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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Regulation of glucose and lipid metabolism in health and disease显示文摘Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the most abundant sterol in mammals, is a key component of cell membranes although it does not generate ATP. The metabolisms of glucose, fatty acids and cholesterol are often intertwined and regulated. For example, glucose can be converted to fatty acids and cholesterol through de novo lipid biosynthesis pathways. Excessive lipids are secreted in lipoproteins or stored in lipid droplets. The metabolites of glucose and lipids are dynamically transported intercellularly and intracellularly, and then converted to other molecules in specific compartments. The disorders of glucose and lipid metabolism result in severe diseases including cardiovascular disease, diabetes and fatty liver. This review summarizes the major metabolic aspects of glucose and lipid, and their regulations in the context of physiology and diseases. | Ligong Chen Xiao-Wei Chen Xun Huang Bao-Liang Song Yan Wang Yiguo Wang | 2019 | Science China(Life Sciences)2019，62，11： | 40 |
| 3 | Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana显示文摘规划房间死亡(PCD ) 是一个基本生物过程。在马赛克死亡 1 的缺乏(MOD1 ) ,质体局部性的 enoyl-ACP reductase,导致反应的氧种类(ROS ) 和 PCD 的累积,它能被 mitochondrial 建筑群压制我变化,从叶绿体显示一个信号到线粒体。然而,这个信号尚待被阐明。在这研究,通过克隆并且分析一系列 mod1 suppressors,我们揭示调整 mitochondrial ROS 和扳机 PCD 的产生的一条全面细胞器通讯小径。我们证明在 PLASTIDIAL NAD 依赖的 MALATE 脱氢酶(plNAD-MDH ) 的变化, chloroplastic DICARBOXYLATE TRANSPORTER 1 (DiT1 ) 并且(mMDH1 ) MITOCHONDRIAL MALATE 脱氢酶 1 能各在 mod1 救 ROS 累积和 PCD 显型,经由 malate 梭从叶绿体表明直接通讯到线粒体。进一步的研究证明这些元素在不同光周期条件下面在氧化还原作用动态平衡和植物生长起关键作用。而且,我们表明 ROS 水平和 PCD 显著地在房间,它能是戏剧性地稀释了由的对待 malate 的 HeLa 被增加人的基因 MDH2 击倒, Arabidopsis mMDH1 的 ortholog。这些结果揭开在植物和动物系统的一条保存导致 malate 的 PCD 小径,革命化我们在细胞器之间的通讯的理解。 | Yannan Zhao Lilan Luo Jiesi Xu Peiyong Xin Hongyan Guo Jian Wu Lin Bai Guodong Wang Jinfang Chu Jianru Zuo Hong Yu Xun Huang Jiayang Li | 2018 | Cell Research2018，28，4： | 24 |
| 4 | Identification of rice cultivars with low brown rice mixed cadmium and lead contents and their interactions with the micronutrients iron,zinc,nickel and manganese显示文摘Paddy fields in mining areas are usually co-contaminated by a cocktail of mixed toxic heavy metals(e.g.,Cd and Pb in Pb/Zn mines).However,previous studies on rice cultivars screened for effective metal exclusion have mostly focused on individual metals,and have been conducted under pot-trial or hydroponic solution conditions.This study identified rice cultivars with both low Cd and Pb accumulation under Cd-and Pb-contaminated field conditions,and the interactions of the toxic elements Cd and Pb with the micronutrient elements Fe,Zn,Mn and Ni were also studied.Among 32 rice cultivars tested,there were significant differences in Cd(0.06-0.59 mg/kg) and Pb(0.25-3.15 mg/kg) levels in their brown rice,and similar results were also found for the micronutrient elements.Significant decreases in concentrations of Fe and Mn were detected with increasing Cd concentrations and a significant elevation in Fe,Mn and Ni with increasing Pb concentrations.A similar result was also shown by Cd and Ni.Three cultivars were identified with a combination of low brown rice Cd and Pb,high micronutrient and grain yield(Wufengyou 2168,Tianyou 196 and Guinongzhan).Present results suggest that it is possible to breed rice cultivars with low mixed toxic element(Cd,Pb) and high micronutrient contents along with high grain yields,thus ensuring food safety and quality. | Bing Li Xun Wang Xiaoli Qi Lu Huang Zhihong Ye | 2012 | Journal of Environmental Sciences2012，24，10： | 18 |
