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| 1 | Determination of fluoroquinolones, sulfonamides, and tetracyclines multiresidues simultaneously in porcine tissue by MSPD and HPLC-DAD显示文摘An efficient method is provided to detect simultaneously some important veterinary drugs from different classes in highly complex animal tissue matrix. This method using matrix solid-phase dispersion (MSPD) and high performance liquid chromatography (HPLC) with diode array detection (DAD) is developed to effectively determine two fiuoroquinolones (enoxacin and lomefioxacin), two sulfonamides (sulfanilamide and sulfamethoxazole) and one tetracycline (tetracycline) simultaneously in porcine tissues. In the process, MSPD methodology was used to treat samples, washed by n-hexane to remove lipid, eluted the analytes with acetonitrile-dichloromethane (1:1, v/v). Solvent acetonitrile and solvent acetic acid (0.1%) were combined in a gradient. HPLC-DAD analysis of the tissue samples was performed within 15 min at a fiow rate of 1.0 mL/min. The results showed that a recovery at 0.1, 0.5 and 1.0 mg/g fortification levels ranged from 80.6% to 99.2% with satisfactory relative standard deviations (RSDs) (below 6.1%, nfi3) and the limits of quantitation (LOQ) ranged from 7 mg/kg to 34 mg/kg in porcine tissues. Utilization of the method in successfully simultaneous analysis of porcine tissue incurred with veterinary drug multiresidues is described. | Hu Yu, Hui Mu, Ying-Mei Hu Chemistry Department of Science School, Xi’an Jiaotong University, Xi’an 710049, China | 2012 | Journal of Pharmaceutical Analysis2012，2，1： | 15 |
| 2 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 3 | Molecular Characterization of Drug-Resistant Beijing Family Isolates of Mycobacterium Tuberculosis from Tianjin,China显示文摘Objective Tuberculosis remains a severe public health issue,and the Beijing family of mycobacterium tuberculosis(M. tuberculosis) is widespread in East Asia,especially in some areas in China,like Beijing and Tianjin.This study aimed at determining the mutation patterns of drug-resistant Beijing strains of M.tuberculosis isolated from Tianjin,China.Methods A total of 822 M.tuberculosis isolates were screened for drug resistance by an absolute concentration method and the genotype was identified by PCR.169 drug-resistant isolates of the Beijing family were analyzed for the potential mutations in the rpoB, katG,inhA promoter region and in rpsL,rrs and embB genes,which are associated with resistance to rifampin(RFP),isoniazid (INH),streptomycin(SM) and ethambutol(EMB) respectively by PCR and DNA sequencing.Results Fifty-eight out of 63 RFP-resistant isolates were found to carry the mutations within the 81-bp RFP resistance determining region(RRDR) of the rpoB gene and the most frequent mutations occurred at codon 531(44.4%),526(28.6%),and 516(7.9%) respectively.16 mutation patterns affecting 12 different codons around the RRDR of rpoB were found.Of 116 INH-resistant isolates,56(48.3%) had the mutation of katG 315(AGC→ACC)(Ser→Thr),3(2.6%) carried S315N(AGC→AAC) and 27(16.0%) had the mutation of inhA-15A→T.84 out of 122 SM-resistant isolates(68.9%) displayed mutations at the codons 43 or 88 with AAG→AGG(Lys→Arg) of the rpsL gene and 22(18.0%) with the mutations at positions 513A→C,516C→T or 905 A→G in the rrs gene.Of 34 EMB-resistant isolates,6 had mutation with M306V(ATG→GTG),3 with M306I(ATG→ATT),1 with M306I(ATG→ATA),1 with D328Y(GAT→TAT),1 with V348L(GTC→CTC),and 1 with G406S(GGC→AGC) in the embB gene.Conclusion These novel findings extended our understanding of resistance-related mutations in the Beijing strains of M.tuberculosis and may provide a scientific basis for development of new strategies for diagnosis and control of tuberculosis in China and other countries where Beijing strains are prevalent. | GUI-LIAN LI DE-FU ZHAO TONG XIE HAN-FANG JU CHENG MU HUI ZHAO XIE-XIU WANG | 2010 | Biomedical and Environmental Sciences2010，23，3： | 14 |
