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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 3 | 与久坐者相比,职业运动员的肠道菌群在代谢组分,尤其是功能代谢水平上有所不同显示文摘目的有证据表明肠道菌群以及影响其结构和活性的因素在人类代谢、免疫和发育过程中发挥作用。我们曾报道,与久坐者相比,诸如职业运动员,配有相应饮食的极度体育活动者肠道菌群种属和代谢组分发生了改变。这次我们重点研究这些因素对菌群功能/代谢活动的影响,以进一步揭示运动者和久坐者间的差别。方法对专业国际橄榄球联盟球员(样本数为40例)和对照(样本数为46例)的肠道菌群进行代谢表型和功能宏基因组分析,并将结果与生活方式指标(比如饮食习惯)和临床评估指标(比如血清肌酸激酶)进行关联。结果与对照相比,运动员组中与肌肉更新和整体健康相关的信号通路(比如:氨基酸、抗生素生物合成和碳水化合物代谢)和肠道菌群代谢产物(比如:短链脂肪酸乙酸酯、丙酸酯和丁酸酯)有所增加。结论运动和久坐相比,其肠道菌群在宏基因组和代谢组学上比组织水平显示出更大差异,拓展了饮食.运动.肠道微生态模式新视野。 | Barton W Penney NC Cronin O Garcia-Perez I Molloy MG Holmes E Shanahan F Cotter PD O'Sullivan O 毛玲娜 宋震亚 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 4 | Aspects of modeling of high voltage ferroelectric nonlinear ceramic capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1992 | IEEE Trans Compon Hydirds Manuf Technol1992，15，2： | 2 |
| 5 | Relaxation effects in high-voltage barium titanate non-linear ceramic disk capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1993 | IEEE Trans Compon Hydirds Manuf Technol1993，16，4： | 2 |
| 6 | Use of safety-modified reroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer:a pilot trial显示文摘 | Deisseroth AB Holmes F Hortobagyi G | 1996 | Hum Gene Ther1996，7，3： | 1 |
| 7 | Photon-number-state preparation in nondegenerate parametric amplification显示文摘 | Holmes C A Milburn G J Walls D F | 1989 | Phys Rev A1989，39，5： | 1 |
| 8 | The ascent of mouse: advances inmodelling human depression and anxiety显示文摘 | CRYAN J F HOLMES A | 2005 | Nat Rev DrugDiscov2005，4，9： | 1 |
| 9 | Direct histological Validation of diffusion tensor in formaldehyde-fixed myocardium显示文摘 | Holmes A A Scollan D F Winslow R L | 2000 | Magn Reson Med2000，44，： | 1 |
| 10 | Crystal structure of bovine coronavirus spike pro- tein lectin domain 显示文摘 | Peng G Xu L Lin YL Chen L Pasquarella JR Holmes KV Li F | 2012 | J Biol Chem2012，287，41： | 1 |
| 11 | Genome edi- ting with engineered Zinc finger nucleases 显示文摘 | Urnov F D Rebar E J Holmes M C | 2010 | Nature Reviews Genetics2010，11，9： | 1 |
| 12 | Enhanced expression of inflammatory cytokines and activation markers in T-cells from patients with chronic heart failure显示文摘 | Yndestad A Holm AM Muller F | 2003 | Cardiovascular Res2003，60，1： | 1 |
| 13 | A magnetoelastic strange attractor显示文摘 | MOON F C HOLMES P J | 1979 | J Sound Vib1979，65，2： | 1 |
| 14 | Fibrinogen and other coronary risk factors显示文摘 | VONEYBEN F E MOURITSEN E A HOLM J | 2005 | Metabolism2005，54，2： | 1 |
| 15 | Synthesisand applications of one-dimensional semiconductors显示文摘 | BARTH S RAMIREZ F H HOLMES J D | 2010 | Progressin Materials Science2010，55，6： | 1 |
| 16 | Rapid and noninvasive metabonomic characterization of in- flammatory bowel disease显示文摘 | Marchesi JR Holmes E Khan F | 2007 | J Proteome Res2007，6，2： | 1 |
| 17 | Recombi- nation is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratorysyn- drome viruses in China显示文摘 | Shi M Holmes E C Brar M S Leung F C | 2013 | J Virol2013，87，10： | 1 |
| 18 | Intrathoracic blood volume as an end point in resuscitation of the severely bumed:an observational study of 24 patients显示文摘 | Holm C Melcer B Horbrand F | 2000 | J Trauma2000，48，4： | 1 |
| 19 | Inheritance in tobacco of an improved resistance to in- fection by tobacco mosaic virus显示文摘 | Holmes F O | 1960 | Virology1960，12，1： | 1 |
| 20 | Technology Transfer and Spillovers:Does Local Participation with Multinationals Matter显示文摘 | BLOMSTR (O)M M SJ (O)HOLM F | | 0，，43： | 1 |
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