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| 1 | Phosphorus oxoanion-intercalated layered double hydroxides for high-performance oxygen evolution显示文摘合理设计和为氧进化反应(OER ) 的有效、划算的电极的控制制造为探讨崭新的精力危机是批评的。有特定的夹层阴离子的镍铁分层的双氢氧化物(NiFe-LDHs )( 即磷酸盐,亚磷酸盐,和次磷酸盐) 被一个一起沉淀方法制作并且作为氧进化 electrocatalysts 调查了。磷 oxoanion 的置闰在一个碱的答案提高了 OER 活动;最佳的表演(即, 215 mV, 37.7 mV/dec 的一个小 Tafel 斜坡,和稳定的电气化学的行为的一个低发作潜力) 与设置次磷酸盐的 NiFe-LDH 催化剂被完成,在传统的设置碳酸盐的 NiFe-LDH 上的示威戏剧的改进以活动和耐久性。这提高的表演被归因于在设置的磷的 oxoanions 和分享边的瞬间 6 之间的相互作用(M = Ni, Fe ) 层,它修改表面 Ni 地点的电子结构。这个概念应该为更有效的基于 LDH 的氧进化 electrocatalysts 的设计是鼓舞人心的。 | Ma Luo Zhao Cai Cheng Wang Yongmin Bi Li Qian Yongchao Hao Li Li Yun Kuang Yaping Li Xiaodong Lei Ziyang HUO Wen Liu Hailiang Wang Xiaoming Sun Xue Duan | 2017 | Nano Research2017，10，5： | 12 |
| 2 | Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease显示文摘 | Yun-Dai CHEN Wei-Yi FANG Ji-Yan CHEN Zhan-Ming FAN Chuan-Yu GAO Jun-Bo GE Zuo-Xiang HE Yong HUO Lang LI Si-Jin LI Xi-Lie LU Bin LV Ju-Ying QIAN Ya-Jun SHI Zhu-Jun SHEN Jing WANG Yi-Ning WANG Lei XU Li YANG Bo YU Mei ZHANG Jun-Jie YANG Shu-Yang ZHANG Xiao-Li ZHANG Shi-Hua ZHAO Yang ZHENG Yu-Chi HAN Guang ZHI | 2018 | Journal of Geriatric Cardiology2018，15，1： | 10 |
| 3 | Properties of High Basicity Mold Fluxes for Peritectic Steel Slab Casting显示文摘In high speed continuous casting of peritectic steel slabs,mold fluxes with high basicity are required for less surface defect product.However,the basicity of remaining liquid slag film tends to decrease in casting process because of the crystallization of 3CaO·2SiO2·CaF2.Thus,a way is put forward to improve mold fluxes' properties by raising the original basicity.In order to confirm the possibility of this method,the effect of rising original basicity on the properties of mold fluxes is discussed.Properties of high fluorine based mold fluxes with different basicities and contents of CaF2,Na2O,and MgO were measured,respectively.Then,properties of higher basicity mold fluxes were discussed and compared with traditional ones.The results show that increasing the basicity index can improve the melting and flow property of mold fluxes.With the increasing basicity,crystallization rate of mold fluxes increases obviously and crystallization temperature tends to decrease when the basicity exceeds 1.35.The method presented before is proved as a potential way to resolve the contradiction between horizontal heat transfer controlling and solidified shell lubricating for peritectic steel slab casting.But further study on improving the flow property of liquid slag is needed.This work can be used to guide mold fluxes design for high speed continuous casting of peritectic steel slabs. | LONG Xiao HE Sheng-ping XU Jian-fei HUO Xu-ling WANG Qian | 2012 | Journal of Iron and Steel Research(International)2012，19，7： | 9 |
| 4 | Chemical characteristics of precipitation at Nanping Mangdang Mountain in eastern China during spring显示文摘To study the characteristics of precipitation in eastern China,an automatic sampler was used to collect rainwater samples from 19 precipitation events at Mangdang Mountain,Nanping City,Fujiang Province,in the spring of 2009.We used ion chromatography to analyze the ionic components and concentrations,and inductively coupled plasma mass spectrometry (ICP-MS) to analyze element compositions and contents.The results demonstrated remarkable acidic characteristics:in more than 80% of precipitation events the pH was less than 5.6,with an average of 4.81.Mass concentration results showed SO 4 2 was the main anionic component (36.2% of the total anion mass),while NH 4+ was the main cationic component (47.7% of the total cation mass) and main ion for acidity neutralization in the rainwater.Organic acid content accounted for 30.9% of total anion mass.The main trace metals were Ca,K,and Na.The SO 