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| 1 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 2 | Placement of prophylactic pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: A meta-analysis显示文摘AIM:To assess the effectiveness of pancreatic stents for preventing pancreatitis in high-risk patients after endoscopic retrograde cholangiopancreatography(ERCP).METHODS:PubMed,Embase,Science Citation Index,and Cochrane Controlled Trials Register were searched to identify relevant trials published in English.Inclu-sion and exclusion criteria were used to screen for suitable studies.Two reviewers independently judged the study eligibility while screening the citations.The methodological quality of the included trials was assessed using the Jadad scoring system.All results were expressed as OR and 95%CI.Data were analyzed using Stata12.0 software.RESULTS:Ten eligible randomized controlled trials were selected,including 1176 patients.A fixed-effects model in meta-analysis supported that pancreatic duct stents significantly decreased the incidence of postERCP pancreatitis(PEP)in high-risk patients(OR=0.25;95%CI:0.17-0.38;P<0.001).Pancreatic stents also alleviated the severity of PEP(mild pancreatitis after ERCP:OR=0.33;95%CI:0.21-0.54;P<0.001;moderate pancreatitis after ERCP:OR=0.30;95%CI:0.13-0.67;P=0.004).The result of severe pancreatitis after ERCP was handled more rigorously(OR=0.24;95%CI:0.05-1.16;P=0.077).Serum amylase levels were not different between patients with pancreatic stents and control patients(OR=1.08;95%CI:0.82-1.41;P=0.586).CONCLUSION:Placement of prophylactic pancreatic stents may lower the incidence of post-ERCP pancreatitis in high-risk patients and alleviate the severity of this condition. | Qing-Qing Shi Xiao-Yi Ning Ling-Ling Zhan Guo-Du Tang Xiao-Ping Lv | 2014 | World Journal of Gastroenterology2014，20，22： | 15 |
| 3 | Growth and Common Prosperity in China显示文摘This paper introduces a decomposition method that quantifies the contributions to common prosperity of labor market performance and social policies and extends the idea of shared prosperity to a new measure of inequity in opportunities.The resulting common prosperity indices and opportunity equality indices are then applied to five waves of the Chinese Household Income Project data from 1988 to 2018.This paper shows that the labor market performance and social policies have been improving over the last 30 years and have helped China move towards common prosperity for everyone.The indices developed in this paper allow us to quantify the extent of shared prosperity that a country has achieved and to carry out empirical studies on which policy is working and which is not.It can also help us identify the fundamental causes of inequality and aid us in achieving equality in opportunity among all members of society. | Nanak Kahwani Xiaobing Wang Ning Xue Peng Zhan | 2022 | China & World Economy2022，30，1： | 13 |
| 4 | Detection and characterization of an isolate of Tomato mottle mosaic virus infecting tomato in China显示文摘Tomato(Solanum lycopersicum) plants exhibiting severe leaf distortion, mottle and systemic crinkling symptoms were identified in Hainan province in China in 2016. To survey and control the disease, it is necessary to identify and characterize the pathogen causing the disease. Dot enzyme-linked immunosorbent assay showed that the crude saps of the infected tomato samples reacted positively with the monoclonal antibody against Tobacco mosaic virus which indicated that one or more tobamoviruses are likely associated with the disease. RT-p CR and DNA sequence analysis results further elucidated that Tomato mottle mosaic virus(To MMV) in Tobamovirus was the pathogen causing the mottle disease in tomato. We amplified and sequenced the full-length sequence of the genome which showed the highest nucleotide identity with To MMV YYMLJ and To MMV Ti Lha LJ isolates. The putative virus isolate was named To MMV Hainan. Biological indexing studies showed that To MMV Hainan can infect Nicotiana benthamiana, Capsicum annuum and Solanum lycopersicum showing serious symptoms. This was the first identification and characterization of To MMV infecting tomato in Hainan of China. | ZHAN Bin-hui CAO Ning WANG Kai-na ZHOU Xue-ping | 2018 | Journal of Integrative Agriculture2018，17，5： | 7 |
