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1Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction.SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan 2016Biomedical and Environmental Sciences2016,29,6:25
2Drug-resistant gene based genotyping for Acinetobacter baumannii in tracing epidemiological events and for clinical treatment within nosocomial settings显示文摘背景 Acinetobacter baumannfi 在全世界作为与严重感染和医院的爆发有关的重要病原体出现了。经常使用的方法,然而,脉搏地胶化电气泳动(PFGE ) 和在 Acinetobacter baumannii genotyping 的放大碎片长度多型性(AFLP ) 缺乏药抵抗的直接分子的证明。这研究被进行基于药建立一个打字方法与在从2005年1月的医院的流行病或到2005年10月的 outbreak.Methods 的经期的传统的 PFGE 和 AFLP 相对照的抵抗基因鉴定,来自特别护理单位的 Acinetobacter 种类的 27 紧张,在 Ningbo 的第二所隶属于的医院被孤立,包括流行、分散的事件。危险性测试, PFGE, AFLP 和打字的药抵抗基因(DRGT ) 在外面是 carded 证实药抵抗并且分别地分析 genotyping。PFGE 被用作一本参考书评估 Acinetobacter 的 27 紧张显示了的 DRGT 和 AFLP.Results 的 typeability 多重抗菌素抵抗和药抵抗基因,和 -lactamase 基因在 85.2% 紧张被检测。尽管小差别存在, DRGT 的结果比得上在有不同的药抵抗的 Acinetobacter 紧张的 PFGE,并且甚至建议了不同药抵抗的紧张的一堂分子的进化功课。AFLP 显示出在紧张之间的大多型性并且在区分比作 AFLP 和 PFGE 的药 resistance.Conclusion 有弱能力, DRGT 是有用的分析医院的感染和爆发的局部性的分子的传染病学,它将有益于临床的诊断和治疗。JIN Hui XU Xiao-min MI Zu-huang MOU Yi LIU Pei 2009Chinese Medical Journal2009,,3:18
3The Development of A Fluorescence Polarization Immunoassay for Aflatoxin Detection显示文摘A fluorescence polarization immunoassay(FPIA)was developed for the analysis ofaflatoxins(AFs)using an anti-aflatoxin B1(AFB1)monoclonal antibody and a novel fluorescein-labeled AFB1tracer.The FPIA showed an IC50 value of 23.33ng/mL with a limit of detection of 13.12 ng/mL for AFB1.The cross-reactivities of AFB1,AFB2,AFG1,AFG2,AFM1,and AFM2 with the antibody were100%,65.7%,143%,23.5%,111.4%,and 2%,respectively.The group-specificity of anti-AFB1mAb indicated that the FPIA could potentially be used in a screening method for the detection of total AFs,albeit not AFG2 and AFM2.The total time required for analyzing 96 samples in one microplate was less than 5 min.This study demonstrates the potential usefulness of the FPIA as a rapid and simple technique for monitoring AFs.SHENG Ya Jie EREMIN Sergei MI Tie Jun ZHANG Su Xia SHEN Jian Zhong WANG Zhan Hui 2014Biomedical and Environmental Sciences2014,27,2:10
4Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung 2017Cell Research2017,27,11:9
5Evidence of vacuolar compartmentalization of arsenic in the hyperaccumulator Pteris vittata显示文摘Pteris vittata can hyperaccumulate arsenic (As) to >1% of its dry weight without showing any signs of toxicity, indicating the existence of effective plant-internal detoxification mechanisms. Although vacuolar compartmentalization is known to play an important role in heavy metal detoxification and tolerance, direct evidence of arsenic compartmentalization in this hyperaccumulator was lacking. Here we report the subcellular localization of As in the callus of P. vittata. The callus induced from gametophytes of P. vittata exposed to 0.2 mmol/L arsenate for 20 days were examined by directly isolating cell walls, protoplasts and vacuoles, and determining arsenic concentrations. Of the total As in the callus, about 94% was in the protoplast, and of that, 91% was present in the vacuoles, indicating that vacuoles are a major storage site for As in P. vittata. In addition, the changes in the chemical components of vacuoles were analyzed by Fourier transform infrared spectroscopy (FTIR).YANG XueXi CHEN Hui DAI XiaoJing XU WenZhong HE ZhenYan MA Mi 2009Chinese Science Bulletin2009,54,22:8
