|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidemiological characteristics of pulmonary tuberculosis in patients with pneumoconiosis based on its social determinants and risk factors in China:a cross-sectional study from 27 provinces显示文摘Background:Patients with pneumoconiosis have an elevated risk of contracting pulmonary tuberculosis(PTB)and need particular attention.However,extensive population-based studies on the prevalence of PTB in patients with pneumoconiosis have not been reported in China since 1992.This study aimed to investigate the epidemiological characteristics of PTB in patients with pneumoconiosis based on its social determinants and risk factors in China.Methods:Based on the Commission on Social Determinants of Health(CSDH)framework,data were obtained from a questionnaire survey of patients with pneumoconiosis from China’s 27 provinces(autonomous regions,municipalities)from December 2017 to June 2021.By chi-square and multivariate logistic regression analyses,the epidemiological characteristics of PTB in the patients were identified based on its prevalence and odds ratio(OR)and associated social determinants and risk factors.The population attributable fractions(PAFs)of significant risk factors were also calculated.Results:The prevalence of PTB in patients with pneumoconiosis(n=10,137)was 7.5%(95%confidence interval[CI]:7.0-8.0%).Multivariate logistic regression analysis showed that risk factors included in-hospital exposure to patients with PTB(OR=3.30,95%CI:2.77-3.93),clinically diagnosed cases(OR=3.25,95%CI:2.42-4.34),and northeastern regions(OR=2.41,95%CI:1.76-3.31).In addition,lack of work-related injury insurance(WRII),being born in a rural area,being unemployed,living in western regions,household exposure to patients with PTB,smoking,being underweight,complications of pulmonary bullae or pneumothorax,hospitalization history,and former drinkers among the rural patients were also statistically significant risk factors.Being born in a rural area,lack of WRII and in-hospital exposure to patients with PTB had higher PAFs,which were 13.2%(95%CI:7.9-18.5%),12.5%(95%CI:8.3-16.7%),and 11.6%(95%CI:8.8-14.3%),respectively.Conclusion:The prevalence of PTB in pneumoconiosis remains high in China;it is basically in line with the CSDH models and has its characteristics. | Huanqiang Wang Huaping Dai Jiayu He Xiangpei Lyu Xinran Zhang Tao Li | 2022 | Chinese Medical Journal2022，135，24： | 7 |
| 2 | Construction of Multilayer Porous Scaffold Based on Magnetically Guided Assembly of Microfiber显示文摘这份报纸建议有磁力地指导的汇编的一个新奇方法为三维的房间文化构造多层的多孔的支架由使用磁性的 microfibers。Microfibers 与同类的磁性的 nanoparticles 由 biocompatible 和可被细菌破坏的 alginate 答案组成,它被注射泵的精确压力控制连续地从一台 microfluidic 设备旋转。磁性的 nanoparticles 在 microfibers 上启用磁场的控制。同时,吸引了设备与一个圆永久磁铁结合被利用指导喷出的 microfibers 的分发。设备被纯铁电线数组和蜡填写,它为 microfibers 的俘获和集会刺激强大的磁性的流动密度和磁场坡度。因此,磁性的 microfibers 被 micromanipulation 机器人的运动控制在吸引的设备的需要的地方上旋转,并且精确地点被磁性的力量调整结合玻璃 micropipette 的 assist。以后, microfibers 被周期的磁性的力量空间地组织并且穿过 layer-by-layer 与 650 m 的长度和宽度形成微毛孔的结构。最后,作者与高孔构造多层的基于 microfiber 的脚手架为长期的房间文化提供令人满意的环境。试验性的结果表明建议方法的有效性。 | LI Xingfu WANG Huaping SHI Qing SUN Tao HUANG Qiang FUKUDA Toshio | 2018 | Journal of Systems Science & Complexity2018，31，3： | 1 |
| 3 | On Angle Feedback and Antenna Shufflingin Double Space-time Transmit Diversity Systems显示文摘 | Xu Tao Liu Huaping | 2010 | IEEECommunication Letter2010，14，8： | 1 |
| 4 | 定位于内质网膜的转录因子MYRF经剪切后入核以调控秀丽线虫神经元突触发育重塑显示文摘文章简介本研究以遗传筛选的方式鉴别到突变体具有突触重塑障碍,并鉴别出该突变是个单点突变,发生在MYRF-1上。进一步的研究发现,MYRF-1蛋白全长定位在内质网上,并能发生剪切,之后释放出蛋白的氮端,氮端具有结合DNA的功能域,它进入细胞核并参与转录调控。 | Jun Meng Xiaoxia Ma Huaping Tao Xia Jin Daniel Witvliet James Mitchell Ming Zhu Meng-Qiu Dong Mei Zhen Yishi Jin 齐瀛川 | 2018 | 科学新闻2018，0，4： | 0 |
| 5 | Chlorothalonil induces the intestinal epithelial barrier dysfunction in Caco-2 cell-based in vitro monolayer model by activating MAPK pathway显示文摘The widespread use of chlorothalonil(CTL)has caused environmental residues and food contamination.Although the intestinal epithelial barrier(IEB)is directly involved in the metabolism and transportation of various exogenous compounds,there are few studies on the toxic effects of these compounds on the structure and function of IEB.The disassembly of tight junction(TJ)is a major cause of intestinal barrier dysfunction under exogenous compounds intake,but the precise mechanisms are not well understood.Here,we used Caco-2 cell monolayers as an in vitro model of human IEB to evaluate the toxicity of