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| 1 | A New SHRIMP Age of the Xiamaling Formation in the North China Plate and Its Geological Significance显示文摘建立 hypostratotype 近来前寒武纪是关于中央的研究的主要目的 -- 并且在诺思中国的 Neoproterozoic。chronostratigraphic 位置是在这研究的钥匙。然而,许多关键地平线没与高质量的同位素的年龄被校准。用有敏感高分辨率的离子 Microprobe (虾 II ) 的报导新 U-Pb 年龄,锆石 U-Pb 年龄在诺思中国板中在 Xiamaling 形成灰床被获得,产出 1368+-12 妈的加权的吝啬的 ^(206 )Pb/^(238 ) U 年龄。现在是从在北方中国板中的 Xiamaling 形成的第一虾 U-Pb 年龄,并且代表 Xiamaling 形成的中间的部分的扔的时间。锆石年龄起一个重要作用到在中央期间理解北方中国板的地质的进化 -- 并且 Neoproterozoic。 | GAO Linzhi ZHANG Chuanheng SHI Xiaoying ZHOU Hongrui WANG Ziqiang SONG-Biao | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 35 |
| 2 | Decratonic gold deposits显示文摘The North China Craton(NCC) hosts numerous gold deposits and is known as the most gold-productive region of China. The gold deposits were mostly formed within a few million years in the Early Cretaceous(130–120 Ma), coeval with widespread occurrences of bimodal magmatism, rift basins and metamorphic core complexes that marked the peak of lithospheric thinning and destruction of the NCC. Stable isotope data and geological evidence indicate that ore-forming fluids and other components were largely exsolved from cooling magma and/or derived from mantle degassing during the period of lithospheric extension. Gold mineralization in the NCC contrasts strikingly with that of other cratons where gold ore-forming fluids were sourced mostly from metamorphic devolatization in compressional or transpressional regimes. In this paper, we present a summary and discussion on time-space distribution and ore genesis of gold deposits in the NCC in the context of the timing, spatial variation, and decratonic processes. Compared with orogenic gold deposits in other cratonic blocks, the Early Cretaceous gold deposits in the NCC are quite distinct in that they were deposited from magma-derived fluids under extensional settings and associated closely with destruction of cratonic lithosphere. We argue that Early Cretaceous gold deposits in the NCC cannot be classified as orogenic gold deposits as previously suggested, rather, they are a new type of gold deposits, termed as 'decratonic gold deposits' in this study. The westward subduction of the paleo-West Pacific plate(the Izanagi plate) beneath the eastern China continent gave rise to an optimal tectonic setting for large-scale gold mineralization in the Early Cretaceous. Dehydration of the subducted and stagnant slab in the mantle transition zone led to continuous hydration and considerable metasomatism of the mantle wedge beneath the NCC. As a consequence, the refractory mantle became oxidized and highly enriched in large ion lithophile elements and chalcophile elements(e.g., Cu, Au, Ag and Te). Partial melting of such a mantle would have produced voluminous hydrous, Au- and S-bearing basaltic magma, which, together with crust-derived melts induced by underplating of basaltic magma, served as an important source for ore-forming fluids. It is suggested that the Eocene Carlin-type gold deposits in Nevada, occurring geologically in the deformed western margin of the North America Craton, are comparable with the Early Cretaceous gold deposits of the NCC because they share similar tectonic settings and auriferous fluids. The NCC gold deposits are characterized by gold-bearing quartz veins in the Archean amphibolite facies rocks, whereas the Nevada gold deposits are featured by fine-grained sulfide dissemination in Paleozoic marine sedimentary rocks. Their main differences in gold mineralization are the different host rocks, ore-controlling structures, and ore-forming depth. The similar tectonic setting and ore-forming fluid source, however, indicate that the Carlin-type gold deposits in Nevada are actually analogous to decratonic gold deposits in the NCC. Gold deposits in both the NCC and Nevada were formed in a relatively short time interval(<10 Myr) and become progressively younger toward the subduction zone. Younging of gold mineralization toward subduction zone might have been attributed to retreat of subduction zone and rollback of subducted slab. According to the ages of gold deposits on inland and marginal zones, the retreat rates of the Izanagi plate in the western Pacific in the Early Cretaceous and the Farallon plate of the eastern Pacific in the Eocene are estimated at 8.8 cm/yr and 3.3 cm/yr, respectively. | ZHU RiXiang FAN HongRui LI JianWei MENG QingRen LI ShengRong ZENG QingDong | 2015 | Science China Earth Sciences2015，58，9： | 37 |
