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| 1 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 2 | Biomimetic strategies for tendon/ligament-to-bone interface regeneration显示文摘Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex structure,composition,cell population and mechanics of the interface.With rapid advances in tissue engineering,a variety of strategies including advanced biomaterials,bioactive growth factors and multiple stem cell lineages have been developed to facilitate the healing of this tissue interface.Given the important role of structure-function relationship,the review begins with a brief description of enthesis structure and composition.Next,the biomimetic biomaterials including decellularized extracellular matrix scaffolds and synthetic-/natural-origin scaffolds are critically examined.Then,the key roles of the combination,concentration and location of various growth factors in biomimetic application are emphasized.After that,the various stem cell sources and culture systems are described.At last,we discuss unmet needs and existing challenges in the ideal strategies for tendon/ligament-to-bone regeneration and highlight emerging strategies in the field. | Tingyun Lei Tao Zhang Wei Ju Xiao Chen Boon Chin Heng Weiliang Shen Zi Yin | 2021 | Bioactive Materials2021，6，8： | 6 |
| 3 | Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration显示文摘Stable integration of hydrogel implants with host tissues is of critical importance to cartilage tissue engineering.Designing and fabricating hydrogels with high adhesive strength,stability and regeneration potential are major challenges to be overcome.This study fabricated injectable adhesive hyaluronic acid(HA)hydrogel modified by aldehyde groups and methacrylate(AHAMA)on the polysaccharide backbone with multiple anchoring mechanisms(amide bond through the dynamic Schiff base reaction,hydrogen bond and physical interpenetration).AHAMA hydrogel exhibited significantly improved durability and stability within a humid environment(at least 7 days),together with higher adhesive strength(43 KPa to skin and 52 KPa to glass),as compared to commercial fibrin glue(nearly 10 KPa)and HAMA hydrogel(nearly 20 KPa).The results showed that AHAMA hydrogel was biocompatible and could be easily and rapidly prepared in situ.In vitro cell culture experiments showed that AHAMA hydrogel could enhance proliferation(1.2-folds after 3 days)and migration(1.5-folds after 12 h)of bone marrow stem cells(BMSCs),as compared to cells cultured in a culture dish.Furthermore,in a rat osteochondral defect model,implanted AHAMA hydrogel significantly promoted integration between neo-cartilage and host tissues,and significantly improved cartilage regeneration(modified O’Driscoll histological scores of 16.0±4.1 and 18.3±4.6 after 4 and 12-weeks of post-implantation in AHAMA groups respectively,12.0±2.7 and 12.2±2.8 respectively in HAMA groups,9.8±2.4 and 11.5±2.1 respectively in untreated groups).Hence,AHAMA hydrogel is a promising adhesive biomaterial for clinical cartilage regeneration and other biomedical applications. | Jiaqing Chen Jiabei Yang Li Wang Xuewei Zhang Boon Chin Heng Dong-An Wang Zigang Ge | 2021 | Bioactive Materials2021，6，6： | 6 |
| 4 | Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis显示文摘Endothelial tip cell outgrowth of blood-vessel sprouts marks the initiation of angiogenesis which is critical in physiological and pathophysiological procedures.However,how mechanical characteristics of extracellular matrix(ECM)modulates tip cell formation has been largely neglected.In this study,we found enhanced CD31 expression in the stiffening outer layer of hepatocellular carcinoma than in surrounding soft tissues.Stiffened matrix promoted sprouting from endothelial cell(EC)spheroids and upregulated expressions of tip cell-enriched genes in vitro.Moreover,tip cells showed increased cellular stiffness,more actin cytoskeleton organization and enhanced YAP nuclear transfer than stalk and phalanx ECs.We further uncovered that substrate stiffness regulates FAK and Paxillin phosphorylation in focal adhesion of ECs promoting Rac1 transition from inactive to active state.YAP is subsequently activated and translocated into nucleus,leading to increased tip cell specification.p-Paxillin can also loosen the intercellular connection which also facilitates tip cell specification.Collectively our present study shows that matrix stiffness modulates tip cell formation through p-PXN-Rac1-YAP signaling axis,shedding light on the role of mechanotransduction in tip cell formation.This is of special significance in biomaterial design and treatment of some pathological situations. | Yaru Guo Feng Mei Ying Huang Siqin Ma Yan Wei Xuehui Zhang Mingming Xu Ying He Boon Chin Heng Lili Chen Xuliang Deng | 2022 | Bioactive Materials2022，7，1： | 4 |
