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| 1 | Advances in understanding and treating liver diseases during pregnancy:A review显示文摘Liver disease in pregnancy is rare but pregnancyrelated liver diseases may cause threat to fetal and maternal survival.It includes pre-eclampsia;eclampsia;haemolysis,elevated liver enzymes,and low platelets syndrome;acute fatty liver of pregnancy;hyperemesis gravidarum;and intrahepatic cholestasis of pregnancy.Recent basic researches have shown the various etiologies involved in this disease entity.With these advances,rapid diagnosis is essential for severe cases since the decision of immediate delivery is important for maternal and fetal survival.The other therapeutic options have also been shown in recent reports based on the clinical trials and cooperation and information sharing between hepatologist and gynecologist is important for timely therapeutic intervention.Therefore,correct understandings of diseases and differential diagnosis from the pre-existing and co-incidental liver diseases during the pregnancy will help to achieve better prognosis.Therefore,here we review and summarized recent advances in understanding the etiologies,clinical courses and management of liver disease in pregnancy.This information will contribute to physicians for diagnosis of disease and optimum management of patients. | Kenya Kamimura Hiroyuki Abe Hirokazu Kawai Hiroteru Kamimura Yuji Kobayashi Minoru Nomoto Yutaka Aoyagi Shuji Terai | 2015 | World Journal of Gastroenterology2015，21，17： | 15 |
| 2 | Primary intestinal follicular lymphoma:How to identify follicular lymphoma by routine endoscopy显示文摘A 69-year-old Japanese female was diagnosed with primary intestinal follicular lymphoma. Esophagogas-troduodenoscopy with high-definition imaging revealed not only the typical feature of whitish polyps of up to 2 mm in diameter in the duodenal second and third portions, but also more detailed morphology, such as enlarged whitish villi and tiny whitish depositions. These findings appeared to reflect the pathological structures; infiltration of lymphoma cells into the villi were probably seen as enlargement of the villi, and the formation of lymphoid follicles were shown as opaque white spots or tiny white depositions. Thus, the above features might contribute to the distinct diagnosis of intestinal follicular lymphoma. This case indicates that routine esophagogastroduodenoscopy can visualize microsurface structures, which can be pathognomonic and help to diagnose intestinal follicular lymphoma, even without magnifying endoscopy. | Masaya Iwamuro Yoshinari Kawai Katsuyoshi Takata Seiji Kawano Tadashi Yoshino Hiroyuki Okada Kazuhide Yamamoto | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，1： | 4 |
| 3 | Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene显示文摘AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue(MALT) lymphoma with extra copies of MALT1.METHODS This is a multi-centered,retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1(Group A,n = 88),patients with t(11;18) translocation(Group B,n = 27),and patients with extra copies of MALT1(Group C,n = 31). The clinical background,treatment,and outcomes of each group were investigated.RESULTS Groups A and C showed slight female predominance,whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A(69.3%),22 in Group B(81.5%),and 21 in Group C(67.7%). Helicobacter pylori(H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B,14 patients underwent radiotherapy alone,which resulted in lymphoma disappearance. Although the difference was not statistically significant,event-free survival in Group C tended to be inferior to that in Group A(P = 0.10).CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication,similar to patients without t(11;18) translocation or extra copies of MALT1. | Masaya Iwamuro Ryuta Takenaka Masahiro Nakagawa Yuki Moritou Shunsuke Saito Shinichiro Hori Tomoki Inaba Yoshinari Kawai Tatsuya Toyokawa Takehiro Tanaka Tadashi Yoshino Hiroyuki Okada | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 4 | The Evaluation of Duct-to-mucosal Pancreaticojejunostomy in pancreaticoduodenectomy显示文摘 | Masaji Tani M.D. Hironobu Onishi M.D. Hiroyuki Kinoshita M.D. Manabu Kawai M.D. Masaki Ueno M.D. Takashi Hama M.D. Kazuhisa Uchiyama M.D. Hiroki Yamaue M.D | 2005 | World Journal of Surgery2005，，1： | 1 |
