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| 1 | CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma:a cross-talk between FGF21 and the NRF2 pathway显示文摘The treatment of hepatocellular carcinoma(HCC)has been dominated by multikinase inhibitors for more than a decade.However,drug resistance can severely restrict the efficacy of these drugs.Using CRISPR/CAS9 genome library screening,we evaluated Kelch-like ECH-associated protein 1(KEAP1)as a key regulator of sorafenib’s susceptibility in HCC.We also investigated whether KEAP1’s knockdown can stabilize nuclear factor(erythroid-derived 2)-like 2(NRF2)protein levels that led to sorafenib’s resistance,including an NRF2 inhibitor that can synergize with sorafenib to abolish HCC’s growth in vitro and in vivo.Furthermore,we clarified that fibroblast growth factor 21(FGF21)is an important downstream regulator of NRF2 in HCC.Intriguingly,we observed that FGF21 bound to NRF2 through the C-terminus of FGF21,thereby stabilizing NRF2 by reducing its ubiquitination and generating a positive feedback loop in sorafenib-resistant HCC.These findings,therefore,propose that targeting FGF21 is a promising strategy to combat HCC sorafenib’s resistance. | Jiang Chen Shi Jiang Huijiang Shao Bixia Li Tong Ji Daniel Staiculescu Jiayan He Jie Zhao Liuxin Cai Xiao Liang Junjie Xu Xiujun Cai | 2022 | Science China(Life Sciences)2022，65，10： | 4 |
| 2 | Optimal Decay Estimates on the Linearized Boltzmann Equation with Time Dependent Force and their Applications显示文摘 | Renjun Duan Seiji Ukai Tong Yang Huijiang Zhao | 2008 | Communications in Mathematical Physics2008，，1： | 1 |
| 3 | Global Existence of Classical Solutions to the Vlasov-Poisson-Boltzmann System显示文摘 | Tong Yang Huijiang Zhao | 2006 | Communications in Mathematical Physics2006，，3： | 1 |
| 4 | Cauchy Problem for the Vlasov–Poisson–Boltzmann System显示文摘 | Tong Yang Hongjun Yu Huijiang Zhao | 2006 | Archive for Rational Mechanics and Analysis2006，，3： | 1 |
| 5 | Convergence Rate to Stationary Solutions for Boltzmann Equation with External Force显示文摘为有在在空格变量的一个潜在的函数的坡度形式的外部力量的 Boltzmann 方程,它的静止解决方案的稳定性被 S 作为 localMaxwellians 学习。Ukai 等。(2005 ) 通过精力方法。在分析集中率到可压缩的海军司烧方程的静止解决方案上把稳定性分析和一些技术基于这,在这篇论文,我们学习集中率到是在为非平衡的统计物理的一个基本方程的 Boltzmann 方程的上述静止解决方案使精的气体。由通过庆祝 H 定理在非液体部件上在液体部件和驱散上从粘性和热电导率联合驱散,象为 compressibleNavier 司烧的那的一样的顺序的集中率被构造某精力 functionals 获得。 | Seiji UKAI Tong YANG Huijiang ZHAO | 2006 | Chinese Annals of Mathematics,Series B2006，27，4： | 1 |
| 6 | Global smooth solutions for a class of guasilinear hyprebolic systems with dissipative terms显示文摘 | Yang Tong Zhu Changjiang Zhao Huijiang | 1997 | Proc Roy Soc Edinburgh1997，127，： | 1 |
| 7 | Existence and asymptotic behaviors of solutions to 2 × 2 hyperbolic quadratic conservation laws with viscosity 显示文摘 | Lu Yunguang Zhao Huijiang | 1991 | Nonlinear Analysis TMA1991，17，2： | 1 |
| 8 | Optimal temporal decay estimates for the solution to the multidimensional generalized BBM-Burgers equations with dissipative term 显示文摘 | Zhao Huijiang | 2000 | Applicable Analysis2000，75，12： | 1 |
| 9 | Existence and convergence of solutions for the generalized BBM-Burgers equations with dissipative term 显示文摘 | Zhao Huijiang Xuan Benjin | 1997 | Nonlinear Analysis : Theory Methods & Applications1997，28，11： | 1 |
| 10 | Existence and convergence of solutions for the generalized BBM-Burgers equations with dissipative term I1 :the multidimensional case 显示文摘 | Zhao Huijiang | 2000 | Applicable Analysis2000，75，12： | 1 |
| 11 | The non-cutoff Vlasov-Maxwell-Boltzmann system with weak angular singularity显示文摘We establish the global existence of small-amplitude solutions near a global Maxwellian to the Cauchy problem of the Vlasov-Maxwell-Boltzmann system for non-cutoff soft potentials with weak angular singularity. This extends the work of Duan et al.(2013), in which the case of strong angular singularity is considered, to the case of weak angular singularity. | Yingzhe Fan Yuanjie Lei Shuangqian Liu Huijiang Zhao | 2018 | Science China Mathematics2018，61，1： | 1 |
| 12 | DECAY RATES TOWARD STATIONARY WAVES OF SOLUTIONS FOR DAMPED WAVE EQUATIONS显示文摘 | Fan Lili Yin Hui Zhao Huijiang | 2008 | Journal of Partial Differential Equations2008，21，2： | 1 |
| 13 | The Vlasov–Poisson–Boltzmann system in the whole space: The hard potential case显示文摘 | Renjun Duan Tong Yang Huijiang Zhao | 2012 | Journal of Differential Equations2012，，12： | 1 |
