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| 1 | Design of a new dynamical core for global atmospheric models based on some efficient numerical methods显示文摘A careful study on the integral properties of the primitive hydrostatic balance equations for baroclinic atmosphere is carried out, and a new scheme todesign the global adiabatic model of atmospheric dynamics ispresented. This scheme includes a method of weighted equal-areamesh and a fully discrete finite difference method with quadraticand linear conservations for solving the primitive equationsystem. Using this scheme, we established a new dynamical corewith adjustable high resolution acceptable to the availablecomputer capability, which can be very stable without anyfiltering and smoothing. Especially, some important integralproperties are kept unchanged, such as the anti-symmetries of thehorizontal advection operators and the vertical convectionoperator, the mass conservation, the effective energy conservationunder the standard stratification approximation, and so on. Somenumerical tests on the new dynamical core, respectively regardingits global conservations and its integrated performances inclimatic modeling, incorporated with the physical packagesfrom the Community Atmospheric Model Version 2 (CAM2) of NationalCenter for Atmospheric Research (NCAR), are included. | WANG Bin, WAN Hui, Jl Zhongzhen, ZHANG Xin, YU Rucong, YU Yongqiang & LIU HongtaoState Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Department of Computational Mathematics, Academy of Mathematics and System Sciences, Peking University, Beijing 100871, China | 2004 | Science China Mathematics2004，47，z1： | 92 |
| 2 | Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats显示文摘Objective To investigate the mechanism of Tojapride,a Chinese herbal formula extract,on strengthening the barrier function of esophageal epithelium in rats with reflux esophagitis(RE).Methods Ten out of 85 SD rats were randomly selected as the sham group(n10),and 75 rats were developed a reflux esophagitis model(RE)by the esophageal and duodenal side-to-side anastomosis.Fifty successful modeling rats were divided into different medicated groups through a random number table including the model,low-,medium-,and high-dose of Tojapride as well as omeprazole groups(n10).Three doses of Tojapride[5.73,11.46,22.92 g/(kg•d)]and omeprazole[4.17 mg/(kg•d)]were administrated intragastrically twice daily for 3 weeks.And the rats in the sham and model groups were administered 10 mL/kg distilled water.Gastric fluid was collected and the supernatant was kept to measure for volume,pH value and acidity.Esophageal tissues were isolated to monitor the morphological changes through hematoxylin-eosin(HE)staining,and esophageal epithelial ultrastructure was observed by transmission electron microscopy.The expressions of nuclear factor kappa-light-chain-enhancer of activated B cells p65(NF-KBp65),κB kinase beta(IKKß),occludin,and zonula occludens-1(ZO-1)in the esophageal tissues were measured by immunohistochemistry and Western blot,respectively.Results The gastric pH value in the model group was significantly lower than the sham group(P<0.05).Compared with the model group,gastric pH value in the omeprazole and medium-dose of Tojapride groups were significantly higher(P<0.05).A large area of ulceration was found on the esophageal mucosa from the model rats,while varying degrees of congestion and partially visible erosion was observed in the remaining groups.Remarkable increase in cell gap width and decrease in desmosome count was seen in RE rats and the effect was reversed by Tojapride treatment.Compared with the sham group,the IKKßlevels were significantly higher in the model group(P<0.05).However,the IKKßlevels were down-regulated after treatment by all doses of Tojapride(P<0.01 or P<0.05).The occluding and ZO-1 levels decreased in the model group compared with the sham group(Ps0.01 or Ps0.05),while