| 5 | Engineering synthetic optogenetic networks for biomedical applications显示文摘 | Meiyan Wang Yuanhuan Yu Jiawei Shao Boon Chin Heng Haifeng Ye | 2017 | Frontiers of Electrical and Electronic Engineering in China2017，5，2： | 1 |
| 6 | Aberrant profile of gene expression in cloned mouse embryos derived from donor cumulus nuclei显示文摘 | Guo Qing Tong Boon Chin Heng Lay Geok Tan Soon Chye Ng | 2006 | Cell and Tissue Research2006，，2： | 1 |
| 7 | Nanosecond pulsed electric fields prime mesenchymal stem cells to peptide ghrelin and enhance chondrogenesis and osteochondral defect repair in vivo显示文摘Mesenchymal stem cells(MSCs) are important cell sources in cartilage tissue development and homeostasis,and multiple strategies have been developed to improve MSCs chondrogenic differentiation with an aim of promoting cartilage regeneration.Here we report the effects of combining nanosecond pulsed electric fields(ns PEFs) followed by treatment with ghrelin(a hormone that stimulates release of growth hormone) to regulate chondrogenesis of MSCs.ns PEFs and ghrelin were observed to separately enhance the chondrogenesis of MSCs,and the effects were significantly enhanced when the bioelectric stimulation and hormone were combined,which in turn improved osteochondral tissue repair of these cells within Sprague Dawley rats.We further found that ns PEFs can prime MSCs to be more receptive to subsequent stimuli of differentiation by upregulated Oct4/Nanog and activated JNK signaling pathway.Ghrelin initiated chondrogenic differentiation by activation of ERK1/2 signaling pathway,and RNA-seq results indicated 243 genes were regulated,and JAK-STAT signaling pathway was involved.Interestingly,the sequential order of applying these two stimuli is critical,with ns PEFs pretreatment followed by ghrelin enhanced chondrogenesis of MSCs in vitro and subsequent cartilage regeneration in vivo,but not vice versa.This synergistic prochondrogenic effects provide us new insights and strategies for future cell-based therapies. | Kejia Li Litong Fan Jianjing Lin Boon Chin Heng Zhantao Deng Qiujian Zheng Jue Zhang Yangzi Jiang Zigang Ge | 2022 | Science China(Life Sciences)2022，65，5： | 1 |
| 8 | Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles显示文摘 | Jia Lin Chen Zi Yin Wei Liang Shen Xiao Chen Boon Chin Heng Xiao Hui Zou Hong Wei Ouyang | 2010 | Biomaterials2010，，36： | 1 |
| 9 | Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization显示文摘Musculoskeletal disorders are common in clinical practice.Repairing critical-sized defects in musculoskeletal systems remains a challenge for researchers and surgeons,requiring the application of tissue engineering biomaterials.Successful application depends on the response of the host tissue to the biomaterial and specific healing process of each anatomical structure.The commonly-held view is that biomaterials should be biocompatible to minimize local host immune response.However,a growing number of studies have shown that active modulation of the immune cells,particularly macrophages,via biomaterials is an effective way to control immune response and promote tissue regeneration as well as biomaterial integration.Therefore,we critically review the role of macrophages in the repair of injured musculoskeletal system soft tissues,which have relatively poor regenerative capacities,as well as discuss further enhancement of target tissue regeneration via modulation of macrophage polarization by biomaterial-mediated immunomodulation(biomaterial properties and delivery systems).This active regulation approach rather than passive-evade strategy maximizes the potential of biomaterials to promote musculoskeletal system soft tissue regeneration and provides alternative therapeutic options for repairing critical-sized defects. | Jinchun Ye Chang Xie Canlong Wang Jiayun Huang Zi Yin Boon Chin Heng Xiao Chen Weiliang Shen | 2021 | Bioactive Materials2021，6，11： | 1 |
| 10 | Human umbilical cord mesenchymal stromal cells promote the regeneration of severe endometrial damage in a rat model显示文摘Due to the influence of various social and environmental factors,the incidence of infertility is increasing,and the application of assisted reproductive technology(ART)is becoming more and more widespread.At present,the clinical pregnancy rate of in vitro fertilization(IVF)is 40%~60%,and decreased endometrial receptivity is one of the reasons for implantation failure.Endometrial receptivity refers to the capacity of the endometrium to accept embryos.Intrauterine adhesions(IUA),also known as Asherman syndrome(AS). | Mei Zhuang Wuwen Zhang Nuo Cheng Ling Zhou Dan Liu Hua Yan Ge Fang Boon Chin Heng Yan Sun Guoqing Tong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 1 |
| 11 | Vitrified-warmed blastocyst transfer cycles yield higher pregnancy and implantation rates compared with fresh blastocyst transfer cycles—time for a new embryo transfer strategy?显示文摘 | Dandan Zhu Juanjuan Zhang Shanren Cao Junqiang Zhang Boon Chin Heng Meiling Huang Xiufeng Ling Tao Duan Guo Qing Tong | 2011 | Fertility and Sterility2011，，5： | 1 |