| 4 | Sonographic appearance of anal cushions of hemorrhoids显示文摘AIM To evaluate the diagnostic value of different sonographic methods in hemorrhoids.METHODSForty-two healthy volunteers and sixty-two patients with gradesⅠ-Ⅳhemorrhoids received two different sonographic examinations from January 2013 to January2016 at the First and Second Hospitals of Xinjiang Medical University in a prospective way.We analyzed the ultrasonographic findings of these participants and evaluated the outcomes.Resected gradesⅢandⅣhemorrhoid tissues were pathologically examined.The concordance of ultrasonographic results with pathologyresults was assessed with the Cohen’s kappa coefficient.RESULTS All healthy volunteers and all patients had no particular complications related to sonography.There were no statistically significant differences between the participants regarding age(P=0.5919),gender(P=0.4183),and persistent symptoms(P>0.8692).All healthy control participants had nospecial findings.However,30 patients with hemorrhoids showed blood signals around the dentate line on ultrasonography.When gradesⅠandⅡhemorrhoids were analyzed,there were no significant differences between transrectal ultrasound(TRUS),transperianal ultrasound(TPUS),and transvaginal ultrasound(TVUS)(P>0.05).GradesⅢandⅣhemorrhoids revealed blood flow with different directions which could be observed as a'mosaic pattern'.In patients with gradesⅢandⅣhemorrhoids,the number of patients with'mosaic pattern'as revealed by TRUS,TPUS and TVUS was 22,12,and 4,respectively.Patients with gradesⅢandⅣdisease presented with a pathologically abnormal cushion which usually appeared as a'mosaic pattern'in TPUS and an arteriovenous fistula in pathology.Subepithelial vessels of resected gradesⅢandⅣhemorrhoid tissues were manifested by obvious structural impairment and retrograde and ruptured changes of internal elastic lamina.Some parts of the Trietz’s muscle showed hypertrophy and distortion.Arteriovenous fistulas and venous dilatation were obvious in the anal cushion of hemorhoidal tissues.After pathological results with arteriovenous fistulas were taken as the standard reference,we evaluated the compatibility between the two methods according to the Cohen’s kappa coefficiency calculation.The compatibility(Cohein kappa co-efficiency value)between'mosaic pattern'in the TPUS and arteriovenous fistula in pathology was very good(?=0.8939).When compared between different groups,TRUS presented the advantage that the mosaic pattern could be confirmed in more patients,especially for group A.There was a statistical difference when comparing group A with group B or C(P<0.05 for both).There were obvious statistical differences between group A and group B with regard to the vessel diameter and blood flow velocity measured by TRUS(P<0.05).CONCLUSION Patients with gradesⅢandⅣhemorrhoids present with a pathologically abnormal cushion which usually appears as a'mosaic pattern'in sonography,which is in accord with an arteriovenous fistula in pathology.There are clearly different hemorrhoid structures shown by sonography.'Mosaic pattern'may be a parameter for surgical indication of gradesⅢandⅣhemorrhoids. | Adilijiang Aimaiti Ma Mu Ti Jiang A Ba Bai Ke Re Irshat Ibrahim Hui Chen Maimaitituerxun Tuerdi Mayinuer | 2017 | World Journal of Gastroenterology2017，23，20： | 11 |
