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| 1 | Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy显示文摘Treatment strategies,whether as follow-up or'total incisional biopsy'for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic treatment.Based on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive tumors.Therefore,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during follow-up.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade neoplasms.Future studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness. | Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 18 |
| 2 | A rare case of hyaline-type Castleman disease in the liver显示文摘Castleman disease often develops in the neck, mediastinum and pulmonary hilum. Its onset in the peritoneal cavity is very rare. The patient, a woman in her 70s, was referred to our department for a detailed examination of an abdominal mass. On abdominal ultrasonography, computed tomography scan, magnetic resonance imaging and positron emission tomography, a mass approximately 15 mm in diameter was noted in the hepatic S6. We attempted radical treatment and conducted a laparoscope-assisted right lobectomy. On the basis of histopathological findings, the patient was diagnosed as having hyaline type Castleman disease in the liver, a very rare condition. | Hisaaki Miyoshi Shima Mimura Takako Nomura Joji Tani Asahiro Morishita Hideki Kobara Hirohito Mori Hirohito Yoneyama Akihiro Deguchi Takashi Himoto Naoki Yamamoto Keiichi Okano Yasuyuki Suzuki Tsutomu Masaki | 2013 | World Journal of Hepatology2013，5，7： | 14 |
| 3 | Risk factors and prevention of biliary anastomotic complications in adult living donor liver transplantation显示文摘AIM: To evaluate risk factors of biliary anastomotic complications (BACs) and outcomes according to type of biliary reconstruction. METHODS: A total of 33 consecutive adult living donor liver transplantation (LDLT) were reviewed, 17 of which had undergone Duct-to-Duct anastomosis (D-D). The remaining 16 patients received Roux-en-Y anastomosis (R-Y). The perioperative factors, such as the type of graft and the number of graft bile ducts, were analyzed retrospectively. RESULTS: The overall incidence of BACs was 39.4%. The incidence of BACs was significantly higher in the patients with than without neoadjuvant chemotherapy (71.4% vs 10%, P = 0.050). There was no signifi cant difference in the incidence of biliary leakage in patients with D-D vs those with R-Y. The incidence of biliary strictures following the healing of biliary leakage was significantly higher in D-D (60%) than in R-Y (0%) (P = 0.026). However, the incidence of BACs related bacteremia was signifi cantly higher in R-Y than in D-D (71.4% vs 0%, P = 0.008). In D-D, use of T-tube stent remarkably reduced the incidence of BACs, compared with straight tube stent (0% vs 50%, P = 0.049). CONCLUSION: Our experience showed an increase of BACs related bacteremia in the patients with R-Y. Therefore, D-D might be a preferred biliary reconstruction. However, the surgical refi nement of D-D should be required because of the high incidence of biliary strictures. Use of the T-tube stent might lead to a signifi cant reduction of BACs in D-D. | Satoshi Yamamoto Yoshinobu Sato Hiroshi Oya Hideki Nakatsuka Takashi Kobayashi Yoshiaki Hara Takaoki Watanabe Isao Kurosaki Katsuyoshi Hatakeyama | 2007 | World Journal of Gastroenterology2007，13，31： | 6 |
| 4 | A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone显示文摘Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism. | Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura | 2020 | Bone Research2020，8，4： | 6 |
| 5 | Application of Rainbow Schlieren Deflectometry for Axisymmetric Supersonic Jets (Comparison of Experiments with Numerical Analysis)显示文摘This paper analyzes the correctly-expanded supersonic jet from a convergent-divergent axisymmetric nozzle by using numerical simulation of turbulent flow.And the calculated density distributions in this flow are compared with the present experimental data using rainbow schlieren deflectometry.The value of the density from the experimental data agrees well with the results calculated by this simulation.Therefore,the present method of the measurement using rainbow schlieren deflectometry is useful for the measurement of the density of the correctly-expanded supersonic jet. | Hideki Yamamoto Masayuki Irie Yoshiaki Miyazato Kazuyasu Matsuo | 2010 | Journal of Thermal Science2010，19，3： | 5 |
| 6 | Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development显示文摘AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients. | Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto | 2015 | World Journal of Hepatology2015，7，19： | 3 |