| 5 | Laparoscopic vs open total gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis comparing laparoscopic total gastrectomy(LTG)with open total gastrectomy(OTG)for the treatment of gastric cancer.METHODS:Major databases such as Medline(PubMed),Embase,Academic Search Premier(EBSCO),Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials(CENTRAL)in The Cochrane Library were searched for studies comparing LTG and OTG from January 1994 to May 2013.Evaluated endpoints were operative,postoperative and oncological outcomes.Operative outcomes included operative time and intraoperative blood loss.Postoperative recovery included time to first fatus,time to first oral intake,hospital stay and analgesics use.Postoperative complications comprised morbidity,anastomotic leakage,anastomotic stenosis,ileus,bleeding,abdominal abscess,wound problems and mortality.Oncological outcomes included positive resection margins,number of retrieved lymph nodes,and proximal and distal resection margins.The pooled effect was calculated using either a fixed effects or a random effects model.RESULTS:Fifteen non-randomized comparative studies with 2022 patients were included(LTG-811,OTG-1211).Both groups had similar short-term oncological outcomes,analgesic use(WMD-0.09;95%CI:-2.39-2.20;P=0.94)and mortality(OR=0.74;95%CI:0.24-2.31;P=0.61).However,LTG was associated with a lower intraoperative blood loss(WMD-201.19 mL;95%CI:-296.50--105.87 mL;P<0.0001)and overall complication rate(OR=0.73;95%CI:0.57-0.92;P=0.009);fewer wound-related complications(OR=0.39;95%CI:0.21-0.72;P=0.002);a quicker recovery of gastrointestinal motility with shorter time to frst fatus(WMD-0.82;95%CI:-1.18--0.45;P<0.0001)and oral intake(WMD-1.30;95%CI:-1.84--0.75;P<0.00001);and a shorter hospital stay(WMD-3.55;95%CI:-5.13--1.96;P<0.0001),albeit with a longer operation time(WMD 48.25 min;95%CI:31.15-65.35;P<0.00001),as compared with OTG.CONCLUSION:LTG is safe and effective,and may offer some advantages over OTG in the treatment of gastric cancer. | Jun-Jie Xiong Quentin M Nunes Wei Huang Chun-Lu Tan Neng-Wen Ke Si-Ming Xie Xun Ran Hao Zhang Yong-Hua Chen Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，44： | 11 |
| 6 | An experimental and thermodynamic equilibrium investigation of the Pb,Zn,Cr,Cu,Mn and Ni partitioning during sewage sludge incineration显示文摘The effects of different chlorides and operational conditions on the distribution and speciation of six heavy metals(Pb, Zn, Cr, Cu, Mn and Ni) during sludge incineration were investigated using a simulated laboratory tubular-furnace reactor. A thermodynamic equilibrium investigation using the Fact Sage software was performed to compare the experimental results. The results indicate that the volatility of the target metals was enhanced as the chlorine concentration increased. Inorganic-Cl influenced the volatilization of heavy metals in the order of Pb > Zn > Cr > Cu > Mn > Ni. However, the effects of organic-Cl on the volatility of Mn, Pb and Cu were greater than the effects on Zn, Cr and Ni.With increasing combustion temperature, the presence of organic-Cl(PVC) and inorganic-Cl(NaCl) improved the transfer of Pb and Zn from bottom ash to fly ash or fuse gas. However,the presence of chloride had no obvious influence on Mn, Cu and Ni. Increased retention time could increase the volatilization rate of heavy metals; however, this effect was insignificant. During the incineration process, Pb readily formed Pb SiO4 and remained in the bottom ash. Different Pb compounds, primarily the volatile PbCl2, were found in the gas phase after the addition of NaCl; the dominant Pb compounds in the gas phase after the addition of PVC were PbCl2, Pb(ClO4)2and Pb Cl2O4. | Jingyong Liu Jiewen Fu Xun'an Ning Shuiyu Sun Yujie Wang Wuming Xie Shaosong Huang Sheng Zhong | 2015 | Journal of Environmental Sciences2015，27，9： | 11 |
| 7 | Clinical features of acute hepatitis E super-infections on chronic hepatitis B显示文摘AIM To examine the clinical features and risk factors for adverse outcomes in chronic hepatitis B(CHB) superimposed with hepatitis E virus(HEV).METHODS This retrospective cohort study included 228 patients with acute HEV infection(showing clinical acute hepatitis symptomology and positivity for anti-HEV immunoglobulin M) with underlying CHB(confirmed by positivity for hepatitis B surface antigen and/or hepatitis B virus(HBV) DNA over 6 mo) who had been admitted to the Shanghai Public Health Clinical Center, which represents the regional tertiary hospital for infectious diseases in Shanghai city, China. Data for adverse outcomes were collected, and included severe liver diseases(defined as liver failure and/or acute