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| 1 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 2 | Fuzzy Control of LED Tunnel Lighting and Energy Conservation显示文摘Current highway tunnel lighting control systems are often manually controlled,resulting in significant energy waste.This article designs a fuzzy control algorithm for tunnel lighting energy control systems.The system uses LED (Light Emitting Diode) lighting,so the fuzzy control algorithm is designed for LED lights.The traffic and the natural illumination level are used as parameters in the intelligent lighting control algorithm.This system has been deployed in the Lengshui tunnel on the 49th provincial highway of Zhejiang province and operated for more than six months.The performance results show that the energy conservation system provides sufficient lighting levels for traffic safety with significant energy conservation. | Hong Zeng Jian Qiu Xingfa Shen Guojun Dai Peng Liu Shuping Le | 2011 | Tsinghua Science and Technology2011，16，6： | 17 |
| 3 | Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma显示文摘Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients.Endoscopic nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical costs.In this study,we examined whether ENPG could be an effective treatment for localized stage I NPC.Methods:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center.Simultaneously,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort.The survival outcomes,quality of life(QOL),and medical costs between two groups were compared.Results:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with ENPG.The 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy.However,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results. | You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui Sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen | 2019 | Cancer Communications2019，39，1： | 17 |
| 4 | Slip rate along the Lijiang-Ninglang fault zone estimated from repeating microearthquakes显示文摘Seismicity 并且沿着在 1999 和 2006 之间的 Lijiang-Ninglang 差错地区滑动率被调查,波形数据由云南数字地震网络记录了。由双差别方法的重定位的 seismicity 清楚地展出在北、南部的片断之间的不同特征。超过 76% 地震在丽江区域附近发生在差错的南部的片断。重定位的 seismicity 看起来反映学习区域的外壳的速度结构。用跨关联的分析,我们识别了显示出高波形类似的 92 件马甲和 70 根多重谱线的一个总数。大多数这些序列是非周期的,复发间隔从一些分钟变化到几百天。用在学习时期上定期发生了的二个序列,我们获得了一个差错在 ∼23 km 滑动约 5 mm/a 的率,在对的好同意地质并且表面 GPS 测量。 | LI Le CHEN QiFu NIU FengLin FU Hong LIU RuiFeng HOU YanYan | 2009 | Chinese Science Bulletin2009，54，3： | 16 |
| 5 | Liver targeting and the delayed drug release of the nanoparticles of adriamycin polybutylcyanoacrylate in mice显示文摘指向药交货系统的背景肝能改进药品效果并且减轻在带治疗学的药的肝 diseases.Nanoparticles 的治疗的药当前在有大临床的意义的热调查下面的化疗的 cytotoxicity。这研究被瞄准经由侧面的尾巴静脉在注射以后在老鼠身体调查 theadriamycin polybutylcyanoacrylate nanoparticle (ADM-PBCA-NP ) 的不同组织分发,并且学习在正常老鼠肝上在不同直径指向 ADM-PBCA-NP 的效果的肝。180 只 Kunming 老鼠随机在各个带着 30 只老鼠被划分成 6groups 的方法组织(在不同直径范围的 ADM-PBCA-NP 的 5 个处理组,非结合的免费 adriamycin 注射作为控制组被采用) 。结合的任何一个或免费 adriamycin 的单个剂量等于身体重量的 2 mg/kg 经由尾巴静脉被交付。在每条小道的五个鼠标在 5 点被牺牲, 15, 30 分钟, 1, 5 和 12 小时帖子注射分别地。adriamycin 集中在分别地镇定肝,肾,怒气,心,肺和血浆与荧光察觉者用高效液体层析被表明。结果与控制组,相比, adriamycin 几乎没在处理组的心肌肉被检测(P <
0.05 ) 。结合 nanoparticle 的 adriamycin 从肾织物快速被清理。在试验性的组的鼠标肝和怒气的 adriamycin 集中在控制组比那显著地高,除了有 nanoparticles 直径的组(22.3 ± 6.2 ) nm (P <
0.05 ) 。ADM-PBCA-NP 在(101.0 ± 20.3 ) nm 直径有最高的肝分发,并且在肝的第二最高的 adriamycindistribution 是组(143.0 ± 2 3.5 ) nm 直径(P <
0.05 ) 。而且,在试验性的组在察觉时期期间在肝慢慢地释放的 adriamycinwas。ADM-PBCA-NPin (22.3 ± 6 .2 ) nm 直径没在肝,肾,心,怒气,和肺的织物被散布。在 100-150 nm 直径范围的结论 ADM-PBCA-NP 有最好的肝与慢药版本的一个特征指向。它也减少在心,肾和肺的药分发。在肝癌症的治疗, polybutylcyanoacrylate nanoparticles 系统有一个好肝指向能力,它增加反癌症活动并且显著地减少 adriamycin 的毒性。 | SHEN Liang-fang ZHANG Yang-de SHEN Hai-ju ZENG Shan WANG Xin WANG Cheng LE Yuan SHEN Hong | 2006 | Chinese Medical Journal2006，，15： | 15 |
| 6 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 7 | Effect of the Shensong Yangxin Capsule on Energy Metabolism in Angiotensin II-lnduced Cardiac Hypertrophy显示文摘 | Bei-Lei Liu Mian Cheng Shan Hu Shun Wang Le Wang Zheng-Qing Hu Cong-Xin Huang Hong Jiang Gang Wu | 2018 | Chinese Medical Journal2018，，19： | 7 |
