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| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | Regeneration of 2-amino-2-methyl-1-propanol used for carbon dioxide absorption显示文摘为了改进二氧化碳的效率骑车,处理并且减少新生能量消耗,一个位的联盟者妨碍了 2-amino-2-methyl-1-propranol (安培) 的胺被调查作为 CO2 吸收剂决定它的新生行为。CO2 吸收和胺新生特征试验性地在各种各样的操作条件下面被检验。新生效率在 358 ~ 403 K 的温度范围期间从 86.2% ~ 98.3% 增加了。为安培的最合适的新生温度是 383 K,处于这个实验条件,并且吸收 / 新生的新生效率变从 98.3% ~ 94.0% 下降了。很多热马厩盐(HSS ) 能在 CO2 吸收容量和新生效率引起减小。结果显示水的安培更容易比另外的胺与吸收容量的更少的损失再生,例如,单音的乙醇胺(MEA ) , diethanolamine (DEA ) , diethylenetriamine (DETA ) ,和 N-methyldiethanolamine (MDEA ) 。 | ZHANG Pei SHI Yao WEI Jianwen ZHAO Wei YE Qing | 2008 | Journal of Environmental Sciences2008，20，1： | 21 |
| 3 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 4 | Long-term Efficacy of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A 5-year Follow-up Study in China显示文摘 | Lu-Lu Jiang Jin-Long Liu Xiao-Li Fu Wen-Biao Xian Jing Gu Yan-Mei Liu Jing Ye Jie Chen Hao Qian Shao-Hua Xu Zhong Pei Ling Chen | 2015 | Chinese Medical Journal2015，，18： | 13 |
| 5 | Expression of lens-related microRNAs in transparent infant lenses and congenital cataract显示文摘AIM:To identify the expression of lens-related micro RNAs(miRNAs)in the central epithelium of transparent infant lenses and congenital cataract. METHODS:Lens-related mi RNAs were retrieved from Pub Med database. The expression levels of these mi RNAs in transparent infant lenses and congenital cataract were determined by stem-loop reverse transcription-polymerase chain reaction(RT-PCR). mi Randa algorithm was used to predict the target genes of these differentially expressed mi RNAs. The target m RNA was validated.RESULTS:Six lens-related mi RNAs were retrieved from screening Pub Med database. The most abundant mi RNA in transparent infant lenses according to stem-loop RT-PCR was mi R-184. miR-182 was up-regulated in congenital cataract. Contrarily,miR-204 and miR-124 was down-regulated.mi R-204 exhibited a more significant decrease in expression than mi R-124. In addition,Meis2 was predicted to be the target of mi R-204 using mi Randa algorithm. mi R-204mimic/antagomir transfection experiments suggested the negative correlation between the expression of mi R-204 and Meis2.CONCLUSION:The expression levels of miR-182,miR-204 and mi R-124 differ between the central epithelium of transparent infant lens and congenital cataract,suggesting their involvement in the pathogenesis of congenital cataract. miR-204 may act via silencing Meis2 to regulate lens development and congenital cataract formation. | Chang-Rui Wu Min Ye Li Qin Yue Yin Cheng Pei | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 11 |
| 6 | Effect of a Traditional Chinese Medicine combined therapy on adolescent idiopathic scoliosis:a randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness of a combined Traditional Chinese Medicine(TCM) therapy versus conventional treatment on adolescent idiopathic scoliosis.METHODS:One hundred twenty outpatients with mild and moderate adolescent idiopathic scoliosis were randomly divided into a TCM group(TCMG)and a brace group(CG).TCMG patients underwent Daoyin,Tuina,and acupotomology therapies.CG patients were treated with a Milwaukee brace.Each patient's Cobb angle was measured after 12 and 24 months of treatment,and pulmonary function was determined after 12 months of treatment.Average electromyogram(AEMG) ratio of the surface electromyogram was measured after 6 and 12 months of treatment and followed-up after 18 and 24 months.RESULTS:The Cobb angle significantly decreased in both groups after 12 months of treatment compared with before treatment(P< 0.05).The percentages of original Cobb angle in TCMG and CG were51.4%and 47.8%(P > 0.05) after 12 months and62.5%and 34.7%(P < 0.05) after 24 months,respectively.Pulmonary function significantly improved after 12 months in TCMG(P < 0.05) but significantly decreased in CG(P < 0.05).The AEMG ratio was significantly lower(P < 0.01) and tended to remain at1 after stopping treatment in TCMG,but increased in CG(P<0.05).CONCLUSION:TCM combined therapy can prevent the progression of scoliosis.The AEMG ratio is a promising index that could replace radiography in the evaluation of treatment effect and progression in scoliosis. | Wei Hui Xu Jinyuan Jiang Zhong Ye Shuliang Song Hongquan Ning Xitao Huang Huanmin Chen Wei Pei Jianwei Jiang Nengyi Chen Shao Du Honggen | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 9 |
