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| 1 | A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone显示文摘Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism. | Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura | 2020 | Bone Research2020，8，4： | 6 |
| 2 | Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease显示文摘AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction score.RESULTS: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD. | Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita | 2016 | World Journal of Gastroenterology2016，22，23： | 2 |
| 3 | Impact on Outcome of Additional Microvascular Anastomosis—Supercharge—on Colon Interposition for Esophageal Replacement: Comparative and Multivariate Analysis显示文摘 | Hiromasa Fujita Hideaki Yamana Susumu Sueyoshi Ichiro Shima Teruhiko Fujii Kazuo Shirouzu Yojiro Inoue Kensuke Kiyokawa Hiroko Yanaga Tanabe Yosiaki Tai Hiroki Inutsuka | 1997 | World Journal of Surgery1997，，9： | 1 |
| 4 | Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C显示文摘 | Mika Miura Shinya Maekawa Makoto Kadokura Ryota Sueki Kazuki Komase Hiroko Shindo Takako Ohmori Asuka Kanayama Kuniaki Shindo Fumitake Amemiya Yasuhiro Nakayama Takatoshi Kitamura Tomoyoshi Uetake Taisuke Inoue Minoru Sakamoto Shunichi Okada Nobuyuki Enom | 2012 | Hepatology International2012，，1： | 1 |
| 5 | Quality of Image of Grating Target Placed in Model Eye and Observed Through Toric Intraocular Lenses显示文摘 | Makoto Inoue Toru Noda Kazuhiko Ohnuma Hiroko Bissen-Miyajima Akito Hirakata | 2012 | American Journal of Ophthalmology2012，，： | 1 |
| 6 | A cross - cultural study on ex- pressed emotion in carers of people with dementia and schizo- phrenia:Japan and England显示文摘 | Hiroko Nomura Shimpei Inoue | 2005 | Soc Psychiatry Psychiatr Epide- miol2005，40，： | 1 |
| 7 | Cap polyposis cured by Helicobacter pylori eradication therapy显示文摘 | Hideto Oiya Kiyotaka Okawa Tetsuya Aoki Hiroko Nebiki Takeshi Inoue | 2002 | Journal of Gastroenterology2002，，6： | 1 |
| 8 | Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C显示文摘 | Mika Miura Shinya Maekawa Makoto Kadokura Ryota Sueki Kazuki Komase Hiroko Shindo Takako Ohmori Asuka Kanayama Kuniaki Shindo Fumitake Amemiya Yasuhiro Nakayama Takatoshi Kitamura Tomoyoshi Uetake Taisuke Inoue Minoru Sakamoto Shunichi Okada Nobuyuki Enom | 2012 | Hepatology International2012，，1： | 1 |
| 9 | Gene therapy for pancreatic cancer based on genetic characterization of the disease显示文摘 | Makoto Sunamura Toshimasa Yatsuoka Fuyuhiko Motoi Dan G. Duda Mitsuhiro Kimura Tadayoshi Abe Tadaaki Yokoyama Hiroko Inoue Masaru Oonuma Kazunori Takeda Seiki Matsuno | 2002 | Journal of Hepato - Biliary - Pancreatic Surgery2002，，1： | 1 |
| 10 | Clinical impact of coronary artery spasm in patients with no significant coronary stenosis in acute coronary syndromes显示文摘 | Shinji Satoh Soichiro Omura Hiroko Inoue Takahiro Mori Katsuhiko Takenaka Kotaro Numaguchi Etsuo Mori Akemi Aso Toshihiro Nakamura Koji Hiyamuta | 2013 | Journal of Cardiology2013，，6： | 1 |
| 11 | Treatment of salivary gland hypofunction by transplantation with dental pulp cells显示文摘 | Yuka Yamamura Hiroyuki Yamada Takashi Sakurai Fumio Ide Hiroko Inoue Takashi Muramatsu Kenji Mishima Yoshiki Hamada Ichiro Saito | 2013 | Archives of Oral Biology2013，，8： | 1 |
| 12 | The periodontal pathogen Porphyromonas gingivalis induces the Epstein–Barr virus lytic switch transactivator ZEBRA by histone modification显示文摘 | Kenichi Imai Harumi Inoue Muneaki Tamura Marni E. Cueno Hiroko Inoue Osamu Takeichi Kaoru Kusama Ichiro Saito Kuniyasu Ochiai | 2011 | Biochimie2011，，3： | 1 |
| 13 | A New Prognostic Staging System for Hepatocellular Carcinoma: Value of the Biomarker Combined Japan Integrated Staging Score显示文摘 | Kitai Satoshi Kudo Masatoshi Minami Yasunori Ueshima Kazuomi Chung Hobyung Hagiwara Satoru Inoue Tatsuo Ishikawa Emi Takahashi Shunsuke Asakuma Yutaka Haji Seiji Osaki Yukio Oka Hiroko Seki Toshihito Kasugai Hiroshi Sasaki Yo Matsunaga Ta | 2008 | Intervirology2008，，： | 1 |
| 14 | Selective determination of total normal microcystin by colorimetry,LC/UV detection and/or LC/MS显示文摘 | Kunimitsu Kaya Tomoharu Sano Hiroko Inoue | 2001 | Analytica Chimica Acta2001，450，1： | 1 |
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