liver decompensation) and liver-related mortality. Logistic regression modeling was performed to determine the risk factors for adverse outcomes.RESULTS The symptoms caused by superimposed acute hepatitis E(AHE) were much more severe in cirrhotic patients(n = 94) than in non-cirrhotic patients(n = 134), as evidenced by significantly higher liver complications(77.7% vs 28.4%, P < 0.001) and mortality rate(21.3% vs 7.5%, P = 0.002). Most of the cirrhotic patients(n = 85, 90.4%) had no prior decompensation. Among the non-cirrhotic patients, superimposed AHE caused progressively more severe diseases that corresponded with the CHB disease stages, from immune tolerant to immune reactivation phases. Few risk factors were identified in the cirrhotic patients, but risk factors for non-cirrhotic patients were found to be intermediate HBV DNA levels(OR: 5.1, P = 0.012), alcohol consumption(OR: 6.4, P = 0.020), and underlying diabetes(OR: 7.5, P = 0.003) and kidney diseases(OR: 12.7, P = 0.005). Only 28.7% of the cirrhotic patients and 9.0% of the non-cirrhotic patients had received anti-HBV therapy previously and, in all cases, the efficacy had been suboptimal. CONCLUSION CHB-related cirrhosis and intermediate HBV DNA level were associated with severe disease in superinfected patients, and successful antiviral treatment might counter this outcome. | Chong Chen Shu-Ye Zhang Dan-Dan Zhang Xin-Yan Li Yu-Ling Zhang Wei-Xia Li Jing-Jing Yan Min Wang Jing-Na Xun Chuan Lu Yun Ling Yu-Xian Huang Liang Chen | 2016 | World Journal of Gastroenterology2016，22，47： | 10 |
| 8 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 9 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 10 | Protective effects of a novel drug RC28-E blocking both VEGF and FGF2 on early diabetic rat retina显示文摘AIM: To investigate protective effects of a novel recombinant decoy receptor drug RC28-E on retinal damage in early diabetic rats.METHODS: The streptozotocin(STZ)-induced diabetic rats were randomly divided into 6 groups: diabetes mellitus(DM) group(saline, 3 μL/eye); RC28-E at low(0.33 μg/μL, 3 μL), medium(1 μg/μL, 3 μL), and high(3 μg/μL,3 μL) dose groups; vascular endothelial growth factor(VEGF) Trap group(1 μg/μL, 3 μL); fibroblast growth factor(FGF) Trap group(1 μg/μL, 3 μL). Normal control group was included. At week 1 and 4 following diabetic induction,the rats were intravitreally injected with the corresponding solutions. At week 6 following the induction, apoptosis in retinal vessels was detected by TUNEL staining.Glial fibrillary acidic protein(GFAP) expression was examined by immunofluorescence. Blood-retinal barrier(BRB) breakdown was assessed by Evans blue assay.Ultrastructural changes in choroidal and retinal vessels were analyzed by transmission electron microscopy(TEM).Content of VEGF and FGF proteins in retina was measured by enzyme linked immunosorbent assay(ELISA). The retinal expression of intercellular cell adhesion molecule-1(ICAM-1), tumor necrosis factor-α(TNF-α), VEGF and FGF genes was examined by quantitative polymerase chain reaction(qPCR).RESULTS: TUNEL staining showed that the aberrantly increased apoptotic cells death in diabetic retinal vascular network was significantly reduced by treatments of medium and high dose RC28-E, VEGF Trap, and FGF Trap(all P<0.05), the effects of medium and high dose RC28-E or FGF Trap were greater than VEGF Trap(P<0.01). GFAP staining suggested that reactive gliosis was substantially inhibited in all RC28-E and VEGF Trap groups, but the inhibition in FGF Trap group was not as prominent.Evans blue assay demonstrated that only high dose RC28-E could significantly reduce vascular leakage in early diabetic retina(P<0.01). TEM revealed that the ultrastructures in choroidal and retinal vessels were damaged in early diabetic retina, which was ameliorated to differential extents by each drug. The expression of VEGF and FGF2 proteins was significantly upregulated in early diabetic retina, and normalized by RC28-E at all dosages and by the corresponding Traps. The upregulation of ICAM-1 and TNF-α in diabetic retina was substantially suppressed by RC28-E and positive control drugs.CONCLUSION: Dual blockade of VEGF and FGF2 by RC28-E generates remarkable protective effects, including anti-apoptosis, anti-gliosis, anti-leakage, and improving ultrastructures and proinflammatory microenvironment,in early diabetic retina, thereby supporting further development of RC28-E into a novel and effective drug to diabetic retinopathy(DR). | Qian-Hui Yang Yan Zhang Jing Jiang Mian-Mian Wu Qian Han Qi-Yu Bo Guang-Wei Yu Yu-Sha Ru Xun Liu Min Huang Ling Wang Xiao-Min Zhang Jian-Min Fang Xiao-Rong Li | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 9 |