| 5 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 6 | Role of the inter-pass cooling rate in recrystallization behaviors of Ni-based superalloy during interrupted hot compression显示文摘The microstructural evolution of a Ni-based superalloy under interrupted hot compressive deformation with different cooling rates in the inter-pass stage is investigated. It is found that metadynamic recrystallization(MDRX) in the inter-pass stage is more sensitive to the accumulated strain than the deformation temperature which is above the recrystallization temperature. The variations of both the grain distribution and the texture intensity caused by MDRX during the interpass stage result in variations of the yield stress(YS) and the work hardening(WH) rate in each stage. Results also show that the MDRX process in the inter-pass stage has a considerable influence on the final microstructure of three-pass compression. The final grain distribution is more uniform,and the compression texture gradually transforms into recrystallization texture with an increasing degree of MDRX. In order to predict the MDRX fraction in the inter-pass cooling stage, a modified kinetic equation is established, which can reasonably predict the MDRX behavior under multi-pass compression with different conditions in the inter-pass stage. Meanwhile, the influence of the interpass cooling stage on the mechanism of dynamic recrystallization(DRX) is studied. It is universally acknowledged that the discontinuous dynamic recrystallization(DDRX) process is the major deformation mechanism for the Ni-based superalloy. However, the continuous dynamic recrystallization(CDRX) process is promoted in the compression stage with a decrease of the cooling rate in each inter-pass stage. | Xin ZHANG Hongwei LI Mei ZHAN Siliang YAN Ning ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 5 |
| 7 | Gravity Changes Before Large Earthquakes in China: 1998-2005显示文摘Although it is well known that coseismic gravity changes take place during an earthquake, previous research has not yielded convincing evidence demonstrating that significant gravity changes occur before large earthquakes. Furthermore, even if we suspect that gravity changes occur before large earthquakes, we have yet to demonstrate how to consistently observe these changes for useful earthquake forecast that would bring benefits to society. We analyzed ground gravity survey data obtained in 1998, 2000, 2002, and 2005 at stations of the Crustal Movement Observation Network of China (CMONOC) and examined gravity changes be-fore the occurrence of nine large (Ms≥6.8) earthquakes that ruptured within or near China's Mainland and Taiwan from November 2001 to August 2008. Results from this analysis show that significant gravity changes occurred across a large region before each of these nine large earthquakes, and these changes were detected by repeated ground gravity surveys through CMONOC. Although these gravity changes were significant, more research is needed to investigate whether these gravity changes could be viewed as precursors of large earthquakes. Limitations and uncertainties in the data include sparseness of the gravity monitoring network, long time intervals between consecutive gravity surveys, inevitable measurement errors, hydrological effects on gravity, and effects of vertical crustal movements on gravity. Based on these observations, we make several recommendations about possible future direc-tions in earthquake-related research using gravity monitoring data. | ZHAN F. Benjamin ZHU Yiqing NING Jinsheng ZHOU Jiangcun LIANG Weifeng XU Yunma | 2011 | Geo-Spatial Information Science2011，14，1： | 5 |
| 8 | Detection of the Urinary Biomarkers PYD, CTX-Ⅱ, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China显示文摘Kashin-Beck disease(KBD) is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type Ⅱ collagen(CTX-Ⅱ), pyridinoline(PYD), and deoxypyridinoline(DPD) among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-Ⅱ, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805.59 ng/μmol.cre, 546.47 ng/μmol.cre, and 718.15 pml/μmol.cre, respectively. The differences between KBD patients and healthy controls were statistically significant(Z = 4.405, 3.653, and 3.724; P < 0.001). The higher levels of PYD, CTX-Ⅱ, and DPD detected in KBD patients indicate that they could be used as biomarkers of KBD. | ZHAO Zhi Jun PU Guang Lan ZHAN Pei Zhen LI Qiang WU Chun Ning WANG Li Hua | 2017 | Biomedical and Environmental Sciences2017，30，5： | 5 |