| 8 | Graphene-based catalysts for electrochemical carbon dioxide reduction显示文摘Electrochemical carbon dioxide(CO2)reduction is considered to be an efficient strategy to produce usable fuels and overcome the concerns regarding global warming.For this purpose,an efficient,earth abundant,and a low cost catalyst has to be designed.It has been found that graphene-based materials could be promising candidates for CO2 conversion because of their unique physical,mechanical,and electronic properties.In addition,the surface of graphenebased materials can be modified by using different strategies,including doping,defect engineering,producing composite structures,and wrapping shapes.In this review,the fundamentals of electrochemical CO2 reduction and recent progress of graphene-based catalysts are investigated.Furthermore,recent studies on graphene-based materials for CO2 reduction are summarized. | Amirhossein Hasani Mahider Asmare Teklagne Ha Huu Do Sung Hyun Hong Quyet Van Le Sang Hyun Ahn Soo Young Kim | 2020 | Carbon Energy2020，2，2： | 7 |
| 9 | Population-level economic burden of lung cancer in China:Provisional prevalence-based estimations,2017-2030显示文摘Objective:Population-level economic burden is essential for prioritizing healthcare resources and healthcare budget making in the future.However,little is known about the economic burden of lung cancer in China.Methods:A prevalence-based approach was adopted to estimate the economic burden of lung cancer,including direct expenditure(medical and non-medical)and indirect cost(disability and premature death).Data on direct expenditure and work-loss days per patient in each year post-diagnosis were obtained from two primary surveys.Other parameters were obtained from literatures and official reports.Projections were conducted based on varying parameters.All expenditure data were reported in United States dollars(USD)using 2017 value(exchange rate:1 USD=6.760 CNY),with the discount rate of 3%.Results:The total economic burden of lung cancer was estimated to be 25,069 million USD in China in 2017(0.121%of gross domestic productivity,GDP).The estimated direct expenditure was 11,098 million USD,up to1.43%of total healthcare expenditure for China,covering 10,303 million USD and 795 million USD for medical and non-medical expenditure,respectively.The estimated indirect cost was 13,971 million,including 1,517 million USD due to disability and 12,454 million USD due to premature death.Under current assumptions,the projected total economic burden would increase to 30.1 billion USD,40.4 billion USD,and 53.4 billion USD in 2020,2025,and 2030,accounting for 0.121%,0.131%,and 0.146%of China's GDP,respectively.However,if China meets the United Nation sustainable development goal of reducing premature death from non-communicable diseases by one-third by 2030,the total economic burden in 2030 would be 31.9 billion USD,0.087%of China's GDP.Conclusions:The economic burden of lung cancer in China in 2017 is substantial and more likely to increase significantly in the future.Policy makers need to take urgent actions in budget making for health systems.The economic burden could be alleviated by reducing the disease burden of lung cancer via effective control and prevention actions. | Chengcheng Liu Jufang Shi Hong Wang Xinxin Yan Le Wang Jiansong Ren Mark Parascandola Wanqing Chen Alin Dai | 2021 | Chinese Journal of Cancer Research2021，33，1： | 6 |
| 10 | Three new phenanthrenes from Monomeria barbata Lindl.显示文摘Three new monophenanthrene compounds were isolated from an acetone extract of the tubers of Monomeria barbata Lindl. (Orchidaceae).Using spectroscopic methods,the structures of compounds 1-3 were determined as 1,4,7-trihydroxy-2-methoxy- 9,10-dihydrophenanthrene(1),1-(p-hydroxybenzoyl)-2-methoxy-4,7-dihydroxy-9,10-dihydrophenanthrene(2),1,3,8-tri(p-hydroxybenzyl) -4-methoxy-phenanthrene-4,7-diol(3).These compounds showed cytotoxicities on four tumor cell lines(HepG2, HL-60,Skov-3,A431). | Yang, Ming Hui Cai, Le Li, Mei Hong Zeng, Xiang Hui Yang, Ya Bin Ding, Zhong Tao | 2010 | Chinese Chemical Letters2010，21，3： | 5 |
