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| 1 | Twenty-four hour intra-arterial infusion of 5-fluorouracil,cisplatin,and leucovorin is more effective than 6-hour infusion for advanced hepatocellular carcinoma显示文摘AIM: To evaluate the time dependence of intra-arterial 5-fluorouracil (5-FU) therapy for advanced hepatocellular carcinoma (aHCC). METHODS: Thirty-seven adult Japanese patients who had aHCC and liver cirrhosis were treated with combined intra-arterial 5-FU, cisplatin (CDDP), and leucovorin (LV). The Japan Integrated Staging score (JIS score) of each patient was 3 or more. The patients were divided into two groups, after which the 15 patients in group S were treated with 6-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 4 h) and the 22 patients in group L were treated with 24-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 22 h). Continuous infusion chemotherapy was performed via the proper hepatic artery every 5 d for 4 wk using an implanted drug reservoir. RESULTS: The percentages of patients with a partial response after 4 wk of chemotherapy were 6.7% in group S and 31.8% in group L. The survival of group L was significantly better than that of group S, with the median survival time being 496 d in group L and 226 d in group S (P < 0.05). CONCLUSION: Continuous 24-h intra-arterial infusion is more effective for aHCC and can markedly prolong survival time as compared to 6-h infusion. | Hidenari Nagai Masahiro Kanayama Katsuya Higami Kouichi Momiyama Akiko Ikoma Naoki Okano Katsuhiko Matsumaru Manabu Watanabe Koji Ishii Yasukiyo Sumino Kazumasa Miki | 2007 | World Journal of Gastroenterology2007，13，2： | 6 |
| 2 | 用于液晶盒偶氮染料光致取向层的合成和性质显示文摘我们研究了可用于光致取向液晶(LCs)偶氮染料的合成和性质,提出了偶氮染料的结构与合成过程。偶氮染料光致取向完全是因为分子吸收振子垂直于UV光偏振方向的再取向。讨论了在偏振光场中,偶氮染料分子旋转扩散现象的定性模型。测量了波长为372nm时,偏振吸收光谱的有序参数S=-0.4(80%的最大绝对值Sm=-0.5)。对一个偶氮染料膜,利用在正常的正入射偏振光之后,紧跟一个斜入射的非偏振光两步曝光,可以获得温度稳定的5.3°预倾角。光致取向基片的方位角锚定能为Aφ≈10-4Jm-2,这与摩擦聚酰亚胺(PI)层的锚定能相同。我们发现,光致取向液晶盒的电压保持率甚至比摩擦PI层取向的还高,因此,偶氮染料完全可以用作有源矩阵液晶显示器的取向层。光致取向偶氮染料层的热稳定性很高,但UV稳定性需通过诸如聚合等来改良。于是,我们设想了一种新的基于聚合偶氮染料层的LCD取向技术。 | 郭海成 Vladimir Chigrinov Elena Prudnikova Vladimir Kozenkov Hidenari Akiyama Tatsuo Kawara Hirokazu Takada Haruyoshi Takatsu | 2003 | 现代显示2003，，4： | 4 |
| 3 | Effect of unilateral dentate nucleus lesions on amygdaloid kindling in rats 显示文摘 | Noriko Tsuru Hidenari Kawasaki | 1992 | Epilepsia1992，33，2： | 1 |
| 4 | MR flu-id viscous coupling and its torque delivery control显示文摘 | KOSUKE N AKIHISA S HIDENARI Y | 2007 | Tribology International2007，40，： | 1 |
| 5 | Quantitation of aeetazolamide in rat plasma, brain tissue and cerebrospinal fluid by high-performance liquid chromatography显示文摘 | NOBUHIRO I KOHJI N HIDENARI H | 1998 | Journal of Pharmaceutical and Biomedical Analysis1998，17，8： | 1 |
| 6 | MR fluid viscous coupling and its torque delivery control 显示文摘 | KOSUKE N AKIHISA S HIDENARI Y | 2007 | Tri- bology International2007，40，： | 1 |
| 7 | Prevalence rates of type 2 diabetes and hypertension are elevated among middle-aged Japanese men with colonic diverticulum显示文摘 | Hidenari Sakuta Takashi Suzuki | 2007 | Environmental Health and Preventive Medicine2007，，2： | 1 |
