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| 1 | Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition显示文摘改变的新陈代谢是癌症房间的特点之一。戊糖磷酸盐小径(PPP ) 是细胞的新陈代谢的一个基本部件。Glucose-6-phosphate 脱氢酶(G6PD ) , PPP 的限制率的酶,在许多癌症被提高并且由通过 PPP 生产 ribose-5-phosphate 和 NADPH 贡献肿瘤生长。然而,在 hepatocellular 的 G6PD 的角色癌(HCC ) 转移和在 HCC 前进和预后的 G6PD 的临床的意义一直不是很好坚定的。在这研究,由从 HCC 病人和 HCC 房间线调查织物样品,我们发现那提高的 G6PD 表情显著地与 HCC 转移和差的预后被联系 HCC,和那 G6PD 击倒在 vitro 禁止 HCC 房间线的增长,移植和侵略。进一步的研究表明 G6PD 由通过信号变换器的激活和抄写 3 的使活跃之物(STAT3 ) 导致上皮间充质的转变贡献 HCC 移植和 hepatocellular 癌房间的侵略小径。我们的调查结果建议那指向的 G6PD 能为转移干预开创可能性并且为 HCC 改进病人结果。 | Ming Lu Lu Lu Qiongzhu Dong Guangyang Yu Jinhong Chen Lunxiu Qin Lianxin Wang Wenwei Zhu Huliang Jia | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 10 |
| 2 | Natural Frequency and Stability Tuning of Cantilevered CNTs Conveying Fluid in Magnetic Field显示文摘This paper investigates the dynamics of cantilevered CNTs conveying fluid in longitudinal magnetic field and presents the possibility of controlling/tuning the stability of the CNT system with the aid of magnetic field. The slender CNT is treated as an Euler-Bernoulli beam. Based on nonlocal elasticity theory, the equation of motion with consideration of magnetic field effect is developed. This partial differential equation is then discretized using the differential quadrature method(DQM). Numerical results show that the nonlocal small-scale parameter makes the fluid-conveying CNT more flexible and can shift the unstable mode in which flutter instability occurs first at sufficiently high flow velocity from one to another. More importantly,the addition of a longitudinal magnetic field leads to much richer dynamical behaviors of the CNT system. Indeed, the presence of longitudinal magnetic field can significantly affect the evolution of natural frequency of the dynamical system when the flow velocity is successively increased.With increasing magnetic field parameter, it is shown that the CNT system behaves stiffer and hence the critical flow velocity becomes higher. It is of particular interest that when the magnetic field parameter is equal to or larger than the flow velocity, the cantilevered CNT conveying fluid becomes unconditionally stable, indicating that the dynamic stability of the system can be controlled due to the presence of a longitudinal magnetic field. | Lin Wang Yuanzhuo Hong Huliang Dai Qiao Ni | 2016 | Acta Mechanica Solida Sinica2016，29，6： | 8 |
| 3 | Down-regulation of SDFI-α expression in tumor microenvironment is associated with aspirin- mediated suppression of the pro-metastasis effect of sorafenib in hepatocellular carcinoma显示文摘 | Lu Lu Ming Lu Yuan Pei Jinhong Chen Lunxiu Gin Wenwei Zhu Huliang Jia | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 6 |
| 4 | GOLM1 exacerbates CD8^(+)T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages显示文摘The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses.Golgi membrane protein 1(GOLM1)is correlated to hepatocellular carcinoma(HCC)progression and metastasis.However,little is known about the role of GOLM1 in regulating the immunosuppressive environment and its impact on immunotherapeutic efficacy in HCC.In this study,GOLM1 was positively correlated with infiltrating tumor-associated macrophages(TAMs)expressed high levels of programmed death-ligand 1(PD-L1)and CD8^(+)T cell suppression in HCC tissues.Both gain-and loss-of-function studies determined a close correlation between GOLM1 and immunosuppression.In the mechanism,GOLM1 promoted COP9 signalosome 5-mediated PD-L1 deubiquitination in HCC cells and increased the transport of PD-L1 into exosomes via suppression of Rab27b expression.Furthermore,co-culture with exosomes derived from HCC cells upregulated the expression of PD-L1 on macrophages.Zoledronic acid in combination with anti-PD-L1 therapy reduced PD-L1^(+)TAMs infiltration and alleviated CD8^(+)T cell suppression,resulting in tumor growth inhibition in the mouse HCC model.Together,our study unveils a mechanism by which GOLM1 induces CD8^(+)T cells suppression through promoting PD-L1 stabilization and transporting PD-L1 into TAMs with exosome dependent.Targeting PD-L1^(+)TAM could be a novel strategy to enhance the efficacy of anti-PD-L1 therapy in HCC. | Jinhong Chen Zhifei Lin Lu Liu Rui Zhang Yan Geng Minghao Fan Wenwei Zhu Ming Lu Lu Lu Huliang Jia Jubo Zhang Lun-Xiu Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 5 |
