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| 1 | Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder:a voxelbased morphometry study显示文摘Bipolar disorder and unipolar depressive disorder(UD) may be different in brain structure. In the present study,we performed voxel-based morphometry(VBM) to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder(BP1) and 23 patients with UD,and 23 age-,gender-,and educationmatched healthy controls(HCs) using magnetic resonance imaging. We found that compared with the HC and UD groups,the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus,while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition,correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together,the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD,and decreasedgrey matter volume in the right middle cingulate gyrus may be specifi c to BP1. | Yi Cai Jun Liu Li Zhang Mei Liao Yan Zhang Lifeng Wang Hongjun Peng Zhong He Zexuan Li Weihui Li Shaojia Lu Yuqiang Ding Lingjiang Li | 2015 | Neuroscience Bulletin2015，31，1： | 11 |
| 2 | Heterogeneous reaction of NO_2 on the surface of NaCl particles显示文摘The heterogeneous reaction of NO2 on NaCl particles has been investigated with the new sample preparation and the mode of gas-solid free diffusion. Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) is used to characterize the adsorbed products in situ, combined with Ion Chromatographic (IC), X-ray Photoelectron Spectroscopy (XPS) and Scan Electron Micros- copy (SEM). Our results indicate that the reaction is not limited to the surface of the NaCl particles, but penetrated into the upper layers. Surface reactive sites determine the reaction. Kinetic measurements show that nitrate formation on sodium chloride is second order in NO2 concentration and reactive uptake coefficient is (1.54 ± 0.70) × 10?5. | LI Hongjun ZHU Tong DING Jie CHEN Qi XU Bingye | 2006 | Science China Chemistry2006，49，4： | 9 |
| 3 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 4 | Numerical simulation for erosion effects of three-phase flow containing sulfur particles on elbows in high sour gas fields显示文摘Sulfur particles carried by high-speed flow impact pipelines,which may cause equipment malfunctions and even failure.This paper investigates the scouring effect of mist gas containing sulfur particles on elbows in highly sour gas fields.The multiphase-flow hydrodynamic model of the 90elbow was established by using the computational fluid dynamics(CFD)method.The scouring effects of the gasliquid mist fluid with the water-liquid fraction of 20%and particles with the diameter of 0.01 e0.05mm on elbows were explored within the flow velocity range of 0e20 m/s.In addition,the influences of secondary collision,mean curvature radius to diameter(R/D)ratio,inertial force,drag force,and Stokes number on trajectories of sulfur particles were studied.Moreover,the influences of hydrodynamic parameters of multiphase flow on corrosion inhibitor film were analyzed with the wall shear stress as the reference value.Serious erosion mainly occurred in the extrados of elbow as well as the junction between downstream pipeline and the intrados of elbow,the maximum erosion area occurs at 61.9.When the incident position of the particle was far away from the top of the inlet plane,the probability of secondary collision became smaller.Furthermore,the erosion rate decreased with the rise in the R/D radio.The maximum erosion rate of elbow increased with the increase in the Stoke number.The maximum erosion rate reached 0.428 mm/a at 0.05mm particle diameter and 20 m/s fluid velocity.The wall shear stress increased with the increase in fluid velocity and mass flow rate of particle,the fitting function of the wall shear stress curve was the Fourier type.The results indicated that highvelocity particles had a serious erosion effect on elbows and affected the stability of the corrosion inhibitor film.The erosion effect could be retarded by controlling the velocity and diameter of particles.The results provided technical supports for the safe production in highly sour gas fields. | Enbo Zhang Dezhi Zeng Hongjun Zhu Shuanggui Li Dongbo Chen Jie Li Yanyan Ding Gang Tian | 2018 | Petroleum2018，4，2： | 5 |