| 5 | Adenosquamous carcinoma of the gallbladder with tumor thrombus in left portal trunk显示文摘 | Shinsuke Iyomasa Yasutaka Matsuzaki Ken Hiei Masami Kawai Hiroyuki Matsunaga Yoshimasa Yamaguchi | 1997 | Journal of Hepato - Biliary - Pancreatic Surgery1997，，3： | 1 |
| 6 | Physicochemical and immunological characterization of hepatitis B virus envelope particles exclusively consisting of the entire L (pre-S1+pre-S2+S) protein显示文摘 | Tadanori Yamada Hidehiko Iwabuki Takashi Kanno Hiroyuki Tanaka Tomoji Kawai Hideki Fukuda Akihiko Kondo Masaharu Seno Katsuyuki Tanizawa Shun’ichi Kuroda | 2001 | Vaccine . 2001 (23-2)2001，，23： | 1 |
| 7 | Serum antibody againstHelicobacter pylori assayed by a new capture ELISA显示文摘 | Hiroya Nakata Hidekazu Itoh Yukihiro Yokoya Jun Kawai Shingo Nishioka Kazuaki Miyamoto Noritoshi Kitamoto Hiroyuki Miyamoto Tomoyuki Tanaka | 1995 | Journal of Gastroenterology1995，，3： | 1 |
| 8 | New Pancreas-preserving Total Duodenectomy Technique显示文摘 | Masayuki Imamura M.D. Izumi Komoto M.D. Ryuichiro Doi M.D. Hisashi Onodera M.D. Hiroyuki Kobayashi M.D. Yasuhiro Kawai M.D | 2005 | World Journal of Surgery2005，，2： | 1 |
| 9 | Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats显示文摘 | Akari Ishisaka Satomi Ichikawa Hiroyuki Sakakibara Mariusz K. Piskula Toshiyuki Nakamura Yoji Kato Mikiko Ito Ken-ichi Miyamoto Akira Tsuji Yoshichika Kawai Junji Terao | 2011 | Free Radical Biology and Medicine2011，，7： | 1 |
| 10 | Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle显示文摘 | Atsufumi Kawabata Ryotaro Kuroda Naoko Kuroki Hiroyuki Nishikawa Kenzo Kawai Hiromasa Araki | 2000 | Life Sciences2000，，20： | 1 |
| 11 | Hippocampal transaction for treatment of left temporal epilepsy with preservation of verbal memory显示文摘 | Hiroyuki Shimizu Kensuke Kawai Shigeki Sunaga | 2006 | Journal of Clinical Neuroscience2006，13，： | 1 |
| 12 | NIED seismic moment tensor catalogue for regional earthquakes around Japan: quality test and application显示文摘 | Atsuki Kubo Eiichi Fukuyama Hiroyuki Kawai | 2002 | Tectonophysics2002，356，： | 1 |
| 13 | Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement显示文摘AIM:To investigate the capacity for 18F-fluorodeoxyglucose(18F-FDG) positron emission tomography(PET) to evaluate patients with gastrointestinal lesions of follicular lymphoma.METHODS:This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten different institutions between November 1996 and October 2011.Data for endoscopic,radiological,and biological examinations performed were retrospectively reviewed from clinical records.A semi-quantitative analysis of 18F-FDG uptake was performed for each involved area by calculating the maximum standardized uptake value(SUVmax).Based on the positivity of 18F-FDG uptake in the gastrointestinal lesions analyzed,patients were subdivided into two groups.To identify potential predictive factors for 18F-FDG positivity,these two groups were compared with respect to gender,age at diagnosis of lymphoma,histopathological grade,pattern of follicular dendritic cells,mitotic rate,clinical stage,soluble interleukin-2 receptor levels detected by 18F-FDG-PET,lactate dehydrogenase(LDH) levels,hemoglobin levels,bone marrow involvement,detectability of gastrointestinal lesions by computed tomography(CT) scanning,and follicular lymphoma international prognostic index(FLIPI) risk.RESULTS:Involvement of follicular lymphoma in the stomach,duodenum,jejunum,ileum,cecum,colon,and rectum was identified in 1,34,6,3,2,3,and 6 patients,respectively.No patient had esophageal involvement.In total,19/41(46.3%) patients exhibited true-positive 18F-FDG uptake in the lesions present in their gastrointestinal