4 2/NO 3 ratio was 1.4,indicating that precipitation in this region was influenced by complex air pollution-the product of individual coal-burning combined with vehicle exhaust pollution.Correlation analysis of the chemical composition of the precipitation indicated that acidity in this region was determined by a combination of all acidic and neutralization ions rather than any single ion component.The results also showed that Na+ and Cl contributions were mainly by seawater;Mg 2+ by seawater and crustal materials;the NH 4+,K+,Ca 2+,NO 3 and SO 4 2 by anthropogenic sources;the trace metals were from the Earth's crust;and organic acids were potentially from combustion of biomass. | Yanli Cheng Ying Liu Mingqun Huo Qian Sun Huixiang Wang Zhongming Chen Yuhua Bai | 2011 | Journal of Environmental Sciences2011，23，8： | 8 |
| 5 | Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage显示文摘Hydrocephalus is often treated with a cerebrospinal fluid shunt(CFS) for excessive amounts of cerebrospinal fluid in the brain.However,it is very difficult to distinguish whether the ventricular enlargement is due to hydrocephalus or other causes,such as brain atrophy after brain damage and surgery.The non-trivial evaluation of the consciousness level,along with a continuous drainage test of the lumbar cistern is thus clinically important before the decision for CFS is made.We studied 32 secondary mild hydrocephalus patients with different consciousness levels,who received T1 and diffusion tensor imaging magnetic resonance scans before and after lumbar cerebrospinal fluid drainage.We applied a novel machine-learning method to find the most discriminative features from the multi-modal neuroimages.Then,we built a regression model to regress the JFK Coma Recovery Scale-Revised(CRS-R) scores to quantify the level of consciousness.The experimental results showed that our method not only approximated the CRS-R scores but also tracked the temporal changes in individual patients.The regression model has high potential for the evaluation of consciousness in clinical practice. | Jiayu Huo Zengxin Qi Sen Chen Qian Wang Xuehai Wu Di Zang Tanikawa Hiromi Jiaxing Tan Lichi Zhang Weijun Tang Dinggang Shen | 2020 | Neuroscience Bulletin2020，36，9： | 7 |
| 6 | Comparison of yield traits in rice among three mechanized planting methods in a rice-wheat rotation system显示文摘Understanding the differences in yield traits of rice among pothole seedling of mechanical transplanting(PSMT), carpet seedling of mechanical transplanting(CSMT) and mechanical direct seeding(MDS) is of great importance not only for rice scientists but also for rice farmers to develop a high-yield production system under mechanical conditions in a rice-wheat rotation system. However, such traits are yet to be studied among rice varieties of japonica-indica hybrid rice(JIHR), japonica conventional rice(JCR) and indica hybrid rice(IHR). Field experiments were conducted in 2014 and 2015, where six cultivars of the three rice types JIHR, JCR and IHR were grown individually with PSMT, CSMT and MDS methods, under respective managements for each method to achieve the maximum attainable yield. Results showed that(i) the PSMT significantly increased grain yield of JIHR by 22.0 and 7.1%, of JCR by 15.6 and 3.7% and of IHR by 22.5 and 7.4%, compared to MDS and CSMT on average across the two years, respectively. The highest yield was produced by the combination of JIHR and PSMT;(ii) high yield under PSMT was mainly attributed to large sink capacity and high-efficient dry matter accumulation. With sufficient panicles per hectare, the increase of spikelet number per panicle, especially the increase in spikelet number of the secondary rachis-branches was determined to be the optimal approach for developing a large sink capacity for rice under PSMT. The