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| 1 | Scutellaria baicalensis in Stroke Management:Nature's Blessing in Traditional Eastern Medicine显示文摘Scutellaria baicalensis Georgi is the most widely used medicinal plant in traditional Eastern medicine,especially in Chinese medicine.The major phytochemicals isolated from S.baicalensis are flavonoids,glycosides and their glucoronides such as baicalin,baicalein,wogonin etc.More than 30 different kinds of flavonoids are isolated from this plant.S.baicalensis and its flavonoids are reported to have several pharmacological activities,which includes anti-allergic,antioxidant,anti apoptic,anti-inflammatory effects and many more.Recently,S.baicalensis and its isolated flavonoids have been studied for their neuroprotective effects,through a variety of in vitro and in vivo models of neurodegenerative diseases,plausibly suggesting that S.baicalensis has salutary effect as a nature's blessing for neuroprotection.In this review,we are focousing on the neuroprotective effects of S.baicalensis and its flavonoids in ischemia or stroke-induced neuronal cell death.We aimed at compiling all the information regarding the neuroprotective effect of S.baicalensis in various experimental models of cerebral ischemia or stroke. | Bhakta Prasad Gaire Sang-Kwan Moon Hocheol Kim | 2014 | Chinese Journal of Integrative Medicine2014，20，9： | 8 |
| 2 | Amomum villosum induces longitudinal bone growth in adolescent female rats显示文摘OBJECTIVE:This study was conducted to evaluate the effect of Amomum villosum on longitudinal bone growth.METHODS:Adolescent female Sprague-Dawley rats were divided into 3 groups and treated for 4 days:control(distilled water,p.o.),recombinant human growth hormone(rhGH;100 μg/kg,s.c.),and A.villosum(500 mg/kg,p.o.) groups.On day 3,tetracycline(20 g/kg,i.p.) was injected for growth plate identification.On days 2,3 and 4,5-bromo-2'-deoxyuridine(BrdU)(50 mg/kg,i.p.) was injected to label proliferating cells.On day 5,tibias were dissected and fixed in 4% paraformaldehyde,dehydrated,and sectioned for immunohistochemistry and histomorphometry.RESULTS:The rate of bone growth in the A.villosum and rhGH groups increased to(410 ± 44) and(389 ± 46) μm/day(P<0.01),respectively,as compared with the control(330.7 ± 34.7) μm/day.The thickness of the growth plates also increased to(591 ± 37) and(598 ± 32) μm,respectively,as compared with the control(524± 89) μm(P<0.001).The number of BrdU-positive cells in the chondrocytes of the A.villosum and rhGH groups was also significantly higher(126±24) and(143±18) cells/mm 2,respectively) than in the control(109 ± 25) mm 2(P<0.05).Insulin-like growth factor-1 and bone morphogenetic protein-2 in the A.villosum and rhGH groups were highly expressed in the growth plate as compared with the control samples,indicating increased bone formation.CONCLUSIONS:A.villosum could be used to treat growth retardation during adolescence. | Sun Haeng Lee Ji Young Kim Hocheol Kim Seul Ki Park Cho Young Kim Sun Yong Chung Gyu Tae Chang | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 6 |
| 3 | Neuroprotective effects of Fructus Chebulae extracts on experimental models of cerebral ischemia显示文摘OBJECTIVE:To investigate the neuroprotective effects of Fructus Chebulae extract using both in vivo and invitromodels of cerebral ischemia.METHODS:As an in vitro model,oxygen glucose deprivation followed by reoxygenation(OGD-R)and hydrogen peroxide(H2O2)induced cellular damage in rat pheochromocytoma(PC12)cells was used to investigate the neuroprotective effects of extract of Fructus Chebulae.3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to calculate cell survival.For in vivo,occlusion of left middle cerebral artery on rats was carried out as a focal cerebral ischemic model.RESULTS:Fructus Chebulae extract increases the PC12 cell survival against OGD-R and H2O2by 68%and 91.4%respectively.Fructus Chebulae also de-creases the cerebral infarct volume by 39%and extent of hemisphere swelling from 17%in control group to 10%in FructusChebulaetreated group.CONCLUSION:Fructus Chebulae,as a traditional medicine,can rescue the neuronal cell death against ischemia related damage.The possible mechanism for the neuroprotection might be the inhibition of oxidative damages occurring after acute phase of cerebral ischemia. | Bhakta Prasad Gaire Hocheol Kim | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 2 |