| 11 | Correlation of Deactivation of Ni-Mo-W/Al2O3 during Ultra-Low-Sulfur Diesel Production with Surface Carbon Species显示文摘The deactivation of a Ni-Mo-W/Al_2O_3 catalyst during ultra-low-sulfur diesel production was investigated in a pilot plant. The reasons of catalyst deactivation were analyzed by the methods of elemental analysis, BET and TG-MS. The results showed that the catalyst deactivation rate was notable at the beginning of run, and then gradually reached a steady state after 448 h. In the initial period the catalyst deactivation may mainly be caused by the formation of the carbon deposits. The carbon deposits blocked the catalyst pores and the accessibility of active center decreased. The TG-MS analysis identified three types of carbon species deposited on the catalysts, viz.: the low temperature carbon deposit with high H/C atomic ratio, the medium temperature carbon deposit, and the high temperature carbon with low H/C atomic ratio. The amount of high temperature carbon deposits on the catalyst determined the overall activity and, therefore the high temperature carbon was a major contributor to the deactivation of Ni-Mo-W catalyst. | Ge Panzhu Zhang Le Ding Shi Li Dadong Nie Hong | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 5 |
| 12 | Study on Sulfidation Degree and Morphology of MoS_2 Catalyst Derived from Various Molybdate Precursors显示文摘The MoS_2 catalysts were prepared from various molybdate precursors including inorganic and organic molybdate compounds. The sulfidation degree and morphology of active phases of MoS_2 activated by various molybdate precursors in H_2S/H_2 stream at different temperatures were studied by X-ray photoelectron spectroscopy(XPS) and high-resolution transmission electron microscopy(HRTEM). The organic molybdate precursors lead to MoS_2 catalysts with higher sulfidation degree and smaller active phases to demonstrate higher catalytic activity during hydrodesulfurizaiton(HDS) of 4,6-DMDBT. | Zhang Le Li Mingfeng Nie Hong | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，2： | 4 |
| 13 | Synthesis of Multiester-appended and Multicarboxylic-appended Imidazolium Ionic Liquids显示文摘Multiester-appended imidazolium ionic liquids were synthesized in a quaternizationreaction between the imidazole derivatives carrying single or double esters and ethyl chloroacetateor bromoethane. Multicarboxylic-appended imidazolium ionic liquids were achieved from thehydrolysis of the corresponding ionic liquids. The influences of multifunctional groups on thetransition temperatures and viscosity of these new ionic liquids were investigated. | Wei Guo GENG Xuc Hui LI Le Fu WANG Hong Li DUAN Wei Ping PAN | 2006 | Chinese Chemical Letters2006，17，2： | 4 |
| 14 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 15 | Alternative splicing as a biomarker and potential target for drug discovery显示文摘其他的拼接在 pre-mRNA 成熟期间是 multi-exonic 基因表示的一个关键过程。在这个过程,基因的特别 exons 将被包括在以内或从最后的成熟 mRNA,和产生抄本排除了产生多样的蛋白质 isoforms。最近的证据证明有多重 exons 的约 95% 人的基因经历在 pre-mRNA 成熟期间的其他的拼接。因此,其他的拼接在生理的进程和房间开发程序起一个关键作用,其他的拼接的 and.dysregulation 高度与人的疾病被联系例如癌症,糖尿病和 neurodegenerative 疾病。在这评论,我们讨论其他的拼接的规定,检验在其他的拼接和人的疾病之间的关系,并且描述修改其他的拼接的几条途径,它能帮助人的疾病诊断和治疗。 | Kai-qin LE Bellur S PRABHAKAR Wan-jin HONG Liang-cheng LI | 2015 | Acta Pharmacologica Sinica2015，36，10： | 4 |
| 16 | Fruit and vegetable consumption and its relation to risk of asthenopia among Chinese college students显示文摘AIM: To investigate the associations between fruit and vegetable consumption and risk of asthenopia among Chinese college students.METHODS: A total of 1022 students were selected from five universities by a multi-stage stratified cluster sampling method. They were surveyed via a self-administered questionnaire including socio-demographic features,dietary and lifestyle habits, eye-related symptoms, eye care habits and history of diseases. Ascertainment of asthenopia was based on participants' subjectively reported symptoms. The associations