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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 3 | Does dying at home influence the good death of terminal cancer patients? 显示文摘 | Yao C A Hu W Y Lai Y F | 2007 | J Pain Symptom Manage2007，34，5： | 1 |
| 4 | Analysis of direct toque control in permanent magnet synchronous motor drives 显示文摘 | Zhong L Rahman M F Hu W Y | 1997 | IEEE Transactions on Power Electronics1997，12，3： | 1 |
| 5 | Analysis of Direct Torque Control in Permanent Magnet Synchronous Motor Drives 显示文摘 | Zhong L Rahman M F Hu Y W | 1997 | IEEE Transactions on Power Electronics1997，12，3： | 1 |
| 6 | Friction and wear of the film formed in the immersion test of oil containing antiwear and extreme pressure additives 显示文摘 | Liu W M Hu L T Zhang Z F | 1995 | Thin Solid Film1995，271，： | 1 |
| 7 | Biomacromolecules显示文摘 | Chen Y Ding D Mao Z Q He Y F Hu Y Wu W Jiang X Q | 2008 | 9(10):2609-26142008，9，10： | 1 |
| 8 | Optimal diets for prevention of coro- nary heart disease 显示文摘 | HU F B WILLETT W C | 2002 | JAMA2002，288，20： | 1 |
| 9 | Effect of ambroxol on pneumonia caused by Pseudomonas aeruginosa with biofilm formation in an endotracheal intubation rat model显示文摘 | Li F Wang W Hu L | | 0，，02： | 1 |
| 10 | Analysis direct torque controller for permanent magnet synchronous motor drives显示文摘 | ZHONG L RAHMAN M F HU W Y | | 0，，03： | 1 |
| 11 | Significance of clinical factors as prognostic indicators for patients with peripheral T- cell non-Hodgkin lymphoma: A retrospective analysis of 252 cases 显示文摘 | Xie W Hu K Xu F | 2013 | Mol Clin Oncol2013，1，5： | 1 |
| 12 | Embrittlement of T-200 Maraging Steel in a Hydrogen Sulfide Solution显示文摘 | TSAY L W HU Y F CHEN C | 2005 | Corro- sion Science2005，47，4： | 1 |
| 13 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 14 | Preparation and characterization of flame retardant ABS/montmorillonite nanocomposlte 显示文摘 | Wang S F Hu Y Zong R W | 2004 | Applied Clay Science2004，25，： | 1 |
| 15 | Thermogravimetric evaluation of PC/ABS/montmorillonite Nanocomposite显示文摘 | ZONG R W HU Y WANG S F | 2004 | Polym Degrad Stab2004，83，： | 1 |
| 16 | Approximate solution of creep of orthogonal anisotropic concrete thin plates 显示文摘 | Zhou R G Hu Y X Duan L Chen W F | 1993 | Engineering Structure1993，15，1： | 1 |
| 17 | A Direct Torque Control- ler for Permanent Magnet Synchronous Motor Drives 显示文摘 | Zhong L Rahman M F Hu Y W | 1999 | IEEE Transactions on Energy Conversion1999，14，3： | 1 |
| 18 | Dense and long carbon nanotube arrays decorated with Mn304 nanoparticles for electrodes of electrochemical supercapacitors 显示文摘 | CUI X HU F WEI W | 2011 | Car- bon2011，49，4： | 1 |
| 19 | Oridonin Induces Apoptosis and Senescence in Colorectal Cancer Ceils by Increasing Histone Hyperacetylation and Regulation of p16,p21,p27 and c-myc 显示文摘 | Gao F H Hu X H Li W | 2010 | BMC Cancer2010，10，： | 1 |
| 20 | N-stearoyl-L-tyrosine ameliorates sevoflurane induced neuroapoptosis via MEK/ERK1/2 MAPK signaling pathway in the developing brain 显示文摘 | WANG W Y YANG R HU S F | 2013 | Neurosci Lett2013，，541： | 1 |
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