| 7 | Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma显示文摘 | Hideaki Kinugasa Kazuhiro Nouso Yasuto Takeuchi Tetsuya Yasunaka Hideki Onishi Shin-ichiro Nakamura Hidenori Shiraha Kenji Kuwaki Hiroaki Hagihara Fusao Ikeda Yasuhiro Miyake Akinobu Takaki Kazuhide Yamamoto | 2012 | Journal of Gastroenterology2012，，4： | 2 |
| 8 | Do liver metastases from gastric cancer contraindicate aggressive surgical resection?A 14-year single-center experience显示文摘BACKGROUND Advanced gastric cancer(GC)with liver metastasis is often characterized by multiple and bilobular metastases and may also be associated with extrahepatic metastatic lesions.Hence,many physicians consider that radical surgeries are contraindicated for liver metastases from GC(LMGC).According to the 2017 Japanese treatment guideline for GC,a smaller number of liver metastases without unresectable factors may be an indication for liver resection(LR)with curability.The actual 5-year overall survival(OS)rate ranges from 0 to 0.37.AIM To present the institutional indications for LR for LMGC and identify important factors for prognostic outcomes.METHODS In total,30 patients underwent LR for LMGC during a 14-year period,and we evaluated the clinical,surgical,and oncological findings.In all patients,radical surgery with intentional lymphadenectomy was performed for the primary GC.The median follow-up duration after the initial LR was 33.7 mo,and three patients with no recurrence died of causes unrelated to the LMGC.The OS and recurrence-free survival rates after the initial LR were assessed.RESULTS Seventeen patients had metachronous LMGC.The initial LR achieved curability in 29 patients.Perioperative chemotherapy was introduced in 23 patients.The median greatest LMGC dimension was 30 mm,and the median number of LMGC was two.Twenty-two patients had unilobular LMGC.The 5-year OS and recurrence-free survival rates were 0.48 and 0.28,respectively.The median survival duration and recurrence-free duration after the initial LR were 16.8 and 8.6 mo,respectively.Twenty-one patients developed recurrence after the initial LR.Additional surgeries for recurrence were performed in nine patients,and these surgeries clearly prolonged the patients’survival.Pathological serosal invasion was an independent predictor of a poor prognostic outcome after the initial LR.Aggressive LR may be indicated for carefully selected patients with LMGC.CONCLUSION Our results of LR for LMGC seem acceptable.Additional surgeries for recurrence after the initial LR might prolong OS.Pathological serosal invasion is important for poor prognostic outcomes. | Takefumi Yazawa Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto MasahiroYamada Masaki Tani Asahi Sato Yasuyuki Kamada Ryotaro Tani Ryuhei Aoyama Yudai Sasaki MasazumiZaima | 2020 | World Journal of Gastrointestinal Pharmacology and Therapeutics2020，11，5： | 2 |
| 9 | Gene expression analysis in the larval silk gland of the eri silkworm Samia ricini显示文摘昆虫为目的一个范围生产丝绸。在鳞翅目,丝绸为茧生产作为材料被利用并且服务保护幼虫免受不利环境条件或食肉动物的伤害。在 Saturniidae 家庭的种类例如,生产茧的一个特别宽的变化有许多小洞的大、金色的有颜色的茧和那些。尽管在国内蚕(Bombyx mori L.) 的丝绸腺的基因表示广泛地被学习了,更加,更少调查集中了于天蚕蛾家庭的成员。这里,我们从 eri 蚕(Samia ricini ) 的丝绸腺建立了表示顺序标签,天蚕蛾种,并且使用这些分析基因表示。尽管我们识别了丝心蛋白在确定的图书馆的重链基因,为另外的主要丝绸蛋白质的基因例如丝心蛋白光链和 fibrohexamerin,是不在的。这发现与这些后者蛋白质缺乏天蚕蛾丝绸的以前的报告一致。最近,一系列象 fibrohexamerin 一样基因在 Bombyx 染色体被识别。我们使用了这个信息进行这里建立的图书馆的详细分析。这分析识别了这些基因的通常认为的相当或相同事物。我们也发现几编码也是在另外的鳞翅目的丝绸的现在的小丝绸蛋白质分子的基因。基因表示模式在 eri 和国内蚕之间被比较,并且保存并且 nonconserved 表示模式为测试基因被识别。如此的微分基因表示可能是在在这些之间的丝绸性质的差别的主要原因之一种类。我们相信我们的学习能作为为丝绸腺基因表示的一个基本目录具有值,它将让步到丝绸进化的进一步的理解。 | Takuya Tsubota Kimiko Yamamoto Kazuei Mita Hideki Sezutsu | 2016 | Insect Science2016，23，6： | 2 |
| 10 | Relation of risk factors with response to carvedilol in heart failure with preserved ejection fraction – A report from the Japanese Diastolic Heart Failure Study (J-DHF)显示文摘 | Kazuhiro Yamamoto Hideki Origasa Yasushi Suzuki Toshiaki Takahashi Tsuyoshi Shinozaki Tomoyuki Watanabe Yasushi Sakata Chisato Izumi Kayano Taira Masatsugu Hori | 2013 | Journal of Cardiology2013，，： | 1 |
| 11 | microRNA-504 inhibits cancer cell proliferation via targeting CDK6 inhypopharyngeal squamous cell carcinoma显示文摘 | Naoko Kikkawa Takashi Kinoshita Nijiro Nohata Toyoyuki Hanazawa Noriko Yamamoto Ichiro Fukumoto Takeshi Chiyomaru Hideki Enokida Masayuki Nakagawa Yoshitaka Okamoto Naohiko Seki | 2014 | International Journal of Oncology2014，，： | 1 |