| 12 | Extrapolating neurogenesis of mesenchymal stem/stromal cells on electroactive and electroconductive scaffolds to dental and oral-derived stem cells显示文摘The high neurogenic potential of dental and oral-derived stem cells due to their embryonic neural crest origin,coupled with their ready accessibility and easy isolation from clinical waste,make these ideal cell sources for neuroregeneration therapy.Nevertheless,these cells also have high propensity to differentiate into the osteo-odontogenic lineage.One strategy to enhance neurogenesis of these cells may be to recapitulate the natural physiological electrical microenvironment of neural tissues via electroactive or electroconductive tissue engineering scaffolds.Nevertheless,to date,there had been hardly any such studies on these cells.Most relevant scientific information comes from neurogenesis of other mesenchymal stem/stromal cell lineages(particularly bone marrow and adipose tissue)cultured on electroactive and electroconductive scaffolds,which will therefore be the focus of this review.Although there are larger number of similar studies on neural cell lines(i.e.PC12),neural stem/progenitor cells,and pluripotent stem cells,the scientific data from such studies are much less relevant and less translatable to dental and oral-derived stem cells,which are of the mesenchymal lineage.Much extrapolation work is needed to validate that electroactive and electroconductive scaffolds can indeed promote neurogenesis of dental and oral-derived stem cells,which would thus facilitate clinical applications in neuroregeneration therapy. | Boon Chin Heng Yunyang Bai Xiaochan Li Xuehui Zhang Xuliang Deng | 2022 | International Journal of Oral Science2022，14，2： | 0 |
| 13 | A novel gene-activated matrix composed of PEI/plasmid-BMP2 complexes and hydroxyapatite/chitosan-microspheres promotes bone regeneration显示文摘The incorporation of pro-osteogenic growth factors into bone graft materials to enhance bone regeneration is a key research area within the field of bone tissue engineering and regenerative medicine.However,growth factors directly incorporated in protein form are easily degraded,and have a limited active half-life,which cannot exert long-term and stable osteoinductive and oteoconductive effects.The combination of gene therapy and tissue engineering through gene-activated matrix(GAM)may provide a good alternative solution to overcome such limitations.Scaffold materials can be combined together with plasmid DNA and a chemical-based transfection agent to form GAM,through which transfected cells could secrete growth factors in a sustained manner over a longer time duration;thereby enabling bone graft materials to act as a repository of therapeutic genes,while providing structural support and a scaffold matrix for new bone tissue ingrowth.In this study,we prepared hydroxyapatite/chitosan-microspheres(HA/CS-MS)with microfabrication technology and emulsification method,and loaded the polyethylene imine/bone morphogenetic protein 2 plasmid(PEI/pBMP2)complexes with high transfection capacity(transfection efficiency up to 54.79%±4.95%),thus forming a novel GAM system with superior bone regeneration capacity—PEI/pBMP2-HA/CS-MS.The in vitro experiments in this study demonstrated that our GAM had excellent biocompatibility(with cell viability over 95%),and that the as-fabricated microsphere material possessed a nano-network fibrous structure similar to natural extracellular matrix(ECM),together with a higher surface area that can provide more cell adhesion sites.The sizes of the prepared microspheres were mainly distributed in the 160–180μm range,while the maximal loading rate of PEI-pBMP2 complexes was 59.79%±1.85%.As a loaded complexes system,the GAM can release plasmids in a slow controlled manner,effectively transfecting surrounding target cells(release effect for up to 21 days),while cells adherent to the material can also take up plasmids,resulting in sustained secretion of the target protein,thereby effectively promoting bone regeneration.In vivo data from micro-computed tomography(micro-CT)and histological staining showed that the use of the composite materials effectively enhanced bone regeneration in defect areas.These findings thus demonstrated that the novel GAM system had excellent osteoinductivity with significant clinical potential. | Ruyuan Ding Yajun Liu Dawei Cheng Gang Yang Wenjing Wu Haoran Du Xin Jin Yihan Chen Yuanyin Wang Boon Chin HENG Qing Yang Jianguang XU | 2022 | Nano Research2022，15，7： | 0 |