| 7 | Optical tuning of exciton and trion emissions in monolayer phosphorene显示文摘Monolayer phosphorene provides a unique two-dimensional(2D)platform to investigate the fundamental dynamics of excitons and trions(charged excitons)in reduced dimensions.However,owing to its high instability,unambiguous identification of monolayer phosphorene has been elusive.Consequently,many important fundamental properties,such as exciton dynamics,remain underexplored.We report a rapid,noninvasive,and highly accurate approach based on optical interferometry to determine the layer number of phosphorene,and confirm the results with reliable photoluminescence measurements.Furthermore,we successfully probed the dynamics of excitons and trions in monolayer phosphorene by controlling the photo-carrier injection in a relatively low excitation power range.Based on our measured optical gap and the previously measured electronic energy gap,we determined the exciton binding energy to be~0.3 eV for the monolayer phosphorene on SiO_(2)/Si substrate,which agrees well with theoretical predictions.A huge trion binding energy of~100 meV was first observed in monolayer phosphorene,which is around five times higher than that in transition metal dichalcogenide(TMD)monolayer semiconductor,such as MoS_(2).The carrier lifetime of exciton emission in monolayer phosphorene was measured to be,220 ps,which is comparable to those in other 2D TMD semiconductors.Our results open new avenues for exploring fundamental phenomena and novel optoelectronic applications using monolayer phosphorene. | Jiong Yang Renjing Xu Jiajie Pei Ye Win Myint Fan Wang Zhu Wang Shuang Zhang Zongfu Yu Yuerui Lu | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 8 | Adaptive Algorithms of Nonlinear Approximation with Finite Terms显示文摘This paper deals with realizable adaptive algorithms of the nonlinear approximation withfinite terms based on wavelets.We present a concrete algorithm by which we may find the requiredindex set A_m for the greedy algorithm G_m^p(·,Ψ).This makes the greedy algorithm realize the nearbest approximation in practice.Moreover,we study the efficiency of the finite-term approximation ofanother algorithm introduced by Birge and Massart. | Wen Bin WEI Yue Sheng XU Pei Xin YE | 2007 | Acta Mathematica Sinica,English Series2007，23，9： | 7 |
| 9 | Cesarean delivery on maternal request and childhood intelligence: a cohort study显示文摘背景剖腹产出生稳定地在过去的十年一直在增加并且在母亲的请求以后在 China.Cesarean 交货成为了流行病是到这个向上的趋势的一个主要贡献者,并且有具有关于它的影响在上的许多担心的母亲并且母亲的孩子 health.Most 相信在母亲的请求以后的恺撒的交货能改进孩子的智力,但是直接证据是 sparse.In 这队研究,我们试图直接在 materna | LI Hong-tian YE Rong-wei PEI Li-jun REN Ai-guo ZHENG Xiao-ying LIU Jian-meng | 2011 | Chinese Medical Journal2011，，23： | 7 |
| 10 | Carbon-Based Flexible and All-Solid-State Micro-supercapacitors Fabricated by Inkjet Printing with Enhanced Performance显示文摘By means of inkjet printing technique, flexible and all-solid-state micro-supercapacitors(MSCs) were fabricated with carbon-based hybrid ink composed of graphene oxide(GO,98.0vol.%) ink and commercial pen ink(2.0vol.%). A small amount of commercial pen ink was added to effectively reduce the agglomeration of theGO sheets during solvent evaporation and the following reduction processes in which the presence of graphite carbon nanoparticles served as nano-spacer to separate GO sheets. The printed device fabricated using the hybrid ink,combined with the binder-free microelectrodes and interdigital microelectrode configuration, exhibits nearly 780%enhancement in areal capacitance compared with that of pure GO ink. It also shows excellent flexibility and cycling stability with nearly 100% retention of the areal capacitance after 10,000 cycles. The all-solid-state device can be optionally connected in series or in parallel to meet the voltage and capacity requirements for a given application.This work demonstrates a promising future of the carbonbased hybrid ink for directly large-scale inkjet printing MSCs for disposable energy storage devices. | Zhibin Pei Haibo Hu Guojin Liang Changhui Ye | 2017 | Nano-Micro Letters2017，9，2： | 7 |
