|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 2 | Effect of Cl^- on photosynthetic bicarbonate uptake in two cyanobacteria Microcystis aeruginosa and Synechocystis PCC6803显示文摘Photosynthetic inorganic carbon utilization was investigated in two cyanobacteria Microcystis aeruginosa and Synechocystis PCC6803 grown in standing culture. Photosynthetic rates for the two algae reached about 10 times the theoretical CO2 supply rate at low dissolved inorganic carbon (DIC) of 100 μmol/L, and the rates were unaffected by the addition of 20 mmol/L Na+, indicating that the two algae possessed Na+-independent HCO3- utilization for photosynthesis under low DIC. Their photo- synthetic rates at low DIC were inhibited by higher Cl- and the degrees of inhibition were increased with the rise of CI- concentration, and in the presence of Diphenylamine-2-carboxylate (DPC), a reported Cl- channel inhibitor, the rates decreased by 74%-82%, implying that putative DPC-sensitive Cl- channels participate in Na+-independent HCO3? uptake for photosynthesis. The experiment of intracellular 14C-DIC accumulation for photosynthesis showed that internal DIC pools decreased by about 80% with 200 μmol/L DPC and by 64%-70% with 100 mmol/L Cl-. The experiment of chlorophyll a fluorescence quenching showed that initial rates and extents of fluorescence quenching obviously decreased with 200 μmol/L DPC or 100 mmol/L Cl-. The two experiments gave further evidence that putative DPC-sensitive Cl- channels participate in Na+-independent HCO3- uptake for photosynthesis in the two algae grown in standing culture. | CHEN Zhen CHENG HuiMin CHEN XiongWen | 2009 | Chinese Science Bulletin2009，54，7： | 8 |
| 3 | Distribution and accumulation of biogenic silica in the intertidal sediments of the Yangtze Estuary显示文摘沉积源於生物的硅石被知道是一个重要参数在河口和沿海的生态系统理解 biogeochemical 进程和 paleoenviromental 记录。因而,在沉积调查源於生物的硅石的累积和分发意义大。二拍子的圆舞温和酸温和的碱的抽取过程被用来沥滤源於生物的硅石和它的早 diagenetic 产品在内部 Yangtze 河口的潮汐的沉积。结果显示出那全部的源於生物的硅石( t-BSi )在内部潮汐的沉积从 237.7-419.4 亩摩尔 Si/g 变化了,当时可滤取的硅石( Si-HCl )和温和碱的可滤取的硅石( Si-Alk )在 25.1-72.9 亩摩尔 Si/g 和 208.1-350.4 亩 rnol Si/g 的范围的温和的酸, respectively.Significant 关联为沉积和不同源於生物的硅石水池的粒度分布被观察在内部潮汐的沉积。这证实粒度分发能显著地在沉积影响源於生物的硅石内容。有器官的碳和氮的源於生物的硅石的关系也是的结束发现在源於生物的硅石和有机物 biogeochemical 之间有强壮的联合在,反映那内部 Yangtze 河口的潮汐的系统。另外,在沉积的源於生物的硅石的早 diagenetic 变化在现在的学习被讨论。 | HOU Lijun LIU Min XU Shiyuana YAN Huimin OU Dongni CHENG Shubo LIN Xiao | 2008 | Journal of Environmental Sciences2008，20，5： | 7 |
| 4 | Effect of cold rolling process on microstructure and mechanical properties of high strength β titanium alloy thin sheets显示文摘The microstructure and mechanical properties of Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe high strength titanium alloy sheets prepared by unidirectional cold rolling and two-step cross cold rolling were investigated. Results showed that the β phase grains were refined significantly by cold rolling followed by solution treatment for a short time.Compared to unidirectional cold rolling, the short time solution treatment after two-step cross rolling could significantly reduce the non-uniformity of the microstructure of the alloy sheets. After aging treatment at 550 ℃,the anisotropy of the mechanical properties still existed in the unidirectional rolled sheets, and the tensile strength was highest along the rolling direction. After solution and aging treatment, the anisotropy of the mechanical properties of the two-step cross rolling process sheet was not obvious than unidirectional cold rolling,and alloy had good strength and plasticity matching. | Yan Ma Zhaoxin Du Xiaoming Cui Jun Cheng Guolong Liu Tianhao Gong Huimin Liu Xiaopeng Wang Yuyong Chen | 2018 | Progress in Natural Science:Materials International2018，28，6： | 6 |