optimal tillers development, large leaf area index at heading stage, and high leaf area duration, crop growth rate and net assimilation rate during grain-filling phase could be the cause of sufficient dry matter accumulation for rice under PSMT;(iii) moreover, the PSMT favored plant growth as well as enriched the stems plus sheaths during grain-filling phase, as compared with CSMT and MDS. These results suggest that PSMT may be an alternative approach to increasing grain yield in a rice-wheat rotation system in the lower reaches of the Yangtze River in China. | XING Zhi-peng HU Ya-jie QIAN Hai-jun CAO Wei-wei GUO Bao-wei WEI Hai-yan XU Ke HUO Zhong-yang ZHOU Gui-sheng DAI Qi-gen ZHANG Hong-cheng | 2017 | Journal of Integrative Agriculture2017，16，7： | 6 |
| 7 | Microbial bioavailability of dissolved organic nitrogen(DON) in the sediments of Lake Shankou,Northeastern China显示文摘Dissolved organic nitrogen(DON)extracted from Lake Shankou sediments using KCl was isolated into hydrophobic and hydrophilic fractions.The bioavailabilities of the hydrophobic and hydrophilic fractions to three types of bacterial communities collected from sediments,activated sludge and compost products were examined.The DON recoveries obtained by DAX-8 and cation exchange resins treatment were 96.17% ± 1.58% and 98.14% ±0% for the samples obtained from N4 and N14 stations,respectively.After 25 days of incubation at 25°C,most DON(59% to 96%)was degraded.Hydrophilic DON exhibited a higher reduction rate than hydrophobic DON during the growth phase.Untreated wastewater from Changshuihe town was the main degradable DON source to station N4,and 93% of hydrophilic DON and 80% of hydrophobic DON were degraded.Station N14 received a large amount of refractory DON from forest soils and exhibited DON degradation rates of 82% and 71% for the hydrophilic and hydrophobic fractions,respectively.Amino acid contents and fluorescence intensities were also analyzed.Approximately 27% to 74% of amino acids were taken up by day 5,and their concentration gradually increased in the following days due to the decomposition of dissolved proteins.Parallel factor analysis resulted in identification of tryptophan-like proteins,tyrosine-like proteins and FA-like substances.During the growth phase,40%–51% of the tryptophan-like proteins were taken up by bacteria,and the accumulation of tyrosine-like proteins was attributed to the release of biotic substances.The concentration of the FA-like substances decreased due to microbial decomposition. | Mingzhou Su Jingtian Zhang Shouliang Huo Beidou Xi Fei Hua Fengyu Zan Guangren Qian Jianyong Liu | 2016 | Journal of Environmental Sciences2016，28，4： | 5 |
| 8 | Effect of side deep placement of nitrogen on yield and nitrogen use efficiency of single season late japonica rice显示文摘Side deep placement of nitrogen plays an important role in improving rice yield and nitrogen use efficiency.Few studies have examined the effects of reducing the times of nitrogen(RTN)application and reducing the nitrogen rate(RNR)of application on rice yield and nitrogen use efficiency under side deep placement of nitrogen in paddy fields.Therefore,a field experiment of RNT and RNR treatments was conducted with nine fertilization modes during the 2018–2019 rice growing seasons in a rice–wheat cropping system of the lower reaches of the Yangtze River,China.Rice yield and nitrogen use efficiency were investigated under side deep placement of nitrogen.We found that under the same nitrogen application rate,the yield of RTN3 increased by 9.64 and 10.18%in rice varieties NJ9108 and NJ5718,respectively,compared with the farmers’fertilizer practices(FFP).The nitrogen accumulation of RTN3 was the highest at heading stage,at 11.30 t ha^(–1)across 2018 and 2019.Under the same nitrogen application rate,the N agronomic