| 11 | Numerical study of methane/air jet flame in vitiated co-flow using tabulated detailed chemistry显示文摘Two different combustion models,the autoignition(AI)model and flamelet/progress variable(FPV)model,have been applied to study the auto-ignition process of methane/air jet flame in vitiated co-flow.A priori study was conducted to test the validity of the two models.Results show that the different range of predicted reaction rates is mainly responsible for their different performances in large eddy simulation(LES)studies.In this paper,beta PDF was used to model the mixture fraction distribution,while two different shapes of PDF,delta function and beta function,were applied for the reaction progress.Compared to the FPV model,the AI model combined with beta function for reaction progress could capture the auto-ignition process and predict the exact lifted height.Also the results indicate that the variance of reaction progress plays an important role in predicting the flame lifted height. | HAN Chao ZHANG Pei YE TaoHong CHEN YiLiang | 2014 | Science China(Technological Sciences)2014，57，9： | 7 |
| 12 | CRISPR/Cas9 editing of wheat TaQ genes alters spike morphogenesis and grain threshability显示文摘The Ta Q alleles as one of the AP2-like transcription factors in common wheat(Triticum aestivum) play an important role in the evolution of spike characteristics from wild and domesticated emmer to modern wheat cultivars. Its loss-of-function mutant not only changed threshability and spike architecture but also affected plant height, flowering time, and floret structure. However, the comprehensive functions of Ta AQ and Ta Dq genes in wheat have not been fully elucidated yet. Here, CRISPR/Sp Cas9 was used to edit wheat Ta AQ and Ta Dq. We obtained homozygous plants in the T1 generation with loss of function of only Ta AQ or Ta Dq and simultaneous loss of function of Ta AQ and Ta Dq to analyze the effect of these genes on wheat spikes and floret shapes. The results demonstrated that the Ta AQ-edited plants and the Ta AQ and Ta Dq simultaneously-edited plants were nearly similar in spike architecture, whereas the Ta Dq-edited plants were different from the wild-type ones only in plant height. Moreover, the Ta AQ-edited plants or the Ta AQ and Ta Dq simultaneously-edited plants were more brittle than the wild-type and the Ta Dqedited plants. Based on the expression profiling, we postulated that the VRN1, FUL2, SEP2, SEP5, and SEP6 genes might affect the number of spikelets and florets per spike in wheat by regulating the expression of Ta Q. Combining the results of this report and previous reports, we conceived a regulatory network of wheat traits, including plant height, spike shape, and floral organs, which were influenced by AP2-like family genes. The results achieved in this study will help us to understand the regulating mechanisms of Ta AQ and Ta Dq alleles on wheat floral organs and inflorescence development. | Huiyun Liu Ke Wang Huali Tang Qiang Gong Lipu Du Xinwu Pei Xingguo Ye | 2020 | Journal of Genetics and Genomics2020，47，9： | 6 |