6Microstructure and tensile properties of low cost titanium alloys at different cooling rate显示文摘Titanium and titanium alloys have several advantages, but the cost of titanium alloys is very expensive compared with the traditional metal materials. This article introduces two new low-cost titanium alloys Ti-2.1Cr-1.3Fe (TCF alloy) and Ti-3Al-2.1Cr-1.3Fe (TACF alloy). In this study, we used Cr-Fe master alloy as one of the raw materials to develop the two new alloys. We introduce the microstructure and tensile properties of the two new alloys from β solution treated with different cooling methods. Optical microscopy (OM), X-ray diffractometry (XRD), and transmission electron microscopy (TEM) were employed to analyze the phase constitution, and scanning electron microscopy (SEM) was used to observe the fracture surfaces. The results indicate that the microstructures consist of β grain boundary and α′ martensite after water quenching (WQ), β matrix and α phase after air cooling (AC) and furnace cooling (FC), respectively. Also, the microstructure is the typical basketweave structures after FC. Of course, athermal ω is also observed by TEM after WQ. The strength increases with decreasing cooling rates and the plasticity is reversed. Because of the athermal ω, the strength and ductility are highest and lowest when the cooling method is WQ. The strength of TACF alloy is higher than the TCF alloy, but the plasticity is lower. The fracture surfaces are almost entirely covered with dimples under the cooling methods of AC and FC. Also, we observe an intergranular fracture area that is generated by athermal ω, although some dimples are observed after WQ.Wang Guo Hui Songxiao Ye Wenjun Mi Xujun Wang Yongling Zhang Wenjing 2012Rare Metals2012,31,6:8
7High density methane inclusions in Puguang Gasfield:Discovery and a T-P genetic study显示文摘Based on measurement of homogenization temperature of inclusions and Raman spectral analysis, high density methane inclusions were discovered in the Triassic reservoirs of Puguang Gasfield. The methane inclusions show a homogenization temperature Th = -117.5― -118.1℃, a corresponding density of 0.3455―0.3477 g/cm3, and a Raman scatter peak v1 shift varying between 2911―2910 cm-1, which signifies a very high density of methane inclusions. The salt water inclusions paragenetic with methane inclusions show a homogenization temperature Th=170―180℃. Based on the composition of methane inclusions as determined by Raman spectra, PVTsim software was used to simulate the trapping pressure for high density methane inclusions in geologic history, and the trapping pressure was found to be as high as 153―160 MPa. Even though Puguang Gasfield is currently a gas pool of normal pressure, and the fluid pressure for the gas pool ranges between 56―65 MPa. However, data from this study indicates that remarkable overpressure may be generated at the stage of mass production of gas cracked from oils in Cretaceous, as high density methane inclusions constitute key evidence for overpressure in gas pool in geologic history. Meanwhile, discovery of small amounts of H2S, CO2 or heavy hydrocarbon in part of the high density methane inclusions indicates that the geochemical environment for trapping of inclusions may be related to formation of H2S. Therefore, the observation results can help to explore the thermochemical sulfate reduction (TSR) conditions for oil cracking and H2S formation.LIU Delian DAI JinXing XIAO XianMing TIAN Hui YANG Chun HU AnPing MI JingKui SONG ZhiGuang 2009Chinese Science Bulletin2009,54,24:8
8An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients.Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang 2023Journal of Clinical and Translational Hepatology2023,11,2:7
9Cultivation Ages Effect on Soil Physicochemical Properties and Heavy Metal Accumulation in Greenhouse Soils显示文摘The intensive management practices in greenhouse production may alter the soil physicochemical properties and contribute to the accumulation of heavy metals(HMs). To determine the HM concentrations in vegetable soil in relation to soil physicochemical properties and cultivation age, we conducted a soil survey for typical greenhouse soils in Shouguang, China. The results indicated that Cd is a major HM pollutant in the tested soils, as the only HM element exceeding the allowed limit for vegetable soil. The surveyed data was analyzed with regression analysis, correlation analysis and canonical correspondence analysis(CCA). A positive correlation is observed between HM pollution level and cultivation age. CCA results suggest that the HM pollution level and distribution in soil are significantly affected by soil physicochemical properties, which was a function of years of cultivation as revealed by regression analysis. In summary, cultivation age is an important factor to affect soil physicochemical properties(organic matter and inorganic nutrients) as well as HM contamination.WANG Jun MI Wenkui SONG Peipei XIE Hui ZHU Lusheng WANG Jinhua 2018Chinese Geographical Science2018,28,4:5