use efficiency(NAE),N physiological efficiency(NPE)and N recovery efficiency(NRE)of RTN3 were 8.1–21.28%,8.51–41.76%and 0.28–14.52%higher than those of the other fertilization modes,respectively.RNR led to decreases in SPAD value,leaf area index(LAI),dry matter accumulation,nitrogen accumulation,and nitrogen use efficiency.These results suggest that RTN3 increased rice yield and nitrogen use efficiency under the side deep placement of nitrogen,and RNR1 could achieve the goals of saving cost and increasing resource use efficiency.Two fertilization modes RTN3 and RNR1 both could achieve the dual goals of increasing grain yield and resource use efficiency and thus are worth further application and investigation. | ZHAO Can HUANG Heng QIAN Zi-hui JIANG Heng-xin LIU Guang-ming XU Ke HU Ya-jie DAI Qigen HUO Zhong-yang | 2021 | Journal of Integrative Agriculture2021，20，6： | 5 |
| 9 | Association between serum uric acid and large-nerve fiber dysfunction in type 2 diabetes:a cross-sectional study显示文摘Background:Large-nerve fiber dysfunction,as assessed by vibration perception threshold (VPT) predicts risks of ulceration,amputation,and mortality in diabetes.Serum uric acid (UA) is closely associated with various metabolic disorders,especially diabetes.Thus,we sought to investigate the clinical relevance of UA to large-nerve fiber dysfunction,among patients with type 2 diabetes (T2D).Methods:Medical records of consecutive patients with T2D who were admitted to Beijing Friendship Hospital Pinggu Campus between May 2014 and December 2016 were collected.Data for the 824 eligible patients included in the final analysis were extracted using a structured form.A VPT value ≥15 in either foot was defined as abnormal.We compared the clinical characteristics between patients with abnormal VPT and those with normal VPT (VPT value <15 in both feet) in the overall population and in gender subgroups.Logistic regression analysis was performed to explore the association of abnormal VPT with UA level.One-way analysis of variance was used to compare VPT values across four UA quartiles.Results:UA levels were significantly lower in T2D patients with abnormal VPT than in those with normal VPT (294.5 ± 84.0 vs.314.9 ± 92.8 μmol/L,P<0.01),especially among male patients (311.7 ± 85.2 vs.336.9 ± 89.6 μmol/L,P<0.01).From the logistic regression analysis,hyperuricemia (males >420 μmol/L;females >360 μmol/L) was associated with a reduced risk of abnormal VPT (odds ratio [OR],0.60;95% confidence interval [CI],0.39–0.91;P<0.05).This association was robust in male patients (OR,0.43;95% CI,0.24–0.76;P<0.01) but not in female patients (OR,0.92;95% CI,0.47–1.82;P = 0.816),even after adjustment for confounding factors.For the younger male subgroup (age <65 years),VPT values decreased as the UA level increased (P for trend = 0.002),but this trend was not significant in older male subgroup (age ≥65 years;P for trend = 0.400).Conclusions:Low serum UA levels showed a significant association with an increased risk of large-nerve fiber dysfunction in male patients with T2D,but not in female patients with T2D.In addition,in only the younger subgroup of male patients (<65 years),lower levels of UA also correlated with higher VPT values. | Tian-Nan Jiang Yu-Feng Li Li-Li Huo Qian Zhang Lian-Ying Wang Cui-Ling Zhao Li-Ge Liu | 2019 | Chinese Medical Journal2019，，9： | 4 |