| 9 | Effects of sand-fixing and windbreak forests on wind flow:a synthesis of results from field experiments and numerical simulations显示文摘Sand-fixing and windbreak forests are widely used to protect or/and improve the ecological environments in arid and semi-arid regions. A full understanding of wind flow characteristics is essential to arranging the patterns of these protective forests for enhancing the effectiveness. In this study, the wind velocity over the underlying surface with sand-fixing forests and windbreak forests at the heights of 1–49 m was monitored from two 50-m high observation towers in an oasis of Minqin, Gansu Province of China. The wind velocities were simulated at different locations over these protective forests between those two towers by a two-dimensional Computational Fluid Dynamics(CFD) model. The results showed that at the heights of 1–49 m, the wind velocity profiles followed a classical logarithm law at the edge of the oasis and a multilayer structure inside the oasis. With increasing number of sand-fixing forest and windbreak forest arrays, the wind velocity at the heights of 1–49 m generally decreased along the downstream direction of the prevailing wind. Specifically, below the height of windbreak forests, the wind velocity decelerates as the airflow approaches to the windbreak forests and then accelerates as the airflow passes over the windbreak forests. In contrast, above the height of windbreak forests, the wind velocity accelerates as the airflow approaches to the windbreak forests and then generally decelerates as the airflow passes over the windbreak forests. Both the array number and array spacing of sand-fixing and windbreak forests could influence the wind velocity. The wind protection effects of sand-fixing forests were closely related to the array spacing of windbreak forests and increased with the addition of sand-fixing forests when the array of the forests was adequately spaced. However, if the array spacing of windbreak forests was smaller than seven times of the heights of windbreak forests, the effects were reduced or completely masked by the effects of windbreak forests. The results could offer theoretical guidelines on how to systematically arrange the patterns of sand-fixing and windbreak forests for preventing wind erosion in the most convenient and the cheapest ways. | ZHAN Kejie LIU Shizeng YANG Zihui FANG Etian ZHOU Lanping HUANG Ning | 2017 | Journal of Arid Land2017，9，1： | 4 |
| 10 | Repetitive Transcranial Magnetic Stimulation for the Treatment of Restless Legs Syndrome显示文摘 | Yi-Cong Lin Yang Feng Shu-Qin Zhan Ning Li Yan Ding Yue Hou Li Wang Hua Lin Ying Sun Zhao-Yang Huang Qing Xue Yu-Ping Wang | 2015 | Chinese Medical Journal2015，，13： | 4 |
| 11 | Runoff of arid and semi-arid regions simulated and projected by CLM-DTVGM and its multi-scale fluctuations as revealed by EEMD analysis显示文摘Runoff is a major component of the water cycle,and its multi-scale fluctuations are important to water resources management across arid and semi-arid regions.This paper coupled the Distributed Time Variant Gain Model(DTVGM)into the Community Land Model(CLM 3.5),replacing the TOPMODEL-based method to simulate runoff in the arid and semi-arid regions of China.The coupled model was calibrated at five gauging stations for the period 1980–2005 and validated for the period 2006–2010.Then,future runoff(2010–2100)was simulated for different Representative Concentration Pathways(RCP)emission scenarios.After that,the spatial distributions of the future runoff for these scenarios were discussed,and the multi-scale fluctuation characteristics of the future annual runoff for the RCP scenarios were explored using the Ensemble Empirical Mode Decomposition(EEMD)analysis method.Finally,the decadal variabilities of the future annual runoff for the entire study area and the five catchments in it were investigated.The results showed that the future annual runoff had slowly decreasing trends for scenarios RCP 2.6 and RCP 8.5 during the period 2010–2100,whereas it had a non-monotonic trend for the RCP 4.5 scenario,with a slow increase after the 2050 s.Additionally,the future annual runoff clearly varied over a decadal time scale,indicating that it had clear divisions between dry and wet periods.The longest dry period was approximately 15 years(2040–2055)for the RCP 2.6 scenario and 25 years(2045–2070)for the RCP 4.5 scenario.However,the RCP 8.5 scenario was predicted to have a long dry period starting from 2045.Under these scenarios,the water resources situation of the study area will be extremely severe.Therefore,adaptive water management measures addressing climate change should be adopted to proactively confront the risks of water resources. | NING Like XIA Jun ZHAN Chesheng ZHANG Yongyong | 2016 | Journal of Arid Land2016，8，4： | 4 |