| 5 | Variation Character of Grain Yield per Unit Area in Main Grain-producing Area of Northeast China显示文摘Based on the surveys and the statistic data during 1980-2003, the variation character of grain yield per unit area in Northeast China and its main factors have been discussed by the methods of statistics and grey correlation analysis. The results show that: 1) the grain yield per unit area has been taking on an increasing trend in the recent 20 years. It increased from 2519.80kg/ha in 1980 to 4216.11kg/ha in 2003, with an increasing rate of 67.32%; 2) the variation of grain yield per unit area is considerably prominent and its range is also very great, with the maximal increase rate of 42.59% and maximal decrease rate of 21.13%, respectively, which are far above the whole Chinese average level; 3) the variation of main crops' yield per unit area is remarkable, which takes on the character that the yield of corn is much higher than that of soybean and rice; and 4) the grey correlation analysis shows that the most important factors impacting the variation of grain yield per unit area are the total power of agricultural machinery, the consumption of chemical fertilizer and effective irrigated area. However, the influence of natural disaster and income level should not be ignored. Effective ways to improve grain yield per unit area are to construct farmland improvement groundwork, reclaim the middle- and low-yield farmland, etc. | CHENG Yeqing ZHANG Pingyu ZHANG Huimin | 2007 | Chinese Geographical Science2007，17，2： | 5 |
| 6 | Two-dimensional porphyrin- and phthalocyanine-based covalent organic frameworks显示文摘Covalent organic frameworks(COFs) represent an emerging class of porous crystalline materials and have recently shown interesting applications from catalysis to optoelectronic devices.In this review,by covering most of the reported work,we summarized the research progress of two-dimensional(2D)porphyrin- and phthalocyanine-based COFs,with highlighting the synthesis of these 2D COFs via various dynamic covalent reactions and emphasizing their potential applications in different areas. | Hongmin Wang Huimin Ding Xiangshi Meng Cheng Wang | 2016 | Chinese Chemical Letters2016，27，8： | 5 |
| 7 | Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure显示文摘Background and Aims:Nonbiological artificial liver(NBAL)is frequently used as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF).This study aimed to compare the therapeutic efficacy and cost-effectiveness ratio(CER)of comprehensive medical treatment,plasma exchange(PE),and double plasma molecular adsorption system(DPMAS)plus half-dose PE(DPMAS+PE)in patients with HBV-ACLF.Methods:A total of 186 patients with HBV-ACLF randomly received comprehensive medical treatment,PE,or DPMAS+PE and were prospectively evaluated.Patients were divided into four subgroups based on the pretreatment prothrombin activity(PTA):Group I(PTA>40%),group II(PTA 30–40%),group III(PTA 20–30%),and group IV(PTA<20%).The main outcome measures were 28 day effectiveness;90 day liver transplantation-free survival;change of biochemical parameters;and CER.Results:DPMAS+PE treatment was associated with significantly higher 28 day effectiveness and 90 day liver transplantation-free survival compared with PE treatment in patients with group I liver failure.Clearance of serum total bilirubin(TBIL),AST,and creatinine(Cr)were significantly higher in the DPMAS+PE group than in the PE group.For subjects with group I liver failure,DPMAS+PE treatment had advantages of lower CER values and better cost-effectiveness.Conclusions:Compared with comprehensive medical treatment and PE alone,DPMAS with halfdose sequential PE treatment more effectively improved TBIL,AST,and Cr in HBV-ACLF patients,improved 28 day effectiveness and 90 day survival rates in patients with group I liver failure,and was more cost effective.DPMAS+PE is a viable NBAL approach for treatment of HBV-ACLF. | Cichun Wu Wenting Peng Da Cheng Huimin Gu Fei Liu Shifang Peng Lei Fu | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 5 |
