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| 1 | Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection显示文摘Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that influenza virus PR8 directly infected NK cells during natural infection, which wasconsistent with our previous findings obtained from an in vitro investigation of human NK cells. The impairments incytotoxicity and IFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic T lymphocytes (CTLs). Importantly, the weakened CTL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy donors.Taken together, our data provide direct evidence supporting the contribution of NK cells to antiviral T-cellresponses. This study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses. | Yuan Liu Jian Zheng Yinping Liu Liyan Wen Lei Huang Zheng Xiang Kwok-Tai Lam Aizhen Lv Huawei Mao Yu-Lung Lau Wenwei Tu | 2018 | Cellular & Molecular Immunology2018，15，9： | 6 |
| 2 | Avian influenza virus directly infects human natural killer cells and inhibits cell activity显示文摘Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity. | Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung Lau Wenwei Tu | 2017 | Virologica Sinica2017，32，2： | 4 |
| 3 | Changes in Protein Content and Chitinase and β-1,3- glucanase Activities of Rice with Blast Resistance Induced by Ag-antibiotic 702显示文摘[Objective] The paper was to explore the effect of rice blast resistance induced by Ag-antibiotics 702 on protein content and chitinase and β-1,3-glucanase activities in rice. [Method]At the fourth leaf stage of Luliangyou 996,15 μg/m L Ag-antibiotic 702 was sprayed,while Validamycin and distilled water were sprayed as positive control and negative control,respectively. All treatments were inoculated with spore fluid of Magnaporthe grisea at 48 h post spraying,and the rice inoculated with only distilled water was used as blank control. The enzymes activities( endochitinase,exochitinase and β-1,3-glucanase) and total protein content in rice leaves were determined every 24 h within 168 h post spraying. [Result] Compared with the blank control,the rice inoculated with spore fluid of M. grisea could significantly increase the total protein content and the activities of β-1,3-glucanase and chitinase. The induction effect of Ag-antibiotics 702 exceeded that of Validamycin treatment. And the changes in activities of β-1,3-glucanase and chitinase had obvious synchronicity. [Conclusion] Ag-antibiotic 702 can significantly improve the total protein content and the activities of β-1,3-glucanase and chitinase,thus enhancing the resistance to rice blast. | Hu Neng Tu Xiaorong Li Kuntai Ding Hao Li Huan Zhang Huawei Tu Guoquan Huang Lin | 2017 | Plant Diseases and Pests2017，8，4： | 2 |
| 4 | Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Ting Feng Fan Yang Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Wenwei Tu Meng Mao | 2013 | Cellular & Molecular Immunology2013，10，3： | 1 |
| 5 | Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold显示文摘 | GuoGang Tu ShaoHua Li HuiMing Huang Gang Li Fang Xiong Xi Mai HuaWei Zhu BinHai Kuang Wen Fang Xu | 2008 | Bioorganic & Medicinal Chemistry2008，，14： | 1 |
| 6 | Application of self-adaptive temperature recognition in cold-start of an air-cooled proton exchange membrane fuel cell stack显示文摘The Self-adaptive control of the temperature can achieve the start of fuel cell at different operating temperatures, which is very important for the successful cold-start of the air-cooled PEMFC. The temperature distribution characteristics during the cold-start process were analyzed based on adaptive temperature recognition control in this paper. Preheating model and cold-start model were established and the optimal balance between the hot air flow rate and the temperature required to promote a uniform temperature distribution in the stack was explored in the preheating stage. Finally, the non-equilibrium mass transfer, as well as the temperature rise in the catalyst layer and gas diffusion layer with different current densities, were analyzed in the start-up stage. The results indicate that the air-cooled PEMFC stack can be successfully started up at -40 ◦C within 10 min by means of external gas heating. The current density and air velocity have significant impacts on the temperature of aircooled PEMFC stack. Dynamic analysis of air-cooled PEMFCs and real-time monitoring are suitable for machine learning and self-adaptive control to set the operation parameters to achieve successful cold start. Optimize the matching of load current and cathode inlet speed to achieve thermal management in low temperature environment. | Xianxian Yu Huawei Chang Junjie Zhao Zhengkai Tu Siew Hwa Chan | 2022 | Energy and AI2022，9，3： | 1 |
| 7 | Review of studies on target acquisition in virtual reality based on the crossing paradigm显示文摘Crossing is a fundamental paradigm for target selection in human-computer interaction systems.This paradigm was first introduced to virtual reality(VR)interactions by Tu et al.,who investigated its performance in comparison to pointing,and concluded that crossing is generally no less effective than pointing and has unique advantages.However,owing to the characteristics of VR interactions,there are still many factors to consider when applying crossing to a VR environment.Thus,this review summarizes the main techniques for object selection in VR and crossing-related studies.Then,factors that may affect crossing interactions are analyzed from the perspectives of the input space and visual space.The aim of this study is to provide a reference for future studies on target selection based on the crossing paradigm in virtual reality. | Susu HUANG Daqing QI Jiabin YUAN Huawei TU | 2019 | Virtual Reality & Intelligent Hardware2019，1，3： | 1 |
| 8 | A unified user behavior model for trajectory-based tasks with different types of path constraints显示文摘An important research branch of human-computer interaction(HCI)is to develop predictive models for human performance in fundamental interactions[1].On today's graphical user interface(GUI),users often implicitly perform various trajectory-based interactions,such as navigating through menus[2],entering the boundary of a button. | Hao ZHANG Jin HUANG Huawei TU Feng TIAN Guozhong DAI Hongan WANG | 2023 | Science China(Information Sciences)2023，66，10： | 0 |
| 9 | mpaired NK cell antiviral cytokine response against nfluenza virus in small-for-gestational-age neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Fan Yang Ting Feng Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Meng Mao Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，5： | 0 |
| 10 | Conservation of T cell epitopes between seasonal influenza viruses and the novel influenza A H7N9 virus显示文摘A novel avian influenza A(H7N9) virus recently emerged in the Yangtze River delta and caused diseases, often severe, in over 130 people. This H7N9 virus appeared to infect humans with greater ease than previous avian influenza virus subtypes such as H5N1 and H9N2. While there are other potential explanations for this large number of human infections with an avian influenza virus, we investigated whether a lack of conserved T-cell epitopes between endemic H1N1 and H3N2 influenza viruses and the novel H7N9 virus contributes to this observation. Here we demonstrate that a number of T cell epitopes are conserved between endemic H1N1 and H3N2 viruses and H7N9 virus. Most of these conserved epitopes are from viral internal proteins. The extent of conservation between endemic human seasonal influenza and avian influenza H7N9 was comparable to that with the highly pathogenic avian influenza H5N1. Thus, the ease of inter-species transmission of H7N9 viruses(compared with avian H5N1 viruses) cannot be attributed to the lack of conservation of such T cell epitopes. On the contrary, our findings predict significant T-cell based cross-reactions in the human population to the novel H7N9 virus. Our findings also have implications for H7N9 virus vaccine design. | Huawei Mao Hui-Ling Yen Yinping Liu Yu-Lung Lau J.S.Malik Peiris Wenwei Tu | 2014 | Virologica Sinica2014，29，3： | 0 |
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