| 11 | Hierarchically porous nitrogen-doped carbon as cathode for lithium–sulfur batteries显示文摘Porous nitrogen-doped carbon is an especially promising material energy storage due to its excellent conductivity, stable physicochemical properties, easy processability, controllable porosity and low price.Herein, we reported a novel well-designed hierarchically porous nitrogen-doped carbon(HPNC) via a combination of salt template(ZnCl_2) and hard template(SiO_2) as sulfur host for lithium–sulfur batteries. The low-melting ZnCl_2 is boiled off and leaves behind micropores and small size mesopores during pyrolysis process, while the silica spheres are removed by acid leaching to generate interconnected 3D network of macropores. The HPNC-S electrode exhibits an initial specific capacity of 1355 mAh g^(–1) at 0.1 C(1 C = 1675 m Ah g^(–1)), a high-rate capability of 623 m Ah g^(–1) at 2 C, and a small decay of 0.13% per cycle over 300 cycles at 0.2 C. This excellent rate capability and remarkable long-term cyclability of the HPNC-S electrode are attributed to its hierarchical porous structures for confining the soluble lithium polysulfide as well as the nitrogen doping for high absorbability of lithium polysulfide. | Rui Wu Siguo Chen Jianghai Deng Xun Huang Yujie Song Ruiyi Gan Xiaoju Wan Zidong Wei | 2018 | Journal of Energy Chemistry2018，27，6： | 8 |
| 12 | Wolbachia infection dynamics by reaction-diffusion equations显示文摘Dengue fever is caused by the dengue virus and transmitted by Aedes mosquitoes.A promising avenue for eradicating the disease is to infect the wild aedes population with the bacterium Wolbachia driven by cytoplasmic incompatibility(CI).When releasing Wolbachia infected mosquitoes for population replacement,it is essential to not ignore the spatial inhomogeneity of wild mosquito distribution.In this paper,we develop a model of reaction-diffusion system to investigate the infection dynamics in natural areas,under the assumptions supported by recent experiments such as perfect maternal transmission and complete CI.We prove non-existence of inhomogeneous steady-states when one of the diffusion coefficients is sufficiently large,and classify local stability for constant steady states.It is seen that diffusion does not change the criteria for the local stabilities.Our major concern is to determine the minimum infection frequency above which Wolbachia can spread into the whole population of mosquitoes.We find that diffusion drives the minimum frequency slightly higher in general.However,the minimum remains zero when Wolbachia infection brings overwhelming fitness benefit.In the special case when the infection does not alter the longevity of mosquitoes but reduces the birth rate by half,diffusion has no impact on the minimum frequency. | HUANG Mu Gen TANG Mo Xun YU Jian She | 2015 | Science China Mathematics2015，58，1： | 8 |
| 13 | Dynamic tensile properties and microstructural evolution of extruded EW75 magnesium alloy at high strain rates显示文摘The dynamic tensile properties and microstructural evolution of an extruded EW75 magnesium alloy deformed at ambient temperature and different high strain rates(from 1000 to 3000 s^(-1))along extrusion direction(ED)were investigated by Split Hopkinson Tension Bar(SHTB).The corresponding deformation mechanisms,texture evolution and microstructure changes were analyzed by optical microscope(OM),electron backscatter diffraction(EBSD)and transmission electron microscope(TEM).The results show that the extruded EW75 magnesium alloy along ED exhibits a conventional positive strain rate sensitivity that the dynamic flow stresses increase with in creasing strain