| 3 | Coesite inclusions in zircon from gneisses identified by laser Raman microspectrometer in ultra-high pressure zone of Dabie Mountains,China显示文摘The mineral inclusions in zircon from gneisses in ultra-high pressure (UHP) zone of the Dabie Mountains were identified by using a laser Raman microspectrometer. Coesite occurs as inclusions in zircons from all types of gneiss. Other important minerals, such as jadeite, omphacite, aragonite, barite, and anhydrite were also found as inclusion minerals. These discoveries indicate that ( i) gneissic country rocks had metamorphosed at the same time as the enclosed eclogites; and (ii) SO4-2 -bearing fluids were presentin the UHP metamorphic process, which is manifested by occurrence of barite and anhydrite coexisting with coesite. | LIU Jingbo YE Kai CONG Bolin Maruyama Shegnori FAN Hongrui | 2001 | Chinese Science Bulletin2001，46，22： | 22 |
| 4 | DESIGN OF 6-AXIS FORCE/TORQUE SENSOR BASED ON STEWART PLATFORM RELATED TO ISOTROPY显示文摘DESIGNOF6AXISFORCE/TORQUESENSORBASEDONSTEWARTPLATFORMRELATEDTOISOTROPYWangHongruiGaoFengHuangZhenMechanicalEngineeringInstit... | Wang, Hongrui Gao, Feng Huang, Zhen | 1998 | Chinese Journal of Mechanical Engineering1998，11，3： | 19 |
| 5 | In situ Nd isotopic measurement of natural geological materials by LA-MC-ICPMS显示文摘Using newly determined Sm isotopic abundances for correcting the isobaric interference of 144Sm on 144Nd and the established mass bias relationship between Sm and Nd, a series of in situ Nd isotopic measurements were conducted for relatively high Nd concentrations of natural geological materials, including apatite, titanite, monazite and perovskite on a Neptune multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS), coupled to a 193 nm ArF excimer laser ablation system. The results show that Ce has no significant influence on the precision and accuracy of Nd isotopic analyses for LREE-enriched geological minerals and that our approach is efficient in obtaining reliable 143Nd/144Nd and 147Sm/144Nd ratios for those materials with Sm/Nd<1 (147Sm/144Nd<0.6). When combined with trace element and U-Pb isotope data, the in situ Nd isotopic data can provide important information on geological processes. | YANG YueHeng SUN JinFeng XIE LieWen FAN HongRui WU FuYuan | 2008 | Chinese Science Bulletin2008，53，7： | 18 |
| 6 | Dual origins of Xiaoqinling gold-bearing quartz veins:Fluid inclusion evidence显示文摘Fluid inclusion research in Archean metamorphic rocks, Yanshanian granite and gold-bearing quartz veins shows that regional metamorphic fluids are high temperature and high saline, Yanshanian post-granitic fluids are CO2-bearing low saline, and ore-forming fluids are also CO2-rich low saline. In gold-barren/free parts of quartz veins in gold deposits, daughter mineral-bearing high saline inclusions related with metamorphic fluids remained. This proclaims quartz veins hosting gold ores might have been formed in early metamorphism, and overlapped or mineralized by late Yanshanian gold-bearing fluids. | Hongrui Fan Yihan Xie Rui Zhao Yinglan Wang | 2000 | Chinese Science Bulletin2000，45，15： | 17 |
| 7 | Zircon U-Pb dating of basement gneisses in the super-large Bayan Obo REE-Fe-Nb deposit, Inner Mongolia显示文摘Zircon U-Pb ages have been determined for basement gneisses in the Bayan Obo REE-Fe-Nb deposit. On the U-Pb concordia diagram data of three samples yield up-per intercept ages of 1948-1917 Ma. Thus, these basement gneisses are of Paleoproterozoic. Rock association of these basement gneisses includes tonalite, syenite and paragneiss, not belonging to a sedimentary package. It is more appro-priate to consider this association as a basement complex rather than a stratigraphic 'Group'. | WANG Kaiyi FAN Hongrui XIE Yihan LI Huimin | 2002 | Chinese Science Bulletin2002，47，3： | 16 |
