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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | AN IMPROVED HYBRID BOUNDARY NODE METHOD IN TWO-DIMENSIONAL SOLIDS显示文摘The hybrid boundary node method (HBNM) is a promising method for solving boundary value problems with the hybrid displacement variational formulation and shape functions from the moving least squares(MLS) approximation. The main idea is to reduce the dimensionality of the former and keep the meshless advantage of the latter. Following its application in solving potential problems, it is further developed and numerically implemented for 2D solids in this paper. The rigid movement method is employed to solve the hyper-singular integrations. Numerical examples for some 2D solids have been given to show the characteristics. The computation results obtained by the present method are in excellent agreement with the analytical solution.The parameters that influence the performance of this method are studied through numerical examples. | Miao Yu Wang Yuanhan Jiang Heyang | 2005 | Acta Mechanica Solida Sinica2005，18，4： | 5 |
| 3 | An overview of polymeric nanomicelles in clinical trials and on the market显示文摘Polymeric nanomedicine is a promising and rapidly evolving field.Among the different polymeric carriers,polymeric micelle(PM) with nanoscale size exhibit potent physical and biological advantages including excellent solubility and pharmacokinetics,enhanced efficacy and lower toxicity.PM has garnered increasing intere st in research and in the clinic.This review will highlight the clinical outcomes of several PM-based formulations,and further summarized their preparation methods,strengths and challenges. | Xue Zheng Jizhen Xie Xing Zhang Weiting Sun Heyang Zhao Yantuan Li Cheng Wang | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 4 | Temporal enhanced sentence-level attention model for hashtag recommendation显示文摘 | Jun Ma Chong Feng Ge Shi Xuewen Shi Heyang Huang | 2018 | CAAI Transactions on Intelligence Technology2018，3，2： | 2 |
| 5 | Study of the synergistic effect of a triazine-dithiocarbamate derivative with TCP in vegetable oil显示文摘 | He Zhongyi Song Yuping Shao Heyang | 2005 | Journal of Synthesis Lubrication2005，21，4： | 1 |
| 6 | Selective formation of luminescent chiral cocrystal:Molecular self-assembly of 2,20-binaphthol and 2-(3-pyridyl)-1H-benzimidazole显示文摘Luminescent cocrystals have been received much attention in fluorescence imaging and sensor application. In this work, we report that the high-quality chiral luminescent cocrystal can be obtained through a molecular self-assembly process of 2,20-binaphthol and 2-(3-pyridyl)-1 H-benzimidazole. The assembly modes and stacking fashions of as-obtained cocrystal were determined by single crystal X-ray diffractometer. The structure and optical properties of the cocrystals were characterized by fluorescence emission, fluorescence decay, Raman and circular dichroism spectra. The results show that both the pristine co-assembled units(R-BINOL and S-BINOL) give rise to the R conformation within the final cocrystal, suggesting that the formation of cocrystal can be an effective way to achieve R/S-isomeric transformation of 2,20-binaphthol. It is also expected that the co-crystallization approach has much flexibility and potential applications for the design and selective formation of chiral luminescent materials. | Yanluo Lu Yanqun Tang Heyang Lin Xiaoyu Fang Bo Lu Dan Li Dongpeng Yan | 2018 | Chinese Chemical Letters2018，29，10： | 1 |
| 7 | Study of the tribological behaviors of S, P-containing triazine derivatives as additives in rapeseed oil显示文摘 | Zeng Xiongqiong Shao Heyang He Zhongyi | 2004 | Wear2004，257，： | 1 |
| 8 | A study of the synergistic effect of a triazine-dithiocarbamate derivative with TCP in vegetable oil显示文摘 | He Zhongyi Song Yuping Shao Heyang | 2005 | Journal of synthetic Lubrication2005，21，4： | 1 |
| 9 | Room-temperature plastic inorganic semiconductors for flexible and deformable electronics显示文摘Flexible electronics ushers in a revolution to the electronics industry in the 21st century.Ideally,all components of a flexible electronic device including the functional component shall comply with the deformation to ensure the structural and functional integrity,imposing a pressing need for developing roomtemperature strain-tolerant semiconductors.To this end,there is a long-standing material dilemma:inorganic semiconductors are typically brittle at room temperature except for size-induced flexibility;by contrast,organic semiconductors are intrinsically soft and flexible but the electrical performance is poor.This is why the discovery of bulk plasticity in Ag2S at room temperature and ZnS in darkness is groundbreaking in solving this long-standing material dilemma between the mechanical deformability and the electrical performance.The present review summarizes the background knowledge and latest advances in the emerging field of plastic inorganic semiconductors.At the outset,we argue that the plasticity of inorganic semiconductors is vital to strain tolerance of electronic devices,which has not been adequately emphasized.The mechanisms of plasticity are illustrated from the perspective of chemical bonding and dislocations.Plastic inorganic materials,for example,ionic crystals(insulators),ZnS in darkness,and Ag2S,are discussed in detail in terms of their prominent mechanical properties and potential applications.We conclude the article with several key scientific and technological questions to address in the future study. | Heyang Chen Tian-Ran Wei Kunpeng Zhao Pengfei Qiu Lidong Chen Jian He Xun Shi | 2021 | InfoMat2021，3，1： | 1 |
| 10 | Dynamic Analysis on the Rotating Band's Engraving Process显示文摘 | Heyang SUN Jisheng M A Jiajun YAO | 2010 | Advanced Materials Research2010，，139： | 1 |