rate.Texture measurements show that after dynamic tension,the initial weak texture of extruded EW75 magnesium alloy tansforms to a relatively strong<10-10>//ED texture with increasing strain rates.The microstructural analysis demonstrates that dislocation motion are main deformatin mode to accommodate dynamic tensile deformation at high strain rates.In addition,the interactions of dislocation-dislocation and dislocation-second phase lead to the in crease of flow stress and strain hardening with increasing strain rate. | Jincheng Yu Bo Song Dabiao Xia Xun Zeng Yuanding Huang Norbert Hort Pingli Mao Zheng Liu | 2020 | Journal of Magnesium and Alloys2020，8，3： | 7 |
| 14 | Isolation and identification of symbiotic bacteria from the skin, mouth, and rectum of wild and captive tree shrews显示文摘Endosymbionts influence many aspects of their hosts’ health conditions, including physiology, development, immunity, metabolism, etc. Tree shrews(Tupaia belangeri chinensis) have attracted increasing attention in modeling human diseases and therapeutic responses due to their close relationship with primates. To clarify the situation of symbiotic bacteria from their body surface, oral cavity, and anus, 12 wild and 12 the third generation of captive tree shrews were examined. Based on morphological and cultural characteristics, physiological and biochemical tests, as well as the 16 S rDNA full sequence analysis, 12 bacteria strains were isolated and identified from the wild tree shrews: body surface: Bacillus subtilis(detection rate 42%), Pseudomonas aeruginosa(25%), Staphlococcus aureus(33%), S. Epidermidis(75%), Micrococcus luteus(25%), Kurthia gibsonii(17%); oral cavity: Neisseria mucosa(58%), Streptococcus pneumonia(17%); anus: Enterococcus faecalis(17%), Lactococus lactis(33%), Escherichia coli(92%), Salmonella typhosa(17%); whereas, four were indentified from the third generation captive tree shrews: body surface: S. epidermidis(75%); oral cavity: N.mucosa(67%); anus: L. lactis(33%), E. coli(100%). These results indicate that S. epidermidis, N. mucosa, L. lactis and E. coli were major bacteria in tree shrews, whereas, S. aureus, M. luteus, K. gibsonii, E. faecalis and S. typhosa were species-specific flora. This study facilitates the future use of tree shrews as a standard experimental animal and improves our understanding of the relationship between endosymbionts and their hosts. | Gui LI Ren LAI Gang DUAN Long-Bao LYU Zhi-Ye ZHANG Huang LIU Xun XIANG | 2014 | Zoological Research2014，35，6： | 6 |
| 15 | Isolation and characterization of two new 2-isobutylmalates from Bletilla striata显示文摘The present study isolated 17 compounds from the tubers of Bletilla striata(Orchidaceae), using various chromatographic techniques. Their structures were identified based on their physical-chemical properties and spectroscopic analyses. Among them, two new 2-isobutylmalates, named bletimalates A(1) and B(2), together with other fifteen known compounds(3-17), were isolated and identified. Additionally, compounds 3, 4, and 8 were isolated from this plant for the first time. | GUAN Huan-Yu YAN Yan WANG Yong-Lin WANG Ai-Min LIU Jun-Hong HE Xun LI Yong-Jun HUANG Yong LIAO Shang-Gao | 2016 | Chinese Journal of Natural Medicines2016，14，11： | 6 |
| 16 | Residual Fatigue Life Prediction of Ball Bearings Based on Paris Law and RMS显示文摘Paris law can reflect the failure mechanism of materials and is usually used to be a method to predict fatigue life or residual fatigue life.But the variable which can represent the health of machine is hardly measured on line.To a degree,the difficulty of on-line application restricts the scope of application of Paris law.The relationship between characteristic values of vibration signals and the variable in the Paris equation which can describe the health of machine is investigated by taking ball bearings as investigative objects.Based on 6205 deep groove ball bearings as a living example,historical lives and vibration signals are analyzed.The feasibility of describing that variable in the Paris equation by the characteristic value of vibration signals is inspected.After that vibration signals decomposed by empirical mode