| 10 | DDX3X regulates cell survival and cell cycle during mouse early embryonic development显示文摘DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA transcription,RNA splicing,and mRNA transport,translation,and nucleo-cytoplasmic transport.It is highly expressed in metaphaseⅡ(MⅡ)oocytes and is the predominant DDX3 variant in the ovary and embryo.However,whether it is important in mouse early embryo development remains unknown.In this study,we investigated the function of DDX3X in early embryogenesis by cytoplasmic microinjection with its siRNA in zygotes or single blastomeres of 2-cell embryos.Our results showed that knockdown of Ddx3x in zygote cytoplasm led to dramatically diminished blastocyst formation,reduced cell numbers,and an increase in the number of apoptotic cells in blastocysts.Meanwhile,there was an accumulation of p53 in RNAi blastocysts.In addition,the ratio of cell cycle arrest during 2-cell to 4-cell transition increased following microinjection of Ddx3x siRNA into single blastomeres of 2-cell embryos compared with control.These results suggest that Ddx3x is an essential gene associated with cell survival and cell cycle control in mouse early embryos,and thus plays key roles in normal embryo development. | Qian Li Pan Zhang Chao Zhang Ying Wang Ru Wan Ye Yang Xuejiang Guo Ran Huo Min Lin Zuomin Zhou Jiahao Sha | 2014 | The Journal of Biomedical Research2014，28，4： | 4 |
| 11 | Modification of magnetic properties in SmCo films by controlling crystallization and phase transition显示文摘A series of Cr/SmCo/Cr films with high Sm concentration(37.7at%) were prepared by magnetron sputtering.Effects of SmCo thickness,annealing temperature,and annealing time on magnetic properties and crystal structure were carefully studied.Results show that crystallization degree and phase transition in the films can be controlled by the SmCo thickness and optimized by properly increasing the annealing temperature and extending the annealing time.Finally,a SmCo film with high magnetic properties and low MEI was constructed. | FENG Chun LINing LI Shuai HUO QianMing LI MingHua ZHAN Qian LI BaoHe JIANG Yong YU GuangHua | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，10： | 3 |
| 12 | Algal uptake of dissolved organic nitrogen in wastewater treatment plants显示文摘The algal uptake of dissolved organic nitrogen(DON) in the anaerobic–anoxic–oxic(A_2O)process was investigated in this study. Anaerobic, aerobic and effluent DON samples from two wastewater treatment plants(WWTPs) were separated into hydrophilic and hydrophobic fractions using a DAX-8 resin coupled with an anion exchange resin and a nanofiltration(NF)pretreatment. Hydrophilic DON accounted for 66.66%–88.74% of the entire DON for the two plants evaluated. After a 15-day incubation, 16.95%–91.75% DON was bioavailable for algal growth, and untreated samples exhibited higher DON bioavailability, with 52.83% DON average uptake rates, compared with the hydrophilic and hydrophobic fractions(45.53% and 44.40%, respectively) because the pretreatment caused the inorganic salt to be resistant to algae. Anaerobic untreated samples, hydrophilic fractions and hydrophobic fractions showed higher DON reduction rates and higher biomass accumulation compared with the other DON fractions due to the decomposition of resistant organics by anaerobic and anoxic bacteria.DON in aerobic and effluent samples of plant A was more bioavailable than that of plant B with usages of 27.49%–55.26% DON. DON bioavailability in the anaerobic–anoxic–oxic process decreased in the following order: anaerobic > effluent > aerobic. The DON contents were reduced after anaerobic treatment in the two plants. The EEM-PARAFAC model identified three DON components, including two humic acid-like substances and one protein-like substance in plant A and two protein-like substances and one humic acid-like substance in plant B. | Jingtian Zhang Mingzhou Su Beidou Xi Guangren Qian Jianyong Liu Fei Hua Shouliang Huo | 2016 | Journal of Environmental Sciences2016，28，12： | 3 |
