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1Analysis of status and countermeasures of cancer incidence and mortality in China显示文摘Cancer is the leading cause of human deaths in the world and produces serious economic burdens. On September 12, 2018, the academic journal A Cancer Journal for Clinicians published an article about the latest statistics of cancers worldwide, which provided a status report on the global burden of 36 cancers in 185 countries worldwide. Cancer has also become a serious public health problem in China and caused more and more attention of the government and people in recent years. This review analyzes the incidence, mortality and prevalent trend of cancers in China, discusses the reasons behind this status, and reviews the potential countermeasures for cancer prevention and control in China.Chunchun Wu Mengna Li Hanbing Meng Yukun Liu Weihong Niu Yao Zhou Ran Zhao Yumei Duan Zhaoyang Zeng Xiaoling Li Guiyuan Li Wei Xiong Ming Zhou 2019Science China(Life Sciences)2019,62,5:175
2Comparative study of gas accumulations in the Permian Changxing reefs and Triassic Feixianguan oolitic reservoirs between Longgang and Luojiazhai-Puguang in the Sichuan Basin显示文摘Reef and oolitic gas reservoirs in the Permian Changxing and Triassic Feixianguan formations have been discovered in both the Luojiazhai-Puguang and Longgang areas of the Sichuan Basin, but the accumulation scale, abundance and distribution patterns differ greatly. In fact, the two areas have more differences than they have similarities. Similarities include: (1) the lithology, properties and types of porosity of the reef and oolitic reservoirs are primarily consistent in the two areas; (2) well-developed regional caprocks that seal the fluid system; and (3) accumulation process histories, with liquid hydrocarbon charging at an early stage, cracking into gas at a high to over-mature stage, adjustment of gas reservoirs at an uplifting stage, and final reservoir generation at a late stage. Differences include: (1) gas accumulations in the Luojiazhai-Puguang area that are dominated by oil-type cracked gas, with multiple and sufficient gas sources, contrasting with gas accumulations in the Longgang area that are dominated by coal-sourced gas with insufficient gas sources; (2) heterogeneity and horizontal diversity of reservoirs in the Longgang area that are stronger than in the Luojiazhai-Puguang area; and (3) the development of deep and large faults in the Luojiazhai-Puguang area that link source, reservoir and migration pathways, contrasting with poorly developed faults in Longgang area, where laterally variable fractures are the major migration pathway. Because of these differences, abundant large-scale structurally-controlled gas accumulations are developed in the Luojiazhai-Puguang area, whereas lithology plays a more important role in gas accumulation in the Longgang area where accumulations are smaller-scale and have lower gas-bearing abundance. We suggest that future exploration for reef and oolitic gas accumulations should be strengthened in NE Sichuan and NW Sichuan Jiulongshan. In particular, the transitional zone between Longgang and Kaijiang-Liangping Bay has the best potential for new discoveries.ZHAO WenZhi XU ChunChun WANG TongShan WANG HongJun WANG ZeCheng BIAN CongSheng LI Xia 2011Chinese Science Bulletin2011,56,31:21
3Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan 2018Cell Research2018,28,5:12
45-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer显示文摘Non-small-cell lung cancer(NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine(5 hmC) signatures in circulating cell-free DNA(cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here,we employed a sensitive and reliable method to map genome-wide 5 hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5 hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identified six potential biomarkers from 66 patients and 67 healthy controls(mean decrease accuracy>3.2, P < 3.68E-19) using machine-learning-based tumor classifiers with high accuracy. Thus,the unique signature of 5 hmC in tumor patient's cfDNA identified in our study may provide valuable information in facilitating the development of new diagnostic and therapeutic modalities for NSCLC.Ji Zhang Xiao Han Chunchun Gao Yurong Xing Zheng Qi Ruijuan Liu Yueqin Wang Xiaojian Zhang Yun-Gui Yang Xiangnan Li Baofa Sun Xin Tian 2018Genomics, Proteomics & Bioinformatics2018,16,3:7