| 8 | Characteristics of the crystalline basement beneath the Ordos Basin:Constraint from aeromagnetic data显示文摘Aeromagnetic anomaly zonation of the Ordos Basin and adjacent areas was obtained by processing highprecision and large-scale aeromagnetic anomalies with an approach of reduction to the pole upward continuation.Comparative study on aeromagnetic and seismic tomography suggests that aeromagnetic anomalies in this area are influenced by both the magnetic property of the rock and the burial depth of the Precambrian crystalline basement.Basement depth might be the fundamental control factor for aeromagnetic anomalies because the positive and negative anomalies on the reduction to the poleupward-continuation anomaly maps roughly coincide with the uplifts and depressions of the crystalline basement in the basin.The results,together with the latest understanding of basement faults,SHRIMP U-Pb zircon dating of metamorphic rock and granite,drilling data,detrital zircon ages,and gravity data interpretation,suggest that the Ordos block is not an entirety of Archean. | Zhentao Wang Hongrui Zhou Xunlian Wang Xiuchun Jing | 2015 | Geoscience Frontiers2015，6，3： | 15 |
| 9 | Problems in wavelet analysis of hydrologic series and some suggestions on improvement显示文摘使用小浪理论和方法调查象降水和流量那样的水疗院逻辑过程是一个热领域。然而,切断,在研究的方面通常被忽略:小浪功能和为时期, find 结果上的一个水疗院逻辑时间系列的长度的效果,和在为小浪分析的异例和原来的时间系列之间的选择的察觉的噪音的骚乱的可被考虑的状况的效果。在这篇论文,这些问题充分被讨论。来自 Lanzhou 降水车站的降水数据为案例研究被拿。结果显示在水疗院逻辑系列的小浪分析,降噪方法应该被用来消除噪音的影响。MexHat 小浪函数满足可被考虑的条件,它保证水疗院逻辑进程的周期的性质能被为分解使用 MexHat 小浪很好代表。在分析被给以前,应该被丢弃的水疗院逻辑系列的影响范围。异例系列应该被用来加亮水疗院逻辑系列的实际波动,这也被建议。 | WANG Hongrui YE Letian LIU Changming YANG Chi LIU Peng | 2007 | Progress in Natural Science:Materials International2007，17，1： | 13 |
| 10 | Information flow and controlling in regularization inversion of quantitative remote sensing显示文摘In order to minimize uncertainty of the inversed parameters to the largest extent by making full use of the limited information in remote sensing data, it is necessary to understand what the information flow in quantitative remote sensing model inversion is, thus control the information flow. Aiming at this, the paper takes the linear kernel-driven model inversion as an example. At first, the information flow in different inversion methods is calculated and analyzed, then the effect of information flow controlled by multi-stage inversion strategy is studied, finally, an information matrix based on USM is defined to control information flow in inversion. It shows that using Shannon entropy decrease of the inversed parameters can express information flow more properly. Changing the weight of a priori knowledge in inversion or fixing parameters and partitioning datasets in multi-stage inversion strategy can control information flow. In regularization inversion of remote sensing, information matrix based on USM may be a better tool for quantitatively controlling information flow. | YANG Hua, XU Wangli, ZHAO Hongrui, CHEN Xue & WANG Jindi Research Center for Remote Sensing and GIS, School of Geography, Beijing Normal University, State Key Laboratory of Remote Sensing Science, Beijing Key Laboratory for Remote Sensing of Environment and Digital Cities, Beijing 100875, China Department of Mathematics, Beijing Normal University, Beijing 100875, China | 2005 | Science China Earth Sciences2005，48，1： | 12 |
| 11 | Genetic Types of Meter-Scale Cyclic Sequences and Fabric Natures of Facies Succession显示文摘Different genetic types of meter-scale cyclic sequences in stratigraphic records result from episodic accumulation of strata related to Milankovitch cycles. The distinctive fabric natures of facies succession result from the sedimentation governed by different sediment sources and sedimentary dynamic conditions in different paleogeographical backgrounds, corresponding to high-frequency sea-level changes. Naturally, this is the fundamental criterion for the classification of genetic types of meter-scale cyclic sequences. The widespread development in stratigraphic records and the regular vertical stacking patterns in long-term sequences, the evolution characters of earth history and the genetic types reflected by specific fabric natures of facies successions in different paleogeographical settings, all that show meter-scale cyclic sequences are not only the elementary working units in stratigraphy and sedimentology, but also the replenishment and extension of parasequence of sequence stratigraphy. Two genetic kinds of facies succession for meter-scale cyclic sequence in neritic-facies strata of carbonate and clastic rocks, are normal grading succession mainly formed by tidal sedimentation and inverse grading succession chiefly made by wave sedimentation, and both of them constitute generally shallowing upward succession, the thickness of which ranges from several tens of centimeters to several meters. The classification of genetic types of meter-scale cyclic