| 8 | Ion paired chromatography of iron (II,III), nickel (II) and copper (II) as their 4,7-Diphenyl-1,10-phenanthroline chelates显示文摘 | Mudasir Naoki Yoshioka Hidenari Inoue | 1997 | Talanta1997，，7： | 1 |
| 9 | Effect of Sho-Saiko-To on the pharmacokinetics and pharmacodynamics of tolbutamide in rats显示文摘 | Nobuhiro Nishimura Kohji Naora Hidenari Hirano | 1998 | Journal of Pharmacy Pharmacology1998，50，2： | 1 |
| 10 | What is the factor that most influ-ences QOL among rheumatoid arthritis patients? 显示文摘 | Kiyomi S Hidenari F Eizo S | 2001 | Mod Rheuma-tol2001，11，1： | 1 |
| 11 | Separation and characterization of manganese ( Ⅱ / Ⅲ ) chlorophylls 显示文摘 | Saijun Li Hidenari Inoue | 1991 | Anal Sci1991，79，： | 1 |
| 12 | Changes of host immunity in relation to efficacy in liver cirrhosis patients with advanced hepatocellular carcinoma treated by intra-arterial chemotherapy显示文摘 | Kouichi Momiyama Hidenari Nagai Yasukiyo Sumino | 2009 | Cancer Chemotherapy and Pharmacology2009，，2： | 1 |
| 13 | An activated sludge process without excess sludge production 显示文摘 | Yoshio Sakai Tetsuro Fukase Hidenari Yasui | 1997 | Water Science and Technology1997，36，11： | 1 |
| 14 | Resolution of epidural hematoma related to osteoporotic fracture after percutaneous vertebroplasty显示文摘We are the first to report a case that showed spontaneous resolution of epidural hematoma which was related to a steroid-induced osteoporotic compression fracture.The patient had a painful fracture with an intravertebral cleft at L1 accompanying an epidural hematoma posteriorly.Immediate pain relief was achieved after percutaneous vertebroplasty.Complete resolution of hematoma was noted three months after procedure.We theorized that intravertebral stability after treatment might have played a role in this patient. | Hidenari Hirata Akio Hiwatashi Takashi Yoshiura Osamu Togao Koji Yamashita Hironori Kamano Kazufumi Kikuchi Hiroshi Honda | 2013 | World Journal of Radiology2013，5，8： | 1 |
| 15 | Thoracic involvement of type a aortic dissection and intramural hematoma:diagnostic accuracy-comparison of emergency helical CT and surgical findings显示文摘 | Satoru Y Hidenari A Mitsuharu T | 2003 | Radiology2003，228，7： | 1 |
| 16 | Mechanism for Separating Inclusions from Molten Steel Stirred with a Rotating Electro - magnetic Field 显示文摘 | Yuji Miki Hidenari Kitaoka | 1992 | ISU International1992，32，1： | 1 |
| 17 | Effect of unilateral dentate nucleus lesions on amygdaloid kinding in rats显示文摘 | Noriko Tsuru Hidenari Kawasaki | 1992 | Epilepsia1992，33，2： | 1 |
| 18 | Sorafenib Prevents Escape from Host Immunity in Liver Cirrhosis Patients with Advanced Hepatocellular Carcinoma显示文摘 | Hidenari Nagai Takanori Mukozu Daigo Matsui Takenori Kanekawa Masahiro Kanayama Noritaka Wakui Kouichi Momiyama Mie Shinohara Kazunari Iida Koji Ishii Yoshinori Igarashi Yasukiyo Sumino Julie R. Ostberg | 2012 | Clinical and Developmental Immunology2012，，： | 1 |
| 19 | 显示文摘 | Hideaki Nagashima Shin'ya Fujita Hidenari Inoue | 2004 | Crystal Growth & Design2004，，1： | 1 |
| 20 | A Chinese traditional medicine, Sho- Saiko- To (Xiao- Chaihu-Tang), reduces the bioavailability of Tolbutamide after oral administration in rats显示文摘 | Nobuhiro Nishimura Kohji Naora Hidenari Hirano | 1999 | American Journal of Chinese Medicine1999，17，： | 1 |
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