CTL exposure on the structure and function of IEB.Results showed that CTL exposure increased the paracellular permeability of the monolayers and downregulated mRNA levels of the TJ genes(ZO-1,OCLN,and CLDN1),polarity marker gene(SI),and anti-apoptosis gene(BCL-2)but upregulated the mRNA levels of apoptosis-related genes,including BAD,BAX,CASP3,and CASP8.Western blot analysis and immunofluorescence assay results showed the decreased levels and disrupted distribution of TJ protein network,including ZO-1 and CLDN1 in CTL-exposed IEB.In addition,the accumulation of intracellular reactive oxygen species,decreased mitochondrial membrane potential,and increased active CASP3 expression were observed in treated IEB.The result of TUNEL assay further confirmed the occurrence of cell apoptosis after CTL exposure.In addition,the phosphorylation of mitogen-activated protein kinases,including ERK,JNK and p38,was increased in CTL-exposed IEB.In summary,our results demonstrated that CTL exposure induced IEB dysfunction in Caco-2 cell monolayers by activating the mitogen-activated protein kinase pathway. | Huaping Tao Zhiwei Bao Zhengwei Fu Yuanxiang Jin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 0 |
| 6 | Accurate modulation of photoprinting under stiffness imaging feedback for engineering ECMs with high-fidelity mechanical properties显示文摘Engineered extracellular matrices(ECMs)that replicate complex in-vivo features have shown great potential in tissue engineering.Biocompatible hydrogel microstructures have been widely used to replace these native ECMs for physiologically relevant research.However,accurate reproduction of the 3D hierarchical and nonuniform mechanical stffness inside one integrated microstructure to mimic the complex mechanical properties of native ECMs presents a major challenge.Here,by using digital holographic microscopy(DHM)-based stffness imaging feedback,we propose a novel closed-loop control algorithm to achieve high-accuracy control of mechanical properties for hydrogel microstructures that recapitulate the physiological properties of native ECMs with high fidelity.During photoprinting,the photocuring area of the hydrogel is divided into microscale grid areas to locally control the photocuring process.With the assistance of a motorized microfluidic channel,the curing thickness is controlled with layer-by-layer stacking.The DHM-based stiffness imaging feedback allows accurate adjustment of the photocuring degree in every grid area to change the crosslinking network density of the hydrogel,thus enabling large-span and high-resolution modulation of mechanical properties.Finally,the gelatin methacrylate was used as a typical biomaterial to construct the highfidelity biomimetic ECMs.The Young's modulus could be flexibly modulated in the 10 kPa to 50 kPa range.Additionally,the modulus gradient was accurately controlled to within 2.9 kPa.By engineering ECM with locally different mechanical properties,cell spreading along the stff areas was observed successfully.We believe that this method can regenerate complex biomimetic ECMs that closely recapitulate in-vivo mechanical properties for further applications in tissue engineering and biomedical research. | Xin Li Huaping Wang Xinyi Dong Qing Shi Tao Sun Shingo Shimoda Qiang Huang Toshio Fukuda | 2022 | Microsystems & Nanoengineering2022，8，3： | 0 |
| 7 | A Survey on Blockchain-Based Federated Learning:Categorization,Application and Analysis显示文摘Federated Learning(FL),as an emergent paradigm in privacy-preserving machine learning,has garnered significant interest from scholars and engineers across both academic and industrial spheres.Despite its innovative approach to model training across distributed networks,FL has its vulnerabilities;the centralized server-client architecture introduces risks of single-point failures.Moreover,the integrity of the global model—a cornerstone of FL—is susceptible to compromise through poisoning attacks by malicious actors.Such attacks and the potential for privacy leakage via inference starkly undermine FL’s foundational privacy and security goals.For these reasons,some participants unwilling use their private data to train a model,which is a bottleneck in the development and industrialization of federated learning.Blockchain technology,characterized by its decentralized ledger system,offers a compelling solution to these issues.It inherently prevents single-point failures and,through its incentive mechanisms,motivates