| 13 | Effects of imidazolium-based ionic liquids on the isobaric vapor–liquid equilibria of methanol+dimethyl carbonate azeotropic systems显示文摘The separation of methanol(MeOH)and dimethyl carbonate(DMC)is important but difficult due to the formation of an azeotropic mixture.In this work,isobaric vapor–liquid equilibrium(VLE)data for the ternary systems containing different imidazolium–based ionic liquids(ILs),i.e.MeOH+DMC+1-butyl-3-methy-limidazolium bis[(trifluoromethyl)sulfonyl]imide([Bmim][Tf2N]),MeOH+DMC+1-ethyl-3-methyl-imidazolium bis[(trifluoromethyl)sulfonyl]imide([Emim][Tf2N]),and MeOH+DMC+1-ethyl-3-methylimidazolium hexafluorophosphate([Emim][PF6])were measured at 101.3 kPa.The mole fraction of IL was varied from0.05 to 0.20.The experimental data were correlated with the NRTL and Wilson equations,respectively.The results show that imidazolium-based ILs were beneficial to improve the relative volatility of MeOH to DMC,and[Bmim][Tf2 N]showed a much more excellent performance on the activity coefficient of MeOH.The interaction energies of system components were calculated using Gaussian program,and the effects of cation and anion on the separation coefficient of the azeotropic system were discussed. | Songsong Chen Li Dong Junping Zhang Weiguo Cheng Feng Huo Qian Su Wei Hua | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 3 |
| 14 | Design ofL-Cysteine Functionalized Au@SiO2@Fe3O4/Nitrogen-doped Graphene Nanocomposite and Its Application in Electrochemical Detection of Pb2+显示文摘 | NIE Jing HE Bin CHENG Yanmei YIN Wei HOU Changjun HUO Danqun QIAN Linlin QIN Yunan FA Huanbao | 2017 | Chemical Research in Chinese Universities2017，33，6： | 3 |
| 15 | Successful treatment with tocilizumab in a patient with rapidly progressive interstitial lung disease with positive anti-melanoma differentiation-associated gene-5 antibody显示文摘To the Editor:Anti-melanoma differentiation-associated gene 5(MDA-S)positive interstitial lung disease(ILD)is featured by rapidly progressing respiratory failure and limited hospital survival.No standard therapy has been established or proven to be beneficial.Herein,we report a case of a rapidly progressing patient diagnosed of ILD with positive anti-MDA-5 antibody receiving tocilizumab treatment. | Fei Teng Jin-Min Peng Qian Wang Xin-Lun Tian Zhen Huo Li Weng | 2021 | Chinese Medical Journal2021，，8： | 3 |
| 16 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 17 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
| 18 | Contribution of the Akt2 gene to type 2 diabetes in the Chinese Han population显示文摘背景 Akt2 蛋白质 kinase 被认为是胰岛素信号 transduction 进程的一个关键调停人。Akt2 被建议在合适的脂肪质的织物和小岛质量的葡萄糖新陈代谢和发展或维护起一个作用。为了决定 Akt2 基因是否在类型 2 糖尿病的致病起一个作用,并且如果在这基因的变化与类型 2 糖尿病有一种关系,进一步识别,由胰岛素抵抗描绘了,我们定序全部编码区域并且拼接 Akt2 的连接并且让进一步的盒子控制学习在我们选择了的中国汉 population.Methods 在这基因和类型 2 糖尿病探索在单个核苷酸的多型性( SNP )之间的协会有 typ 的 23 probands 所有参加者的身体团索引比他们的 28 kg/m2 和所有是胰岛素抵抗的的低(fasting 胰岛素水平 100 pmol/L 或 16 lU/ml ) 。全部编码区域并且拼接 Akt2 的连接直接在这 23 probands 被定序。有超过 20% 的次要的等位基因的频率的 SNP 被选择进一步在盒子控制研究被学习。我们作为 2 个糖尿病的病人作为盒子组织的控制组和 742 类型选了 743 为非糖尿病的题目。所有这些题目是 genotyped。一个快照技术平台(应用 Biosystems ) 被用于 genotyping.Results 从所有 23 个题目的 Akt2 基因成功地被定序。我们没在类型识别任何变化 2 糖尿病的家谱。二 SNP 被识别, 13010323TC 和 13007939GT。13010323TC 在 intron 9,它是在 Genbank 报导的 rs2304188 的地点。它的次要的等位基因频率是 13.04% 。13007939GT 在 exon 的 3'-untranslated 区域(UTR ) 14,它是在 Genbank 报导的 rs2304186 的地点。它的次要的等位基因频率是 34.78% 。rs2304188 和 rs2304186 的等位基因频率与频率在 Genbank 报导了一致。在与 742 个病人和 743 控制一起的盒子控制学习,为 rs2304186 的等位基因频率的二个组之间没有重要差别(奇怪的比率:0.96, 95% 信心间隔:0.82-1.12, P=0.597 ) Akt2 基因不是的 .Conclusions 在一张非肥胖的中国汉人口的糖尿病的一个主要原因由胰岛素抵抗描绘了。在 rs2304186 之间没有重要关系并且在中国汉人口打 2 糖尿病。 | SUN Xiu-qin LUO Ying-ying AN Ling-wang CHU Lin HUO Li-li HAN Xue-yao ZHOU Xiang-hai REN Qian JI Li-nong | 2011 | Chinese Medical Journal2011，，5： | 2 |