| 13 | Phytosterol content and the campesterol:sitosterol ratio influence cotton fiber development: role of phytosterols in cell elongation显示文摘Phytosterols play an important role in plant growth and development,including cell division,cell elongation,embryogenesis,cellulose biosynthesis,and cell wall formation.Cotton fiber,which undergoes synchronous cell elongation and a large amount of cellulose synthesis,is an ideal model for the study of plant cell elongation and cell wall biogenesis.The role of phytosterols in fiber growth was investigated by treating the fibers with tridemorph,a sterol biosynthetic inhibitor.The inhibition of phytosterol biosynthesis resulted in an apparent suppression of fiber elongation in vitro or in planta.The determination of phytosterol quantity indicated that sitosterol and campesterol were the major phytosterols in cotton fibers;moreover,higher concentrations of these phytosterols were observed during the period of rapid elongation of fibers.Furthermore,the decrease and increase in campesterol:sitosterol ratio was associated with the increase and decease in speed of elongation,respectively,during the elongation stage.The increase in the ratio was associated with the transition from cell elongation to secondary cell wall synthesis.In addition,a number of phytosterol biosynthetic genes were down-regulated in the short fibers of ligon lintless-1mutant,compared to its near-isogenic wild-type TM-1.These results demonstrated that phytosterols play a crucial role in cotton fiber development,and particularly in fiber elongation. | Shasha Deng Ting Wei Kunling Tan Mingyu Hu Fang Li Yunlan Zhai Shue Ye Yuehua Xiao Lei Hou Yan Pei Ming Luo | 2016 | Science China(Life Sciences)2016，59，2： | 5 |
| 14 | Creation of Transgenic Bananas Expressing Human Lysozyme Gene for Panama Wilt Resistance显示文摘Human lysozyme (HL) inhibits Fusarium oxysporum (FocR4) growth in vitro. To obtaintransgenic bananas (Musa spp.) that are resistant to Panama wilt (F. oxysporum), we introduced an HL genethat is driven by a constitutive cauliflower mosaic virus 35S promoter into the banana via Agrobacterium-mediated transformation. PCR confirmed that 51 transgenic plants were obtained. The development ofPanama wilt symptoms were examined after the plants had been grown in pots. The non-transgenic plantsdeveloped typical fusarium symptoms 60 d after FocR4 inoculation, whereas 24 of 51 transgenic plants remained healthy. The transgenic banana plants that showed resistance to FocR4 in the pots were then planted in a field that was heavily infected with FocR4 for further investigation. Eleven of 24 plants developed symptoms before bud emergence; another 11 plants showed symptoms after bud emergence and the remaining two plants, H-67 and H-144, remained healthy and were able to fruit. Northern blotting analysisdemonstrated that H-67 and H-144, bearing the strongest resistance to Panama wilt, had the highest level ofHL expression and that the expression of HL was well correlated with the FocR4 resistance of transgenicplants. We conclude that Agrobacterium-mediated transformation, with the assistance of particlebombardment, is a powerful approach for banana transformation and that a transgenic HL gene can causeresistance of the crop to FocR4 in the field. | Xin-Wu PEI Shi-Kai CHEN Rui-Ming WEN Shang YE Jia-Qin HUANG Yong-Qiang ZHANG Bing-Shan WANG Zhi-Xing WANG Shi-Rong JIA | 2005 | Journal of Integrative Plant Biology2005，47，8： | 5 |
| 15 | Effects of Ligustrum robustum on gut microbes and obesity in rats显示文摘AIM: To investigate the anti-obesity and antibacterial effects of Ligustrum robustum(L. robustum) in vivoand in vitro and its possible mechanisms. METHODS: The effects of L. robustum aqueous extract(LR) on various gut bacteria in vitro were evaluated. The effects of LR on high-fat diet-fed(HFD) rats in vivo were also assessed. Culture methods,quantitative polymerase chain reaction,and terminalrestriction fragment length polymorphism were used to analyze the effects of LR on gut bacteria. Biochemical tests were also performed to detect the changes in obesity-related indicators after LR treatment. RESULTS: LR treatment lowered adipose weight and decreased Lee's index,blood glucose,total cholesterol,and lipid in the tested groups relative to control(P < 0.05). To determine the reasons for these changes,we assessed the potential bacteriostatic and bactericidal effects of LR on specific bacterial species in vitro. LR affected the richness,diversity,and evenness of gut bacteria,increased fecal Lactobacillus,and decreased Enterococci in HFD rats(P < 0.05). CONCLUSION: L. robustum may be a safe and effective food for weight loss and obesity control,and the effects of L. robustum might be mediated by the regulation of gut bacteria. | Zhi-Mei Xie Tao Zhou Hong-Yu Liao Qian Ye Shan Liu Lu Qi Jing Huang Hao-Jiang Zuo Xiao-Fang Pei | 2015 | World Journal of Gastroenterology2015，21，46： | 5 |