5Ethylene glycol-assisted synthesis, photoelectrochemical and photocatalytic properties of BiOI microflowers显示文摘Hierarchical bismuth oxyiodide(BiOI) microflower photocatalysts were synthesized by hydrolysis at room temperature. The concentration of ethylene glycol modulated the resulting BiOI morphology. The morphology, elemental composition, crystal phase structure, and absorption properties of the BiOI samples were characterized. Under visible light irradiation(k [ 400 nm), BiOI(S10) with a microflower morphology exhibited the highest photocatalytic activity in the degradation of methyl orange. The corresponding apparent pseudo-first-order rate constant was 0.826 h-1. The trend in photocatalytic activities of the prepared BiOI samples coincided with the trend in their photocurrents. A strategy for preparing hierarchical BiOI microflowers with good visible lightinduced photocatalytic activity is provided.Haili Lin Chunchun Zhou Jing Cao Shifu Chen 2014Chinese Science Bulletin2014,59,27:7
6Evaluation of droplet deposition and effect of variable-rate application by a manned helicopter with AG-NAV Guía system显示文摘The variable-rate application is an important aspect of precision agriculture.In order to determine the regular patterns of droplet deposition and compare the actual variable-rate spraying effect of the AS350B3e helicopter with the AG-NAV Guía system,spray tests were conducted with different operating parameters and operating methods.In this study,the deposition distribution of droplets in the effective swath area was evaluated for six single-pass applications at four different flight velocities.The effects of adding adjuvant on droplet deposition,drift and droplet size were compared,and the actual variable effect of the forth-back application was verified.The analysis results showed that the position of the effective swath area was affected by natural wind velocity and wind direction,and would shift to the downwind direction area from the helicopter route of a different degree.The effective swath width increased slowly and then decreased sharply with the increase of flight velocity.It was found that flight velocity of 100 km/h was the peak inflection point of effective spray width variation.Moreover,the effect of flight velocity on the distribution uniformity of droplet deposition in the effective swath area was not significant.In the single-pass application of 90 km/h,adding adjuvant could increase droplet size in the effective swath area.The deposition increased by 8.98%,and the total drift decreased by 28.65%,of which the upwind drift decreased by 28.31%and the downwind drift decreased by 29.06%.In the forth-back application of 90 km/h,the error between actual application volume and system setting dose was 12%.The results of this study can provide valuable references for future research and practices on variable-rate aerial applications by manned helicopters.Weixiang Yao Yubin Lan Sheng Wen Huihui Zhang Yali Zhang Juan Wang Chunchun Xie 2019International Journal of Agricultural and Biological Engineering2019,12,1:6
7Preparation, characterization, antimicrobial and cytotoxicity studies of copper/zincloaded montmorillonite显示文摘Background: A series of modified montmorillonites(Mt) including zinc-loaded Mt(Zn-Mt), copper-loaded Mt(Cu-Mt), copper/zinc-loaded Mt with different Cu/Zn ratio(Cu/Zn-Mt-1, Cu/Zn-Mt-2, Cu/Zn-Mt-3) were prepared by an ion-exchange reaction, and characterized using X-ray diffraction(XRD), fourier transformed infrared spectroscopy(FTIR) and transmission electron microscopy(TEM). The specific surface areas, antimicrobial activity and cytotoxicity of the modified Mt were investigated.Results: In the modified Mt, hydrated Cu ions and Zn ions were exchanged in the interlayer space of Mt and the particles were irregular