participants to contribute computing power.Thus,blockchain-based FL(BCFL)emerges as a natural progression to address FL’s challenges.This study begins with concise introductions to federated learning and blockchain technologies,followed by a formal analysis of the specific problems that FL encounters.It discusses the challenges of combining the two technologies and presents an overview of the latest cryptographic solutions that prevent privacy leakage during communication and incentives in BCFL.In addition,this research examines the use of BCFL in various fields,such as the Internet of Things and the Internet of Vehicles.Finally,it assesses the effectiveness of these solutions. | Yuming Tang Yitian Zhang Tao Niu Zhen Li Zijian Zhang Huaping Chen Long Zhang | 2024 | Computer Modeling in Engineering & Sciences2024，139，6： | 0 |
| 8 | POMDP-Based Real-Time Path Planning for Manipulation of Multiple Microparticles via Optoelectronic Tweezers显示文摘With high throughput and high flexibility,optoelectronic tweerers(OETs)hold huge potential for massively parallel micromanipulation.However,the trajectory of the virtual electrode has been planned in advance in most synchronous manipulations for multiple targets based on an optically induced dielectrophoresis(ODEP)mechanism,which is insuficient to ensure the stability and eficiency in an environment with potential collision risk.In this paper,a synchronously discretized manipulation method based on a centralized and decoupled path planner is proposed for transporting microparticles of diferent types with an OET platform.An approach based on the K uhn-Munkres algorithm is utilized to achieve the goal assignment between target microparticles and goal positions.With the assistance of a visual feedback module,a path planning approach based on the POMDP algorithm dynamically determines the motion strategies of the particle movement to avoid potential collisions.The geometrical parameters of the virtual electrodes are optimized for different types of particles with the goal of maximum transport speed.The experiments of micropatterning with different morphologies and transporting multiple micropartides(e.g,polystyrene microspheres and 3T3 cells)to goal positions are performed.These results demonstrate that the proposed manipulation method based on optoelectronic tweezers is effective for multicell transport and promises to be used in biomedical manipulation tasks with high flexibility and efficiency. | Jiaxin Liu Huaping Wang Menghua Liu Ran Zhao Yanfeng Zhao Tao Sun Qing Shi | 2022 | Cyborg and Bionic Systems2022，，1： | 0 |
| 9 | Interfacial Interaction of CFRP Reinforced Steel Beam Structures显示文摘Due to the increase of service life,the phenomenon of performance degradation of bridge structures becomes more and more common.It is important to strengthen the bridge structures so as to restore the resistance level and extend the normal service life.Carbon fiber reinforced polymer(CFRP)materials are thus used for the assembly reinforcement of bridges for the advantages of high strength,light weight,corrosion resistance and long-term stability of physical and chemical properties,etc.In view of this,based on the previous theoretical study and the established formula of the interfacial shear stress of CFRP reinforced steel beam and the normal stress of CFRP plate,this paper discusses the sensitive parameters that affect the interfacial interaction of CFRP strengthened beam structures.Through the analysis,the priority design indicators and suggestions are accordingly given for the design of reinforced beam structures.Young’s modulus of CFRP composite and shear modulus of the adhesive have the greatest influence on the interfacial interaction,which should be carefully considered.It is suggested that CFRP material with Ec close to 300 GPa and thickness no less than 3 mm,and adhesive material with Ga less than 5 GPa and 3-mm thickness can be adopted in CFRP reinforced steel beam.The conclusions of this paper can provide guidance for the interfacial damage control of CFRP reinforced steel beam structures. | Huaping Wang Hengyang Li Siyuan Feng Tao Song | 2020 | Journal of Architectural Environment & Structural Engineering Research2020，3，4： | 0 |