| 8 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 9 | Adsorption and Regeneration of Volatile Organic Compounds(VOCs)on Coal-Based Activated Carbon by Ferric Nitrate Modification显示文摘In this study,the Heishan coal was used to prepare a series of activated carbon(AC)samples via a vapor deposition method.The effects of the Fe(NO_(3))3/coal weight ratio on the physicochemical properties of the activated carbon were systematically investigated,and the AC samples were analyzed by the N2 adsorption-desorption technique,the scanning electron microscopy,the X-ray diffraction,the Raman spectroscopy,and the Fourier transform infrared spectroscopy.Furthermore,the adsorption properties of ethyl acetate were investigated.The results indicated that as the Fe(NO_(3))3/coal mass ratio increased from 1:8 to 1:2,the specific surface area,the total pore volume and the micropore volume initially increased and then decreased.The specific surface area increased from 560.86 m^(2)/g to 685.90 m^(2)/g,and then decreased to 299.56 m^(2)/g.The total pore volume and micropore volume increased from 0.29 cm^(3)/g and 0.17 cm^(3)/g to 0.30 cm^(3)/g and 0.22 cm^(3)/g,and then decreased to 0.16 cm^(3)/g and 0.10 cm^(3)/g,respectively.The optimized ratio was 1:8.During the activation process,iron ions infiltrated the activated carbon to promote the development of the pore structure,the pore size of which was between 2.5 nm and 3 nm in daimeter.This approach could enhance the capacity for adsorption of ethyl acetate.It is worth noting that the ACs displaying the largest specific surface area and total pore volume(685.90 m^(2)/g and 0.30 cm^(3)/g)were formed under the optimized activation conditions(950℃,20%(volume)of CO_(2),ratio 1:5),and the maximum AC capacity for adsorption of ethyl acetate was 962.62 mg/g.After seven repeated thermal regeneration experiments,the saturated AC adsorption capacity was still above 90%. | Jin Chunjiang Chen Huimin Wang Luyuan Cheng Xingxing Sun Rongfeng | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，3： | 4 |
| 10 | Effects of modified Wenjing decoction on microcirculation in reproductive organs in rats with symptom patterns of cold coagulation and blood stasis显示文摘OBJECTIVE: To investigate the relationship between symptom patterns of cold coagulation and blood stasis(CCBS) and microcirculation disturbance. In addition, we determined the efficacy of modified Wenjing decoction(WJD) for the treatment of CCBS.METHODS: CCBS was induced in rats with an icewater bath treatment. The ovarian function, microvascular and circulatory status of reproductive organs, and function of local microvascular endothelial cells(VECs) and vascular smooth muscle cells(VSMCs) were evaluated.RESULTS: Ovarian dysfunction was observed in the rats with CCBS. It was characterized by the presence of an estrous cycle disorder and a decrease in reproductive hormone levels. Microvascular circulation disorders were associated with an imbalance in vasoconstriction, relaxation substances, nitric oxide, abnormal blood flow in whole blood, and decreased blood flow in the auricle and uterus. VECs were damaged, and VSMCs contracted and proliferated in ovarian and uterine tissues.CONCLUSION: Our findings suggest that the dysfunctional reproductive organs observed in gynecological CCBS may be closely related to the microcirculation disturbance of local tissues, microvascular contraction, and vascular remodeling. Modified WJD can be used to treat CCBS by improving microcirculation in reproductive organs. | Wang Di Cheng Xiumei Fang Huimin Ren Yanqing Li Xinhua Ren Weiwei Xue Bing Yang Cairui | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 4 |
| 11 | From Symbols to Embeddings:A Tale of Two Representations in Computational Social Science显示文摘Computational Social Science(CSS),aiming at utilizing computational methods to address social science problems,is a recent emerging and fast-developing field.The study of CSS is data-driven and significantly benefits from the availability of online user-generated contents and social networks,which contain rich text and network data for investigation.However,these large-scale and multi-modal data also present researchers with a great challenge:how to represent data effectively to mine the meanings we want in CSS?To explore the answer,we give a thorough review of data