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| 1 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘POU 抄写因素 OCT4 不仅在维持 pluripotent 和房间而且幕作为通过基因剂量的一个房间命运决定因素完成的胚胎的茎(ES ) 的自我更新的状态起一个必要作用。然而,控制细胞内部的 OCT4 蛋白质水平的分子的机制留下逃犯。这里,我们报导那人的 WWP2, E3 ubiquitin (Ub ) 蛋白质 ligase,通过它的 WW 领域明确地与 OCT4 交往并且在 vitro 并且在 vivo 提高 OCT4 的 Ub 修正。我们首先证明在人的 ES 房间的内长的 OCT4 能被 Ub post-translationally 修改。而且,我们发现 WWP2 以一种剂量依赖者方式,和 WWP2 的活跃地点半胱氨酸残余通过 26S proteasome 支持了 OCT4 的降级在 OCT4 上为它的酶的活动和解朊的效果被要求。显著地,我们当 WWP2 表示是由特定的 RNA 干扰(RNAi ) 的 downregulated 时,内长的 OCT4 蛋白质水平显著地被提高的数据表演,建议那 WWP2 是为在人的 ES 房间维持合适的 OCT4 蛋白质水平的一个重要管理者。而且,北污点分析证明 WWP2 抄本在多样的人的织物 / 器官是广泛地在场的并且高度在无差别的人的 ES 房间表示了。然而,它的表示水平快速在区分的人的 ES 房间以后被减少,显示 WWP2 表示力量发展地被调整。我们的调查结果证明 WWP2 是在人的 ES 房间的 OCT4 蛋白质水平的一个重要管理者。 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，5： | 8 |
| 2 | Identifying changes in the wheat kernel proteome under heat stress using iTRAQ显示文摘Wheat(Triticum aestivum L.) is one of the three major global food crops. Hightemperature stress can affect its yield and quality. Studies of the effect of hightemperature stress on wheat kernel development are important because they can reveal the stability of wheat quality and lead to the genetic improvement of wheat quality traits. In this study, the isobaric tags for relative and absolute quantitation(iTRAQ)method was adopted to analyze changes in the protein expression profile of wheat cultivars under high temperature stress. The protein content of wheat grain increased under heat stress, while the SDS-sedimentation value and starch content decreased.Grain filling was deficient under high temperature stress, which reduced thousandkernel weight but did not affect wheat kernel length. The 207 differentially expressed proteins identified in Gaocheng 8901 under heat stress were associated with energy metabolism, growth and development, and stress response. Gene Ontology enrichment analysis showed that the annotated proteins that were differentially expressed in Gaocheng 8901 under heat stress were involved mainly in stimulus response, abiotic stress response, stress response, and plasma membrane. A set of 78 differentially expressed proteins were assigned to 83 KEGG signaling/metabolic pathways. KEGG pathway enrichment analysis showed that this set of proteins was significantly enriched in members of 51 pathways, and the proteins participated mainly in protein synthesis in the endoplasmic reticulum, starch and sucrose metabolism, and reaction on ribosomes. Five differentially expressed proteins were involved in protein–protein interaction networks that may greatly influence the yield and quality of wheat grain. In wheat, high-temperature stress leads to a variety of effects on protein expression and may ultimately cause changes in yield and quality. | Yufeng Zhang Hongyao Lou Dandan Guo Ruiqi Zhang Meng Su Zhenghong Hou Haiying Zhou Rongqi Liang Chaojie Xie Mingshan You Baoyun Li | 2018 | The Crop Journal2018，6，6： | 5 |
| 3 | 3D urchin like V-doped CoP in situ grown on nickel foam as bifunctional electrocatalyst for efficient overall water-splitting显示文摘Cobalt phosphide (CoP) is considered to be a potential candidate in the field of electrocatalysis due to its low-cost, abundant resources and high electrochemical stability. However, there is a great space for further improvement of its electrocatalytic performance since its charge transfer rate and catalytic activity have not reached a satisfactory level. Herein, we design and fabricate a three dimensional urchins like V-doped CoP with different amounts of V-doping on nickel foam electrode. The V-doped CoP/NF electrode with optimized amounts of V-doping (10%) exhibits outstanding hydrogen evolution reaction (HER) performance under universal-pH conditions and preeminent oxygen evolution reaction (OER) performance in alkaline media. Notably, the assembled water-splitting cell displays a cell voltage of only 1.53 V at 10 mA·cm−2 and has excellent durability, much better than many reported related bifunctional catalysts. The experiment results and theoretical analysis revealed that vanadium atoms replace cobalt atoms in CoP lattice. Vanadium doping can not only raise the density of electronic states near the Fermi level enhancing the conductivity of the catalyst, but can also optimize the free energy of hydrogen and oxygen-containing intermediates adsorption over CoP, thus promoting its catalytic activity. Moreover, the unique nanostructure of the catalyst provides the various shortened channels for charge transfer and reactant/electrolyte diffusion, which accelerates the electrocatalytic process. Also, the in situ growth strategy can improve the conductivity and stability of the catalyst. | Hongyao Xue Alan Meng Haiqin Zhang Yusheng Lin Zhenjiang Li Chuansheng Wang | 2021 | Nano Research2021，14，11： | 4 |