shapes. The results showed that Cu/Zn-Mt enhanced antibacterial and antifungal activity compared with Zn-Mt and Cu-Mt possibly due to the synergistic effect between Cu and Zn. Among the Cu/Zn-Mt with different Cu/Zn raitos, Cu/Zn-Mt with a Cu/Zn ratio of 0.98 or 0.51 showed higher antimicrobial activity against gram-negative bacteria(Escherichia coli), gram-positive bacteria(Staphylococcus aureus), fungi(Candida albicans).Moreover, the antimicrobial activity of Cu/Zn-Mt was correlated with its specific surface area. Cytotoxicity studies on IPEC-J2 cell showed a slight cytotoxicity of Cu/Zn-Mt.Conclusions: The current data provide clear evidence that in terms of its antimicrobial activity and relatively low toxicity, the Cu/Zn-Mt holds great promise for applications in animal husbandry.Lefei Jiao Fanghui Lin Shuting Cao Chunchun Wang Huan Wu Miaoan Shu Caihong Hu 2017Journal of Animal Science and Biotechnology2017,8,3:4
8Effects of Rice-Fish Co-culture on Oxygen Consumption in Intensive Aquaculture Pond显示文摘Rice-fish co-culture has gained increasing attention to remediate the negative environmental impacts induced by intensive aquaculture. However, the effect of rice-fish co-culture on oxygen depletion has rarely been investigated. We constructed a rice-fish co-culture system in yellow catfish(Pelteobagrus fulvidraco) and freshwater shrimp(Macrobrachium nipponense) ponds using a new high-stalk rice variety, and conducted a field experiment to investigate the effect of rice-fish co-culture on water parameters and oxygen consumption. The results showed that rice-fish co-culture reduced the nutrients(total nitrogen, ammonia-N, total phosphorous and potassium) and the dissolved oxygen content in fish and shrimp ponds. However, they showed similar seasonal change of dissolved oxygen in the water of fish and shrimp ponds. Rice-fish co-culture reduced the total amount of oxygen consumption and optimized the oxygen consumption structure in pond. The respiration rates in water and sediment were significantly reduced by 66.1% and 31.7% in the catfish pond, and 64.4% and 38.7% in the shrimp pond, respectively, by additional rice cultivation. Rice-fish co-culture decreased the proportions of respiration in sediment and water, and increased the proportion of fish respiration. These results suggest that rice-fish co-culture is an efficient way to reduce hypoxia in intensive culture pond.LI Fengbo SUN Zhiping QI Hangying ZHOU Xiyue XU Chunchun WU Dianxin FANG Fuping FENG Jinfei ZHANG Ning 2019Rice science2019,26,1:4
9Impact of Rice-Catfish/Shrimp Co-culture on Nutrients Fluxes Across Sediment-Water Interface in Intensive Aquaculture Ponds显示文摘Exchange of nitrogen and phosphorus across sediment-water interface plays an important role in the management of nutrient recycling in the aquaculture pond. In this study, a plot experiment was conducted to study the effect of rice-catfish/shrimp co-culture on the micro-profile of oxygen (O2), pH and nutrient exchange across sediment-water interface in the intensive culture ponds. The results showed that rice-catfish co-culture increased the concentration and penetrating depth of O2, but decreased the pH value across the sediment-water interface, compared with catfish monoculture. Additional rice cultivation significantly reduced the flux rates of ammonium (NH4+) and nitrate (NO3-) across sediment-water interface in the catfish and shrimp ponds. The flux rates of NO2 - and soluble phosphorus (PO43-) showed no significant difference between rice-catfish/shrimp co-culture ponds and catfish/shrimp monoculture ponds. Rice only affected the dissolved inorganic nitrogen and phosphorus fractions in the sediment. The concentrations of NH4 + were significantly lower in the sediment of co-culture ponds than in the monoculture ponds. Additional rice cultivation also significantly reduced the content and percentage of dissolved inorganic phosphorus in the sediment of catfish ponds.LIU Yaobin QIN Lin LI Fengbo ZHOU Xiyue XU Chunchun JI Long CHEN Zhongdu FENG Jinfei FANG Fuping 2019Rice science2019,26,6:4
