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| 1 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 2 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 3 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 4 | Age and menopausal status are important factors influencing the serum human epididymis secretory protein 4 level:a prospective cross-sectional study in healthy Chinese people显示文摘Background::Human epididymis secretory protein 4(HE4)is a new ovarian cancer biomarker.The factors influencing HE4 levels are not clear,and the reference data in China are limited.Here,we aim to evaluate the effects of menopause and age on HE4 levels and to provide a possible reference value for HE4 in healthy Chinese people.Methods::A total of 2493 healthy females aged 40 years or older were recruited from March 2013 to March 2017 with the cooperation of four medical institutions across Beijing,China.The serum levels of HE4 and cancer antigen 125(CA125)were measured by enzyme-linked immunosorbent assay.The Wilcoxon rank-sum test of variance and a stratified analysis were used to analyze the relationships among age,menopausal status,and levels of HE4 or CA125.Confidence intervals(5%-95%)were determined for reference ranges in different populations.Results::There was a statistically significant difference in median HE4 levels between the post-menopausal(n=2168)and premenopausal groups(n=325)(36.46 vs.24.04 pmol/L,Z=-14.41,P<0.001).HE4 increased significantly with age in the post-menopausal groups(H=408.18,P<0.001)but not in the pre-menopausal subjects(Z=-0.43,P=0.67).The upper 95th percentile of HE4 levels were 44.63 pmol/L for pre-menopausal women,78.17 pmol/L for post-menopausal women,and 73.3 pmol/L for all women.In the post-menopausal population,the HE4 reference ranges were 13.15 to 47.31,14.31 to 58.04,17.06 to 73.51,24.50 to 115.25,and 35.71 to 212.37 pmol/L for different age groups from forty divided by decade.The CA125 level was affected mainly by menopausal status and not age.Conclusions::Menopausal status and age were both important factors influencing the level of HE4,and age affected HE4 levels mainly in post-menopausal women.The HE4 level was higher in the post-menopausal population than in the pre-menopausal population and increased with age. | Hong-Yan Cheng Lin Zeng Xue Ye Rui-Qiong M a Zhi-Jian Tang Hong-Ling Chu Yi-M ing Zhao Li-Rong Zhu Yu-Nong Gao Xiao-Hong Chang Heng Cui | 2020 | Chinese Medical Journal2020，，11： | 6 |
| 5 | Mini-Cog测试结果与老年骨折患者并发症及谵妄高风险有关显示文摘既位对于围手术期危险因素的分析,通常采用美国麻醉医师协会(American Society of Anesthesiologists,ASA)评分等全身状态分类方法。Mini-Cog测试是一种快速、易行、有效且观察者间变异较小的认知评估工具,可测量急性应激状态下患者在执行功能障碍和回忆方面的认知储备。 | Heng M Eagen CE Javedan H 胡玮 杨进城 | 2016 | 中国骨科临床与基础研究杂志2016，8，4： | 3 |
| 6 | 老年人与交通事故的调查分析(英文)显示文摘目的中国目前正在经历老年人口与交通车辆的同时快速增长。随着人口的老龄化加剧以及社会的发展,老年驾驶者人数将预期明显增加。国际上对老年人交通安全的经验可能对中国即将增加的老年驾驶者有借鉴作用。方法检索并分析了中国以及一些发达国家,如美国等有关老年驾驶者以及交通事故安全的论文及论著。结果尽管老年人较少开车且普遍地使用安全带,但他们交通事故发生数以及死亡率较其他年龄组高。老年人视觉以及感知功能的损害也增加了发生交通事故的危险性,同时也产生了其独特的事故形式。与年轻人相比,在相同的受伤程度下,老年人体格上的衰退和疾病因素可能对会产生更坏的结果。虽然老年驾驶者在中国还是少数,与其他年龄组相比,老年人有较高的交通事故伤害率、步行者死亡率和较高的农村老年人受害率。结论国际上对老年人交通安全的经验,比如更好的道路安全设计,高可视安全标识和安全带法律的实施,安全带使用的公共教育,以及老年驾驶证的更新等对中国的交通安全设计者以及法律的制定者可能会有帮助。这些经验对损伤预防研究者在老年人交通事故危险因素的识别方面,以及对工程师在驾驶环境和车辆设计等方面也有着重要的意义。 | HENG Kenneth PAN Shuming LAYDE M Peter ZHU Shankuan | 2006 | 中华急诊医学杂志2006，15，1： | 3 |
| 7 | Use of the FAO CROPWAT model in deficit irrigation studies显示文摘 | Smith M Kivumbi D Heng L K | | Defieit Irrigation Practices0，22，： | 1 |
| 8 | Model for the coal hydrogenation process and its applications显示文摘 | SHIBAOKA M HENG S | 1984 | Fuel1984，63，2： | 1 |
| 9 | An optical bio- sensor for dichlovos using stacked sol - gel films contai- ning acetylcholinesterase and a lipophilic chromoionophore 显示文摘 | Wong F C M Ahmad M Heng L Y | 2006 | Talanta2006，69，4： | 1 |
| 10 | A Hap-tic Needle Manipulation Simulator for Chinese Acupuncture Learning and Training显示文摘 | Heng P A Wong T T Leung K M | 2006 | International Journal of Image and Graphics2006，6，2： | 1 |
| 11 | Response of inertinites from some Australian coals to non-catalytic hydrogenation in tetralin显示文摘 | SHIBAOKA M HENG S OKADA K | 1985 | Fuel1985，64，5： | 1 |
| 12 | Anti-angiogenic targets in the treatment of advanced renal cell carcinoma显示文摘 | Heng D Y Bukowski R M | 2008 | Curr Cancer Drug Targets2008，8，8： | 1 |
| 13 | Particle swarm optimization for resource-constrained project scheduling显示文摘 | ZHANG Hong LI Heng TAM C M | 2006 | International Journal of Project Management2006，24，1： | 1 |
| 14 | Shape matching and modeling using skeletal context显示文摘 | Xie J Heng P A Shah M | | 0，，05： | 1 |
| 15 | Impaired perception of temporal fine structure and musical timbre in cochlear implant users 显示文摘 | Heng J Cantarero G Elhilali M | 2011 | Hear Res2011，280，12： | 1 |
| 16 | Cross sectional echocardiography, 3: analysis of mathematic models for quantifying volume of symmetric and asymmetric left ventricles显示文摘 | WYATT H L MEERBAUM S HENG M K | 1980 | Am Heart J1980，100，： | 1 |
| 17 | Late complication after singie-rod instrumentation显示文摘 | Hengeness M H Esses S I Wellborn C C | 2010 | Spine2010，24，1： | 1 |
| 18 | Alcoholysis of palm oil mid-fraction by lipase from Rhizopus rhizopodiformis显示文摘 | Basri M Heng A C Razak C A N | 1997 | Journal of Ameriean Oil Chemists'' Society1997，74，2： | 1 |
| 19 | Analysis of pesticides in dried hops by liquid chromatography - tandem mass spectrometry显示文摘 | HENGE M J MILLER M | 2008 | J Agric Food Chem2008，56，16： | 1 |
| 20 | Critical success factors of inter-organizational information systems-a case study of cisco and xiao tong in china 显示文摘 | Lu X-H Huang L-H Heng M S H | 2006 | Informarion & Management2006，43，： | 1 |
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