| 11 | Experimental studies of explosion energy output with different igniter mass显示文摘For study the energy output law of cylindrical charge with shell induced by different input energies,four different black powder masses were selected to ignite the main charge.Fragmentation degree of the shell was qualitatively analyzed by the area of holes on the witness plate and the recovered fragments mass.Through theoretical analysis,established the functional relationship between the average mass of fragments and the relative energy output of warhead,obtained how the relative energy output of charge changed with different initial energy input.The results showed that the change of input energy could lead to obvious variation in fragment characteristics,and could also control the output of charge.When the igniter mass increases from 1.55 g to 5.00 g,the relative energy output of the charge increases by 26.28%.Excessive initial input energy will destroy the shell confine in advance,resulting in a decrease in the relative energy output of charge. | Heyang Xu Weibing Li Wenbin Li Yajun Wang | 2019 | Defence Technology(防务技术)2019，15，5： | 1 |
| 12 | Study of the tribological behaviors of S, P-containing triazine derivatives as additives in rapeseed oil显示文摘 | Zhongyi He Jinliang Lu Xiangqiong Zeng Heyang Shao Tianhui Ren Weimin Liu | 2004 | Wear2004，，3： | 1 |
| 13 | Tribological study of trioctylthiotriazine derivative as lubricating oil additive显示文摘 | Zeng Xiangqiong Shao Heyang Rao Wenqia | 2005 | Wear2005，，： | 1 |
| 14 | Downregulation of HDPR1 is associated with poor prognosis and affects expression levels of p120‐catenin and β‐catenin in nonsmall cell lung cancer显示文摘 | Zhi‐QiangYang YueZhao YangLiu Jun‐YiZhang ShengZhang Gui‐YangJiang Peng‐XinZhang Lian‐HeYang DiLiu Qing‐ChangLi En‐HuaWang | 2010 | Mol Carcinog2010，，5： | 1 |
| 15 | Volume fraction measurement of oil-water two-phase flow using a coaxial conductivity sensor显示文摘The accurate measurement of volume fraction of oil-water two-phase flow on line is important in the oil field.This paper presents a new coaxial conductivity sensor for measuring the volume fraction of oil-water two-phase flow.This structure may get the more uniform sensitivity field and the vertical installation may get the more axial symmetry of the flow field,which improve the measurement accuracy.In order to minimize the influence of the edge effect,guard electrodes were designed.An anti-edge effect degree Ae was defined to optimize the length of the guard electrode.Different models of effective conductivity of two materials were used in calculating the oil volume fraction of oil-water two-phase flow.The experimental results indicate that Maxwell model is the best model under the condition of oil volume fraction less than 50%and the mean value of the calculation results using Maxwell model and Bruggeman model possesses higher accuracy in the range of oil volume fraction(50%-70%).The experimental results show that the sensor obtains similar measurement performance in both vertical upward and downward flow conditions.The accuracy of the sensor system is 2%when the oil volume fraction less than 50%,and the accuracy is about 5%when the oil volume fraction between 50%and 70%. | WANG Chao YU Heyang WU Dongyue | 2014 | Instrumentation2014，1，1： | 1 |
| 16 | Study of the synergistic effect of a triazine dithiocarbamate derivative with TCP in vegetable oil显示文摘 | He Zhongyi Song Yuping Shao Heyang | 2005 | J Synthetic Lubrication2005，21，： | 1 |
| 17 | Variations of the glass-transition temperature in the imidization of poly(styrene-co-maleic anhydride)显示文摘 | Liu Heyang Cao Kun Yao Zhen | 2007 | Journal of Applied Polymer Science2007，104，4： | 1 |
| 18 | Tribological Study of Trioctylthiotriozine Derivative as Lubricating Oil Additive显示文摘 | Zeng Xiangqiong Shao Heyang Rao Weiqi | 2005 | Wear2005，258，56： | 1 |
| 19 | Phylogenetic diversity of Archaea in prawn farm sediment显示文摘 | Peng Shao Yueqin Chen Hui Zhou Lianghu Qu Ying Ma Heyang Li Nianzhi Jiao | 2004 | Marine Biology2004，，1： | 1 |
| 20 | Virtual strain loading method for low temperature cohesive failure of asphalt binder显示文摘Cohesive failure is one of the primary reasons for low-temperature cracking in asphalt pavements.Understanding the micro-level mechanism is crucial for comprehending cohesive failure behavior.However,previous literature has not fully reported on this aspect.Moreover,there has been insufficient attention given to the correlation between macroscopic and microscopic failures.To address these issues,this study employed molecular dynamics simulation to investigate the low-temperature tensile behavior of asphalt binder.By applying virtual strain,the separation work during asphalt binder tensile failure was calculated.Additionally,a correlation between macroscopic and microscopic tensile behaviors was established.Specifically,a quadrilateral asphalt binder model was generated based on SARA fractions.By applying various combinations of virtual strain loading,the separation work at tensile failure was determined.Furthermore,the impact of strain loading combinations on separation work was analyzed.Normalization was employed to establish the correlation between macroscopic and microscopic tensile behaviors.The results indicated that thermodynamic and classical mechanical indicators validated the reliability of the tetragonal asphalt binder model.The strain loading combination consists of strain rate and loading number.All strain loading combinations exhibited the similar tensile failure characteristic.The critical separation strain was hardly influenced by strain loading combination.However,increasing strain rate significantly enhanced both the maximum traction stress and separation work of the asphalt binder.An increment in the loading number led to a decrease in separation work.The virtual strain combination of 0.5%-80 provided a more accurate representation of the actual asphalt's tensile behavior trend. | Heyang Ding Hainian Wang Ziye Ma Zhen Leng Ponan Feng Tangjie Wang Xin Qu | 2023 | Journal of Road Engineering2023，3，3： | 0 |
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