between fruit and vegetable intake with asthenopia risk were assessed using multivariate logistic regression analysis.RESULTS: There were no significant associations between total fruit and vegetable, total vegetable, or fruit and the risk of asthenopia. Higher intake of dark-green leafy vegetable was likely to be inversely associated with asthenopia risk [odd ratio(OR): 0.60; 95%CI: 0.37-0.97;P_(trend)=0.21] after controlling for nondietary and dietary risk factors. Stratified analysis showed that the inverse association between dark-green leafy vegetable intake and asthenopia risk was limited to participants with suboptimal eyesight(OR: 0.45; 95%CI: 0.25-0.82; Ptrend=0.05), wearing glasses(OR: 0.35; 95%CI: 0.17-0.72; Ptrend=0.03) or using computer ≥3 h/d(OR: 0.48; 95%CI: 0.25-0.93; Ptrend=0.08).CONCLUSION: A higher consumption of dark-green leafy vegetable is associated with a lower asthenopia risk among college students with suboptimal eyesight and poor eye care habits. | Fang Guo Qiang Zhang Meng-Nan Fan Le Ma Chu Cken Xiao-Hong Liu Hong Jiang Yan Liu | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 4 |
| 17 | A simple and efficient synthesis of 2-substituted benzothiazoles catalyzed by H_2O_2/HCl显示文摘A simple and efficient procedure for the synthesis of substituted benzothiazoles through condensation of 2-aminothiophenol with aromatic aldehydes in the presence of H_2O_2/HCl system in ethanol at room temperature is described.The target compounds have been characterized by ~1H NMR,^(13)C NMR,IR and MS.Short reaction time,easy and quick isolation of the products,and excellent yields are the main advantages of this procedure. | Hong Yun Guo Ji Chao Li You Le Shang | 2009 | Chinese Chemical Letters2009，20，12： | 4 |
| 18 | Postoperative survival analysis and prognostic nomogram model for patients with portal hypertension显示文摘AIM To analyse the postoperative survival of patients with portal hypertension and determine the factors that influence survival and construct nomograms.METHODS We retrospectively followed 1045 patients who underwent splenectomy plus pericardial devascularisation(SPD) between January 2002 and December 2017. Two SPD types are used in our department: splenectomy plus simplified pericardial devascularisation(SSPD) and splenectomy plus traditional pericardial devascularisation(STPD). The Kaplan-Meier method and Cox regression analysis were used to evaluate the prognostic effects of multiple parameters on overall survival(OS), diseasespecific survival(DSS) and bleeding-free survival(BFS). Significant prognostic factors were combined to build nomograms to predict the survival rate of individual patients.RESULTS Five hundred and fifty-seven(53.30%) patients weresuccessfully followed with 192 in the SSPD group and 365 in the STPD group; 93(16.70%) patients died, of whom 42(7.54%) died due to bleeding. Postoperative bleeding was observed in 84(15.10%) patients. The 5-and 10-year OS, DSS and BFS rates in the group of patients who underwent SSPD were not significantly different from those in patients who underwent STPD. Independent prognostic factors for OS were age, operative time, alanine transaminase level and albumin-bilirubin score. Independent prognostic factors for BFS were male sex, age, intraoperative blood loss and time to first flatus. Independent prognostic factors for DSS were the Comprehensive Complication Index and age. These characteristics were used to establish nomograms, which showed good accuracy in predicting 1-, 3-and 5-year OS and BFS.CONCLUSION SSPD achieves or surpasses the long-term survival effect of traditional pericardial devascularisation and is worthy of clinical promotion and application. Nomograms are effective at predicting prognosis. | Ya-Fei Zhang Hong Ji Hong-Wei Lu Le Lu Lei Wang Jin-Long Wang Yi-Ming Li | 2018 | World Journal of Gastroenterology2018，24，39： | 4 |