| 19 | Temperature and solar radiation utilization of rice for yield formation with different mechanized planting methods in the lower reaches of the Yangtze River,China显示文摘Several studies have demonstrated the effect of planting methods on rice yield, but information on the climate resources is limited. This study aims to reveal the effects of planting methods on climate resources associated with rice yield in a rice-wheat rotation system in the lower reaches of the Yangtze River, China. Field experiments were conducted in 2014 and 2015 with two japonica, two indica hybrid, and two japonica-indica hybrid varieties grown under three mechanized planting methods: carpet seedling of mechanical transplanting(CT), mechanical direct seeding(DS), and pot-hole seedling of mechanical transplanting(PT). The rice yield and total dry matter under PT were greater than those under CT and DS methods. Besides, the entire growth duration and daily production showed significant positive relations with rice yield. Compared with CT and DS, the effective accumulated temperature and cumulative solar radiation of rice under PT were higher in phenological phases. In addition, the dry matter/effective accumulated temperature and solar energy utilization of rice under CT and DS were higher during vegetative phase and lower during reproductive and grain filling phases in contrast to PT. The mean daily temperature and mean daily solar radiation in the entire growth duration showed significant positive correlation with rice yield, total dry matter, and harvest index. This study demonstrated that when the mean daily temperature is <25.1°C in vegetative phase and >20.1°C in grain filling phase, rice yield could be increased by selecting mechanized planting methods. Most varieties under PT method exhibited high yield and climate resources use efficiency compared with CT and DS. In conclusion, the PT method could be a better cultivation measure for high rice yield, accompanied with high temperature and solar radiation use efficiency in a rice-wheat rotation system in the lower reaches of the Yangtze River, China. | XING Zhi-peng WU Pei ZHU Ming QIAN Hai-jun HU Ya-jie GUO Bao-wei WEI Hai-yan XU Ke HUO Zhong-yang DAI Qi-gen ZHANG Hong-cheng | 2017 | Journal of Integrative Agriculture2017，16，9： | 2 |
| 20 | Rapid inactivation of multidrug-resistant bacteria and enhancement of osteoinduction via titania nanotubes grafted with polyguanidines显示文摘The rapid in situ inhibition of bacterial contamination and subsequent infection without inducing drug resistance is highly vital for the successful implantation and long-term service of titanium(Ti)-based orthopedic implants.However,the instability and potential cytotoxicity of current coatings have deterred their clinical practice.In this study,anodic oxidized titania nanotubes(TNT)were modified with antibacterial polyhexamethylene guanidine(PG)with the assistance of 3,4-dihydroxyphenylacetic acid.Interestingly,the prepared TNT-PG coating exhibited superior in vitro antibacterial activity than flat Ti-PG coating and effectively killed typical pathogens such as Escherichia coli and superbug methicillinresistant Staphylococcus aureus with above 4-log reduction(>99.99%killed)in only 5 min.TNT-PG coating also exerted excellent hemocompatibility with red blood cells and nontoxicity toward mouse pre-osteoblasts(MC3 T3-E1)in 1 week of coculture.In addition,the efficient in vivo anti-infective property of this coating was observed in a rat subcutaneous infection model.More importantly,TNT-PG coating improved the expression of alkaline phosphatase and enhanced the extracellular matrix mineralization of pre-osteoblasts,denoting its osteoinductive capacity.This versatile TNT-PG coating with excellent antibacterial activity and biocompatibility could be a promising candidate for advanced orthopedic implant applications. | Wei Feng Nian Liu Lingling Gao Qian Zhou Luofeng Yu Xiaoting Ye Jingjing Huo Xiao Huang Peng Li Wei Huang | 2021 | Journal of Materials Science & Technology2021，，10： | 2 |
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