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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Room-temperature plastic inorganic semiconductors for flexible and deformable electronics显示文摘Flexible electronics ushers in a revolution to the electronics industry in the 21st century.Ideally,all components of a flexible electronic device including the functional component shall comply with the deformation to ensure the structural and functional integrity,imposing a pressing need for developing roomtemperature strain-tolerant semiconductors.To this end,there is a long-standing material dilemma:inorganic semiconductors are typically brittle at room temperature except for size-induced flexibility;by contrast,organic semiconductors are intrinsically soft and flexible but the electrical performance is poor.This is why the discovery of bulk plasticity in Ag2S at room temperature and ZnS in darkness is groundbreaking in solving this long-standing material dilemma between the mechanical deformability and the electrical performance.The present review summarizes the background knowledge and latest advances in the emerging field of plastic inorganic semiconductors.At the outset,we argue that the plasticity of inorganic semiconductors is vital to strain tolerance of electronic devices,which has not been adequately emphasized.The mechanisms of plasticity are illustrated from the perspective of chemical bonding and dislocations.Plastic inorganic materials,for example,ionic crystals(insulators),ZnS in darkness,and Ag2S,are discussed in detail in terms of their prominent mechanical properties and potential applications.We conclude the article with several key scientific and technological questions to address in the future study. | Heyang Chen Tian-Ran Wei Kunpeng Zhao Pengfei Qiu Lidong Chen Jian He Xun Shi | 2021 | InfoMat2021，3，1： | 1 |
| 3 | Phylogenetic diversity of Archaea in prawn farm sediment显示文摘 | Peng Shao Yueqin Chen Hui Zhou Lianghu Qu Ying Ma Heyang Li Nianzhi Jiao | 2004 | Marine Biology2004，，1： | 1 |
| 4 | Pharmacodynamics of frigid zone plant Taxus cuspidata S.et Z.against skin melanin deposition,oxidation,inflammation and allergy显示文摘Background:Taxus cuspidata S.et Z.is a precious species of frigid zone plant belonging to the Taxaceae family,which possesses anticancer,anti-inflammatory,hypoglycemic,and antibacterial pharmacological properties.While taxane extracted from Taxus chinensis has been reported to elicit antioxidant activities,whether Taxus cuspidata S.et Z.has skin-protective actions against injuries remained unknown.This study aims to explore the pharmacological effects of three Taxus extracts on skin melanin deposition,oxidation,inflammation,and allergy so as to provide new ideas for the prevention and treatment of various diseases related to skin damage.Methods:Skin melanin deposition was evaluated by measuring melanin content in the skin of guinea pigs by alkali lysis method.Antioxidant capacity was evaluated by measuring superoxide dismutase(SOD)concentration and glutathione(GSH)content in skin tissue homogenates of Kunming mice by SOD assay kit and micro reduced GSH assay kit.The quantitative real-time polymerase chain reaction(qRT-PCR)and western blotting were used to examine the levels of both SOD and recombinant glutathione peroxidase 4(GPX4).Skin inflammation was evaluated by xylene-induced ear swelling test and egg-white-induced paw swelling test in mice.In a mouse model of skin allergy induced by 4-aminopyridine(4-AP),allergy was determined by licking body counts and histamine concentrations in tissue homogenates using enzyme-linked immunosorbent assay(ELISA)kits.Two proinflammatory factors tumor necrosis factor(TNF)-αand interleukin(IL)-1βwere measured by qRT-PCR.Hematoxylin and eosin(HE)staining was conducted to assess the degree of skin lesion.Results:All three Taxus extracts including Taxus chinensis essential oil,Taxus chinensis extract and Taxus chinensis extract compound reduced the melanin deposits in the back skin relative to the non-treated control animals,of which Taxus chinensis essential oil produced the greatest effect.In contrast,the three Taxus extracts elevated SOD and GSH levels in the skin tissues,and the highest increase was seen with Taxus chinensis essential oil.Three Taxus extracts,especially Taxus chinensis essential oil,effectively reduce the rate of ear and paw swelling.All three Taxus extracts reduced the number of body licks,the levels of TNF-αand IL-1β,and the histamine content in tissue homogenates of mice and alleviated skin damage.Consistently,Taxus chinensis essential oil yielded the greatest magnitude of decreases.Conclusion:While all three Taxus extracts possessed the anti-skin melanin deposition,oxidation,and allergy properties,Taxus chinensis essential oil produced the superior effects. | Yang Shi Ling Liu Heyang Sun Chen Chen Jing Feng Yongchao Chen Yuan Lin Philipp Kopylov Qi Wang Yong Zhang | 2023 | Frigid Zone Medicine2023，3，1： | 0 |
