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| 1 | Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes:current strategies and future perspectives显示文摘mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors. | Gantumur Battogtokh Yeon Su Choi Dong Seop Kang Sang Jun Park Min Suk Shim Kang Moo Huh Yong-Yeon Cho Joo Young Lee Hye Suk Lee Han Chang Kang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 17 |
| 2 | Protective effects of electroacupuncture on acetylsalicylic acid-induced acute gastritis in rats显示文摘AIM: To investigate the protective effects of electroacupuncture (EA) pretreatment on acetylsalicylic acid (ASA)-induced ulceration in rats. METHODS: We randomly divided 72 rats into three groups including control (administered with distilled water), ASA group (administered 100 mg/kg ASA) and EA group (administered EA + 100 mg/kg ASA). Each rat was fasted for 18 to 24 h before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured. RESULTS: The lesion scores of the EA group were significantly lower than those of the ASA group. Gastric acidity of the ASA and EA groups was reduced compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and ASA groups, and NO levels were also significantly increased in the EA group as compared to the ASA group. CONCLUSION: These results suggest that EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components. | Hye Suk Hwang Kyung-Ju Han Yeon Hee Ryu Eun Jin Yang Yoo Sung Kim Sang Yong Jeong Young-Seop Lee Myeong Soo Lee Sung Tae Koo Sun-Mi Choi | 2009 | World Journal of Gastroenterology2009，15，8： | 7 |
| 3 | Impact of Baseline Plaque Components on Plaque Progression in Nonintervened Coronary Segments in Patients With Angina Pectoris on Rosuvastatin 10 mg/day显示文摘 | Young Joon Hong Myung Ho Jeong Yun Ha Choi Eun Hye Ma Jum Suk Ko Min Goo Lee Keun Ho Park Doo Sun Sim Nam Sik Yoon Hyun Ju Youn Kye Hun Kim Hyung Wook Park Ju Han Kim Youngkeun Ahn Jeong Gwan Cho Jong Chun Park Jung Chaee Kang | 2010 | The American Journal of Cardiology2010，，9： | 1 |
| 4 | Hospital‐based influenza surveillance in Korea: Hospital‐based influenza morbidity and mortality study group显示文摘 | Joon Young Song Hee Jin Cheong Sung Hyuk Choi Ji Hyeon Baek Seung Baik Han Seong‐Heon Wie Byung Hak So Hyo Youl Kim Young Keun Kim Won Suk Choi Sung Woo Moon Jacob Lee Gu Hyun Kang Hye Won Jeong Jung Soo Park Woo Joo Kim | 2013 | J Med Virol2013，，5： | 1 |
| 5 | Induction of apoptosis by a stilbene analog involves bax translocation regulated by p38 MAPK and Akt显示文摘 | Kwang Sup So Ji Eun Oh Jee Hye Han Hong Keun Jung Young Suk Lee Sang Hee Kim Young Jin Chun Mie Young Kim | 2008 | Archives of Pharmacal Research2008，，4： | 1 |
| 6 | Combination of epithelial-mesenchymal transition and cancer stem cell–like phenotypes has independent prognostic value in gastric cancer显示文摘 | Han Suk Ryu Do Joong Park Hyung Ho Kim Woo Ho Kim Hye Seung Lee | 2012 | Human Pathology2012，，4： | 1 |
| 7 | Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer显示文摘 | Kyung-Hun Lee Hye Jung Chang Sae-Won Han Do-Youn Oh Seock-Ah Im Yung-Jue Bang Sun Young Kim Keun-Wook Lee Jee Hyun Kim Yong Sang Hong Tae Won Kim Young Suk Park Won Ki Kang Sang Joon Shin Joong Bae Ahn Gyeong Hoon Kang Seung-Yong Jeong Kyu Joo Park Jae-Ga | 2013 | Cancer Chemotherapy and Pharmacology2013，，4： | 1 |
| 8 | Downregulation of cell‐free miR‐198 as a diagnostic biomarker for lung adenocarcinoma‐associated malignant pleural effusion显示文摘 | Hye‐Suk Han Jieun Yun Sung‐nam Lim Joung‐Ho Han Ki Hyeong Lee Seung Taik Kim Min‐Ho Kang Seung‐Myoung Son Yong‐Moon Lee Song‐Yi Choi Seok Joong Yun Wun‐Jae Kim Ok‐Jun Lee | 2013 | Int. J. Cancer2013，，3： | 1 |
| 9 | Downregulation of cell‐free miR‐198 as a diagnostic biomarker for lung adenocarcinoma‐associated malignant pleural effusion显示文摘 | Hye‐Suk Han Jieun Yun Sung‐nam Lim Joung‐Ho Han Ki Hyeong Lee Seung Taik Kim Min‐Ho Kang Seung‐Myoung Son Yong‐Moon Lee Song‐Yi Choi Seok Joong Yun Wun‐Jae Kim Ok‐Jun Lee | 2013 | Int J Cancer2013，，3： | 1 |
| 10 | Long-term survival after gastrectomy and metastasectomy for gastric cancer with synchronous bone metastasis显示文摘Bone metastasis is a rare event in patients with gastric cancer, but pathologic fracture, paralysis, pain and hematological disorders associated with the bone metastasis may influence the quality of life. We report herein the case of a 53-year-old man who presented with primary remnant gastric cancer with bone metastasis. The patient requested further investigations after detection of a metastatic lesion in the 2 nd lumbar vertebra during evaluation for back pain that had persisted for 3 mo. No other metastatic lesions were detected. He underwent total gastrectomy and palliative metastasectomy to aid in reduction of symptoms, and he received combination chemotherapy with tegafur(S-1) and cisplatin. The patient survived for about 60 mo after surgery. Currently, there is no treatment guideline for gastric cancer with bone metastasis, and we believe that gastrectomy plus metastasectomy may be an effective therapeutic option for improving qualityof life and survival in patients with resectable primary gastric cancer and bone metastasis. | Young Jin Choi Dae Hoon Kim Hye Suk Han Joung-Ho Han Seung-Myoung Son Dong Soo Kim Hyo Yung Yun | 2018 | World Journal of Gastroenterology2018，24，1： | 0 |
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