10Epidemiological characteristics and temporal-spatial analysis of overseas imported dengue fever cases in outbreak provinces of China, 2005–2019显示文摘Background Overseas imported dengue fever is an important factor in local outbreaks of this disease in the mainland of China.To better prevent and control such local outbreaks,the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in provincial-level administrative divisions(PLADs)where dengue fever is outbreak in the mainland of China were explored.Methods Using the Chinese National Notifiable Infectious Disease Reporting Information System(CNNDS),we identified overseas imported dengue fever cases in dengue fever outbreak areas in the mainland of China from 2005 to 2019 to draw the epidemic curve and population characteristic distribution of overseas imported cases in each PLAD.Based on spatial autocorrelation analysis of ArcGIS 10.5 and temporal-spatial scanning analysis of SaTScan 9.5,we analyzed the temporal-spatial distribution of overseas imported dengue fever in dengue fever outbreak areas in the mainland of China.Results A total of 11,407 imported cases,mainly from Southeast Asia,were recorded from 2005 to 2019 in these 13 PLADs.Of which 62.1%were imported into Yunnan and Guangdong Provinces.Among the imported cases,there were more males than females,mainly from the 21–50 age group.The hot spots were concentrated in parts of Yunnan,Guangdong and Fujian Provinces.We found the cluster of infected areas were expanding northward.Conclusions Based on the analysis of overseas imported dengue cases in 13 PLADs of the mainland of China from 2005 to 2019,we obtained the epidemiological characteristics and spatial distribution of imported dengue cases.Border controls need to pay attention to key population sectors,such as 21–50 years old men and education of key populations on dengue prevention.There is a need to improve the awareness of the prevention and control of imported cases in border areas.At the same time,northern regions cannot relax their vigilance.Xinchang Lun Yiguan Wang Chunchun Zhao Haixia Wu Caiying Zhu Delong Ma Mingfang Xu Jun Wang Qiyong Liu Lei Xu Fengxia Meng 2022Infectious Diseases of Poverty2022,11,1:3
11A low-firing melilite ceramic Ba2CuGe207 and compositional modulation on microwave dielectric properties through Mg substitution显示文摘A melilite Ba2CuGe2O7 ceramic was characterized by low sintering temperature and moderate microwave dielectric properties.Sintered at 960℃,the Ba2CuGe2O7 ceramic had a high relative density 97%,a low relative permittivity(εr)9.43,a quality factor(Q×f)of 20,000 GHz,and a temperature coefficient of resonance frequency(τf)-76 ppm/℃.To get a deep understanding of the relationship between composition,structure,and dielectric performances,magnesium substitution for copper in Ba2CuGe2O7 was conducted.Influences of magnesium doping on the sintering behavior,crystal structure,and microwave dielectric properties were studied.Mg doping in Ba2CuGe2O7 caused negligible changes in the macroscopic crystal structure,grain morphology,and size distribution,while induced visible variation in the local structure as revealed by Raman analysis.Microwave dielectric properties exhibit a remarkable dependence on composition.On increasing the magnesium content,the relative permittivity featured a continuous decrease,while both the quality factor and the temperature coefficient of resonance frequency increased monotonously.Such variations in dielectric performances were clarified in terms of the polarizability,packing fraction,and band valence theory.Changzhi YIN Zezong YU Longlong SHU Laijun LIU Yan CHEN Chunchun LI 2021Journal of Advanced Ceramics2021,10,1:3
12The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen显示文摘Dear Editor,Rabbit hemorrhagic disease(RHD)is a fatal infectious disease that primarily affects adult rabbits and causes great economic losses in the rabbit industry(Mitro and Krauss,1993).The causative pathogen is rabbit hemorrhagic disease virus(RHDV),which belongs to the genus Lagovirus and the family Calicivirus(Moussa et al.,1992).In 1984,RHDV was first documented in China.Ruibin Qi Chunchun Meng Jie Zhu Hang Li Qiuhong Miao Jingyu Tang Aoxing Tang Hongyuan Guo Chuncao Liu Chuanfeng Li Zongyan Chen Fang Wang Qinwen Zhang Guangqing Liu 2022Virologica Sinica2022,37,4:3