| 5 | Effect of basic fibroblast growth factor on the proliferation, migration and phenotypic modulation of airway smooth muscle cells显示文摘背景:增长,细胞移行和航线平滑肌房间(ASMC ) 的表型的调整是航线在气喘改变的重要特征。在肺调整 ASMC 增长,移植和表型的调整的精确细胞、分子的机制仍然保持未知。基本成纤维细胞生长因素(bFGF ) ,为许多房间的一个高度特定的趋化性、致有丝分裂的因素打字,看起来涉及航线改变的发展。我们的学习估计了 bFGF 是否直接刺激增长,迁居和 ASMC 的表型的调整。方法:汇合并且生长逮捕了人的 ASMC 与人的 recombinant FGF 被对待。增长被 BrdU 加入并且房间数测量。移植用 Boyden 房间仪器被检验。平滑肌(sm ) 的表情 -alpha-actin 和 sm 肌浆球蛋白重链(MHC ) 对碘氧基苯甲醚 1 被 RT-PCR 和西方的污点分析决定。结果:当增加了 ASMC 时, hrbFGF (10 ng/ml ) 关于控制作为与在 ASMC 移植的控制和重要增加相比由 ASMC 在 BrdU 举起和房间数字导致了重要增加,这被发现。在与 hrbFGF 被刺激的 ASMC 的 sm-alpha-actin 和 sm-MHC 的 mRNA 和蛋白质表情关于控制减少了。结论:然而,看来, bFGF 能直接刺激 ASMC 的增长和移植房间的有收缩力的显型的表达式减少了。 | ZOU Hui NIE Xiu-hong ZHANG Yi HU Mu ZHANG Yu Alex | 2008 | Chinese Medical Journal2008，，5： | 9 |
| 6 | Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration显示文摘The SoxC transcription factors(Sox4,Sox11,and Sox12) play important roles in the development of the vertebrate eye and retina. However,their expression and function during retinal and optic nerve regeneration remain elusive. In this study,we investigated the expression and possible functions of the SoxC genes after retinal and optic nerve injury in adult zebrafish. We found that among the five SoxC members,Sox11b was strongly induced in BrdU-positive cells in the inner nuclear layer(INL) after retinal injury,and morpholino-mediated Sox11b-knockdown significantly reduced the number of proliferating cells in the INL at 4 days post-injury. After optic nerve lesion,both Sox11a and Sox11b were strongly expressed in retinal ganglion cells(RGCs),and knockdown of both Sox11a and Sox11b inhibited RGC axon regrowth in retinal explants. Our study thus uncovered a novel expression pattern of SoxC family genes after retinal and optic nerve injury,and suggests that they have important functions during retinal and optic nerve regeneration. | Zhaoxia Mu Shuqiang Zhang Chunjiao He Haitao Hou Dong Liu Nan Hu Hui Xu | 2017 | Neuroscience Bulletin2017，33，1： | 9 |
| 7 | Defect and Doping Co‑Engineered Non‑Metal Nanocarbon ORR Electrocatalyst显示文摘Exploring low-cost and earth-abundant oxygen reduction reaction(ORR)electrocatalyst is essential for fuel cells and metal–air batteries.Among them,non-metal nanocarbon with multiple advantages of low cost,abundance,high conductivity,good durability,and competitive activity has attracted intense interest in recent years.The enhanced ORR activities of the nanocarbons are normally thought to originate from heteroatom(e.g.,N,B,P,or S)doping or various induced defects.However,in practice,carbon-based materials usually contain both dopants and defects.In this regard,in terms of the co-engineering of heteroatom doping and defect inducing,we present an overview of recent advances in developing non-metal carbon-based electrocatalysts for the ORR.The characteristics,ORR performance,and the related mechanism of these functionalized nanocarbons by heteroatom doping,defect inducing,and in particular their synergistic promotion effect are emphatically analyzed and discussed.Finally,the current issues and perspectives in developing carbon-based electrocatalysts from both of heteroatom doping and defect engineering are proposed.This review will be beneficial for the rational design and manufacturing of highly efficient carbon-based materials for electrocatalysis. | Jian Zhang Jingjing Zhang Feng He Yijun Chen Jiawei Zhu Deli Wang Shichun Mu Hui Ying Yang | 2021 | Nano-Micro Letters2021，13，4： | 8 |
| 8 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 9 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 10 | Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients显示文摘 | Hui Yu Li-Fang Xie Kang Chen Gang-Yi Yang Xiao-Yan Xing Jia-Jun Zhao Tian-pei Hong Zhong-Yan Shan Hong-Mei Li Bing Chen Xu-Lei Tang Ling Qi Jing Yang Yuan Fang Ting Li Shuang-ShuangWang Ya-Qi Yin Yi-Ming Mu | 2016 | Chinese Medical Journal2016，，7： | 7 |