representations in CSS for both text and network.Specifically,we summarize existing representations into two schemes,namely symbol-based and embeddingbased representations,and introduce a series of typical methods for each scheme.Afterwards,we present the applications of the above representations based on the investigation of more than 400 research articles from 6 top venues involved with CSS.From the statistics of these applications,we unearth the strength of each kind of representations and discover the tendency that embedding-based representations are emerging and obtaining increasing attention over the last decade.Finally,we discuss several key challenges and open issues for future directions.This survey aims to provide a deeper understanding and more advisable applications of data representations for CSS researchers. | Huimin Chen Cheng Yang Xuanming Zhang Zhiyuan Liu Maosong Sun Jianbin Jin | 2021 | Journal of Social Computing2021，2，2： | 4 |
| 12 | Enhancing single-cell hyaluronic acid biosynthesis by microbial morphology engineering显示文摘Microbial morphology engineering is a novel approach for cell factory to improve the titer of target product in bio-manufacture.Hyaluronic acid(HA),a valuable glycosaminoglycan polymerized by HA synthase(HAS),a membrane protein,is particularly selected as the model product to improve its single-cell HA-producing capacity via morphology engineering.DivIVA and FtsZ,the cell-elongation and cell division related protein,respectively,were both down/up dual regulated in C.glutamicum via weak promoter substitution or plasmid overexpression.Different from the natural short-rod shape,varied morphologies of engineered cells,i.e.small-ellipsoid-like(DivIVA-reduced),bulb-like(DivIVA-enhanced),long-rod(FtsZ-reduced)and dumbbell-like(FtsZ-enhanced),were observed.Applying these morphology-changed cells as hosts for HA production,the reduced expression of both DivIVA and FtsZ seriously inhibited normal cell growth;meanwhile,overexpression of DivIVA didn't show morphology changes,but overexpression of FtsZ surprisingly change the cell-shape into long and thick rod with remarkably enlarged single-cell surface area(more than 5.2-fold-increase).And finally,the single-cell HA-producing capacity of the FtsZ-overexpressed C.glutamicum was immensely improved by 13.5-folds.Flow cytometry analyses verified that the single-cell HAS amount on membrane was enhanced by 2.1 folds.This work is pretty valuable for high titer synthesis of diverse metabolic products with microbial cell factory. | Yukun Zheng Fangyu Cheng Bo Zheng Huimin Yu | 2020 | Synthetic and Systems Biotechnology2020，5，4： | 3 |
| 13 | A short review on recent progress of Bi/semiconductor photocatalysts:The role of Bi metal显示文摘Bi/semiconductor photocatalysts have extensively been applied in the production of hydrogen,CO_(2) reduction and environmental remediation in recent years.This short review summarizes the role of Bi metal as a plasma photocatalyst and cocatalyst.As a cocatalyst,Bi metal can be electron/hole trappers,charge transfer mediators,or oxygen vacancy coordinators.In addition,the preparation methods of the Bi/semiconductor photocatalysts are also reviewed.Challenges and future research directions related to Bi/semiconductor photocatalysts are discussed and summarized,including the use of advanced characterization techniques to refine the reaction mechanism,the difficulties of preparing Bi single atom catalyst,and the improvement of the reduction ability of Bi-based photocatalysts.This review helps understand the reaction mechanisms of the composite photocatalytic systems containing Bi metal and proposes new perspectives for designing the photocatalysts which can control air pollution via a reductive process. | Qian Chen Xuanrui Cheng Huimin Long Yongfang Rao | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 14 | Analysis of an example of the application of baclofen in the clini- cal treatment of tetanus显示文摘 | Huo Lingbo Shen Luping Cheng Huimin | 2013 | Chinese Journal of Clinicians (Electronic Version)2013，，3： | 1 |