| 5 | Marek's disease virus VP22 enhances potentially the immune response of E SAT-6/CFP-10 against Mycobacterium bovis infection显示文摘对 Mycobacterium bovis 的当前可得到的疫苗,肺结核的原因的代理人,别提供可靠功效,因此对有改进功效的一支新奇疫苗有需要。这里,我们使用蛋白质 transduction 技术交付直接表示 mycobacterial 抗原指向房间的 DNA 疫苗。我们使用了包括 VP22 的领域(PTD ) 蛋白质从 Marek 的疾病病毒 serotype 结合的各种各样的蛋白质 transduction 1 (MDV-1 ) ,作为为编码抗原的 DNA 构造的交货系统,早能分泌的 antigenic target-6 kDa (ESAT-6 ) 蛋白质和文化过滤蛋白质 10 (CFP-10 ) M。bovis。真核细胞的表示 plasmid pZ106,编码抗原 ESAT-6 和 CFP-10,结合了到各种各样的 PTD,被用来构造试验性的准备。我们的调查结果与 CFP-10 独自或在联合表明了那 VP22 : ESAT-6 熔化蛋白质能传播进包围 transfected 房间的房间单层的所有原子核。而激活 trans transcriptional PTD 出现了,熔化蛋白质和 8R 肽的有限交货是不能的交付熔化蛋白质进任何 untransfected 房间。我们证明了有熔化到 VP22 的准备的那免疫导致更高的抗体和干扰素 -- titer (P < 0.05 ) 。一起拿,我们的结果证明 MDV-1 VP22 用 DNA 疫苗在基因治疗和免疫用作潜在的有免疫力的 enhancer,为 M 的预防提供一条新奇途径。bovis 感染。 | Hongjun Chen Wei Wang Cuiping Song Shengqing Yu Chan Ding | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 4 |
| 6 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 7 | Field Test of Optical and Electrical Fire Detectors in Simulated Fire Scenes in a Cable Tunnel显示文摘这份报纸论述火察觉者的三种类型的严峻的结果:电的热察觉到电报,光纤维拉曼温度察觉到察觉者,和光纤维布拉格栅栏(FBG ) 温度察觉到察觉者,在二模仿的火,在一个电报的场面掘。在有有限热放射和没有火焰的小规模的火,火警报仅仅来自直接与热来源一起联系的热传感器。在有大约 5 | Dian FAN Hongjun DING Dorothy Y. WANG Desheng JIANG | 2014 | Photonic Sensors2014，4，2： | 2 |
| 8 | Expression of calbindin D28K in substantia nigra of model rats with Parkinson disease显示文摘BACKGROUND: Previous researches suggested that expression level of calbindin D28K mRNA decreased in substantia nigra (SN) of model rats with Parkinson disease (PD), and this might be related to the decrease of anti-degeneration potentials of dopaminergic neurons. OBJECTIVE: To observe expression changes of calbindin D28K in SN dopaminergic neurons during their degeneration and death in midbrain of PD model rats. DESIGN: Completely randomized grouping design. SETTING: Department of Neurobiology, Xuzhou Medical College. MATERIALS: A total of 92 healthy male SD rats, with the age of 3 months, weighing 200-250 g, were selected from Experimental Animal Center of Xuzhou Medical College [certification: SCXK (su) 2003-0003]. Calbindin D28K(CB), tyroxine hydroxylase (TH), ABC kit, 6-hydroxydopamine (6-OHDA) and Nissl dyes were provided by Sigma Company, and sheep serum was provided by Beijing Zhongshan Company. METHODS: The experiment was carried out in the Neurobiological Center of Xuzhou Medical College from October 2003 to October 2004. ① With lot method, rats were divided into blank control group (n=28), experimental control group (n=28) and experimental group (n=36). Rats in experimental group were injected with 6-OHDA at right corpus striatum for PD modeling; rats in experimental control group were injected with saline at the same site; rats in blank control group did not give any injections. ② On the 7th, 14th, 21st and 28th days, SN segments on right midbrain from every 5 rats in experimental group were fixed, embedded with paraffin and cut into successively coronary pieces. Rats in other two groups were treated with the same methods and then stained with Nissl to show neuronal form. Meanwhile, CB and TH antibodies staining with immunohistochemistry were used to show CB containing dopaminergic neurons and dopaminergic neurons, and cells were calculated and observed under optic microscope. ③ On the 14th and 28th days, every 4 rats in experimental group and every 4 rats in control group were selected to obtain their brains and separate SN on the injured side. Western blot was used to detect expression of calbindin D28K, protein band was scanned with imaging equipment, and data were analyzed with LabWorks software. MAIN OUTCOME MEASURES: ① On the 7th, 14th, 21st and 28th days, Nissl staining results of SN neurons and immunohistochemical staining results of CB and TH antibodies; ② On the 14th and 28th days, Western blot results of calbindin D28K in SN neurons. RESULTS: Among 92 rats, 2 rats in experimental group died after 1 day due to 6-OHDA injection and other 90 rats were involved in the final analysis. ① Nissl staining results: On the 7th day of 6-OHDA injection, most neuronal somas on right SN pars compacta were shown as deep pycnosis or lysis breakage; on the 14th and 21st days, amount of neurons was decreased remarkably; on the 28th day, most neurons in SN pars compacta disappeared. ② Results of immunohistochemical staining: Amount of positive neurons of calbindin D28K in right SN pars compacta