| 16 | Neddylation is required for herpes simplex virus type I (HSV- 1)-induced early phase interferon-beta production显示文摘 | Xueying Zhang Zhenjie Ye Yujun Pei Guihua Qiu Qingyang Wang Yunlu Xu Beifen Shen Jiyan Zhang | 2016 | Cellular & Molecular Immunology2016，13，5： | 5 |
| 17 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 18 | A new isochroman-4-one derivative from the peel of Musa sapientum L.and its total synthesis显示文摘新 isochroman-4-one, 7,8-dihydroxy-3-methylisochroman-4-one 从水被孤立 Musa 智慧弦音器 L 的可溶的部分。它的结构被分光镜的证据决定,它的全部的合成也被报导了。复合显示出的有势力反高血压的活动。 | Hai Qian Wen Long Huang Xiao Ming Wu Hui Bin Zhang Jin Pei Zhou Wen Cai Ye | 2007 | Chinese Chemical Letters2007，18，10： | 4 |
| 19 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
| 20 | Spatial inequality, characteristics of internal migration, and pulmonary tuberculosis in China, 2011–2017: a spatial analysis显示文摘Background: Human migration facilitate the spread of tuberculosis(TB).Migrants face an increased risk of TB infection.In this study,we aim to explore the spatial inequity of sputum smear-positive pulmonary TB(SS+PTB)in China;and the spatial heterogeneity between SS+PTB and internal migration.Methods:: Notified SS+PTB cases in 31 provinces in China's Mainland were obtained from the national web-based PTB surveillance system database.Internal migrant data were extracted from the report on China’s migrant population development.Spatial autocorrelations were explored using the global Moran’s statistic and local indicators of spatial association.The spatial variation in temporal trends was performed using Kulldorff’s scan statistic.Fixed effect and spatial autoregressive models were used to explore the spatial inequity between SS+PTB and internal migration.Results: A total of 2380233 SS+PTB cases were reported in China between 2011 and 2017,of which,1716382(72.11%)were male and 663851(27.89%)were female.Over 70%of internal migrants were from rural households and had lower income and less education.The spatial variation in temporal trend results showed that there was an 9.9%average annual decrease in the notification rate of SS+PTB from 2011 to 2017;and spatial clustering of SS+PTB cases was mainly located in western and southern China.The spatial autocorrelation results revealed spatial clustering of internal migration each year(2011–2017),and the clusters were stable within most provinces.Internal emigration,urban-to-rural migration and GDP per capita were significantly associated with SS+PTB,further,internal emigration could explain more variation in SS+PTB in the eastern region in mainland.However,internal immigration and rural-to-urban migration were not significantly associated with SS+PTB across China.Conclusions: Our study found the spatial inequity between SS+PTB and internal migration.Internal emigration,urban-to-rural migration and GDP per capita were statistically associated with SS+PTB;the negative association was identified between internal emigration,urban-to-rural migration and SS+PTB.Further,we found those migrants with lower income and less education,and most of them were from rural households.These findings can help stakeholders to implement effective PTB control strategies for areas at high risk of PTB and those with high rates of internal migration. | Wen-Chong He Ke Ju Ya-Min Gao Pei Zhang Yin-Xia Zhang Ye Jiang Wei-Bin Liao | 2020 | Infectious Diseases of Poverty2020，9，6： | 4 |
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