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| 1 | SmProt: A Reliable Repository with Comprehensive Annotation of Small Proteins Identified from Ribosome Profiling显示文摘Small proteins specifically refer to proteins consisting of less than 100 amino acids translated from small open reading frames(s ORFs),which were usually missed in previous genome annotation.The significance of small proteins has been revealed in current years,along with the discovery of their diverse functions.However,systematic annotation of small proteins is still insufficient.Sm Prot was specially developed to provide valuable information on small proteins for scientific community.Here we present the update of Sm Prot,which emphasizes reliability of translated s ORFs,genetic variants in translated s ORFs,disease-specific s ORF translation events or sequences,and remarkably increased data volume.More components such as non-ATG translation initiation,function,and new sources are also included.Sm Prot incorporated638,958 unique small proteins curated from 3,165,229 primary records,which were computationally predicted from 419 ribosome profiling(Ribo-seq)datasets or collected from literature and other sources from 370 cell lines or tissues in 8 species(Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Danio rerio,Saccharomyces cerevisiae,Caenorhabditis elegans,and Escherichia coli).In addition,small protein families identified from human microbiomes were also collected.All datasets in Sm Prot are free to access,and available for browse,search,and bulk downloads at http://gffzz47cba05b3f0c4ad7hp9cnnnu906up69q6.ffgz.tsg.suse.edu.cn/SmProt/. | Yanyan Li Honghong Zhou Xiaomin Chen Yu Zheng Quan Kang Di Hao Lili Zhang Tingrui Song Huaxia Luo Yajing Hao Runsheng Chen Peng Zhang Shunmin He | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 1 |
| 2 | Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: Based on published genome-wide association studies in a central Chinese population显示文摘 | Fujiao Duan Wei Xie Lihong Cui Peng Wang Chunhua Song Honghong Qu Kaijuan Wang Jianying Zhang Liping Dai | 2013 | Cancer Epidemiology2013，，： | 1 |
| 3 | Mapping quantitative trait loci for cottonseed oil, protein and gossypol content in a Gossypium hirsutum?×?Gossypium barbadense backcross inbred line population显示文摘 | Jiwen Yu Shuxun Yu Shuli Fan Meizhen Song Honghong Zhai Xingli Li Jinfa Zhang | 2012 | Euphytica2012，，2： | 1 |
| 4 | Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells显示文摘Multicellular organisms such as plants contain various cell types with specialized functions.Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level.Guard cells(GCs)are specialized epidermal cells that regulate the movement of the stomata and gaseous exchange,and provide a model genetic system for analyzing cell fate,signaling,and function.Several proteomics analyses of GC are available,but these are limited in depth.Here we used enzymatic isolation and flow cytometry to enrich GC and mesophyll cell protoplasts and perform in-depth proteomics in these two major cell types in Arabidopsis leaves.We identified approximately 3,000 proteins not previously found in the GC proteome and more than600 proteins that may be specific to GC.The depth of our proteomics enabled us to uncover a guard cell-specific kinase cascade whereby Raf15and Snf1-related kinase2.6(SnRK2.6)/OST1(open stomata 1)mediate abscisic acid(ABA)-induced stomatal closure.RAF15 directly phosphorylated SnRK2.6/OST1 at the conserved Ser175 residue in its activation loop and was sufficient to reactivate the inactive form of SnRK2.6/OST1.ABAtriggered SnRK2.6/OST1 activation and stomatal closure was impaired in raf15 mutants.We also showed enrichment of enzymes and flavone metabolism in GC,and consistent,dramatic accumulation of flavone metabolites.Our study answers the long-standing question of how ABA activates SnRK2.6/OST1 in GCs and represents a resource potentially providing further insights into the molecular basis of GC and mesophyll cell development,metabolism,structure,and function. | Hongliang Wang Yubei Wang Tian Sang Zhen Lin Rongxia Li Weiwei Ren Xin Shen Bing Zhao Xiao Wang Xuebin Zhang Shaoqun Zhou Shaojun Dai Honghong Hu Chun-Peng Song Pengcheng Wang | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 5 | Accelerated partial breast irradiation:Current evidence and future developments显示文摘Whole breast irradiation after breast-conserving surgery for early breast cancer has become one of the standard treatment modes for breast cancer and yields the same effect as radical surgery.Accelerated partial breast irradiation(APBI)as a substitute for whole breast irradiation for patients with early breast cancer is a hot spot in clinical research.APBI is characterised by simple high-dose local irradiation of the tumour bed in a short time,thus improving convenience for patients and saving costs.The implementation methods of APBI mainly include brachytherapy,external beam radiation therapy,and intraoperative radiotherapy.This review provides an overview of the clinical effects and adverse reactions of the main technologies of APBI and discusses the prospects for the future development of APBI. | Dandan Song Honghong Zhang Chengbo Ren Ning Zhan Liangxi Xie Wenjia Xie | 2024 | Cancer Innovation2024，3，1： | 0 |
| 6 | Postmastectomy radiotherapy in breast reconstruction:Current controversies and trends显示文摘Breast cancer is the most common cancer among women worldwide.Postmastectomy radiotherapy(PMRT)is an essential component of combined therapy for early-stage,high-risk breast cancer.Breast reconstruction(BR)is often considered for patients with breast cancer who have undergone mastectomy.There has been a considerable amount of discussion about the optimal approach to combining PMRT with BR in the treatment of breast cancer.PMRT may increase the risk of complications and prevent good aesthetic results after BR,while BR may increase the complexity of PMRT and the radiation dose to surrounding normal tissues.The purpose of this review is to give a broad overview and summary of the current controversies and trends in PMRT and BR in the context of the most recent literature available. | Honghong Zhang Dandan Song Liangxi Xie Ning Zhan Wenjia Xie Jianming Zhang | 2024 | Cancer Innovation2024，3，1： | 0 |
| 7 | A Robust Noninvasive Approach to Study Gut Microbiota Structure of Amphibian Tadpoles by Feces显示文摘The 16S rDNA amplicon high-throughput sequencing technique provides a robust and inexpensive approach to detect the gut microbiota of amphibians. Since different experimental protocols generate technical biases in drawing the gut microbiota profiles, the integrative analysis of gut microbiota produced by different studies must be performed with circumspection. In this study, we compared the efficacy of two DNA extraction methods(i.e., a phenol-chloroform method and TIANamp Stool DNA Kit) in describing intestinal and fecal bacterial communities of transplanted Asiatic toad(Bufo gargarizans) tadpoles. In terms of the DNA extraction quality(i.e., DNA purity and yield rate) and the consistency in between fecal and intestinal microbiota structures(i.e., α and β diversity indices), the phenol-chloroform method was more robust than this commercial stool kit in profiling gut microbiota of tadpoles with feces. | Xiaowei SONG Jinghan SONG Honghong SONG Qi ZENG Keke SHI | 2018 | Asian Herpetological Research2018，9，1： | 0 |
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