| 14 | Enhanced synergy between Cu^(0) and Cu^(+) on nickel doped copper catalyst for gaseous acetic acid hydrogenation显示文摘As the substitution of common noble catalysts in the hydrogenation of carboxylic acid,a highly effective Cu-Ni/SiO_(2) catalyst was prepared by a novel stepwise ammonia evaporation method.Its performance in the gasphase hydrogenation of acetic acid was further examined.With the introduction of Ni dopant,more stable Cu^(δ+) sites,which can adsorb more acetic acid,were formed due to the electron transfer from Cu to Ni.This makes more Cu^(0) sites available for hydrogen adsorption,which was suggested as the rate-determining step in acetic acid hydrogenation.A conversion of 99.6% was successfully achieved on this new Cu/SiO_(2)-0.5Ni catalyst,accompanied by the ethanol selectivity of 90%.The incorporation of nickel between copper nanoparticles enhances the synergistic effect between Cu^(0) and Cu^(+).It also helps mitigate the aggregation of copper nanoparticles due to the Ostwald ripening effect induced by acetic acid and enhance the stability of copper catalyst in the conversion of carboxylic acid. | Jingwei Zhang Lingxin Kong Yao Chen Huijiang Huang Huanhuan Zhang Yaqi Yao Yuxi Xu Yan Xu Shengping Wang Xinbin Ma Yujun Zhao | 2021 | Frontiers of Chemical Science and Engineering2021，15，3： | 0 |
| 15 | The Vlasov-Poisson-Boltzmann system for non-cutof hard potentials显示文摘This paper is concerned with the construction of globally smooth solutions near a given global Maxwellian to the Cauchy problem of the Vlasov-Poisson-Boltzmann system for non-cutof hard potentials in three space dimensions without the neutral condition imposed on the initial perturbation.Our analysis is based on the time-weighted energy method and some delicate estimates. | XIAO QingHua XIONG LinJie ZHAO HuiJiang | 2014 | Science China Mathematics2014，57，3： | 0 |
| 16 | Reconstruction of Cu-ZnO catalyst by organic acid and deactivation mechanism in liquid-phase hydrogenation of dimethyl succinate to 1,4-butanediol显示文摘A reconstructed Cu-ZnO catalyst with improved stability was fabricated by organic acid treatment method for the liquid-phase hydrogenation of dimethyl succinate to 1,4-butanediol.According to the characterization results of the fresh Cu-ZnO and reconstructed Cu-ZnO,three different forms of ZnO were suggested to be presented on the catalysts:ZnO having strong interaction with Cu species,ZnO that weakly interacted with Cu species and isolated ZnO.The first form of ZnO was believed to be beneficial to the formation of efficient active site Cu^(+),while the latter two forms of ZnO took the main responsibility for the deactivation of Cu-ZnO catalysts in the liquid-phase hydrogenation of diesters.The reconstruction of the Cu-ZnO catalyst by the organic acid treatment method resulted in a new Cu-ZnO catalyst with more Cu^(+)and less ZnO species that leads to deactivation.Furthermore,the deactivation mechanism of Cu-ZnO catalysts in liquid-phase diester hydrogenation in continuous flow system was proposed:the deposition of the polyesters on the catalysts via transesterification catalyzed by weakly interacted ZnO and isolated ZnO leads to the deactivation.These results provided meaningful instructions for designing highly efficient Cu-Zn catalysts for similar ester hydrogenation systems. | Fan Sun Huijiang Huang Wei Liu Lu Wang Yan Xu Yujun Zhao | 2023 | Frontiers of Chemical Science and Engineering2023，17，9： | 0 |
| 17 | Reductive amination of n-hexanol to n-hexylamine over Ni-Ce/γ-Al_(2)O_(3) catalysts显示文摘The amination of alkyl alcohols is one of the most promising paths in synthesis of aliphatic amines.Herein,cerium doped nickel-based catalysts were synthesized and tested in a gas-phase amination of n-hexanol to n-hexylamine.It was found that the activity of the Ni/γ-Al_(2)O_(3)catalyst is significantly improved by doping an appropriate amount of cerium.The presence of cerium effectively inhibits the agglomeration of nickel particle,resulting in better Ni dispersion.As Ni particle size plays critical role on the catalytic activity,higher turnover frequency of n-hexanol amination was achieved.Cerium doping also improves the reduction ability of nickel and enhances the interactions between Ni and the catalyst support.More weak acid sites were also found in those cerium doped catalysts,which promote another key step—ammonia dissociative adsorption in this reaction system.The overall synergy of Ni nanoparticles and acid sites of this Ni-Ce/γ-Al_(2)O_(3)catalyst boosts its superior catalytic performance in the amination of n-hexanol. | Pengfei Li Huijiang Huang Zheng Wang Ziying Hong Yan Xu Yujun Zhao | 2023 | Frontiers of Chemical Science and Engineering2023，17，1： | 0 |
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