decomposition(EMD),root mean square(RMS) of intrinsic mode function(IMF) involving fault characteristic frequency has a consistent trend with the diameter of flaws.Based on the trend,two improved Paris models are proposed and the scope of application of them is inspected.These two Paris Models are validated by fatigue residual life data from tests of rolling element bearings and vibration signals monitored in the process of operation of rolling element bearings.It shows that the first improved Paris Model is simple and plain and it can be easily applied in actual conditions.The trend of the fatigue residual life predicted by the second improved Paris model is close to the actual conditions and the result of the prediction is slightly greater than the truth.In conclusion,after the appearance of detectable faults,these improved models based on RMS can predict residual fatigue life on line and a new approach to predict residual fatigue life of ball bearings on line without disturbing the machine running is provided. | XU Dong HUANG Jin'e ZHU Qin CHEN Xun XU Yongcheng WANG Shuang | 2012 | Chinese Journal of Mechanical Engineering2012，25，2： | 6 |
| 17 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 18 | Retinoic acid and sodium butyrate on cell cycle regulators in the treatment of oral squamous carcinoma cells显示文摘 | An Xun Wang Rong Sheng Zeng Hong Zhang Huang | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 5 |
| 19 | Theory and Experimental Verification on Valveless Piezoelectric Pump with Multistage Y-shape Treelike Bifurcate Tubes显示文摘Among most traditional piezo water cooling systems, piezoelectric valve pumps are adopted as their driving sources. The valves in these pumps induce problems of shock and vibration and also make their structure complicated, which is uneasy to minimize and reduce their reliability and applicability of the whole system. In order to avoid these problems caused by valve structure, a novel valveless piezoelectric pump is developed, which integrates both functions of transforming and cooling. The pump's Y-shape tree-like construction not only increases the efficiency of cooling but also the system reliability and applicability. Firstly, a multistage Y-shape treelike bifurcate tube is proposed, then a valveless piezoelectric pump with multistage Y-shape treelike bifurcate tubes is designed and its working principle is analyzed. Then, the theoretical analysis of flow resistance characteristics and the flow rate of the valveless piezoelectric pump are performed. Meanwhile, commercial software CFX is employed to perform the numerical simulation for the pump. Finally, this valveless piezoelectric pump is fabricated, the relationship between the flow rates and driving frequency, as well as the relationship between the back pressure and the driving frequency are experimentally investigated. The experimental results show that the maximum flow rate is 35.6 mL/min under 100 V peak-to-peak voltage (10.3 Hz) power supply, and the maximum back pressure is 55 mm H2O under 100 V (9 Hz) power supply, which validates the feasibility of the valveless piezoelectric pump with multistage Y-shape treelike bifurcate tubes. The proposed research provides certain references for the design of valveless piezoelectric pump and improves the reliability of piezo water cooling systems. | HUANG Jun ZHANG Jianhui XUN Xianchao WANG Shouyin | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 5 |
| 20 | CTC clusters induced by heparanase enhance breast cancer metastasis显示文摘聚集的变形癌症房间,当传播肿瘤房间(CTC ) 聚类,指了,在癌症病人的血是在场的并且贡献癌症转移。然而, CTC 的起源聚类,特别 intravascular 总数,未知的遗体。这里,我们采用暂停文化方法在乳癌病人的循环模仿 CTC 簇形成。用这些方法产生的 CTC 簇展出了被 heparanase (HPSE ) 的 overexpression 定义的一个增加的变形潜力。Heparanase 导致了 FAK-1-dependent 和 ICAM-1-dependent 房间粘附,它支持了 intravascular 房间聚集。而且,它有 JG6 的活动的 heparanase 或抑制击倒,一个 heparanase 禁止者,是足够的堵住房间簇的形成并且压制乳癌转移。我们的数据表明那调停 heparanase 的房间粘附是批评的因为转移由 intravascular CTC 簇调停了。我们也建议在癌症房间传播指向 heparanase 的功能可能限制变形前进。 | Rong-rui WEI Dan-ni SUN Hong YANG Juan YAN Xiong ZHANG Xing-ling ZHENG Xu-hong FU Mei-yu GENG Xun HUANG Jian DING | 2018 | Acta Pharmacologica Sinica2018，39，8： | 5 |
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