes. | Kexuan Wang Zhu Xu Heng Li Huibo Wang Mingzheng Ge Jilei Liu Shengwen Li Zekun Hu Mengyu Zhu Yanyan Zhang Yuxin Tang Shi Chen | 2023 | Journal of Materials Science & Technology2023，，33： | 1 |
| 13 | Geochronology of the Mesozoic volcanic rocks in the Great Xing' an Range, Northeastern China: implications for subduetion-induced detamination 显示文摘 | Zhang Ji heng Gao Shan Ge Wen-chun | 2010 | Chemical Geology2010，276，： | 1 |
| 14 | Pro-inflammatory activities induced by CyPA-EMMPRIN interaction in monocytes显示文摘 | YUAN Wei GE Heng HE Ben | 2010 | Atherosclerosis2010，213，2： | 1 |
| 15 | Adaptive neural control of non-linear time-delay systems with unknown virtual control coefficients 显示文摘 | GE S S FAN H HENG L T | 2004 | IEEE Transactions on Systems Man and Cybernetics Part B: Cy- bernetics2004，34，1： | 1 |
| 16 | Osteoarthritis and therapy显示文摘 | Ge Z G Hu Y Heng B C | 2006 | Arthritis Rheum2006，55，3： | 1 |
| 17 | Genome-wide identification and expression analysis of NtbHLH gene family in tobacco(Nicotiana tabacum)and the role of NtbHLH86 in drought adaptation显示文摘The bHLH transcription factors play pivotal roles in plant growth and development,production of secondary metabolites and responses to various environmental stresses.Although the bHLH genes have been well studied in model plant species,a comprehensive investigation of the bHLH genes is required for tobacco with newly obtained high-quality genome.In the present study,a total of 309 NtbHLH genes were identified and can be divided into 23 subfamilies.The conserved amino acids which are essential for their function were predicted for the NtbHLH proteins.Moreover,the NtbHLH genes were conserved during evolution through analyzing the gene structures and conserved motifs.A total of 265 NtbHLH genes were localized in the 24 tobacco chromosomes while the remained 44 NtbHLH genes were mapped to the scaffolds due to the complexity of tobacco genome.Moreover,transcripts of NtbHLH genes were obviously tissue-specific expressed from the gene-chip data from 23 tobacco tissues,and expressions of 20 random selected NtbHLH genes were further confirmed by quantitative real-time PCR,indicating their potential functions in the plant growth and development.Importantly,overexpressed NtbHLH86 gene confers improve drought tolerance in tobacco indicating that it might be involved in the regulation of drought stress.Therefore,our findings here provide a valuable information on the characterization of NtbHLH genes and further investigation of their functions in tobacco. | Ge Bai Da-Hai Yang Peijian Chao Heng Yao MingLiang Fei Yihan Zhang Xuejun Chen Bingguang Xiao Feng Li Zhen-Yu Wang Jun Yang He Xie | 2021 | Plant Diversity2021，43，6： | 1 |
| 18 | Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells显示文摘 | Jnnfeng Zhang Heng Ge Changqian Wang | 2007 | Int J Cardiol2007，117，3： | 1 |
| 19 | Nanosecond pulsed electric fields prime mesenchymal stem cells to peptide ghrelin and enhance chondrogenesis and osteochondral defect repair in vivo显示文摘Mesenchymal stem cells(MSCs) are important cell sources in cartilage tissue development and homeostasis,and multiple strategies have been developed to improve MSCs chondrogenic differentiation with an aim of promoting cartilage regeneration.Here we report the effects of combining nanosecond pulsed electric fields(ns PEFs) followed by treatment with ghrelin(a hormone that stimulates release of growth hormone) to regulate chondrogenesis of MSCs.ns PEFs and ghrelin were observed to separately enhance the chondrogenesis of MSCs,and the effects were significantly enhanced when the bioelectric stimulation and hormone were combined,which in turn improved osteochondral tissue repair of these cells within Sprague Dawley rats.We further found that ns PEFs can prime MSCs to be more receptive to subsequent stimuli of differentiation by upregulated Oct4/Nanog and activated JNK signaling pathway.Ghrelin initiated chondrogenic differentiation by activation of ERK1/2 signaling pathway,and RNA-seq results indicated 243 genes were regulated,and JAK-STAT signaling pathway was involved.Interestingly,the sequential order of applying these two stimuli is critical,with ns PEFs pretreatment followed by ghrelin enhanced chondrogenesis of MSCs in vitro and subsequent cartilage regeneration in vivo,but not vice versa.This synergistic prochondrogenic effects provide us new insights and strategies for future cell-based therapies. | Kejia Li Litong Fan Jianjing Lin Boon Chin Heng Zhantao Deng Qiujian Zheng Jue Zhang Yangzi Jiang Zigang Ge | 2022 | Science China(Life Sciences)2022，65，5： | 1 |
| 20 | Digital quantum simulation of Floquet topological phases with a solid-state quantum simulator显示文摘Harnessing the dynamics of complex quantum systems is an area of much interest and a quantum simulator has emerged as a promising platform to probe exotic topological phases.Since the flexibility offered by various controllable quantum systems has helped gain insight into the quantum simulation of such complicated problems,an analog quantum simulator has recently shown its feasibility to tackle the problems of exploring topological phases.However,digital quantum simulation and the detection of topological phases still remain elusive.Here,we develop and experimentally realize the digital quantum simulation of topological phases with a solid-state quantum simulator at room temperature.Distinct from previous works dealing with static topological phases,the topological phases emulated here are Floquet topological phases.Furthermore,we also illustrate the procedure of digitally simulating a quantum quench and observing the nonequilibrium dynamics of Floquet topological phases.Using a quantum quench,the 0-andπ-energy topological invariants are unambiguously detected through measuring time-averaged spin polarizations.We believe our experiment opens up a new avenue to digitally simulate and detect Floquet topological phases with fast-developed programmable quantum simulators. | BING CHEN SHUO LI XIANFEI HOU FEIFEI GE FEIFEI ZHOU PENG QIAN FENG MEI SUOTANG JIA NANYANG XU HENG SHEN | 2021 | Photonics Research2021，9，1： | 1 |
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