| 5 | Nonplanar post-buckling analysis of simply supported pipes conveying fluid with an axially sliding downstream end显示文摘In this study,the nonplanar post-buckling behavior of a simply supported fluid-conveying pipe with an axially sliding downstream end is investigated within the framework of a three-dimensional(3 D)theoretical model.The complete nonlinear governing equations are discretized via Galerkin’s method and then numerically solved by the use of a fourth-order Runge-Kutta integration algorithm.Different initial conditions are chosen for calculations to show the nonplanar buckling characteristics of the pipe in two perpendicular lateral directions.A detailed parametric analysis is performed in order to study the influence of several key system parameters such as the mass ratio,the flow velocity,and the gravity parameter on the post-buckling behavior of the pipe.Typical results are presented in the form of bifurcation diagrams when the flow velocity is selected as the variable parameter.It is found that the pipe will stay at its original straight equilibrium position until the critical flow velocity is reached.Just beyond the critical flow velocity,the pipe would lose stability by static divergence via a pitchfork bifurcation,and two possible nonzero equilibrium positions are generated.It is shown that the buckling and post-buckling behaviors of the pipe cannot be influenced by the mass ratio parameter.Unlike a pipe with two immovable ends,however,the pinned-pinned pipe with an axially sliding downstream end shows some different features regarding post-buckling behaviors.The most important feature is that the buckling amplitude of the pipe with an axially sliding downstream end would increase first and then decrease with the increase in the flow velocity.In addition,the buckled shapes of the pipe varying with the flow velocity are displayed in order to further show the new post-buckling features of the pipe with an axially sliding downstream end. | Tianli JIANG Huliang DAI Kun ZHOU Lin WANG | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，1： | 3 |
| 6 | New insight into the stability and dynamics of fluid-conveying supported pipes with small geometric imperfections显示文摘In several previous studies,it was reported that a supported pipe with small geometric imperfections would lose stability when the internal flow velocity became sufficiently high.Recently,however,it has become clear that this conclusion may be at best incomplete.A reevaluation of the problem is undertaken here by essentially considering the flow-induced static deformation of a pipe.With the aid of the absolute nodal coordinate formulation(ANCF)and the extended Lagrange equations for dynamical systems containing non-material volumes,the nonlinear governing equations of a pipe with three different geometric imperfections are introduced and formulated.Based on extensive numerical calculations,the static equilibrium configuration,the stability,and the nonlinear dynamics of the considered pipe system are determined and analyzed.The results show that for a supported pipe with the geometric imperfection of a half sinusoidal wave,the dynamical system could not lose stability even if the flow velocity reaches an extremely high value of 40.However,for a supported pipe with the geometric imperfection of one or one and a half sinusoidal waves,the first-mode buckling instability would take place at high flow velocity.Moreover,based on a further parametric analysis,the effects of the amplitude of the geometric imperfection and the aspect ratio of the pipe on the static deformation,the critical flow velocity for buckling instability,and the nonlinear responses of the supported pipes with geometric imperfections are analyzed. | Kun ZHOU Qiao NI Wei CHEN Huliang DAI Zerui PENG Lin WANG | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，5： | 3 |
| 7 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 8 | Extremely large-amplitude oscillation of soft pipes conveying fluid under gravity显示文摘In this work,the nonlinear behaviors of soft cantilevered pipes containing internal fluid flow are studied based on a geometrically exact model,with particular focus on the mechanism of large-amplitude oscillations of the pipe under gravity.Four key parameters,including the flow velocity,the mass ratio,the gravity parameter,and the inclination angle between the pipe length and the gravity direction,are considered to affect the static and dynamic behaviors of the soft pipe.The stability analyses show that,provided that the inclination angle is not equal to π,the soft pipe is stable at a low flow velocity and becomes unstable via flutter once the flow velocity is beyond a critical value.As the inclination angle is equal to π,the pipe experiences,in turn,buckling instability,regaining stability,and flutter instability with the increase in the flow velocity.Interestingly,the stability of the pipe can be either enhanced or weakened by varying the gravity parameter,mainly dependent on the value of the inclination angle.In the nonlinear dynamic analysis,it is demonstrated that the post-flutter amplitude of the soft pipe can be extremely large in the form of limit-cycle oscillations.Besides,the oscillating shapes for various inclination angles are provided to display interesting dynamical behaviors of the inclined soft pipe conveying fluid. | Wei CHEN Ziyang HU Huliang DAI Lin WANG | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，9： | 2 |
| 9 | Effect of stearic acid, zinc stearate coating on the properties of synthetic hydromagnesite显示文摘 | Hongchang Han Shan Hu Jinqing Feng Huliang Gao | 2010 | Applied Surface Science2010，，7： | 1 |