| 12 | Studies on the structure and catalytic performance of S and P promoted Na-W-Mn-Zr/SiO_2 catalyst for oxidative coupling of methane显示文摘A series of Na-W-Mn-Zr/SiO2 catalysts promoted by different contents of S or/and P were prepared and their catalytic performance for oxidative coupling of methane was investigated to clarify the effect of S and P on the Na-W-Mn-Zr/SiO2 catalyst. The catalysts were characterized by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). From the characterization results, it is found that the addition of S and P to the Na-W-Mn-Zr/SiO2 catalyst helps the formation of active phases, such as α-cristobalite, Na2WO4, ZrO2, and Na2SO4. Moreover, the addition of S and P increases the concentration of surface-active oxygen species by improving the migration of active components from the bulk phase to the surface of the catalyst. According to the activity test, impressive methane conversion and C2 hydrocarbons yield were obtained at a low temperature of 1023 K over the six-component Na-W-Mn-Zr-S-P/SiO2 catalyst, which contained 2 wt% S and 0.4 wt% P simultaneously. The deactivation of Na-W-Mn-Zr-S-P/SiO2 was due to the loss of surface active components. | Wen Zheng, Dangguo Cheng, Ning Zhu, Fengqiu Chen, Xiaoli Zhan Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China | 2010 | Journal of Natural Gas Chemistry2010，19，1： | 4 |
| 13 | Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats显示文摘Our preliminary study found that the long noncoding RNA(LncRNA)-5657 can reduce the expression of inflammatory factors during inflammatory reactions in rat glial cells.However, the role played by LncRNA-5657 during septic brain injury remains unclear.In the present study, rat models of septic encephalopathy were established by cecal ligation and puncture, and then the rats were treated with a hippocampal injection small hairpin RNA(sh RNA) against LncRNA-5657(sh-LnCRNA-5657).The sh-LncRNA-5657 treatment reduced the level of neuronal degeneration and necrosis in the rat hippocampus, reduced the immunoreactivities of aquaporin 4, heparanase, and metallopeptidase-9, and lowered the level of tumor necrosis factor-alpha.Glial cells were pre-treated with sh-LncRNA-5657 and then treated with 1 μg/mL lipopolysaccharide.Sh-LncRNA-5657 transfection decreased the expression of LncRNA-5657 in lipopolysaccharide-treated glial cells and decreased the mRNA and protein levels of tumor necrosis factor-alpha, interleukin-1β, and interleukin-6.These findings suggested that LncRNA-5657 expression can significantly reduce the inflammatory reaction during septic encephalopathy and induce protective effects against this disease.This study was approved by the Institutional Ethics Committee at the First Affiliated Hospital of Nanchang University of China(approval No.2017-004) in 2017. | Yi-An Zhan Xin-Liang Qiu Xu-Zhen Wang Ning Zhao Ke-Jian Qian | 2021 | Neural Regeneration Research2021，16，7： | 3 |
| 14 | Structural properties and catalytic performance of the La-Cu-Zn mixed oxides for CO2 hydrogenation to methanol显示文摘A series of La-Cu-Zn-O mixed oxide catalysts were synthesized by a co-precipitation method and calcined under different temperatures. The XRD, BET, TPR, N_2 O-adsorption, XPS, SEM and TPD techniques were carried out to measure the aimed catalysts. The results indicated that the chemical environment of lanthanum element changes with the increase of calcination temperature. The La_2 CuO_4 perovskite structure is obtained at the temperature higher than 823 K and the special copper species appear in the perovskites due to the special structure property. The catalysts with La_2 CuO_4 perovskite structure show higher methanol selectivity compared with the mixed copper catalyst. For the perovskite catalysts, the conversion of CO_2 changes with the same tendency of the copper species ratio((Cu^(α+)+Cu^0)/(Cu_(Total))%), which implied both Cu^(α+) and Cu^0 are important active sites in the perovskite catalyst for the reaction. | Haijuan Zhan Zhiqiang Wu Ning Zhao Wanyi Liu Wei Wei | 2018 | Journal of Rare Earths2018，36，3： | 3 |