| 4 | Investigation into mechanical properties of austempered ductile cast iron (ADI) in accordance with austempering temperature显示文摘 | Kim Yoon-Jun Shin Hocheol Park Hyounsoo | 2008 | Materials Letters2008，62，： | 1 |
| 5 | A novel chitosan/clay/magnetite composite for adsorption of Cu(II) and As(V)显示文摘 | Dong-Wan Cho Byong-Hun Jeon Chul-Min Chon Yongje Kim Franklin W. Schwartz Eung-Seok Lee Hocheol Song | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 6 | Flavonoid wngonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia显示文摘 | Heasuk Lee Young Ok Kim Hocheol Kim etal | | The FASEB Journal express article0，17，： | 1 |
| 7 | Defluoridation from aqueous solutions by granular ferric hydroxide (GFH)显示文摘 | Eva Kumar Amit Bhatnagar Minkyu Ji Woosik Jung Sang-Hun Lee Sun-Joon Kim Giehyeon Lee Hocheol Song Jae-Young Choi Jung-Seok Yang Byong-Hun Jeon | 2008 | Water Research2008，，2： | 1 |
| 8 | Serum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean men显示文摘 | Chan-Won Kim Yoosoo Chang Eunju Sung Hocheol Shin Seungho Ryu | 2012 | Metabolism2012，，8： | 1 |
| 9 | Adsorption of nitrate and Cr(VI) by cationic polymer-modified granular activated carbon显示文摘 | Dong-Wan Cho Chul-Min Chon Yongje Kim Byong-Hun Jeon Frank W. Schwartz Eung-Seok Lee Hocheol Song | 2011 | Chemical Engineering Journal2011，，： | 1 |
| 10 | Investigation into mechanical properties of austempered ductile cast iron(ADI)in accordance with austempering temperature显示文摘 | Yoon Jun Kim Hocheol Shin Hyounsoo Park | 2008 | Materials Letters2008，62，3： | 1 |
| 11 | Defluoridation from aqueous solutions by granular ferric hydroxide (GFH)显示文摘 | Eva Kumar Amit Bhatnagar Minkyu Ji Woosik Jung Sang-Hun Lee Sun-Joon Kim Giehyeon Lee Hocheol Song Jae-Young Choi Jung-Seok Yang Byong-Hun Jeon | 2008 | Water Research2008，，2： | 1 |
| 12 | Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia显示文摘 | Heasuk Lee Young O k Kim Hocheol Kim et ol | 2003 | The FASEB Journal2003，17，： | 1 |
| 13 | Effects of Angelica sinensis on longitudinal bone growth rate in adolescent female rats显示文摘OBJECTIVE To investigate the effect of A.sinensis on longitudinal bone growth rate in adolescent female rats.METHODS A.sinensis was extracted with 30% EtOH for 3h at 90℃in a reflux apparatus.Female Sprague-Dawley rats(33d-old)were randomly divided into three groups:control(vehicle),recombinant human growth hormone(rhGH;20μg·kg-1·d-1),and A.sinensis(300mg·kg-1·d-1).A.sinensis extracts or vehicle was administered orally twice daily for 4d.Longitudinal bone growth rate in newly synthesized bone was observed using tetracycline labeling(20mg·kg-1,intraperitoneally).RESULTS A.sinensis significantly increased longitudinal bone growth rate in adolescent female rats at 300mg·kg-1(6.1%,357.34±32.67μm·d-1)compared to control group(336.80±14.47μm·d-1).CONCLUSION A.sinensis extract significantly increased longitudinal bone growth rate and growth plate height in adolescent female rats.These results suggest that A.sinensis could be helpful for increasing bone growth rate in children who have growth retardation. | Hai-ling GUO Donghun LEE Young-Sik KIM Jung-bin SONG Hyun Soo KIM Hyun Jung LEE Sung Hyun LEE Juyeon PARK Hocheol KIM | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
| 14 | Effect of Dioscorea batatas on longitudinal bone growth rate in adolescent female rats显示文摘OBJECTIVE The root of Dioscorea batatas,rich in steroidal saponins,alkaloids,tannins,phytosterols,and starch,is an herbal medicine of tonifying qi and nourishing stomach after invigorating spleen with a long history of safe use for treatment of chronic dysentery and weakness of the spleen and stomach in Korea.This study was aimed to investigate the effect of D.batatas on longitudinal bone growth rate in adolescent female rats.METHODS D.batatas was extracted with 30% EtOH for 3h at 90℃in a reflux apparatus.In two groups,we administered a twice daily dosage of D.batatas extract(at 30 and 300mg·kg-1,respectively)per os for 4d,and