10A Stator Current Vector Orientation Based Multi-objective Integrative Suppressions of Flexible Load Vibration and Torque Ripple for PMSM Considering Electrical Loss显示文摘To store energy from the grid into spiral torsion spring(STS)smoothly and efficiently via PMSM,a multi-objective control problem of flexible load’s vibration,PMSM’s torque ripple,and electrical loss is raised,where the current studies on vibration and torque ripple are mostly addressed separately,not to mention electrical loss.This research attempts to propose a multi-objective integrative control scenario that can simultaneously solve these problems satisfactorily in a unitary nonlinear control framework.Firstly,a dynamic mathematical model of PMSM is built under stator current vector orientation,and then the model of PMSM is combined with the vibration model of STS to establish the overall system model of STS driven by PMSM with considering motor’s electrical loss.Then,a backstepping control principle-based multi-objective integrative control approach is proposed to realize the suppression of flexible load’s vibration and the reduction of PMSM’s torque ripple and electrical loss concurrently.Meanwhile,this research also designs a wide range speed identification method based on the least square algorithm with a forgetting factor.Simulation and experimental results have verified that the proposed integrative control method enables the state variables to track their respective references quickly and accurately,both torque ripple and load vibration are effectively suppressed,and the operating efficiency of the whole system is improved.Yang Yu Leyao Cong Xia Tian Zengqiang Mi Yang Li Zhen Fan Hui Fan 2020CES Transactions on Electrical Machines and Systems2020,4,3:5
11Degradation of 2,2′,4,4′-tetrabromodiphenyl ether by Pycnoporus sanguineus in the presence of copper ions显示文摘The degradation of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) by Pycnoporus sanguineus was investigated in order to explore the impact of the heavy metal Cu2+ on BDE-47 decomposition and the subsequent formation of metabolites, as well as to further elucidate the degradation mechanism of BDE-47. An increase in degradation rate from 18.63% to49.76% in the first four days and its stabilization at(51.26 ± 0.08)% in the following days of BDE-47 incubation were observed. The presence of Cu2+ at 1 and 2 mg/L was found to promote the degradation rate to 56.41% and 60.79%, respectively, whereas higher level of Cu2+(≥ 5 mg/L) inhibited the removal of BDE-47. The similar concentration effects of Cu2+ was also found on contents of fungal protein and amounts of metabolites. Both intracellular and extracellular enzymes played certain roles in BDE-47 transportation with the best degradation rate at 27.90% and 27.67% on the fourth and third day, individually. During the degradation of BDE-47, four types of hydroxylated polybrominated diphenyl ethers(OH-PBDEs), i.e., 6′-OH-BDE-47, 5′-OH-BDE-47, 4′-OH-BDE-17, 2′-OH-BDE-28, and two bromophenols, i.e., 2,4-DBP and 4-BP were detected and considered as degradation products. These metabolites were further removed by P. sanguineus at rates of 22.42%,23.01%, 27.04%, 27.96%, 64.21%, and 40.62%, respectively.Meiqian Wang Hua Yin Hui Peng Mi Feng Guining Lu Zhi Dang 2019Journal of Environmental Sciences2019,31,9:4