sequence could be made in terms of the fabric natures of facies succession, and carbonate meter-scale cyclic sequences could be divided into four types: L-M type, deep-water asymmetrical type, subtidal type and peritidal type. Clastic meter-scale cyclic sequences could be grouped into two types: tidal-dynamic type and wave-dynamic type. The boundaries of meter-scale cyclic sequences are marked by instantaneous punctuated surface formed by non-deposition resulting from high-frequency level changes, which include instantaneous exposed punctuated surface, drowned punctuated surface as well as their relative surface. The development of instantaneous punctuated surface used as the boundary of meter-scale cyclic sequence brings about the limitations of Walter’s Law on the explanation of facies distribution in time and space, and reaffirm the importance of Sander’s Rule on analysis of stratigraphic records. These non-continuous surface could be traced for long distance and some could be correlative within same basin range. The study of meter-scale cyclic sequences and their regularly vertical stacking patterns in long-term sequences indicate that the research into cyclicity of stratigraphic records is a useful way to get more regularity from stratigraphic records that are frequently complex as well as non-integrated. | Mei Mingxiang Xu Debin Zhou Hongrui Institute of Earth Sciences and Natural Resources, China University of Geosciences, Beijing 100083 | 2000 | Journal of Earth Science2000，19，4： | 12 |
| 12 | Fischer Plots of Wumishan Cyclothems,Precambrian Records of Third-OrderSea-Level Changes显示文摘The Mesoproterozoic Wumishan Formation ((1310 ± 20 ) Ma - (l 207 ± 10) Ma) in Jixian, Tianjin represents a succession of 3 300 meter thick carbonate strata where are the best developed stromatolite biostromes and thrombolite bioherms. These biostromes and bioherms, together with tidal-flat dolomites and muddy dolostones, form Wumishan cyclothems with approximately symmetrical faciessuccession fabrics, which belong to carbonate meter-scale cyclic sequences of peritidal type. These cyclothems are overlain by lagoon dolomitic mudstones and shales and by frequently developed paleosol layers, indicating that the boundary of Wumishan cyclothems is marked by an instantaneously-exposed punctuated surface. Viewed form the regularly vertical stacking patterns of Wumishan cyclothems in long-term sequences, 26 third-order sequences may be discerned in Wumishan Formation. These thirdorder sequences may also be incorporated into six second-order sequences. In order to study the variation range of third-order sea-level changes and the formation period of third-order sequence, 626 cyclothems are discerned in the middle and upper parts of Wumishan Formation where the outcrops are well developed. In terms of the total thickness and the formation period of Mesoproterozoic Wumishan Formation, the crust subsidence rate in the sedimentary period of Wumishan Formation is supposed to be 3 meters at each interval of 100 thousands years. Based on this assumption, Fischer plot might be designed to simulate the third-order sea-level changing pattern. | Mei Mingxiang Faculty of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083 Ma Yongsheng China Petrochemical Corporation (SINOPEC), Beijing 100029 Zhou Hongrui Du Benming Luo Zhiqing Guo Qingyin Faculty of Earth Sc | 2001 | Journal of China University of Geosciences2001，12，1： | 11 |
| 13 | Bayan Obo Carbonatites:Texture Evidence from Polyphase Intrusive and Extrusive Carbonatites显示文摘大多数所谓的 Bayan Obo 有细密纹理的白云石云石收集了从主要并且东方 orebodies 表演一块 microporphyritic 质地,也就是, microphenocrysts 被放在一个很有细密纹理的矩阵,尽管将近所有他们经历了也变丑或改变引起的再结晶。质地似乎可能坚持说原来的特征。暴烈的岩石的最典型的质地之一是斑状的质地,这被知道,并且 microporphyritic 质地是斑晶和矩阵与显微镜仅仅是可区分的一个在变化。因此,白云石云石总体上并且东方 orebodies 可能与挤出的 carbonatites 有关。另外,也在那里发生有在 Bayan Obo 的不同质地的一些 carbonatite 基石和女同性恋。因此, Bayan Obo carbonatites 是多相的恼人、挤出的 carbonatites。 | WANG Kaiyi FAN Hongrui YANG Kuifeng HU Fangfang MA Yuguang | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 11 |