tract.In contrast,false-negative 18F-FDG uptake was detected in 24 patients(58.5%),while false-positive 18F-FDG uptake was detected in 5 patients(12.2%).In the former case,2/19 patients had both 18F-FDG-positive lesions and 18F-FDGnegative lesions in the gastrointestinal tract.In patients with 18F-FDG avidity,the SUVmax value of the involved gastrointestinal tract ranged from 2.6 to 17.4(median:4.7).For the 18F-FDG-negative(n = 22) and-positive(n = 19) groups,there were no differences in the male to female ratios(10/12 vs 4/15,P = 0.186),patient age(63.6 ± 2.4 years vs 60.1 ± 2.6 years,P = 0.323),presence of histopathological grade 1 vs 2(20/2 and 17/2,P = 1.000),follicular dendritic cell pattern(duodenal/nodal:13/5 vs 10/3,P = 1.000),mitotic rate(low/partly high,14/1 vs 10/3,P = 0.311),clinical stage according to the Ann Arbor system(stages ⅠE and ⅡE/other,15/7 vs 15/4,P = 0.499),clinical stage according to the Lugano system(stages Ⅰ and Ⅱ-1/other,14/8 vs 14/5,P = 0.489),soluble interleukin-2 receptor levels(495 ± 78 vs 402 ± 83,P = 0.884),LDH levels(188 ± 7 vs 183 ± 8,P = 0.749),hemoglobin levels(13.5 ± 0.3 vs 12.8 ± 0.4,P = 0.197),bone marrow involvement(positive/negative,1/8 vs 1/10,P = 1.000),detectability by CT scanning(positive/negative,1/16 vs 4/13,P = 0.335),and FLIPI risk(low risk/other,16/6 vs 13/6,P = 0.763),respectively in each case.CONCLUSION:These findings indicate that it is not feasible to predict 18F-FDG-avidity.Therefore,18FFDG-PET scans represent a complementary modality for the detection of gastrointestinal involvements in follicular lymphoma patients,and surveillance of the entire gastrointestinal tract by endoscopic examinations is required. | Masaya Iwamuro Hiroyuki Okada Katsuyoshi Takata Katsuji Shinagawa Shigeatsu Fujiki Junji Shiode Atsushi Imagawa Masashi Araki Toshiaki Morito Mamoru Nishimura Motowo Mizuno Tomoki Inaba Seiyu Suzuki Yoshinari Kawai Tadashi Yoshino Yoshiro Kawahara Akinobu Takaki Kazuhide Yamamoto | 2012 | World Journal of Gastroenterology2012，18，44： | 1 |
| 14 | Physicochemical and immunological characterization of hepatitis B virus envelope particles exclusively consisting of the entire L (pre-S1+pre-S2+S) protein显示文摘 | Tadanori Yamada Hidehiko Iwabuki Takashi Kanno Hiroyuki Tanaka Tomoji Kawai Hideki Fukuda Akihiko Kondo Masaharu Seno Katsuyuki Tanizawa Shun’ichi Kuroda | 2001 | 2001 (23-2)2001，，23： | 1 |
| 15 | Hipp- ocampal transaction for treatment of left temporal epilepsy with preservation of verbal memory显示文摘 | Hiroyuki Shimizu Kensuke Kawai Shigeki Sunaga | 2006 | J Clini Neurosci2006，13，： | 1 |
| 16 | Kinetic analyses of trans -1-amino-3-[ 18 F]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2显示文摘 | Hiroyuki Okudaira Takeo Nakanishi Shuntaro Oka Masato Kobayashi Hiroshi Tamagami David M. Schuster Mark M. Goodman Yoshifumi Shirakami Ikumi Tamai Keiichi Kawai | 2013 | Nuclear Medicine and Biology2013，，5： | 1 |
| 17 | Utility of Right Ventricular Free Wall Speckle-Tracking Strain for Evaluation of Right Ventricular Performance in Patients with Pulmonary Hypertension显示文摘 | Yuko Fukuda Hidekazu Tanaka Daisuke Sugiyama Keiko Ryo Tetsuari Onishi Hiroyuki Fukuya Munenobu Nogami Yoshiharu Ohno Noriaki Emoto Hiroya Kawai Ken-ichi Hirata | 2011 | Journal of the American Society of Echocardiography2011，，10： | 1 |
| 18 | B acillus C almette– G uerin ( BCG ) immunotherapy for bladder cancer: Current understanding and perspectives on engineered BCG vaccine显示文摘 | Koji Kawai Jun Miyazaki Akira Joraku Hiroyuki Nishiyama Hideyuki Akaza | 2013 | Cancer Sci2013，，1： | 1 |
| 19 | Identification of steel by X- ray fluorescence analysis with a pyroeleetric X-ray generator显示文摘 | Hiroyuki Ida Jun Kawai | 2004 | Analytical and Bioanalytical Chemis-try2004，379，： | 1 |
| 20 | NIED seismic moment tensor catalogue for regional earthquakes around Japan: quality test and application显示文摘 | Atsuki Kubo Eiichi Fukuyama Hiroyuki Kawai | 2002 | Tectonophysics2002，356，： | 1 |
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