| 12 | The influence of hepatitis?B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma显示文摘 | Makoto Chuma Shuhei Hige Toshiya Kamiyama Takashi Meguro Atsushi Nagasaka Kazuaki Nakanishi Yoshiya Yamamoto Mitsuru Nakanishi Toshihisa Kohara Takuya Sho Keiko Yamamoto Hiromasa Horimoto Tomoe Kobayashi Hideki Yokoo Michiaki Matsushita Satoru Todo Masahi | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 13 | Deficiency in Mitochondrial Aldehyde Dehydrogenase Increases the Risk for Late-Onset Alzheimer’s Disease in the Japanese Population显示文摘 | Kouzin Kamino Keiko Nagasaka Masaki Imagawa Hideki Yamamoto Hiroshi Yoneda Akira Ueki Shin Kitamura Kazuhiko Namekata Tetsuro Miki Shigeo Ohta | 2000 | Biochemical and Biophysical Research Communications2000，，1： | 1 |
| 14 | Bacteriological investigation of bile in patients with cholelithiasis显示文摘 | Hideki Ohdan Hisashi Oshiro Yasuji Yamamoto Issei Tanaka Kazuo Inagaki Kazuo Sumimoto Takao Hinoi | 1993 | Surgery Today1993，，5： | 1 |
| 15 | Biliary strictures as a cause of primary intrahepatic bile duct stones显示文摘 | Yoshiro Matsumoto Hideki Fujii Masakazu Yoshioka Takayoshi Sekikawa Toshisue Wada Masayuki Yamamoto Hideo Eguchi Katsuhiko Sugahara | 1986 | World Journal of Surgery1986，，： | 1 |
| 16 | Surgical treatment of gallbladder cancer:An eight-year experience in a single center显示文摘BACKGROUND Gallbladder cancer(GBC)is the most common biliary malignancy and has the worst prognosis,but aggressive surgeries[e.g.,resection of the extrahepatic bile duct(EHBD),major hepatectomy and lymph node(LN)dissection]may improve long-term survival.GBC may be suspected preoperatively,identified intraoperatively,or discovered incidentally on histopathology.AIM To present our data together with a discussion of the therapeutic strategies for GBC.METHODS We retrospectively investigated nineteen GBC patients who underwent surgical treatment.RESULTS Nearly all symptomatic patients had poor outcomes,while suspicious or incidental GBCs at early stages showed excellent outcomes without the need for two-stage surgery.Lymph nodes around the cystic duct were reliable sentinel nodes in suspicious/incidental GBCs.Intentional LN dissection and EHBD resection prevented metastases or recurrence in early-stage GBCs but not in advanced GBCs with metastatic LNs or invasion of the nerve plexus.All patients with positive surgical margins(e.g.,the biliary cut surface)showed poor outcomes.Hepatectomies were performed in sixteen patients,nearly all of which were minor hepatectomies.Metastases were observed in the left-sided liver but not in the caudate lobe.We may need to reconsider the indications for major hepatectomy,minimizing its use except when it is required to accomplish negative bile duct margins.Only a few patients received neoadjuvant or adjuvant chemoradiation.There were significant differences in overall and disease-free survival between patients with stages≤IIB and≥IIIA disease.The median overall survival and disease-free survival were 1.66 and 0.79 years,respectively.CONCLUSION Outcomes for GBC patients remain unacceptable,and improved therapeutic strategies,including neoadjuvant chemotherapy,optimal surgery and adjuvant chemotherapy,should be considered for patients with advanced GBCs. | Yasuyuki Kamada Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto MasahiroYamada Takefumi Yazawa Masaki Tani Asahi Sato Ryotaro Tani Ryuhei Aoyama Yudai Sasaki MasazumiZaima | 2020 | World Journal of Hepatology2020，12，9： | 1 |
| 17 | Prognotic impact of serum follistatin in patients with hepatocellular carcinoma显示文摘 | Takeshi Tomoda Kazuhiro Nouso Koji Miyahara Sayo Kobayashi Hideaki Kinugasa Junki Toyosawa Hiroaki Hagihara Kenji Kuwaki Hideki Onishi Shinichiro Nakamura Fusao Ikeda Yasuhiro Miyake Hidenori Shiraha Akinobu Takaki Kazuhide Yamamoto | 2013 | J Gastroenterol Hepatol2013，，8： | 1 |
| 18 | The influence of hepatitis?B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma显示文摘 | Makoto Chuma Shuhei Hige Toshiya Kamiyama Takashi Meguro Atsushi Nagasaka Kazuaki Nakanishi Yoshiya Yamamoto Mitsuru Nakanishi Toshihisa Kohara Takuya Sho Keiko Yamamoto Hiromasa Horimoto Tomoe Kobayashi Hideki Yokoo Michiaki Matsushita Satoru Todo Masahi | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 19 | Ex pression of Wnt-Sa Is Correlated with Aggressiveness of Gastric Cancer by Stimulating Cell Migration and Invasion 显示文摘 | Manabu Kurayoshi Naohide Oue Hideki Yamamoto | 2006 | Cancer Res2006，66，10： | 1 |
| 20 | Mechanism of zeolite synthesis from coal fly ash by alkali hydrother- real reaction 显示文摘 | Norihiro Murayama Hideki Yamamoto Junji Shibata | 2002 | International Journal of Mineral Processing2002，64，1： | 1 |
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