| 4 | Correlation Between Phase Stability and Tensile Properties of the Ni-Based Superalloy MAR-M247显示文摘Phase stability and its effect on tensile properties of MAR-M247 alloy have been investigated during thermal exposure at 800–900°C for up to 10,000 h.Detailed investigations reveal that the larger secondaryγ′phase has no obvious growth,but the smaller tertiaryγ′phase obviously coarsens and the coalescence occurs during thermal exposure at 850°C and below.γ′coarsening behavior is consistent with the description of Ostwald ripening theory beforeγ′coalescence.Hf-rich blocky MC carbide shows excellent thermal stability,but Ta-rich script-type MC carbide gradually degenerates via reaction,MC+γ→M_(23)C_(6)+γ′and finally formsγ film around MC and M_(23)C_(6) carbides.With increasing thermal exposure time,the tensile strength decreases.The ductility first increases and then decreases during exposure at 800°C,but it decreases continuously at 900°C.In addition,the ductility keeps almost constant when the exposure time is longer than 5000 h. | Linxu Li Xiufang Gong Changshuai Wang Yunsheng Wu Hongyao Yu Haijun Su Lanzhang Zhou | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，6： | 2 |
| 5 | HOW TO EMPHASIZE THE STUDY OF ENGLISH ROOTS AND WORD-BUILDING FOR IMPROVING VOCABULARY TEACHING AT COLLEGE显示文摘Guiding college students to acquire an adequate vocabularyis an important task that is often neglected. The morevocabulary hat is mastered, the higher level a learner of Englishwill have. But in China, the traditional method of teachingvocabulary is learning by rote, and learners of foreign languagesare inclined to learn as much vocabulary as possible this wayregardless of whether these vocabulary is useful or not. Indeed,there are some disadvantageous factors hindering the studentsfrom expanding vocabulary rapidly and efficiently. We have todevelop a scientific method of teaching vocabulary exploringmethods of which is the key to this article. | Li Hongyao | 2001 | Chinese Journal of Applied Linguistics2001，24，4： | 2 |
| 6 | High-throughput 16S rDNA sequencing of the pulmonary microbiome of rats with allergic asthma显示文摘A decrease in microbial infection in adolescents is implicated with an increase in the incidence of asthma and allergic diseases in adulthood,indicating that the microbiome plays a critical role in asthma.However,the microbial composition of the lower respiratory tract remains unclear,hindering the further exploration of the pathogenesis of asthma.This study aims to explore the microbial distribution and composition in the lungs of normal rats and rats with allergic asthma via 16S rDNA sequencing.The DNA of the pulmonary microbiome was extracted from the left lungs collected from normal control group(NC),saline control group(SC),and allergic asthma group(AA)under aseptic conditions.After the 16s rDNA V4eV5 region was amplified,the products were sequenced using Illumina high-throughput technology and subjected to operational taxonomic unit(OTU)cluster and taxonomy analysis.The OTU values of AA increased significantly compared with those of NC and SC.Microbiome structure analysis showed that the dominant phylum of the pulmonary microbiome changed from Proteobacteria in NC to Firmicutes in AA.Linear discriminant analysis indicated that the key microbiomes involved in the three groups varied. | Yang Xiong Sen Hu Hongyao Zhou Hui Zeng Xuan He Dongni Huang Xiaoyu Li | 2020 | Genes & Diseases2020，7，2： | 2 |
| 7 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，6： | 1 |
| 8 | Experimental study on heat transfer coefficient in a rotarytube dryer显示文摘 | Jing Wu Xuanyou Li Hongyao Wang | 2011 | Asia-Pacific Journal of ChemicalEngineering2011，6，2： | 1 |
| 9 | Controllable oxygen vacancies and morphology engineering:Ultra-high HER/OER activity under base–acid conditions and outstanding antibacterial properties显示文摘Introducing vacancy defects and unique morphology is an effective strategy to improve the catalytic performance of transition metal compounds.However,precisely controlling the amount of vacancy defects remains challenging.Here,we propose a facile and efficient hydrothermal accompanying an annealing method to synthesize a series of Mn-doped CoO nanomaterials with controllable oxygen vacancies and unique morphology.The oxygen vacancies amount can be precisely controlled by adjusting the Mndoping content and is positively correlated with catalytic performance.It was found that the oxygen vacancies amount can reach up to 38.2%over the Mn-doped CoO nanomaterials,resulting in ultra-high hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalytic activity(HER:25.6 and 37 m V at 10 m A cm^(-2);OER:301 and 322 m V at 50 m A