| 15 | The immunologic and hematopoietic profiles of mesenchymal stem cells derived from different sections of human umbilical cord显示文摘间充质的干细胞(MSC ) 广泛地在 allogeneic 干细胞移植被使用了。我们比较了 immunologic, MSC 的造血的特征源于整个人的脐的绳索(UC ) ,以及从 UC 的不同的节,包括羊膜的膜(AM ) ,沃顿的果冻(WJ ) ,和脐的容器(紫外) 。房间显型被流动 cytometry 检验。淋巴细胞转变测试和混合淋巴细胞反应被执行评估从 UC 导出的 MSC 的免疫调节的活动。cytokines 的 mRNA 表示被即时聚合酶链反应检测。造血的功能被文化 co MSC 学习, CD34 + 房间从绳索血孤立。我们的结果显示出包括 UC 与这四不同的节分开的那 MSC, WJ,紫外,并且 AM 有类似的生物特征。所有 MSC 有多系区别能力并且能区分进造骨细胞, adipocytes,和 chondrocytes。MSC 也以一种剂量依赖者方式禁止了 allogeneic T 房间的增长。cytokines 的相对 mRNA 表示被检验,并且结果显示出比 MSC 的有的更高的 interleukin-6 (IL6 ) , IL11,干细胞因素,和 FLT3 表示从 UC 的特定的节导出的那 UCMSC。当 co 有教养时, CD34 + 房间有高繁殖效率, MSC 源于 UC, UCMSC 在之中是最有效的喂层的不同的节。我们的学习证明 MSC 能与支持特征的类似的 immunomodulation 和造血作用从整个 UC 或 UC 的特定的节被孤立。 | Man Xu Bin Zhan Yuanlin Liu Jin Zhang Hongxia Sheng Rui Shi Li Liao Na Liu Jiangwei Hu Jun Wang Hongmei Ning Ting Liu Yi Zhang Hu Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 3 |
| 16 | Recent progress in perovskite solar cells:material science显示文摘Perovskite solar cells represent a promising third-generation photovoltaic technology with low fabrication cost and high power conversion efficiency.In light of the rapid development of perovskite materials and devices,a systematic survey on the latest advancements covering a broad range of related work is urgently needed.This review summarizes the recent major advances in the research of perovskite solar cells from a material science perspective.The discussed topics include the devices based on different type of perovskites(organic-inorganic hybrid,all-inorganic,and lead-free perovskite and perovskite quantum dots),the properties of perovskite defects,different type of charge transport materials(organic,polymeric,and inorganic hole transport materials and inorganic and organic electron transport materials),counter electrodes,and interfacial materials used to improve the efficiency and stability of devices.Most discussions focus on the key progresses reported within the recent five years.Meanwhile,the major issues limiting the production of perovskite solar cells and the prospects for the future development of related materials are discussed. | Jiang-Yang Shao Dongmei Li Jiangjian Shi Chuang Ma Yousheng Wang Xiaomin Liu Xianyuan Jiang Mengmeng Hao Luozheng Zhang Chang Liu Yiting Jiang Zhenhan Wang Yu-Wu Zhong Shengzhong(Frank)Liu Yaohua Mai Yongsheng Liu Yixin Zhao Zhijun Ning Lianzhou Wang Baomin Xu Lei Meng Zuqiang Bian Ziyi Ge Xiaowei Zhan Jingbi You Yongfang Li Qingbo Meng | 2023 | Science China Chemistry2023，66，1： | 3 |
| 17 | ExExperimental and numerical studies on the prediction of bendability limit of QSTE340 welded tube in NC bending process显示文摘For a low carbon steel tube with small wall factor D/t and bending radius R,the over-thinning induced localized necking is one dominant failure in tube numerical control(NC) bending process,which strongly restricts the bendability limit of the tube.In addition,the deterioration of bendability of a tube is increased by the existence of the weak weld region.Therefore,an important issue is how to determinate and predict the welded tube bendability limit.In the present study,a finite element(FE) model with weld and subdivided heat affected zones under ABAQUS platform is employed to explore the deformation behaviors of welded tube NC bending.A localized necking criterion based on the critical thickness thinning is used to predict the critical principal strains,critical bending radius and burst location during the forming process.It is found that the failures always occur at the rigid supporting point of mandrel flexible balls near the tangent point at the outside of the bend,where the wall thickness of the tube is the lowest.The bending limit curves(BLCs) of the QSTE340 welded tube are obtained by shifting the standard shaped forming limit curve to the critical principal strains along the major strain axis.Comparison between the numerical and experimental results has shown that the BLC and critical bending radius predictions agree well with the experimental results.In addition,the effect of weld positions on BLC is discussed,the weld region shows an almost negligible effect on the forming limit at a non-critical location that is far away from the outside of the bend.However,when the weld is at the large tensile deformation region on the outside of the bend,a decrease of the forming limit strains is seen. | YANG He REN Ning ZHAN Mei ZHANG ZhiYong QIN YaTao JIANG HaoMin DIAO KeShan CHEN XinPing | 2012 | Science China(Technological Sciences)2012，55，8： | 2 |