13AEROELASTIC PROPERTIES OF SANDWICH BEAM WITH PYRAMIDAL LATTICE CORE CONSIDERING GEOMETRIC NONLINEARITY IN THE SUPERSONIC AIRFLOW显示文摘The equation of motion of sandwich beam with pyramidal lattice core in the supersonic flow considering geometric nonlinearity is formulated using Hamilton's principle. The piston theory is used to evaluate aerodynamic pressure. The structural aeroelastic properties are analyzed using frequency- and time-domain methods, and some interesting phenomena are observed. It is noted that the flutter of sandwich beam occurs under the coupling effect of low order modes. The critical flutter aerodynamic pressure of the sandwich beam is higher than that of the isotropic beam with the same weight, length and width. The influence of inclination angle of core truss on flutter characteristic is analyzed.Fengming Li Zhiguang Song Chunchun Sun 2015Acta Mechanica Solida Sinica2015,28,6:3
14Effects of dietary tributyrin on intestinal mucosa development,mitochondrial function and AMPK-mTOR pathway in weaned pigs显示文摘Background:The objective of this experiment was to investigate the influence of dietary tributyrin on intestinal mucosa development,oxidative stress,mitochondrial function and AMPK-mTOR signaling pathway.Methods:Seventy-two pigs were divided into two treatments and received either a basal diet or the same diet supplemented with 750 mg/kg tributyrin.Each treatment has six replicates of six pigs.After 14 days,6 pigs from each treatment were selected and the jejunal samples were collected.Results:Results showed that supplemental tributyrin increased(P<0.05)villus height and villus height:crypt depth of weaned pigs.Pigs fed tributyrin had greater(P<0.05)RNA/DNA and protein/DNA ratios than pigs on the control group.The mRNA levels of sodium glucose transport protein-1 and glucose transporter-2 in the jejunum were upregulated(P<0.05)in pigs fed the tributyrin diet.Dietary tributyrin supplementation lowered(P<0.05)the malondialdehyde and hydrogen peroxide(H2O2)content in jejunum,enhanced(P<0.05)the mitochondrial function,as demonstrated by decreased(P<0.05)reactive oxygen species level and increased(P<0.05)mitochondrial membrane potential.Furthermore,tributyrin increased(P<0.05)mitochondrial DNA content and the mRNA abundance of genes related to mitochondrial functions,including peroxisomal proliferator-activated receptor-γcoactivator-1α,mitochondrial transcription factor A,nuclear respiratory factor-1 in the jejunum.Supplementation with tributyrin elevated(P<0.05)the phosphorylation level of AMPK and inhibited(P<0.05)the phosphorylation level of mTOR in jejunum compared with the control group.Conclusions:These findings suggest that dietary supplementation with tributyrin promotes intestinal mucosa growth,extenuates oxidative stress,improves mitochondrial function and modulates the AMPK-mTOR signal pathway of weaned pigs.Chunchun Wang Shuting Cao Zhuojun Shen Qihua Hong Jie Feng Yan Peng Caihong Hu 2020Journal of Animal Science and Biotechnology2020,11,2:3
15Inhibition of Axinl in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation显示文摘Axinl is a negative regulator of β-catenin signaling and its role in osteoblast precursor cells remains undefined.In the present studies,we determined changes in postnatal bone growth by deletion of Axinl in osteoblast precursor cells and analyzed bone growth in newborn and postnatal Axin1 O5X mice and found that hypertrophic cartilage area was largely expanded in AxinlOSX KO mice.A larger number of chondrocytes and unabsorbed cartilage matrix were found in the bone marrow cavity of Axin1OSX KO mice.Osteoclast formation in metaphyseal and subchondral bone areas was significantly decreased,demonstrated by decreased TRAPpositive cell numbers,associated with reduction of MMP9-and cathepsin K-positive cell numbers in Axin1 O5X KO mice.OPG expression and the ratio of O p g to Rankl were significantly increased in osteoblasts of Axinl O5X KO mice.Osteoclast