was not changed on the 7th day after 6-OHDA injection; on the 14th day, the amount was higher in experimental group than that in both control groups (P < 0.01) and was decreased till the 21st day, but it was still higher than that in the two control groups (P < 0.05); on the 28th day, positive neurons of calbindin D28K nearly disappeared, and the amount was lower than that in the two control groups (P < 0.01). In addition, on the 7th day after 6-OHDA injection into corpus striatum, positive TH neurons decreased 24% in right SN, and there was significant difference from that in control groups; on the 14th, 21st and 28th days, positive TH neurons decreased 37%, 46% and 64%, respectively. ③ Western blot results: On the 14th day after 6-OHDA injection into corpus striatum, expression of calbindin D28K in right SN was higher in experimental group than that in both control groups (P < 0.05); however, on the 28th day, the expression was lower than that in the two control groups (P < 0.01). CONCLUSION: During degeneration and death of dopaminergic neurons, CB expression in SN pars compacta increases firstly and decreased gradually. | Dianshuai Gao Hongmei Liu Yanxia Ding Hongjun Wang Yanqiang Wang | 2006 | Neural Regeneration Research2006，1，2： | 2 |
| 9 | Mineralogy,Fluid Inclusion and H-O-C-S Stable Isotopes of Mengqiguer Uranium Deposit in the Southern Yili Basin,Xinjiang:Implication for Ore Formation显示文摘The Mengqiguer deposit in the southern Yili basin Ili Basin is a large interlayer-oxidation-zone type uranium deposit.In this paper,we applied multiple methods including microscopic observation,scanning electron microscope and electronic probe,to analyze the systematical alteration characteristics of the ore-bearing sandstone layer.Fluid inclusion and stable isotope studies on the ore-bearing sandstone have also been carried out to discuss the internal relations between fluid activities,epigenetic alteration and the uranium mineralization.Major epigenetic alteration include clay alteration,carbonatization and pyritization,of which biogenetic pyritization is most closely related to the uranium mineralization.This suggests the existence of microorganism during the uranium mineralization process.The mineralization fluids of low temperature,medium density but varied salinities are suggested to be derived from multi-source,including the meteoric water and organic acidic vapor components from coal-bearing strata.Uranium mineralization,grain-dispersed kaolinite,limonite,colloidal pyrite,and the carbonate cements associated with sulfate-reducing bacteria were formed by meteoric water and vermicular-shaped kaolinite,autologous pyrite,and the carbonate cementation associated with the dehydroxylation of organic matter was formed by organic acidic.Based on these results,we consider that the uranium mineralization and epigenetic alteration both resulted from the reciprocity of organic–inorganic fluid and fluid–rock during the formation of the interlayer oxidation zone. | DING Bo LIU Hongxu ZHANG Chuang LIU Hongjun LI Ping ZHANG Bin | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 2 |
| 10 | Formation and microstructural characterization of whey protein isolate/beet pectin coacervations by laccase catalyzed cross-linking显示文摘 | Bingcan Chen Hongjun Li Yangping Ding Huayi Suo | 2012 | LWT - Food Science and Technology2012，，1： | 1 |
| 11 | Enhanced performance of a submerged membrane bioreactor with powdered activated carbon addition for municipal secondary effluent treatment显示文摘 | Lin Hongjun Wang Fangyuan Ding Linxian | 2011 | Journal of Hazardous Materials2011，192，3： | 1 |
| 12 | Enhanced performance of a submerged membrane bioreactor with powdered activated carbon addition for municipal secondary effluent treatment显示文摘 | LIN Hongjun WANG Fangyun DING Linxian | 2011 | Journal of Hazardous Materials2011，152，： | 1 |
| 13 | Purification of scrap aluminum fo il and aluminum melt covering and protecting &atomic purification theory显示文摘 | Ni Hongjun Sun Baode Ding Wenjiang | | 0，，03： | 1 |
| 14 | The Mycoplasma gallisepticum α-enolase is cell surface-exposed and mediates adherence by binding to chicken plasminogen显示文摘 | Hongjun Chen Shengqing Yu Xinyue Shen Danqing Chen Xvsheng Qiu Cuiping Song Chan Ding | 2011 | Microbial Pathogenesis2011，，： | 1 |