| 18 | Paclitaxel formulation with stable sustained-release behavior and its biological safety evaluation显示文摘Biological safety and stable sustained-release of the drug are two crucial issues involved in the formulation of paclitaxel.Focusing on these issues, by using the FDA approved polylactide as carrier material, soybean lecithin as surfactant and maltodextrin as thickener, paclitaxel loaded PLA microspheres were simply prepared by solvent evaporation, thus guaranteeing the biological safety. The introduction of maltodextrin as a thickener aided to a stable sustained-release of paclitaxel. Surface morphology, particle size, drug loading rate, encapsulation efficiency and in vitro drug release behavior were investigated.Biological safety evaluations such as acute toxicity, allergies, hemolysis, skin stimulation and genotoxicity test were also carried out. Results showed that the obtained microspheres were biocompatible and could release paclitaxel at a desirable constant rate.Therefore, the simply prepared paclitaxel formulation with good biological safety and desirable release behavior exhibited great potential of local injection of paclitaxel for the clinical use in the future. | LI XuePing ZHAN Qi QI HongZhao HAN DongLin QIN YaoYao CHEN Ning LONG LiXia ZHAO Jin HOU Xin YUAN XuBo YANG XianJin | 2019 | Science China(Technological Sciences)2019，62，7： | 2 |
| 19 | Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder:a randomized controlled trial显示文摘Background:Transcranial alternating current stimulation(tACS)offers a new approach for adult patients with major depressive disorder(MDD).The study is to evaluate the efficacy and safety of tACS treating MDD.Methods:This is an 8-week,double-blind,randomized,placebo-controlled study.Ninety-two drug-naive patients with MDD aged 18 to 65 years will receive 20 daily 40-min,77.5-Hz,15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks(week 4),following a 4-week observation period(week 8).The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale(HDRS-17)score≤7 at week 8.Secondary outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17,the proportion of participants having improvement in the clinical global impression-improvement,the change in HDRS-17 score(range,0-52,with higher scores indicating more depression)over the study,and variations of brain imaging and neurocognition from baseline to week 4.Safety will be assessed by vital signs at weeks 4 and 8,and adverse events will be collected during the entire study.Discussion:The tACS applied in this trial may have treatment effects on MDD with minimal side effects.Trial registration:Chinese Clinical Trial Registry,ChiCTR1800016479;http://gffzz62a03ee25e6f4a77hww0kx9uunqnf6n9b.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=22048. | Hong-Xing Wang Kun Wang Wen-Rui Zhang Wen-Feng Zhao Xiao-Tong Yang Li Wang Mao Peng Zhi-Chao Sun Qing Xue Yu Jia Ning Li Kai Dong Qian Zhang Shu-Qin Zhan Bao-Quan Min Chun-Qiu Fan Ai-Hong Zhou Hai-Qing Song Lu Yin Tian-Mei Si Jing Huang Jie Lu Hai-Xia Leng Wei-Jun Ding Yuan Liu Tian-Yi Yan Yu-Ping Wang | 2020 | Chinese Medical Journal2020，，1： | 2 |
| 20 | Highly active iridium catalyst for hydrogen production from formic acid显示文摘Formic acid(FA) dehydrogenation has attracted a lot of attentions since it is a convenient method for H_2 production. In this work, we designed a self-supporting fuel cell system, in which H_2 from FA is supplied into the fuel cell, and the exhaust heat from the fuel cell supported the FA dehydrogenation. In order to realize the system, we synthesized a highly active and selective homogeneous catalyst Ir Cp*Cl_2 bpym for FA dehydrogenation. The turnover frequency(TOF) of the catalyst for FA dehydrogenation is as high as7150 h^(-1)at 50°C, and is up to 144,000 h^(-1)at 90°C. The catalyst also shows excellent catalytic stability for FA dehydrogenation after several cycles of test. The conversion ratio of FA can achieve 93.2%, and no carbon monoxide is detected in the evolved gas. Therefore, the evolved gas could be applied in the proton exchange membrane fuel cell(PEMFC) directly. This is a potential technology for hydrogen storage and generation. The power density of the PEMFC driven by the evolved gas could approximate to that using pure hydrogen. | Ying Du Yang-Bin Shen Yu-Lu Zhan Fan-Di Ning Liu-Ming Yan Xiao-Chun Zhou | 2017 | Chinese Chemical Letters2017，28，8： | 2 |
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