| 10 | Vortex-induced vibration of pipes conveying fluid using the method of multiple scales显示文摘The nonlinear dynamics of supported pipes conveying fluid subjected to vortex-induced vibration is evaluated using the method of multiple scales.Frequency response portraits for different internal fluid velocities under lock-in conditions are obtained and the stability of steady-state responses is discussed.Results show that the internal fluid velocity has a prominent effect on the oscillation amplitude and that the steady-state responses incorporating unstable solutions in the lock-in region are also obtained.In addition,the effects of two kinds of fluctuating lift coefficients on the steady-state responses are compared with each other. | Huliang Dai Lin Wang | 2012 | Theoretical & Applied Mechanics Letters2012，2，2： | 1 |
| 11 | The Predictive Value of Chromosome 8p Deletion for Metastasis of Hepatocellular Carcinoma:A Summary of 10 Years' Works显示文摘Hepatocellular carcinoma (HCC) represents an extremely poor prognostic cancer, which is mainly due to the high frequency of metastasis/recurrence after surgical operation. To detect the specific chromosome | Lunxiu QIN Zhaoyou TANG Xinyuan GUAN Huliang JIA Ning REN | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 12 | Dynamic analysis and regulation of the flexible pipe conveying fluid with a hard-magnetic soft segment显示文摘The recently developed hard-magnetic soft(HMS)materials can play a significant role in the actuation and control of medical devices,soft robots,flexible electronics,etc.To regulate the mechanical behaviors of the cantilevered pipe conveying fluid,the present work introduces a segment made of the HMS material located somewhere along the pipe length.Based on the absolute node coordinate formulation(ANCF),the governing equations of the pipe conveying fluid with an HMS segment are derived by the generalized Lagrange equation.By solving the derived equations with numerical methods,the static deformation,linear vibration characteristic,and nonlinear dynamic response of the pipe are analyzed.The result of the static deformation of the pipe shows that when the HMS segment is located in the middle of the pipe,the downstream portion of the pipe centerline will keep a straight shape,providing that the pipe is stable with a relatively low flow velocity.Therefore,it is possible to precisely regulate the ejection direction of the fluid flow by changing the magnetic and fluid parameters.It is also found that the intensity and direction of the external magnetic field greatly affect the stability and dynamic response of the pipe with an HMS segment.In most cases,the magnetic actuation increases the critical flow velocity for the flutter instability of the pipe system and suppresses the vibration amplitude of the pipe. | Zilong GUO Qiao NI Wei CHEN Huliang DAI Lin WANG | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，9： | 0 |
| 13 | Utilization of nonlinear vibrations of soft pipe conveying fluid for driving underwater bio-inspired robot显示文摘Creatures with longer bodies in nature like snakes and eels moving in water commonly generate a large swaying of their bodies or tails,with the purpose of producing significant frictions and collisions between body and fluid to provide the power of consecutive forward force.This swaying can be idealized by considering oscillations of a soft beam immersed in water when waves of vibration travel down at a constant speed.The present study employs a kind of large deformations induced by nonlinear vibrations of a soft pipe conveying fluid to design an underwater bio-inspired snake robot that consists of a rigid head and a soft tail.When the head is fixed,experiments show that a second mode vibration of the tail in water occurs as the internal flow velocity is beyond a critical value.Then the corresponding theoretical model based on the absolute nodal coordinate formulation(ANCF)is established to describe nonlinear vibrations of the tail.As the head is free,the theoretical modeling is combined with the computational fluid dynamics(CFD)analysis to construct a fluid-structure interaction(FSI)simulation model.The swimming speed and swaying shape of the snake robot are obtained through the FSI simulation model.They are in good agreement with experimental results.Most importantly,it is demonstrated that the propulsion speed can be improved by 21%for the robot with vibrations of the tail compared with that without oscillations in the pure jet mode.This research provides a new thought to design driving devices by using nonlinear flow-induced vibrations. | Huliang DAI Yixiang HE Kun ZHOU Zerui PENG Lin WANG P.HAGEDORN | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，7： | 0 |