| 14 | Metallogenesis within continental collision zones: Comparisons of modern collisional orogens显示文摘Modern collisional orogens represent the natural laboratory for the study of metallogeny in continental collision zones. The Pyrenees, Alps, Zagros and Himalaya are all associated with Neo-Tethyan subduction and represent the youngest collisional orogens on Earth. Here, we compare these four orogens in terms of their composition, architecture, tectonic evolution,and metallogenic systems. The four orogens can be divided into simple and composite types. Simple orogens are represented by the Pyrenees and the Alps, and are characterized by narrow linear shapes in plain view and symmetric structures in cross-section,are free of arc magmatism, and are associated with the Mississippi Valley Valley-type Pb-Zn and orogenic gold deposits. The mineral deposits that form in these simple collisional orogens are generally related to processes that occur in the middle and upper crust. In contrast, composite orogens, as exemplified by the Zagros-Iranian and Himalayan-Tibetan Plateaus, are associated with broad orogenic plateaus in plain view and asymmetrical structures in cross-section, record extensive arc magmatism in continental margins, and are associated with a variety of deposit types including carbonatite-related rare earth element(REE),porphyry Cu-Mo, orogenic Au, Mississippi Valley type Pb-Zn, and detachment-fault-related polymetallic deposits. Although the subduction of Neo-Tethys oceanic crust occurred before the creation of simple collisional orogens in the Pyrenees and the Alps,these areas do not show the record of continental arc magmatism. In contrast, the composite collisional orogens are associated with the development of huge continental margin arcs prior to continental subduction, and the subduction was followed by reactivation of the subduction-modified arc lithospheric material, generating the ore-forming systems in these regions. | Hongrui ZHANG Zengqian HOU | 2018 | Science China Earth Sciences2018，61，12： | 10 |
| 15 | Land Use Allocation Based on Interval Multi-objective Linear Programming Model: A Case Study of Pi County in Sichuan Province显示文摘Adjusting and optimizing land use structure is one of the essential approaches to solve the conflict between land supply and demand. In this study,an uncertain interval multi-objective linear programming model was established and applied to analyzing the suitability of land use structure in Pi County of Sichuan Province. An adjustment scheme for optimizing land use structure was proposed on the basis of development planning drawn up by the local government. The results are summarized as follows: 1) the optimal adjustment scope for cropland area ranges from 27 976.75 ha to 31 029.08 ha,and the current area is less than the lower limit of the scope; 2) the optimal adjustment scope for garden land area ranges from 4 736.49 ha to 12 967.11 ha,and the current area is less than the lower limit; 3) the optimal adjustment scope for construction land ranges from 7 761.95 ha to 10 393.18 ha,and the current area is greater than the upper limit; 4) the optimal adjustment scope for industry and mining land ranges from 557.29 ha to 693.54 ha,and the current area exceeds the upper limit; and 5) the areas of forest land,grassland and other agricultural land are within the optimal adjustment scope. In order to maximize comprehensive benefit with the limited resources and the demand of sustainable development,the areas of cropland and garden land are supposed to be expanded properly,while the construction land should be controlled and reduced gradually,and the forest land and other agricultural land can be maintained at the current level in short period. | WANG Hongrui GAO Yuanyuan LIU Qiong SONG Jinxi | 2010 | Chinese Geographical Science2010，20，2： | 10 |
| 16 | High efficient gene targeting in rice field eel Monopterus albus by transcription activator-like effector nucleases显示文摘Genome editing plays an important role in the research of gene functions,gene correction and cell replacement therapy.Traditionally,genome editing is mainly dependent on the technology of homologous recombination(HR)and embryonic stem(ES)cell lines in mammals[1].However,genome editing is severely limited by the low efficiency of HR and lack of ES cell lines in most organisms.Recently,the development of zinc finger nucleases(ZFNs), | Ke Feng Hongrui Luo Yongming Li Ji Chen Yaping Wang Yonghua Sun Zuoyan Zhu Wei Hu | 2017 | Science Bulletin2017，62，3： | 9 |