| 14 | Key considerations on the development of biodegradable biomaterials for clinical translation of medical devices:With cartilage repair products as an example显示文摘With the interdisciplinary convergence of biology,medicine and materials science,both research and clinical translation of biomaterials are progressing at a rapid pace.However,there is still a huge gap between applied basic research on biomaterials and their translational products-medical devices,where two significantly different perspectives and mindsets often work independently and non-synergistically,which in turn significantly increases financial costs and research effort.Although this gap is well-known and often criticized in the biopharmaceutical industry,it is gradually widening.In this article,we critically examine the developmental pipeline of biodegradable biomaterials and biomaterial-based medical device products.Then based on clinical needs,market analysis,and relevant regulations,some ideas are proposed to integrate the two different mindsets to guide applied basic research and translation of biomaterial-based products,from the material and technical perspectives.Cartilage repair substitutes are discussed here as an example.Hopefully,this will lay a strong foundation for biomaterial research and clinical translation,while reducing the amount of extra research effort and funding required due to the dissonance between innovative basic research and commercialization pipeline. | Li Wang Xiaolei Guo Jiaqing Chen Zhen Zhen Bin Cao Wenqian Wan Yuandong Dou Haobo Pan Feng Xu Zepu Zhang Jianmei Wang Daisong Li Quanyi Guo Qing Jiang Yanan Du Jiakuo Yu Boon Chin Heng Qianqian Han Zigang Ge | 2022 | Bioactive Materials2022，7，3： | 0 |
| 15 | Increased expression of nestin in human pterygial epithelium显示文摘AIM: To investigate the distribution of nestin-positive cells in pterygium, as well as the relationship between nestin -positive cells and proliferative cells in the pathogenesis of pterygium. ·METHODS: Nine pterygium specimens and 5 normal conjunctiva specimens were investigated. All explanted specimens were immediately immersed in 5-Ethynyl-2'- deoxyuridine, and were subjected to hematoxylin and eosin staining, as well as immunostaining to detect nestin. ·RESULTS: Small sub-populations of nestin-expressing cells in both normal and pterygial conjunctiva epithelium were found. These were located at the superficial layer of the epithelium, and were significantly increased (P =0.007) and spread out in the pterygial conjunctiva epithelium, even though these cells were mitotically quiescent.·CONCLUSION: In pterygium, more nestin-positive cells were present at the superficial layer of the epithelium. With growing scientific evidence that nestin plays an important role in defining various specialized cell types, such as stem cells, cancer cells and angiogenic cells, further investigations on the roles of nestin -expressing cells in pterygium may help to uncover the mechanisms of initiation, development and the prognosis of this disease. | Dan Wen Hua Wang Boon Chin Heng Hua Liu | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 0 |
| 16 | Differential cytokines expression in cervical exfoliated cells of women with implantation after in vitro fertilization显示文摘In assisted reproductive technology,the quality of embryo and the receptivity of endometrium are the key components for successful pregnancy.Good endometrial receptivity is an important condition to the attachment of embryo[1].In clinical practice,the endometrial thickness,serum hormone level,and some gene expressions are always used to evaluate the functional status of endometrium.However,the hormone levels of serum estrogen and progesterone are out of synchronization of the development of endometrium.The thickness and status of endometrium cannot precisely demonstrate its morphological changes.Meanwhile,the mechanism of embryo implantation is very complicated,and immune cells,immune molecules,cytokines,adhesion molecules,etc. | Li Li Wuwen Zhang Christina(Ling)Tong Hua Yan Ping Yin Kai Li Boon Chin Heng Guoqing Tong | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 0 |
| 17 | Free or fixed state of nHAP differentially regulates hBMSC morphology and osteogenesis through the valve role of ITGA7显示文摘Nano-hydroxyapatite(nHAP)has been widely used in bone repair as an osteo-inductive and naturally-occurring material.However,the optimal applied form of nHAP and the underlying mechanisms involved remain unclear.Herein,to investigate into these,a range of corresponding models were designed,including three applied forms of nHAP(Free,Coating and 3D)that belong to two states(Free or fixed).The results indicate that when fixed nHAP was applied in the 3D form,optimal osteogenesis was induced in human bone marrow stem cells(hBMSCs)with increased bone volume via integrinα7(ITGA7)-mediated upregulation of the PI3K-AKT signaling pathway,while contrary results were observed with free nHAP.Ectopic osteogenesis experiments in mice subcutaneous transplantation model further confirmed the different tendencies of ITGA7 expression and osteogenesis of hBMSCs in free and fixed states of nHAP.Our results revealed that the two states of nHAP play a different regulatory role in cell morphology and osteogenesis through the valve role of ITGA7,providing cues for better application of nanoparticles and a potential new molecular target in bone tissue engineering. | Fangyuan Bao Junzhi Yi Yixiao Liu Yuliang Zhong Hui Zhang Zhonglin Wu Boon Chin Heng Ying Wang Ziyang Wang Lizi Xiao Hua Liu Hongwei Ouyang Jing Zhou | 2022 | Bioactive Materials2022，7，12： | 0 |