| 14 | Nonlinear dynamics of a circular curved cantilevered pipe conveying pulsating fluid based on the geometrically exact model显示文摘Due to the novel applications of flexible pipes conveying fluid in the field of soft robotics and biomedicine,the investigations on the mechanical responses of the pipes have attracted considerable attention.The fluid-structure interaction(FSI)between the pipe with a curved shape and the time-varying internal fluid flow brings a great challenge to the revelation of the dynamical behaviors of flexible pipes,especially when the pipe is highly flexible and usually undergoes large deformations.In this work,the geometrically exact model(GEM)for a curved cantilevered pipe conveying pulsating fluid is developed based on the extended Hamilton's principle.The stability of the curved pipe with three different subtended angles is examined with the consideration of steady fluid flow.Specific attention is concentrated on the large-deformation resonance of circular pipes conveying pulsating fluid,which is often encountered in practical engineering.By constructing bifurcation diagrams,oscillating shapes,phase portraits,time traces,and Poincarémaps,the dynamic responses of the curved pipe under various system parameters are revealed.The mean flow velocity of the pulsating fluid is chosen to be either subcritical or supercritical.The numerical results show that the curved pipe conveying pulsating fluid can exhibit rich dynamical behaviors,including periodic and quasi-periodic motions.It is also found that the preferred instability type of a cantilevered curved pipe conveying steady fluid is mainly in the flutter of the second mode.For a moderate value of the mass ratio,however,a third-mode flutter may occur,which is quite different from that of a straight pipe system. | Runqing CAO Zilong GUO Wei CHEN Huliang DAI Lin WANG | 2024 | Applied Mathematics and Mechanics(English Edition)2024，45，2： | 0 |
| 15 | The predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma:a summary of works in 10 years显示文摘Hepatocellular carcinoma(HCC)represents an extremely poor prognostic cancer,which is mainly due to the high frequency of metastasis/recurrence after surgical operation.Exploring the molecular mechanisms involved in HCC metastasis could be helpful in the pre-diction and early diagnosis of HCC recurrence and could also provide new therapeutic targets for HCC metastasis.In the recent decade,we analyzed the genomic aberrations of the clinical specimens,as well as the metastatic models and cell lines of human HCC to identify the genetic mar-kers related to HCC metastasis and to verify their clinical values in the prediction and control of metastasis of HCC.Using the comparative genomic hybridization(CGH)technique,we compared the differences of chromosomal aberrations between primary HCC tumors and their matched metastatic lesions,and found that chromosome 8p deletions might contribute to HCC metastasis.This novel finding was further confirmed by comparison between nude mice models of HCC with different meta-static potentials.By the more sensitive genome-wide microsatellite analysis,8p deletion was defined to 8p23.3 and 8p11.2,which are two likely regions harboring meta-stasis-related genes of HCC.Using‘8p-specific’microar-rays,two novel metastatic suppressors(HTPAP and MRSA)were identified,and were proven to suppress in vitro invasion and in vivo metastasis of HCC.Clinical studies indicate that 8p deletion detected in HCC or cir-culating plasma DNA of patients is a useful predictor for metastatic recurrence and prognosis,even for patients with early stage HCC.These novel findings are regarded as important advances in the study of the molecular mechanisms of HCC metastasis,which provide not only a holistic view on the molecular cytogenetic bases of HCC metastasis,but also candidate regions for further study to identify metastatic suppressor genes. | Lunxiu QIN Zhaoyou TANG Xinyuan GUAN Qinghai YE Huliang JIA Ning REN | 2008 | Frontiers of Medicine2008，2，3： | 0 |
| 16 | Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma显示文摘Cabozantinib,mainly targeting cMet and vascular endothelial growth factor receptor 2,is the second-line treatment for patients with advanced hepatocellular carcinoma(HCC).However,the lower response rate and resistance limit its enduring clinical benefit.In this study,we found that cMet-low HCC cells showed primary resistance to cMet inhibitors,and the combination of cabozantinib and mammalian target of rapamycin(mTOR)inhibitor,rapamycin,exhibited a synergistic inhibitory effect on the in vitro cell proliferation and in vivo tumor growth of these cells.Mechanically,the combination of rapamycin with cabozantinib resulted in the remarkable inhibition of AKT,extracellular signal-regulated protein kinases,mTOR,and common downstream signal molecules of receptor tyrosine kinases;decreased cyclin D1 expression;and induced cell cycle arrest.Meanwhile,rapamycin enhanced the inhibitory effects of cabozantinib on the migration and tubule formation of human umbilical vascular endothelial cells and human growth factor-induced invasion of cMet inhibitor-resistant HCC cells under hypoxia condition.These effects were further validated in xenograft models.In conclusion,our findings uncover a potential combination therapy of cabozantinib and rapamycin to combat cabozantinib-resistant HCC. | Chao Gao Shenghao Wang Weiqing Shao Yu Zhang Lu Lu Huliang Jia Kejin Zhu Jinhong Chen Qiongzhu Dong Ming Lu Wenwei Zhu Lunxiu Qin | 2022 | Frontiers of Medicine2022，16，3： | 0 |
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