| 10 | Structural Performance of Smart CFRP-FBG Reinforced Steel Beams显示文摘Many beam structures suffer from gradual performance degradation with the increase of service life.To recover the bearing capacity of these beams,carbon fiber reinforced polymer(CFRP)plates are developed to attached on the beam bottom.To check the structural performance of the CFRP reinforced beams,smart CFRP plate with FBGs in series is designed and LVDTs are adopted to measure the deformations.The deflection of the reinforced beam is given based on the elastic conversion cross-section method.The experimental results validate the effectiveness of the proposed algorithm.The study shows that the CFRP reinforced zone has a larger flexural rigidity than the pure steel beam zone.The general distribution of the deflection along the span of the CFRP reinforced beam can be described by the proposed formula.It provides a scientific design guidance for the deflection control of CFRP reinforced structures. | Huaping Wang Tao Song Hengyang Li Siyuan Feng | 2020 | Journal of Architectural Environment & Structural Engineering Research2020，3，4： | 0 |
| 11 | Chlorothalonil exposure induces“liver-gut axis”disorder in mice显示文摘Chlorothalonil(CTL)is a broad spectrum,non-systemic,organochlorine fungicide,widely used in agriculture,silviculture,urban settings,and industrial antifouling.It is found in various environmental media,such as surface water,soil,and air,and even exceeded Maximum residual limit(MRL)in food chain[1,2].Previous studies revealed that CTL is highly toxic to aquatic organisms and amphibian,especially in the early stage of development[3].Under experimental conditions,it may also have toxic effects on rodents,mammalian cells,and other non target organisms.In humans,the main exposure modes of CTL were contacting to the residues in the work/life place or intaking the contaminated dietary,which may cause contact allergic dermatitis,occupational asthma,gastrointestinal problems and other symptoms[4].However,the effects of CTL on the“liver-gut axis”have not been reported yet. | Huaping Tao Zhiwei Bao Yuanxiang Jin | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 0 |
| 12 | Aberrant nuclear lamina contributes to the malignancy of human gliomas显示文摘Glioma is the most common type of tumor in the central nervous system, accounting for around 80% of all malignant brain tumors. Previous studies showed a significant association between nuclear morphology and the malignant progress of gliomas. By virtue of integrated proteomics and genomics analyses as well as experimental validations, we identify three nuclear lamin genes(LMNA, LMNB1, and LMNB2) that are significantly upregulated in glioma tissues compared with normal brain tissues. We show that elevated expressions of LMNB1, LMNB2, and LMNA in glioma cells are highly associated with the rapid progression of the disease and the knockdown of LMNB1, LMNB2, and LMNA dramatically suppresses glioma progression in both in vitro and in vivo mouse models. Moreover, the repression of glioma cell growth by lamin knockdown is mediated by the p Rb-mediated G1-S inhibition. On the contrary, overexpression of lamins in normal human astrocytes dramatically induced nuclear morphological aberrations and accelerated cell growth. Together, our multi-omics-based analysis has revealed a previously unrecognized role of lamin genes in gliomagenesis, providing a strong support for the key link between aberrant tumor nuclear shape and the survival of glioma patients. Based on these findings, lamins are proposed to be potential oncogene targets for therapeutic treatments of brain tumors. | Shunqi Pei Xuehui Wang Xuan Wang Hao Huang Huaping Tao Binghua Xie Aifen Yang Mengsheng Qiu Zhou Tan | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
| 13 | Efficacy,safety and pharmacokinetics of Unecritinib(TQ-B3101)for patients with ROS1 positive advanced non-small cell lung cancer:a Phase I/II Trial显示文摘This phase I/II trial characterized the tolerability,safety,and antitumor activities of unecritinib,a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1,ALK,and c-MET,in advanced tumors and ROS1 inhibitor-naive advanced or metastatic non-small cell lung cancer(NSCLC)harboring ROS1 rearrangements.Eligible patients received unecritinib 100,200. | Shun Lu Hongming Pan Lin Wu Yu Yao Jianxing He Yan Wang Xiuwen Wang Yong Fang Zhen Zhou Xicheng Wang Xiuyu Cai Yan Yu Zhiyong Ma Xuhong Min Zhixiong Yang Lejie Cao Huaping Yang Yongqian Shu Wu Zhuang Shundong Cang Jian Fang Kai Li Zhuang Yu Jiuwei Cui Yang Zhang Man Li Xinxuan Wen Jie Zhang Weidong Li Jianhua Shi Xingxiang Xu Diansheng Zhong Tao Wang Jiajia Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员