cm^(-2))under both basic and acidic conditions,while reaching 10 m A cm^(-2) for an ultra-low cell voltage of only 1.52 V,which exceeds that of Pt/C/RuO_(2) and all reported non-noble metal oxide catalysts.The DFT calculations reveal oxygen vacancies can optimize H*and HOO*intermediates adsorption free energy,thus improving the HER and OER performance.Interestingly,the Mn-doped CoO with rich oxygen vacancies exhibits excellent antibacterial properties in vitro of biomedicine.This work provides new ideas and methods for the rational design and precise control of vacancy defects in transition metal compounds and explores their potential application value in electrochemical water splitting and biomedical fields. | Hongyao Xue Alan Meng Tongqing Yang Zhenjiang Li Chunjun Chen | 2022 | Journal of Energy Chemistry2022，31，8： | 1 |
| 10 | Ferroptosis and its emerging roles in acute pancreatitis显示文摘Acute pancreatitis(AP)is a common and potentially life-threatening pancreatic inflammatory disease.Although it is usually self-limiting,up to 20%of patients will develop into severe AP.It may lead to systemic inflammatory response syndrome and multiple organ dysfunction,affecting the lungs,kidneys,liver,heart,etc.Surviving patients usually have sequelae of varying degrees,such as chronic hyperglycemia after AP(CHAP),pancreatic exocrine insufficiency,and chronic pancreatitis.Lacking specific target treatments is the main reason for high mortality and morbidity,which means that more research on the pathogenesis of AP is needed.Ferroptosis is a newly discovered regulated cell death(RCD),originally described in cancer cells,involving the accumulation of iron and the depletion of plasma membrane polyunsaturated fatty acids,and a caspase-independent RCD.It is closely related to neurological diseases,myocardial infarction,ischemia/reperfusion injury,cancer,etc.Research in the past years has also found the effects of ferroptosis in AP,pancreatic cancer,and AP complications,such as acute lung injury and acute kidney injury.This article reviews the research progress of ferroptosis and its association with the pathophysiological mechanisms of AP,trying to provide new insight into the pathogenesis and treatment of AP,facilitating the development of better-targeted drugs. | Hongyao Li Yujie Lin Ling Zhang Jing Zhao Peiwu Li | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 11 | Performance of Methanol-to-Olefins Catalytic Reactions by the Addition of PEG in the Synthesis of SAPO-34显示文摘SAPO-34, a silicoaluminophosphate zeolite, has been synthesized by the hydrothermal method with the addition of different molecular weights of polyethylene glycol(PEG), and has been characterized with XRD, SEM,N_2 adsorption–desorption, FT-IR, and NH_3 temperatureprogrammed desorption(NH_3-TPD). We studied SAPO-34 as a catalyst in the methanol-to-olefins(MTO) reaction, in a fixed-bed reactor. The results show that the chain length of PEG has a great influence on the particle size and morphology of SAPO-34. PEG acts as inhibitor in the crystallization process. With the increase of the chain length of PEG used in the synthesis, from a relative molecular weight of 400-6000, the morphology of SAPO-34 changes gradually from cubic to nanoplate-like and then changes to cubic again. The particle size decreases markedly at first and then increases to some extent. The catalytic stability in the MTO reaction also increases first and then decreases, with all the catalysts having almost the same selectivity to olefins. When the sample is synthesized with PEG800, the particles become nanoplate-like with a thickness of 46 nm on average, and the catalytic stability is appreciably prolonged, which is attributed to the shorter diffusion paths of the reactants in the zeolite. | Yaquan Wang Zhao Wang Chao Sun Hengbao Chen Hongyao Li Haoyang Li | 2017 | Transactions of Tianjin University2017，23，6： | 1 |
| 12 | Beam tracking method based on reconfigurable intelligent surface for obstructed communication显示文摘This paper proposes a new reconfigurable intelligent surface based three-dimensional beam tracking method to solve the beam tracking problems for the unmanned aerial vehicle with obstacles in communication channels.The proposed beam tracking method can not only regulate the reconfigurable intelligent surfaces to achieve the beam tracking of the obstructed communications,but also optimize the transmission efficiency of the communication.Firstly,a reconfigurable intelligent surface is proposed,which can correlate the transmission signals by adjusting the phaseshift matrix.Meanwhile,a new communication channel is constructed according to the reconfigurable intelligent surface,which consists of two parts.The first one is the channel between the unmanned aerial