| 19 | Individualized minimally invasive treatment for adult testicular hydrocele: A pilot study显示文摘BACKGROUND Hydrocelectomy is the gold standard for the treatment of hydrocele,but it often causes complications after surgery,including hematoma,infection,persistent swelling,hydrocele recurrence,and chronic pain. In recent years,several methods for minimally invasive treatment of hydrocele have been introduced,but they all have limitations. Herein,we introduce a new method of individualized minimally invasive treatment for hydrocele.AIM To present a new method for the treatment of adult testicular hydrocele.METHODS Fifty-two adult patients with idiopathic testicular hydrocele were included. The key point of this procedure was that the scope of the resection of the sheath of the tunica vaginalis was determined according to the maximum diameter(d) of the effusion measured by ultrasound and the maximum diameter of the portion of the sheath pulled out of the scrotum was approximately πd/2. The surgical procedure consisted of a 2-cm incision in the anterior wall of the scrotum,drainage of the effusion,and dissection of part of the sheath of the tunica vaginalis. After the sheath was peeled away to the predetermined target extent,the pulled-out sheath was removed. The intraoperative findings and postoperative complications were analyzed.RESULTS All patients were successfully treated with a median operation time of 18 min.The median maximum diameter of the effusion on ultrasound was 3.5 cm,and the median maximum diameter of the resected sheath was 5.5 cm. Complications occurred in four(7.7%) patients: two(3.8%) cases of mild scrotal edema,one(1.9%) case of scrotal hematoma,and one(1.9%) case of wound infection. All of the complications were grade I-II. Recurrent hydrocele,chronic scrotal pain,and testicular atrophy were not observed during a median follow-up of 12 mo.CONCLUSION We report a new technique for individualized treatment of testicular hydrocele,which is quantitative and minimally invasive and yields good outcomes. Further study is warranted to verify its potential value in clinical practice. | Le Lin Huai-Shan Hong Yun-Liang Gao Jin-Rui Yang Tao Li Qing-Guo Zhu Lie-Fu Ye Yong-Bao Wei | 2019 | World Journal of Clinical Cases2019，7，6： | 4 |
| 20 | NF-κB and FosB mediate inflammation and oxidative stress in the blast lung injury of rats exposed to shock waves显示文摘Blast lung injury(BLI)is the major cause of death in explosion-derived shock waves;however,the mechanisms of BLI are not well understood.To identify the time-dependent manner of BLI,a model of lung injury of rats induced by shock waves was established by a fuel air explosive.The model was evaluated by hematoxylin and eosin staining and pathological score.The inflammation and oxidative stress of lung injury were also investigated.The pathological scores of rats’lung injury at 2 h,24 h,3 days,and 7 days post-blast were 9.75±2.96,13.00±1.85,8.50±1.51,and 4.00±1.41,respectively,which were significantly increased compared with those in the control group(1.13±0.64;P<0.05).The respiratory frequency and pause were increased significantly,while minute expiratory volume,inspiratory time,and inspiratory peak flow rate were decreased in a time-dependent manner at 2 and 24 h post-blast compared with those in the control group.In addition,the expressions of inflammatory factors such as interleukin(IL)-6,IL-8,FosB,and NF-κB were increased significantly at 2 h and peaked at 24 h,which gradually decreased after 3 days and returned to normal in 2 weeks.The levels of total antioxidant capacity,total superoxide dismutase,and glutathione peroxidase were significantly decreased 24 h after the shock wave blast.Conversely,the malondialdehyde level reached the peak at 24 h.These results indicated that inflammatory and oxidative stress induced by shock waves changed significantly in a time-dependent manner,which may be the important factors and novel therapeutic targets for the treatment of BLI. | Hong Wang Wenjuan Zhang Jinren Liu Junhong Gao Le Fang Zhiyong Liu Baoqing Xia Xiaolin Fan Cunzhi Li Qing Lu Airong Qian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 4 |
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