| 11 | New technique: Design and implementation of the highly-reliable, low-cost housekeeping system in the ZDPS-1A pico-satellite显示文摘The ZDPS-1A pico-satellite designed in Zhejiang University with a mass of 3.5 kg and a power consumption of less than 3.5 W is the smallest satellite in China up to now. The housekeeping system (HKS) is the core part of ZDPS-1A. The reliability of HKS has an important influence on the safety of the satellite. Traditional fault-tolerant methods do not apply to ZDPS-1A due to such pico-satellite characteristics as light weight, compactness in size, energy saving, and high integration. This paper deals with a highly-reliable, low-cost design for HKS using industrial devices. The reliable strategies of HKS include a dual modular redundancy scheme, CPU warm backup, a static triple modular redundancy scheme, and two-level watchdogs. Recursive experiments, special tests, and environmental tests show that this system meets the design target. This design has already been applied to ZDPS-1A, which was launched to execute in-orbit tasks on Sept. 22, 2010. To date, the satellite has been in a proper state for more than 15 months. | Yu ZHANG Yang-ming ZHENG Mu YANG Hui LI Zhong-he JIN | 2012 | Journal of Zhejiang University-Science C(Computers and Electronics)2012，13，2： | 6 |
| 12 | Genetic and Antibiotic Resistance Characteristics ofCampylobacterjejuni Isolated from Diarrheal Patients,Poultry and Cattle in Shenzhen显示文摘Objective To investigate genetic and antibiotic resistance characteristics of Campylobacter jejuni(C. jejuni) isolated from Shenzhen. Methods Multilocs sequence typing and agar dilution methods were used to define the genotype and antibiotic resistance of C. jejuni, respectively. Results In total, 126 C. jejuni strains were isolated. The prevalence of C. jejuni was 5.3% in diarrheal patients. The prevalence in poultry meat(36.5%) was higher than that in cattle meat(1.1%). However, the prevalence in poultry cloacal swabs(27.0%) was lower than that in cattle stool(57.3%). Sixty-two sequence types were obtained, among which 27 of the STs and 10 alleles were previously unreported. The most frequently observed clonal complexes were ST-21(11.9%), ST-22(10.3%), and ST-403(7.1%). ST-21, ST-45, ST-354, ST-403, and ST-443 complexes overlapped between isolates from patients and cattle, whereas ST-45 and ST-574 complexes overlapped between isolates from patients and poultry. All C. jejuni were resistant to at least one antibiotic. The highest resistance rate was toward ciprofloxacin(89.7%), followed by tetracycline(74.6%), and nalidixic acid(69.0%). Conclusion This is the first report of the genotypes and antibiotic resistance of C. jejuni in Shenzhen. Overlapping clonal complexes were found between isolates from patients and cattle, and between patients and poultry. | JU Chang Yan ZHANG Mao Jun MA Yan Ping LU Jing Rang YU Mu Hua CHEN Hui LIU Chu Yun GU Yi Xin FU Yan Yan DUAN Yong Xiang | 2018 | Biomedical and Environmental Sciences2018，31，8： | 5 |
| 13 | On the Block Independence in G-Inverse and Reflexive Inner Inverse of A Partitioned Matrix显示文摘由使用多重商单个珍视分解 QQQQQ-SVD,我们在 2 x 2 个划分矩阵的 g 反、反射的内部逆学习块独立,并且证明一 conjecture 在[王一菊,暹罗 J。矩阵肛门。Appl, 19 (2 ) , 407-415 (1998 )] 。 | Yong Hui LIU Mu Sheng WEI | 2007 | Acta Mathematica Sinica,English Series2007，23，4： | 4 |