12Seasonal and spatial distribution of ammonia-oxidizing microorganism communities in surface sediments from the East China Sea显示文摘Ammonia oxidation plays a significant role in the nitrogen cycle in marine sediments. Seasonal and spatial distribution of ammonia-oxidizing archaea(AOA) and betaproteobacteria(β-AOB) in surface sediments from the East China Sea(ECS) were investigated using ammonia monooxygenase α subunit(amo A) gene. In order to characterize the community of AOA and β-AOB, real-time quantitative polymerase chain reaction(q PCR) was carried out in this study, along with environmental parameters. The abundance of β-AOB amo A gene(2.17×106–4.54×107 copy numbers per gram wet weight sediment) was always greater than that of AOA amo A gene(2.18×105–9.89×106 copy numbers per gram wet weight sediment) in all sampling stations. The q PCR results were correlated with environmental parameters. AOA amo A gene copy numbers in April were positively related to temperature and nitrite concentration(p<0.05). β-AOB amo A gene copy numbers in August correlated negatively with salinity(p<0.01), and correlated positively with ammonium concentration(p<0.05). With the increase of salinity, the amo A gene copy ratio of AOB to AOA had a tendency to decrease, which suggested β-AOB dominated in the area of high level ammonium and AOA preferred high salinity area.HE Hui ZHEN Yu MI Tiezhu LU Xinglan YU Zhigang 2015Acta Oceanologica Sinica2015,34,8:3
13Does propofol definitely improve postoperative cognitive dysfunction?-a review of propofol-related cognitive impairment显示文摘Postoperative cognitive dysfunction(POCD)is a common brain function-related complication after surgery.In addition to old age being an independent risk factor,anesthetics are also important predisposing factors.Among them,propofol is the most commonly used intravenous anesthetic in clinical practice.It has a rapid onset,short halflife,and high recovery quality.Many studies report that propofol can attenuate surgery-induced cognitive impairment,however,some other studies reveal that propofol also induces cognitive dysfunction.Therefore,this review summarizes the effects of propofol on the cognition,and discusses possible related mechanisms,which aims to provide some evidence for the follow-up studies.Pengfei Liu Sheng Zhao Hui Qiao Tianzuo Li Weidong Mi Zhipeng Xu Xinying Xue 2022Acta Biochimica et Biophysica Sinica2022,54,7:3
14Molecular Characterization of Sulfate-Reducing Bacteria Community in Surface Sediments from the Adjacent Area of Changjiang Estuary显示文摘Sulfate-reducing bacteria(SRB),which obtain energy from dissimilatory sulfate reduction,play a vital role in the carbon and sulfur cycles.The dissimilatory sulfite reductase(Dsr),catalyzing the last step in the sulfate reduction pathway,has been found in all known SRB that have been tested so far.In this study,the diversity of SRB was investigated in the surface sediments from the adjacent area of Changjiang Estuary by PCR amplification,cloning and sequencing of the dissimilatory sulfite reductase beta subunit gene(dsr B).Based on dsr B clone libraries constructed in this study,diversified SRB were found,represented by 173 unique OTUs.Certain cloned sequences were associated with Desulfobacteraceae,Desulfobulbaceae,and a large fraction(60%) of novel sequences that have deeply branched groups in the dsr B tree,indicating that novel SRB inhabit the surface sediments.In addition,correlations of the SRB assemblages with environmental factors were analyzed by the linear model-based redundancy analysis(RDA).The result revealed that temperature,salinity and the content of TOC were most closely correlated with the SRB communities.More information on SRB community was obtained by applying the utility of Uni Frac to published dsr B gene sequences from this study and other 9 different kinds of marine environments.The results demonstrated that there were highly similar SRB genotypes in the marine and estuarine sediments,and that geographic positions and environmental factors influenced the SRB community distribution.ZHANG Yu ZHEN Yu MI Tiezhu HE Hui YU Zhigang 2016Journal of Ocean University of China2016,15,1:3