| 15 | A Novel Peak-to-Average Power Ratio Reduction Scheme via Tone Reservation in OFDM Systems显示文摘In this paper, a novel signal-to-clipping noise ratio and least squares approximation tone reservation scheme(SCR-LSA TR) is proposed to reduce the peak-to-average power ratio for orthogonal frequency division multiplexing systems. During the SCR procedure, only the element with the maximal amplitude is picked for processing, which not only decreases the algorithm complexity, but also helps to overcome the BER deterioration. With the LSA method, the amplitude of the peak-cancelling signals can approximate to that of the original clipping noise as much as possible. Through the combination of the optimization factor in the LSA method, the classic SCR method can achieve better PAPR reduction with faster convergence. Simulation results show that the proposed SCR-LSA TR scheme has less in-band distortion and smaller out-of-band spectral radiation. The BER of the proposed scheme shows a better performance especially under the 16-QAM over the additive white Gaussian noise channel. | Jurong Bai Yong Li Wei Cheng Huimin Du Yanben Wang | 2017 | China Communications2017，14，11： | 1 |
| 16 | Microcrystal induced emission enhancement of a small molecule probe and its use for highly efficient detection of 2,4,6-trinitrophenol in water显示文摘In this contribution, we reported a very simple and small molecule material, 2,5-dimethoxyterephthalaldehyde(DMA). It exhibited a relatively weak fluorescence in solution, while showed a steadily increased green fluorescence with typical aggregation-induced enhanced emission(AIE) effect for forming a cubic-like microcrystal structure in THF-H2 O mixed solvent.The microcrystals presented significantly higher fluorescence than that of amorphous aggregates. The DMA microcrystals suspension showed a good response to 2,4,6-trinitrophenol(TNP) with a LOD of 1.2×10^(-7) M, which is the best result of TNP detection in aqueous solution. Quantum chemical calculation revealed that DMA is a donor(D)-receptor(A) type molecule with methoxy unit as donor and carbonyl moiety as receptor. Its emission arises from an intramolecular charge transfer(ICT) from methoxy units to carbonyl units. NMR indicated that there is a strong hydrogen bond interaction between DMA and TNP.Hydrogen bond interaction can effectively decrease the intermolecular distance of DMA and TNP, which will increase the efficiency of photoinduced electron transfer(PET) and fluorescence resonance energy transfer(FRET), and hence will be advantageous for its selectivity. The microcrystal induced enhanced emission could be generally used for kinds of target molecules analysis. | Huan Liu Yanyan Fu Wei Xu Qingguo He Huimin Cao Guohua Liu Jiangong Cheng | 2018 | Science China Chemistry2018，61，7： | 1 |
| 17 | Field experiment study on effects of duct-ventilated railway embankment on protecting the underlying permafrost显示文摘 | Niu Fujun Cheng Guodong Xia Huimin Ma Lifeng | 2006 | Cold Regions Science and Technology2006，，3： | 1 |
| 18 | Transactions of Nonferrous Metals Society of China 显示文摘 | Cheng Yingliang Qin Tingwei Wang Huimin | 2009 | 19( 3 ): 517-5242009，19，3： | 1 |
| 19 | Highly efficient gene editing and single cell analysis of hematopoietic stem/progenitor cells from X-linked sideroblastic anemia patients显示文摘Dear Editor,X-linked sideroblastic anemia(XLSA),which is the most common genetic form of congenital sideroblastic anemia,is typically characterized by reduced heme synthesis and the presence of bone marrow(BM)ring sideroblasts containing pathologic iron deposits in the mitochondria. | Riguo Fang Jingliao Zhang Huihui Yang Jia Shi Huimin Zeng Xiaofan Zhu Dong Wei Pengfei Yuan Tao Cheng Yingchi Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 20 | MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme显示文摘 | Yiming Li Weiqing Li Yongji Yang Yicheng Lu Cheng He Guohan Hu Huimin Liu Juxiang Chen Jin He Hongyu Yu | 2009 | Brain Research2009，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员