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| 1 | Mitochondrial markers for the detection of four duck species and the specific identification of Muscovy duck in meat mixtures using the polymerase chain reaction显示文摘 | Irene Martín Teresa García Violeta Fajardo Inés López-Calleja María Rojas Pablo E. Hernández Isabel González Rosario Martín | 2007 | Meat Science2007，，4： | 2 |
| 2 | Re-engineering the toilet for sustainable wastewater management 显示文摘 | Tove A L Irene P Alfredo A | 2001 | ES&T2001，35，9： | 1 |
| 3 | Prevention of the selection of resistant staphylococcus aureus by moxifloxacin plus doxycycline in an in vitro dynamic model:andditive effect of the combination显示文摘 | ALEXANDER A F SERGEY N V IRENE Y L | 2004 | International Journal of Antimicrobial Agents2004，23，： | 1 |
| 4 | Perceptions of heatwave risks to health: interview-based study o:F older people in London and Norwich, UK显示文摘 | Vanessa A Johanna W Irene L | 2009 | Environmental Health Perspectives2009，117，： | 1 |
| 5 | Social capital, individual responses to heat waves and climate change adaptation: an empirical study of two UK cities显示文摘 | Johanna W Neil A Irene L | 2010 | Global Environmental Change2010，20，： | 1 |
| 6 | Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities显示文摘 | Rubio-Cabezas Oscar Minton Jayne A L Kantor Iren Williams Denise Ellard Sian Hattersley Andrew T | 2010 | Diabetes2010，，9： | 1 |
| 7 | Prevention of the selection of resistant Staphylococcus aureus by moxifloxacin plus doxycycline in an in vitro dynamic model : an additive effect of the combination 显示文摘 | Alexander A F Sergey N V Irene Y L | 2004 | International Journal of Antimicrobial Agents2004，23，5： | 1 |
| 8 | Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma: a glyco-proteomic approach 显示文摘 | IRENE L A TERENCE C W P | 2006 | J Proteome Res2006，，10： | 1 |
| 9 | Endogenous sex steroids and bone mineral density in healthy Greek postmenopausal women显示文摘 | Irene L George C Leon A | 2006 | J Bone Miner Metab2006，24，1： | 1 |
| 10 | Pedro Antioxidant effect of rosemary, borage, green tea, pu-erh tea and as- corbic acid on fresh pork sausages packaged in a modified atmosphere: influence of the presence of sodium chloride显示文摘 | Martinez L Irene B Jose A R | 2006 | Journal of the Science of Food and Agriculture2006，86，9： | 1 |
| 11 | Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment显示文摘BACKGROUND Antiviral treatment of patients with chronic hepatitis B(CHB)in the grey zone of treatment comands risk management in order to optimize the health outcome.In this sense,the identification of HBV mutants related with an increased risk of hepatocellular carcinoma(HCC)could be useful to identify subpopulations with potential indication of antiviral treatment.AIM To analyze the prevalence/persistence of hepatitis B virus(HBV)preS and basal core promoter(BCP)/precore/core variants associated to HCC development in CHB patients in the grey zone.METHODS Work was designed as a longitudinal retrospective study,including 106 plasma samples from 31 patients with CHB in the grey zone of treatment:Hepatitis B e antigen negative,HBV-DNA levels between 12-20000 IU/mL,normal or discordant transaminase levels during follow up and mild/moderate necroinflammatory activity in liver biopsy or Fibroscan(up to 9.5 kPa).Serum HBVDNA was tested using the Abbott Real Time HBV Assay and the BCP/precore/core and the hepatitis B surface antigen(HBsAg)coding regions were analyzed in positive samples by PCR/bulk-sequencing to identify the HCCrelated HBV mutants.RESULTS High-risk HCC related mutants were detected in 24(77%)patients:19(61%)in the BCP/precore/core,and 7(23%)in the HBsAg coding region(2 preS1 and 5 preS2 deletions).The prevalence of preS deletions was genotype-dependent:3/5(60%)patients with preS2 deletions and 1/2 with preS1 deletions were infected with the HBV-E genotype.Since HBV-E was the most prevalent in sub-Saharan patients,a correlation between preS deletions and ethnicity was also found:6/8(75%)sub-Saharan vs 1/19(5%)Caucasian patients had preS deletions(P=0.00016).Remarkably,this correlation was maintained in those patients infected with HBV-A,a minor genotype in sub-Saharan patients:2/2 patients infected with HBV-A from West Africa vs 0/6 of Caucasian origin had preS deletions.The HCC related variants were the major strains and persisted over time(up to 48 mo).Patients with preS deletions had a significant higher prevalence of F2 fibrosis stage than the negatives(57%vs 10%,P=0.0078).CONCLUSION HBV genetic analysis of selected populations,like sub-Saharans infected with HBV-E/A genotypes,will allow identification of subpopulations with risk of HCC development due to accumulation of high-risk HBV variants,thus commanding their increased clinical surveillance. | Ana Isabel Gil-García Antonio Madejón Irene Francisco-Recuero Ana López-López Emiliana Villafranca Miriam Romero Araceli García Antonio Olveira Rocío Mena Juan Ramón Larrubia Javier García-Samaniego | 2019 | World Journal of Gastroenterology2019，25，38： | 1 |
| 12 | Perceptions of heatwave risks to health : interview-based study of older people in London and Norwich, UK显示文摘 | Vanessa A Johanna W Irene L | 2008 | J Public Health2008，31，： | 1 |
| 13 | Social capital, individual responses to heat waves and cllmate change adaptation : an empirical study of two UK cities显示文摘 | Johanna W Neil A Irene L | 2010 | Global Environ Chang2010，20，： | 1 |
| 14 | Image analysis for the study of the development of anaerobic biofilms on materials characteristic of landfilled refuse 显示文摘 | Jones L R Irene A Watson C | 1997 | Water Science and Technology1997，36，67： | 1 |
| 15 | Induced pluripotent stem (iPS) cells: A new source for cell-based therapeutics?显示文摘 | Irene de Lázaro A?elya Yilmazer Kostas Kostarelos | 2014 | Journal of Controlled Release2014，，： | 1 |
| 16 | Increase in postprandial serum insulin levels in epileptic with valproic acid therapy显示文摘 | GERHARD L IRENE A FRIEDRICH H | 2002 | Metabolism2002，51，10： | 1 |
| 17 | The lipid treatment assessment project (L TAP) a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid lowering therapy and achieving low density lipoprotein cholesterol goals显示文摘 | THOMAS A P IRENE L HENRY C | 2000 | Arch Intern Med2000，160，4： | 1 |
| 18 | Impact of selected combinations of non-thermal processing technologies on the quality of an apple and cranberry juice blend 显示文摘 | IRENE M C FRANCESCO N ARANTXA M PAUL W DESMOND J M DENIS A C JAMES G L | 2011 | Food Chemistry2011，124，： | 1 |
| 19 | Effects on Escherichia coil inactivation and quality attributes in apple juice treated by combinations of pulsed light and thermosoni- cation显示文摘 | ARANTXA M IRENE M C IZABELA P GIANPIERO P FRANCESCO N DESMOND J M DENIS A C PAUL W GIOVANAN F JAMES G L | 2012 | Food Research International2012，45，： | 1 |
| 20 | Copper adsorption by inactivated cells of Mucor rouxii : effect of esterification of carboxyl groups显示文摘 | JORGE L G T IRENE C A ROBERT W | 1996 | Journal of Hazardous Materials1996，48，123： | 1 |
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