| 5 | The Preparation of Porous Activated Slag Granules/TiO_(2)Photocatalyst and Its De-NO_(x)Performance显示文摘The porous structure and honeycombed structure of granulated blast furnace slag formed by alkali activation(AGBFS)can be used as a promising photocatalysts substrate for the photocatalytic removal of atmospheric or water pollutants.In this study,photocatalytic activated slag granules were synthesized by loading TiO_(2)on AGBFS with immersion method.The physicochemical properties and NO_(x)removal performance of activated slag granules/TiO_(2)photocatalysts were studied by X-ray diffraction(XRD),scanning electron microscope(SEM)and photocatalytic performance test.The effects of slag particle sizes and nano-TiO_(2)loading concentrations on photocatalytic efficiencies of NO_(x)removal were also investigated.It was found that the De-NO_(x)performance of activated slag granules/TiO_(2)photocatalyst increased with the increasing of slag particle size in low TiO_(2)loading concentration situation,while increasing the TiO_(2)loading concentration would result in the opposite De-NO_(x)performance as slag size increased.Nevertheless,for the same size activated slag,the photocatalytic efficiency of activated slag granules/TiO_(2)photocatalyst gradually improved with the increase of loading concentration of TiO_(2). | 朱立德 CHEN Jing SI Heyang FANG Yongle WANG Xinyu WANG Zongsen 杨露 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 0 |
| 6 | RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m^(6)A modification显示文摘Increased rates of ribosome biogenesis have been recognized as hallmarks of many cancers and are associated with poor prognosis.Using a CRISPR synergistic activation mediator(SAM)system library targeting 89 ribosomal proteins(RPs)to screen for the most oncogenic functional RPs in human esophageal squamous cell carcinoma(ESCC),we found that high expression of RPS15 correlates with malignant phenotype and poor prognosis of ESCC. | Yahui Zhao Yang Li Rui Zhu Riyue Feng Heyang Cui Xiao Yu Furong Huang Ruixiang Zhang Xiankai Chen Lei Li Yinghui Chen Yuhao Liu Jinhua Wang Guanhua Du Zhihua Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 0 |
| 7 | Remarkable plasticity and softness of polymorphic InSe van der Waals crystals显示文摘Indium selenide(InSe)crystals are reported to show exceptional plasticity,a new property to twodimensional van der Waals(2D vdW)semiconductors.However,the correlation between plasticity and specific prototypes is unclear,and the understanding of detailed plastic deformation mechanisms is inadequate.Here three prototypes of InSe are predicted to be plastically deformable by calculation,and the plasticity of polymorphic crystals is verified by experiment.Moreover,distinct nanoindentation behaviors are seen on the cleavage and cross-section surfaces.The modulus and hardness of InSe are the lowest ones among a large variety of materials.The plastic deformation is further perceived from chemical interactions during the slip process.Particularly for the cross-layer slip,the initial In-Se bonds break while new In-In and Se-Se bonds are newly formed,maintaining a decent interaction strength.The remarkable plasticity and softness alongside the novel physical properties,endow InSe great promise for application in deformable and flexible electronics. | Yupeng Ma Haoran Huang Yifei Liu Heyang Chen Xudong Bai Kunpeng Zhao Min Jin Tian-Ran Wei Xun Shi | 2023 | Journal of Materiomics2023，9，4： | 0 |
| 8 | Author Correction:Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prog nosis in esophageal squamous cell carcinoma显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfsouf5p95o55vv6fkw.ffgz.tsg.suse.edu.cn/10.1038/s41422-020-0333-6,published online 12 May 2020 In the initial published version of this article,there was an error in the Supplementary information,Table S1.Row 463 and row 80 have the same sample id BDESCC-01-838.After checking the original id of these two samples,we found that they were actually two different samples.This error was caused by Excel random numbering when we assigned the external id to each sample.Thus,we re-assigned a new id BDESCC-01-839 to the row 4P3 sample to fix this issue. | Yongping Cui Hongyan Chen Ruibin Xie Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qi min Zhan Yanhong Li Zhihua Liu | 2022 | Cell Research2022，32，4： | 0 |
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