formation in primary bone marrow derived microphage(BMM)cells was significantly decreased when BMM cells were cultured with conditioned media(CM)collected from osteoblasts derived from Axin1OSX mice compared with BMM cells cultured with CM derived from WT mice.Thus,the loss of Axinl in osteoblast precursor cells caused increased OPG and the decrease in osteoclast formation,leading to delayed bone growth in postnatal Axin1°sx KO mice.Bing Shu Yongjian Zhao Shitian Zhao Haobo Pan Rong Xie Dan Yi Ke Lu Junjie Yang Chunchun Xue Jian Huang Jing Wang Dongfeng Zhao Guozhi Xiao Yongjun Wang Di Chen 2020Bone Research2020,8,3:3
16Microstructures and mechanical properties of extruded Mg-2Sn-xYb(x=0,0.1,0.5 at.%)sheets显示文摘Microstructures and mechanical properties of extruded Mg-2Sn-xYb(x=0,0.1,0.5 at.%)sheets were investigated.The grain size of as-cast Mg-2Sn alloy is significantly reduced with increasing Yb concentration.In addition toα-Mg and Mg_(2)Sn phase,some fine Mg_(2)(Sn,Yb)particles are observed in as-cast Mg-2Sn-0.5Yb alloy,but these fine particles are not observed in as-cast Mg-2Sn-0.1Yb alloy due to a high solubility of Yb in Mg matrix.Tensile tests demonstrated that extruded Mg-2Sn-0.5Yb sheet exhibited the highest tensile strength and available elongation to failure at room temperature,while extruded Mg-2Sn-0.1Yb alloy exhibited the highest tensile properties at 100°C and 200°C.The difference in the tensile properties of extruded sheets mainly arises from the different strengthening roles of grain refinement,solid solution strengthening and precipitation strengthening of particles.Jing Jiang Guangli Bi Jiaan Liu ChunChun Ye Jianshe Lian Zhonghao Jiang 2014Journal of Magnesium and Alloys2014,2,3:2
17Rationally designed Ta_(3)N_(5)/BiOCl S-scheme heterojunction with oxygen vacancies for elimination of tetracycline antibiotic and Cr(Ⅵ):Performance,toxicity evaluation and mechanism insight显示文摘S-scheme heterojunction photocatalysts have been the“stars”in the field of photocatalysis.Herein,a novel S-scheme heterojunction of Ta_(3)N_(5)/BiOCl with oxygen vacancies(OVs)was fabricated via a facile method.The charge separation and transport mechanism of this Ta_(3)N_(5)/BiOCl S-scheme heterojunction was verified by the analyses of band energy structures,active species,photoelectric behaviors and DFT theoretical calculation.Compared with Ta_(3)N_(5)and BiOCl,the Ta_(3)N_(5)/BiOCl unveils substantially upgraded photocatalytic property under visible light,and the photocatalytic efficiency for removal of tetracycline(TC)and hexavalent chromium(Cr(VI))reaches 89.6%and 91.6%,respectively.The substantial enhancement of the photocatalytic activity is attributed to the synergistic effect of the S-scheme hetero-structure and oxygen vacancies,which improves the visible-light absorption,while promoting the spatial separation of charge carriers with the optimum redox capacity,thereby boosting the production of active species for catalytic reactions.The TC degradation pathway is deduced and the toxicity evolution of TC is appraised using the QSAR method.In a nutshell,this work gives a deep understanding of the photocatalytic mechanism based on Ta_(3)N_(5)/BiOCl as well as presents a newfangled thought for developing highly efficient S-scheme heterojunction photocatalysts for water decontamination.Shijie Li Mingjie Cai Chunchun Wang Yanping Liu Neng Li Peng Zhang Xin Li 2022Journal of Materials Science & Technology2022,,28:2
18Ste- reoselective inclusion mechanism of ketoprofen into fl- cyclodextrin: insights from molecular dynamics simu- lations and free energy calculations 显示文摘Mingsong Shi Chunchun Zhang Yani Xie 2014Theoretical ChemistryAccounts2014,133,10:1
19The effect of amount of water and ratio of TEOS/MTES on anti-corrosion property of organic-inorganic film 显示文摘CHEN Yuan WU Chunchun Rare Met Mater Eng (in Chinese)0,,:1
20Characterization of interfacial reaction products in alumina fiber/ barium zir-conate coating/alumina matrix composite 显示文摘Zhong Chunchun Duncan S Chawla K K etal 2002Materials Characterization2002,48,:1
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