both indices were significantly up-regulated in the Tojapride-treated groups(P<0.01 or P<0.05).Conclusions Tojapride could improve the pathological conditions of esophageal epithelium in RE rats.The underlying mechanisms may involve in down-regulating the IKKßexpression and elevating ZO-1 and occludin expression,thereby alleviating the inflammation of the esophagus and strengthening the barrier function of the esophageal epithelium. | YIN Xiao-lan ZHONG Linda LIN Cheng-yuan SHI Xiao-shuang ZHANG Jiao CHEN Zheng-yi CHE Hui MA Xiang-xue TIAN Ya-xin DUAN Yuan-zhi LU Lin Jl Hai-jie ZHAO Ying-pan TANG Xu-dong WANG Feng-yun | 2021 | Chinese Journal of Integrative Medicine2021，27，8： | 4 |
| 3 | Bullatencin, 4-deoxyasimicin and the uvariamicins: additional bioactive annonaceous acetogenins from Annona bullata Rich 显示文摘 | Hui YH Wood KV Mclaughlin JL | 1992 | Nat Toxins1992，，1： | 1 |
| 4 | Diagnosis of near - fatal pulmonary embolus - in - transit with focused eehoear- diography显示文摘 | Fischer Jl Huis in't Veld MA Orland M | 2013 | J Emerg Med2013，45，2： | 1 |
| 5 | Synthesis of ultrafine lanthanum hydroxide nanorods by a simple hy- drothermal process显示文摘 | MA Xiangyang ZHANG Hui Jl Yujie | 2004 | Materials Letters2004，58，7： | 1 |
| 6 | Enhanced syn- chronized switch harvesting: a new energy harvesting scheme/or efficient energy extraction显示文摘 | SHEN Hui QIU Jinghao Jl H | 2010 | Smart Mate rials and Structures2010，19，11： | 1 |
| 7 | Interaction of berberine with human platelet alpha 2 adrenoceptors 显示文摘 | Hui KK Yu JL Chan WF | 1991 | Life Sci1991，，49： | 1 |
| 8 | Annonaceous acetogenins: a review 显示文摘 | Rupprecht JK Hui YH McLaughlin JL | 1990 | J Nat Prod1990，53，2： | 1 |
| 9 | Acupuncture inhibits sympathetic activation during mental stress in advanced heart failure patients显示文摘 | Hui K Yu JL | 2002 | J Card Fail2002，8，6： | 1 |
| 10 | Comparing efficacy of α 1D-receptor an- tagonist naftopidil and α 1A/D-receptor antagonist tamsulosin in management of distal ureteral stones 显示文摘 | Zhou SG Lu JL Hui JH | 2011 | World J Urol2011，29，6： | 1 |
| 11 | Community compliance with carcinoembryonic antigen: follow-up of patients with colorectal cancer 显示文摘 | Spratlin JL Hui D Hanson J | 2008 | Clin Colorectal Cancer2008，7，3： | 1 |
| 12 | Dental surgery assistants in Hong Kong:history of training显示文摘 | Chung MY Leung JL Hui KK | 2007 | Hong Kong Dental Journal2007，4，1： | 1 |
| 13 | Interaction of berberine with human platelet alpha2 adrenoceptors显示文摘 | Hui KK Yu JL Chan WF | 1991 | Life Sci1991，49，4： | 1 |
| 14 | Interaction of berberine with human platelet alpha 2 adrenoceptors 显示文摘 | Hui KK Yu JL Chan WF | 1991 | Life Sci1991，49，4： | 1 |
| 15 | Community compliance with eareinoembryonie antigen: follow-up of patients with eoloreetal cancer 显示文摘 | Spratlin JL Hui D Hanson J | 2008 | Clin Coloreetal Cancer2008，7，2： | 1 |
| 16 | Comparing efficacy of a1D-receptor antagonist naftopidil and a1A/D-receptor antagonist tamsulosin in management of distal ureteral stones显示文摘 | Zhou SG Lu JL Hui JH | 2011 | World J Urol2011，29，6： | 1 |
| 17 | Efficacy of tolterodine for medical treatment of intramural ureteral stone with vesical irritability显示文摘 | Lv JL Tang QN Hui JH | 2011 | Urol Res2011，39，3： | 1 |
| 18 | Effects of simvastatin within two weeks on anti-inflammatory cytokine interleukin-10 in patients with unstable angina显示文摘 | Li JJ Li YS Fang CH Hui RT Yang YJ Cheng JL | | 0，，： | 1 |
| 19 | Comparing efficacy of alphalD-re- ceptor antagonist naftopidil and alphalA/D-receptor antagonist tamsulosin in management of distal ureteral stones显示文摘 | ZHOU SG LU JL HUI JH | 2011 | World J Urol2011，29，6： | 1 |
| 20 | Simultaneous determination of iridoids, phenolic acids, flavonoids, and saponins in Flos Lonicerae and Flos Lonicerae Japonicae by HPLCDAD-ELSD coupled with principal component analysis 显示文摘 | Chun YC Lian WQ Hui JL | 2007 | J Sep Sci2007，30，： | 1 |
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