| 14 | Vertical motions of tide gauge stations near the Bohai Sea and Yellow Sea显示文摘A modified Gauss-Markov model with weighted constraints was constructed by combining satellite altimeter and tide gauge records. Vertical motion rates of nine tide gauge stations around the Bohai Sea and Yellow Sea are estimated. This is the first time systematic estimates have been derived in this region. Downward trends were seen at the six tide gauge stations located at Tanggu, Longkou, Laohutan, Bayuquan, Xiaochangshan, and Yantai; with vertical motion rates of-1.82±0.50,-1.65±0.46,-0.88±0.42,-0.58±0.62,-0.13±0.43, and-0.01±0.43 mm/yr, respectively. Upward trends were seen at the three tide gauge stations located at Qinhuangdao, Huludao and Chengshantou; with vertical motion rates of 1.12±0.46, 0.55±0.49 and 0.26±0.44 mm/yr, respectively. There was significant subsidence in Tanggu and Longkou, and a rising trend in Qinhuangdao. According to our results, the rate of sea level rise calculated from these tide gauge records can be improved using a more accurate measurement of the land elevation accounting for lifting or subsidence. The model derived can be used to estimate vertical motions of tide gauge stations, and can be widely applied to revise the benchmark levels of tide gauges. | LIU ShouHua CHEN ChangLin LIU KeXiu MU Lin WANG Hui WU XinRong ZHANG JianLi DUAN XiaoFeng GAO Jia | 2015 | Science China Earth Sciences2015，58，12： | 4 |
| 15 | A rapid method for the determination of dopamine in porcine muscle by pre-column derivatization and HPLC with fluorescence detection显示文摘A rapid method has been developed based on the sample preparation procedure named as QuEChERS (Quick,Easy,Cheap,Effective,Rugged and Safe),combined with reversed-phase high performance liquid chromatography with fluorescence detector and C 18 column after precolumn derivatization using o-phthalaldehyde and 2-mercaptoethanol to determine dopamine in porcine muscle.Methanol and deionized water (0.1% acetic acid,v/v) with a ratio of 60:40 was used as mobile phase.The flow rate was 0.8 mL/min and dopamine was eluted within 15min.The linearity range was 0.003-8 mg/mL with r 0.9992.The detection limit for dopamine was 4mg/kg and the quantification limit was 9mg/kg.Recovery studies were carried out at 0.1,0.5 and 1.0mg/kg fortification levels and the average recoveries obtained ranged from 90.4% to 98.2% with relative standard deviations between 3.5% and 8.1%.The method was found to be suitable for detection of dopamine in animal product tissues at the maximum residue level. | Hong-Xia Zhao Hui Mu Yan-Hong Bai Hu Yu Ying-Mei Hu | 2011 | Journal of Pharmaceutical Analysis2011，1，3： | 3 |
| 16 | Synthesis and light-emitting properties of 2-(N-phenyl-α-naphthylamino) and 2-dimesitylboron-7-(N-phenyl-α-naphthylamino)-9,9-diethylfluorene显示文摘A fluorescent organic triarylamine with a symmetric structure, 2,7-bis(N-α-naphthyl-phenylamino)-9,9- diethylfluorene (NPAEF) was synthesized using two methods, modified Ullmann coupling and modified palladium-catalyzed amination. An activated copper and a combination of Pd(OAc)2/P(t-Bu)3 and Pd(dba)2/P(t-Bu)3 were selected as catalysts to improve yields of reactions. These synthetic procedures were also successfully applied to an asymmetric 2-dimesitylboron-7-(N-phenyl-α-naphthylamino)-9,9-diethylfluorene (BNPEF). Photoluminescent emission peaks in solid film and in diluted solution of NPAEF were both observed at 461 nm, while the main emission peaks of BNPEF appeared at 422 nm in hexane, and at 480 nm in methanol. The double emission peaks of BNPEF in hexane reflected fine structure in the vibrational state. With an increasing polarity of solvent, the main PL emission peaks were red-shifted and vibrational fine structure disappeared. Additionally, energy levels of NPAEF were investigated and an electroluminescence (EL) device of ITO/PVK:NPAEF/Al was fabricated, which showed a turn-on voltage of 9 V and peaked at 462 nm. The EL spectrum was in good agreement with PL spectrum, which indicated that they were from the same emitting center in the device. | ZHANG WenGuan HE ZhiQun HUI GuanBao MU LinPing WANG YongSheng ZHAO ShengMin JING XiPing | 2009 | Science China Chemistry2009，52，7： | 3 |