| 15 | Construction of mini-Tn4001 transposon vector for Mycoplasma gallisepticum显示文摘The detailed genetic analysis of mycoplasmas has long been hampered by the lack of appropriate tools for genetic manipulation. In this study, the transposon vector, mini-Tn4001tetM, was constructed containing the tnp gene, encoding a transposase gene in Staphylococcus aureus, two copies of the IS256 inverted repeat sequence (inner and outer) and the tetM gene, from the Enterococcus faecalis Tn916 transposon, conferring resistance to tetracycline. This vector was electro-transformed into Mycoplasma gallisepticum (MG). The recombinant cells were screened by tetracycline selection. The results indicated that the transposon vector could replicate in MG strain R by successive passages, indicating that MG is a potential vector for expressing protective antigens of other pathogens. | CHEN HongJun, ZHAO ChunMei, SHEN XieYue, CHEN DanQing, YU ShengQing & DING Chan Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China | 2010 | Science China(Life Sciences)2010，53，11： | 1 |
| 16 | Large-area flexible and transparent UV photodetector based on cross-linked Ag NW@ZnO NRs with high performance显示文摘A series of large-area,flexible and transparent ultraviolet(UV)photodetectors(PDs)based on Ag nanowire(NW)@ZnO nanorods(NRs)are fabricated by an inexpensive,facile and effective approach.These Ag NW@ZnO NRs are successfully synthesized using a two-step method in an oil bath with a high surface-to-volume ratio and good crystallinity.The PDs are fabricated by drop-coating with different drop-coating times on the surface of polyethylene terephthalate(PET)coupled with Au electrodes.By optimizing the cross-linked network of Ag NW@ZnO NRs,PD2 with a size greater than 25 mm exhibits excellent photoresponse under UV light illumination of 365 nm(1.3 m W cm^(-2))with a bias of 5 V:a high sensitivity of over 10^(3),and a much shorter rise/decay time of 2.6 s/2.3 s.Simultaneously,the detector exhibits an average transmittance of more than 70%in the visible light region,as well as good flexibility and excellent mechanical stability under a bending angle of 120°over 1000 circles bending.These integral advantages have significant potential for practical applications and mass production. | Lin Zhang Nuomei Li Qiuchen Ma Jiahui Ding Chuang Chen Zhaocheng Hu Weiwei Zhao Yufeng Li Huanhuan Feng Mingyu Li Hongjun Ji | 2022 | Journal of Materials Science & Technology2022，，15： | 1 |
| 17 | Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus显示文摘 | Chunchun Meng Xvsheng Qiu Shiqiang Jin Shengqing Yu Hongjun Chen Chan Ding | 2012 | Archives of Virology2012，，5： | 1 |
| 18 | Recent progress of quantum dots for energy storage applications显示文摘The environmental problems of global warming and fossil fuel depletion are increasingly severe,and the demand for energy conversion and storage is increasing.Ecological issues such as global warming and fossil fuel depletion are increasingly stringent,increasing energy conversion and storage needs.The rapid development of clean energy,such as solar energy,wind energy and hydrogen energy,is expected to be the key to solve the energy problem.Several excellent literature works have highlighted quantum dots in supercapacitors,lithium-sulfur batteries,and photocatalytic hydrogen production.Here,we outline the latest achievements of quantum dots and their composites materials in those energy storage applications.Moreover,we rationally analyze the shortcomings of quantum dots in energy storage and conversion,and predict the future development trend,challenges,and opportunities of quantum dots research. | Quan Xu Yingchun Niu Jiapeng Li Ziji Yang Jiajia Gao Lan Ding Huiqin Ni Peide Zhu Yinping Liu Yaoyao Tang Zhong-Peng Lv Bo Peng Travis Shihao Hu Hongjun Zhou Chunming Xu | 2022 | Carbon Neutrality2022，1，1： | 1 |
| 19 | Enhanced performance of a submerged membrane bioreactor with powdered activated carbon addition for municipal secondary effluent treatment显示文摘 | LIN Hongjun WANG Fangyuan DING Linxian | 2011 | Journal of Hazardous Materials2011，192，3： | 1 |
| 20 | Formation and microstructural characterization of whey protein isolate/ beet pectin coacervations by laccase catalyzed cross-linking 显示文摘 | Chen Bingcan Li Hongjun Ding yangping | 2012 | LWT- Food Science and Technology2012，47，1： | 1 |
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