vehicle and the reconfigurable intelligent surface,the other is the channel between the reconfigurable intelligent surface and the ground base station.Note that the transmission performance of the communications can be optimized by adjusting the phase shift of each uniform linear array on the reconfigurable intelligent surface.Then,a new beam tracking method for the unmanned aerial vehicle with obstructed communications is proposed on the basis of the reconfigurable intelligent surface.By proposing the mixed genetic algorithm,the estimation accuracy of the azimuth and elevation angles is improved to enhance the performance of the beam tracking.Finally,the simulations are provided to verify the effectiveness of the proposed three-dimensional beam tracking method with reconfigurable intelligent surface. | Hongyao LI Jianxiang XI Ming HE Xicong WANG | 2022 | Chinese Journal of Aeronautics2022，35，8： | 0 |
| 13 | Facile One-Pot Synthesis of ZSM-5 Aggregates with Interand Intra-Crystalline Mesopores for Methanol to Gasoline Conversion显示文摘ZSM-5 aggregates consisting of superfine and hierarchical nanocrystals(combined with micropores and intra-crystalline mesopores) with an average size of 30 nm were prepared through one-pot synthesis with the assistance of anionic polyacrylamide(APAM). The resultant zeolites(AHN-ZSM-5) were characterized by XRD, ICP-OES, SEM, TEM, BET, NH_3-TPD, Py-IR, and TG analyses and evaluated in the methanol to gasoline(MTG) reaction. Characterization results show that the hierarchical ZSM-5 aggregates possessed two kinds of mesopores, namely inter-and intra-crystalline mesopores. The amount of APAM considerably influenced the mesoporosity and textural properties of AHN-ZSM-5 zeolites. With the addition of APAM in the synthesis, the AHN-ZSM-5 zeolites exhibited large mesopore volume, large external surface area, and appropriate acidity. When applied in the MTG reaction, AHN-ZSM-5 demonstrated a catalytic lifetime that was 1.6 times longer than that of conventional ZSM-5 synthesized in the absence of APAM. | Yaquan Wang Chunyang Fan Hongyao Li Xiao Wang Fanjun Meng Chao Sun Liying Sun | 2019 | Transactions of Tianjin University2019，25，1： | 0 |
| 14 | IP-10 and fractalkine induce cytotoxic phenotype of murine NK cells显示文摘We characterized the murine NK cell subsets of the tumor microenvironment(TME)with low expressions of CD16 and NKG2D and investigated the chemokines that deter CD16~low NKG2D^low subsets.Our results demonstrated the activation of primary and KY-1 NK cell by ligands and found that exogenous CXCL10/interferon-gamma-induced protein 10(IP-10)and fractalkine(FKN)can up-regulate the expression of CD16 and NKG2D.Moreover,both IP-10 and FKN are shown to facilitate migration,adhesion and cytotoxicity of NK cell subsets of the TME,due to the up-regulated CD16 and NKG2D.Overall,our data provide a new path by which to enhance murine NK cell cytotoxic potential and improve the quality of NK cells of the TME. | Fang Liu Junfang Qin Hongyao Zhang Ning Li Meihua Shan Lan Lan Yue Wang | 2016 | Science Bulletin2016，61，3： | 0 |
| 15 | A nonenzymatic electrochemical sensor for the detection of hydrogen peroxide in vitro and in vivo fibrosis models显示文摘Fibrosis occurs due to the excessive deposition of extracellular matrix caused by cell injury.After various types of tissue injury,the dysregulation of the internal response can eventually lead to the destruction of organ structure and dysfunction.There is increasing evidence that oxidative stress,which is characterized by excessive production of hydrogen peroxide(H_(2)O_(2)),is an important cause of fibrosis.Therefore,we synthesized a biosensitive and efficient electrochemical H_(2)O_(2)sensor based on PtNi nanoparticle-doped N-reduced graphene oxide(PtNi-N-rGO)to detect H_(2)O_(2)released from transforming growth factorβ1(TGFβ1)-induced myofibroblast.In addition,the sensor could easily detect changes in H_(2)O_(2)in the lung and bronchoalveolar lavage fluid(BALF)of mice with pulmonary fibrosis.Furthermore,the sensor could also detect H_(2)O_(2)in activated hepatic stellate cells and the liver of carbon tetrachloride(CCl_(4))-induced liver fibrosis.Moreover,the alterations in H_(2)O_(2)detected by the sensor were consistent with nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)protein expression and the staining results of pathological sections.Taken together,these results highlight the use of H_(2)O_(2)sensors for the rapid detection of fibrosis and facilitate the rapid evaluation of antifibrotic drug candidates. | Hongyao Liu Yan Yu Taixiong Xue Cailing Gan Yuting Xie Doudou Wang Peilin Li Zhiyong Qian Tinghong Ye | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
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