15Characterization of a broad-energy germanium detector for its use in CJPL显示文摘The broad-energy germanium(BEGe)detector,with the ability of background discrimination using pulse shape discrimination,is a competitive candidate for neutrinoless double beta decay(ovββ)experiments.In this paper,we report our measurements of key parameters for detector modeling in a commercial p-type BEGe detector.Point-like sources are used to investigate energy resolution and linearity of the detector.A cylindrical volume source is used for efficiency calibration.With an assembled device for source positioning and a collimated ^(133)Ba source,the detector is scanned to check its active volume.Using an^(241)Am point-like source,the dead layer thicknesses is measured at about 0.17 mm on the front and 1.18 mm on the side.The detector characterization is of importance for BEGe detectors to be used in the ovββ experiments at China JinPing underground Laboratory(CJPL).Zhi Zeng Yu-Hao Mi Ming Zeng Hao Ma Qian Yue Jian-Ping Cheng Jun-Li Li Rui Qiu Hui Zhang 2017Nuclear Science and Techniques2017,28,1:2
16Dietary Behaviors and Influencing Factors among Rural Left-behind Children Aged below 7 Years in China显示文摘Left-behind children comprise a special population in Chinese rural areas. According to the 2007 China Census, the number of left-behind children aged ≤ 14 years was estimated at 58 million, which suggested that these children constituted a large population, especially in Chinese rural areas[1]. Till date, only a few studies have investigated the problems of dietary behaviors in rural left-behind children. A pilot study indicated that approximately 50% of left-behind children in Chinese rural areas had poor dietary behaviors[2]. Nevertheless, there is still a lack of research with large sample sizes that could reveal the actual background of dietary behaviors in these children. Therefore, we conducted this study to explore the dietary behaviors and their influencing factors among rural left-behind children aged < 7 years in China, which may provide a scientific basis to improve the dietary behaviors of these children.FAN Chun Li MA Quan Fu LUO Jia You WU Xu Feng LUO Mi Yang ZENG Rong LI Xiao Hui LI Ya Mei FANG Jun Qun 2018Biomedical and Environmental Sciences2018,31,12:2
17Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer显示文摘Atherosclerotic cardiovascular disease is the leading cause of death in the world which is resulted from complex interactions among multiple genetic and environmental factors(WHO).Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipids in the arterial wall(Gofman and Lindgren,1950).Tremendous clinical and experimental efforts haveChong Feng Xiaomin Wang Hui Shi Quanmei Yan Min Zheng Jing Li Quanjun Zhang Yumin Qin Yougang Zhong Jidong Mi Liangxue Lai 2018Journal of Genetics and Genomics2018,45,1:2
18Amination of electron deficient aryl chlorides promoted by nano sized Mg(OH)_2 under transition metals free condition显示文摘这份报纸论述缺乏的芳基氯化物由 Mg 支持了的电子的胺化作用反应(哦) 2 没有转变金属。仅仅用 stoichiometric, nano 的数量缩放 Mg (哦) 2,对中等孤立的收益好能在 150  在 24 h 以后在 N-methylpyrrolidone (NMP )Zhi Hao Cui Zi Hui Meng Yan Qing Mi Peng Wang Qi Wang Lin Man Zhao Ke Jian Cui Fang Yu Zhi Bin Xu 2012Chinese Chemical Letters2012,23,2:2
19Delphinidin‐3‐glucoside protects human umbilical vein endothelial cells against oxidized low‐density lipoprotein‐induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway显示文摘Xin Jin Mingliang Chen Long Yi Hui Chang Ting Zhang Li Wang Wanqiang Ma Xiaoli Peng Yong Zhou Mantian Mi 2014Food Res2014,,10:2
20Evolution of thrombec-tomy approaches and devices for acute stroke: A technical re-view 显示文摘Spiotta AM Chaudry MI Hui FK 2015Journal of neurointerventional surgery2015,7,1:1
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