| 18 | Structural and physiological changes of the human body upon SARS-CoV-2 infection显示文摘Since December 2019,the novel coronavirus(severe acute respiratory syndrome coronavirus 2(SARS-CoV-2))has spread to many countries around the world,developing into a global pandemic with increasing numbers of deaths reported worldwide.To data,although some vaccines have been developed,there are no ideal drugs to treat novel coronavirus pneumonia(coronavirus disease 2019(COVID-19)).By examining the structure of the coronavirus and briefly describing its possible pathogenesis based on recent autopsy reports conducted by various teams worldwide,this review analyzes the possible structural and functional changes of the human body upon infection with SARS-CoV-2.We observed that the most prominent pathological changes in COVID-19 patients are diffuse alveolar damage(DAD)of the lungs and microthrombus formation,resulting in an imbalance of the ventilation/perfusion ratio and respiratory failure.Although direct evidence of viral infection can also be found in other organs and tissues,the viral load is relatively small.The conclusion that the injuries of the extrapulmonary organs are directly caused by the virus needs further investigation. | Zhonglin WU Qi ZHANG Guo YE Hui ZHANG Boon Chin HENG Yang FEI Bing ZHAO Jing ZHOU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，4： | 0 |
| 19 | The bioelectrical properties of bone tissue显示文摘Understanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries,as well as improving the design and fabrication of scaffold implants for bone tissue engineering.The bioelectrical properties of bone tissue can be attributed to the interaction of its various cell lineages(osteocyte,osteoblast and osteoclast)with the surrounding extracellular matrix,in the presence of various biomechanical stimuli arising from routine physical activities;and is best described as a combination and overlap of dielectric,piezoelectric,pyroelectric and ferroelectric properties,together with streaming potential and electro-osmosis.There is close interdependence and interaction of the various electroactive and electrosensitive components of bone tissue,including cell membrane potential,voltage-gated ion channels,intracellular signaling pathways,and cell surface receptors,together with various matrix components such as collagen,hydroxyapatite,proteoglycans and glycosaminoglycans.It is the remarkably complex web of interactive cross-talk between the organic and non-organic components of bone that define its electrophysiological properties,which in turn exerts a profound influence on its metabolism,homeostasis and regeneration in health and disease.This has spurred increasing interest in application of electroactive scaffolds in bone tissue engineering,to recapitulate the natural electrophysiological microenvironment of healthy bone tissue to facilitate bone defect repair. | Boon Chin Heng Yunyang Bai Xiaochan Li Yanze Meng Yanhui Lu Xuehui Zhang Xuliang Deng | 2023 | Animal Models and Experimental Medicine2023，6，2： | 0 |
| 20 | Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation显示文摘Stem cells from human exfoliated deciduous teeth(SHED)uniquely exhibit high proliferative and neurogenic potential.Charged biomaterials have been demonstrated to promote neural differentiation of stem cells,but the dose-response effect of electrical stimuli from these materials on neural differentiation of SHED remains to be elucidated.Here,by utilizing different annealing temperatures prior to corona poling treatment,BaTiO_(3)/P(VDF-TrFE)ferroelectric nanocomposite membranes with varying charge polarization intensity(d_(33)≈0,4,12 and 19 pC N^(-1))were fabricated.Enhanced expression of neural markers,increased cell elongation and more prominent neurite outgrowths were observed with increasing surface charge of the nanocomposite membrane indicating a dose-response effect of surface electrical charge on SHED neural differentiation.Further investigations of the underlying molecular mechanisms revealed that intracellular calcium influx,focal adhesion formation,FAK-ERK mechanosensing pathway and neurogenic-related ErbB signaling pathway were implicated in the enhancement of SHED neural differentiation by surface electrical charge.Hence,this study confirms the dose-response effect of biomaterial surface charge on SHED neural differentiation and provides preliminary insights into the molecular mechanisms and signaling pathways involved. | Xiaochan Li Boon Chin Heng Yunyang Bai Qianqian Wang Min Gao Ying He Xinwen Zhang Xuliang Deng Xuehui Zhang | 2023 | Bioactive Materials2023，，2： | 0 |
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