in a control group,we administered vehicle only under the same conditions.Recombinant human growth hormone(rhGH)was subcutaneously injected once daily.All rats were born at same day(33d-old).On day 3,tetracycline was injected intraperitoneally to form a fluorescent band on the growth plates.RESULTS The bone growth rate in groups administered D.batatas 300mg·kg-1 and rhGH was significantly increased to 343.8±20.7,and 359.6±30.2μm·d-1 respectively from control group,320.7±23.2μm·d-1.No difference was observed in the amount of food intake or mean body weight among all groups during the acclimation or administration period.CONCLUSION These results suggest that D.batatas extracts have the potential to induce height increase;however,further research,including clinical trials,is necessary. | Hyun Soo KIM Donghun LEE Young-Sik KIM Jung-bin SONG Hyun Jung LEE Seunggyeong LEE Sung Hyun LEE Juyeon PARK Hocheol KIM | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
| 15 | Inhibitory activity of Cinnamomum Cassia extract on hypersensitivity in mice显示文摘OBJECTIVE Cinnamomum cassia has been used in traditional medicine in East Asian countries to treatallergic disease.Previous studies have demonstrated that C.cassiainhibits the development of mite antigen-induced skin lesions in NC/Nga mice by suppressing the Thelper 2cell response.The objective of this study is to investigate whether C.cassia has an efficient inhibition on systemic anaphylaxis and contact hypersensitivity in mice.METHODS To induce systemic anaphylaxis,mice were injected intraperitoneally with compound 48/80.Mortality was monitored for 1h after the injection.Contact hypersensitivity reaction was induced by topical application of 2,4-dinitrofluorobenzene(DNFB)to the ears of mice.After DNFBchallenge,ear thickness was measured 0,24 and 48h.RESULTS We discovered that C.cassia significantly inhibited compound 48/80-induced anaphylaxis and DNFB-induced ear swelling.Compound 48/80-induced anaphylaxiswas completely inhibited at the dose of 60mg·kg-1 body weight.Ear swelling at 24 h after DNFB-challenge was significantly less than that in the control group(0.16±0.03 vs.0.32±0.03 mm,P<0.01),while C.cassia was administered at the dose of 200mg·kg-1.CONCLUSION These findings indicate that C.cassiasuppresses allergic reactions,thus has potential value for mitigation of atopic dermatitis. | Seunggyeong LEE Jungbin SONG Donghun LEE Young Sik KIM HyunSoo KIM Hailing GUO Juyeon PARK Hocheol KIM | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
| 16 | Bulk-Si photonics technology for DRAM interface[Invited]显示文摘We present photonics technology based on a bulk-Si substrate for cost-sensitive dynamic random-access memory(DRAM)optical interface application.We summarize the progress on passive and active photonic devices using a local-crystallized Si waveguide fabricated by solid phase epitaxy or laser-induced epitaxial growth on bulk-Si substrate.The process of integration of a photonic integrated circuit(IC)with an electronic IC is demonstrated using a 65 nm DRAM periphery process on 300 mm wafers to prove the possibility of seamless integration with various complementary metal-oxide-semiconductor devices.Using the bulk-Si photonic devices,we show the feasibility of high-speed multidrop interface:the Mach–Zehnder interferometer modulators and commercial photodetectors are used to demonstrate four-drop link operation at 10 Gb∕s,and the transceiver chips with photonic die and electronic die work for the DDR3 DRAM interface at 1.6 Gb∕s under a 1∶4 multidrop configuration. | Hyunil Byun Jinkwon Bok Kwansik Cho Keunyeong Cho Hanmei Choi Jinyong Choi Sanghun Choi Sangdeuk Han Seokyong Hong Seokhun Hyun TJJeong Ho-Chul Ji In-Sung Joe Beomseok Kim Donghyun Kim Junghye Kim Jeong-Kyoum Kim Kiho Kim Seong-Gu Kim Duanhua Kong Bongjin Kuh Hyuckjoon Kwon Beomsuk Lee Hocheol Lee Kwanghyun Lee Shinyoung Lee Kyoungwon Na Jeongsik Nam Amir Nejadmalayeri Yongsang Park Sunil Parmar Junghyung Pyo Dongjae Shin Joonghan Shin Yong-hwack Shin Sung-Dong Suh Honggoo Yoon Yoondong Park Junghwan Choi Kyoung-Ho Ha Gitae Jeong | 2014 | Photonics Research2014，2，3： | 0 |
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