| 17 | A data-driven threshold for wavelet sliding window denoising in mechanical fault detection显示文摘Wavelet denoising is an effective approach to extract fault features from strong background noise.It has been widely used in mechanical fault detection and shown excellent performance.However,traditional thresholds are not suitable for nonstationary signal denoising because they set universal thresholds for different wavelet coefficients.Therefore,a data-driven threshold strategy is proposed in this paper.First,the signal is decomposed into different subbands by wavelet transformation.Then a data-driven threshold is derived by estimating the noise power spectral density in different subbands.Since the data-driven threshold is dependent on the noise estimation and adapted to data,it is more robust and accurate for denoising than traditional thresholds.Meanwhile,sliding window method is adopted to set a flexible local threshold.When this method was applied to simulation signal and an inner race fault diagnostic case of dedusting fan bearing,the proposed method has good result and provides valuable advantages over traditional methods in the fault detection of rotating machines. | CHEN YiMin ZI YanYang CAO HongRui HE ZhengJia SUN HaiLiang | 2014 | Science China(Technological Sciences)2014，57，3： | 9 |
| 18 | Advances of research on high-speed railway catenary显示文摘The interaction between the catenary and pantograph is one of the most crucial factors that determine the train operation in high-speed railway. The bad state of catenary is able to directly influence the power supply safety of traction power system. In this paper, four aspects on the catenary research of high-speed railway are reviewed in detail, namely the solution methods for catenary equilibrium state, the dynamic modeling methods of catenary, the non-contact detection methods of catenary, and the static and dynamic evaluation methods of catenary. In addition, their recent advances are described. For the low solution accuracy of the initial equilibrium state of catenary, the structure finding method with multi-objective constraint and nonlinear finite element procedure are introduced to solve the problem. For the catenary's dynamic modeling, considering the influence of environmental wind on the catenary, environmental wind simulations and wind tunnel tests are used to obtain theaerodynamic coefficients and build the wind field along the catenary for analysis of its wind vibration characteristics.In order to improve the detection accuracy of non-contact detection for the catenary, the deep learning theory and real-time detection algorithms should be adopted in the future. In view of the lack of dynamic assessment method for the catenary, the modern spectrum evaluation, time–frequency analysis, big data technology and their combinations will be the important means for future catenary evaluation. | Zhigang Liu Yang Song Ye Han Hongrui Wang Jing Zhang Zhiwei Han | 2018 | Journal of Modern Transportation2018，26，1： | 9 |
| 19 | Convex shaping process simulation during counter-rotating electrochemical machining by using the finite element method显示文摘In counter-rotating electrochemical machining(CRECM), a revolving cathode tool with hollow windows of various shapes is used to fabricate convex structures on a revolving part. During this process, the anode workpiece and the cathode tool rotate relative to each other at the same rotation speed. In contrast to the conventional schemes of ECM machining with linear motion of a block tool electrode, this scheme of ECM is unique, and has not been adequately studied yet. In this paper, the finite element method(FEM) is used to simulate the anode shaping process during CRECM, and the simulation process which involves a meshing model, a moving boundary,and a simulation algorithm is described. The simulated anode profiles of the convex structure at different processing times show that the CRECM process can be used to fabricate convex structures of various shapes with different heights. Besides, the variation of the inter-electrode gap indicates that this process can also reach a relative equilibrium state like that in conventional ECM. A rectangular convex and a circular convex are successfully fabricated on revolving parts. The experimental results indicate relatively good agreement with the simulation results. The proposed simulation process is valid for convex shaping prediction and feasibility studies as well. | Wang Dengyong Zhu Zengwei Wang Hongrui Zhu Di | 2016 | Chinese Journal of Aeronautics2016，29，2： | 8 |
| 20 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
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