| 17 | High electrocatalytic hydrogen evolution activity on a coupled Ru and CoO hybrid electrocatalyst显示文摘Hydrogen evolution reaction (HER) is an essential step in converting renewable energy to clean hydrogen fuel. Exploring highly efficient, stable and cost-effective electrocatalysts is of crucial significance for sustainable HER. Here, we report the design of a coupled ruthenium/cobalt oxide (Ru/CoO) hybrid electrocatalyst for alkaline HER. In this hybrid metal/oxide system, the complicated alkaline HER pathways are overall facilitated;oxygen (O)-vacancy-abundant oxide enhances water splitting and Ru promotes successive hydrogen intermediates to generate hydrogen. The resulting Ru/CoO hybrid electrocatalyst exhibits significantly promoted catalytic activity compared with benchmark Ru catalyst, displaying an overpotential of 55 mV to generate a HER current density of 10 mA cm^-2, comparable with the state-of-the-art Pt/C catalyst and the most efficient alkaline HER electrocatalysts. Furthermore, the strong interaction of Ru nanoparticles with oxide support and the in-situ growth of oxide support on conductive substrate guarantee the long-term stability of as-fabricated Ru/CoO hybrid electrocatalyst. This newly designed hybrid catalyst with abundant metal/oxide interfaces may pave a new pathway for exploring efficient and stable HER electrocatalysts. | Jia-Xin Guo Dong-Yang Yan Kang-Wen Qiu Chuan Mu Dian Jiao Jing Mao Hui Wang Tao Ling | 2019 | Journal of Energy Chemistry2019，28，10： | 3 |
| 18 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 19 | miR-27b synergizes with anticancer drugs via p53 activation and CYPIB1 suppression显示文摘 | Wenjing Mu Chaobo Hu Haibin Zhang Zengqiang Qu Jin Cen Zhixin Qiu Chao Li Haozhen Ren Yixue Li Xianghuo He Xiaolei Shi Lijian Hui | 2015 | Cell Research2015，25，4： | 3 |
| 20 | Benzo[a]pyrene stimulates miR-650 expression to promote the pathogenesis of fatty liver disease and hepatocellular carcinoma via SOCS3/JAK/STAT3 cascades显示文摘Modern diets,which often feature high levels of fat and charcoal-grilled meat,contribute to the pathogenesis of obesity and non-alcoholic fatty liver disease(NAFLD),resulting in liver cancer progression.Benzo(a)pyrene(B[a]P)is a common environ-mental and foodborne pollutant found in smoke and fire-grilled foods,which can have an adverse effect on human health.Hepatocellular carcinoma(HCC)is the fifth leading cause of cancer and the second leading cause of cancer-related deaths worldwide.The epidemiological studies suggest that both environmental risk factors and chronic liver injury including NAFL are important for HCC development,but the precise mechanisms linking eating habits to hepato-carcinogenesis remain unclear.In the present study,we demonstrated that various miRNAs in B[a]P-exposed tumor cells contribute to tumor metastasis,among which miR-650 could be the most potent inducer.Furthermore,we found that the suppressor of cytokine signaling 3(SOCS3)is directly regulated by miR-650 and its suppression regulates the activation of the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3)cascade.Our findings reveal a possible adverse outcome pathway of SOCS3/JAK/STAT3 regulation in B[a]P-induced HCC progress.These results provide a better understanding of the adverse effects of chronic exposure to B[a]P on human health. | Yang Ge Pengfei Gu Wenbo Wang Liyuan Cao Lulu Zhang Jingquan Li Wei Mu Hui Wang | 2021 | Journal of Molecular Cell Biology2021，13，8： | 3 |
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